Browsing Institutt for klinisk medisin by Title

Now showing items 6001-6020 of 10711

  • Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions 
    Olsen, Maria Belland; Sannes, Ann-Christin; Yang, Kuan; Nielsen, Morten Birkeland; Einarsen, Ståle Valvatne; Christensen, Jan Olav; Pallesen, Ståle; Bjørås, Magnar; Gjerstad, Johannes (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Environmental stressors such as repeated social defeat may initiate powerful activation of subconscious parts of the brain. Here, we examine the consequences of such stress (induced by resident-intruder paradigm) on the ...
  • Mapping Schistosoma haematobium for Novel Interventions against Female Genital Schistosomiasis and Associated HIV Risk in KwaZulu-Natal, South Africa 
    Livingston, Mahala; Pillay, Pavitra; Zulu, Siphosenkosi Gift; Sandvik, Leiv; Kvalsvig, Jane D.; Gagai, S.; Galappaththi-Arachchige, Hashini Nilushika; Kleppa, Elisabeth; Ndhlovu, Patricia; Vennervald, Birgitte Jyding; Gundersen, Svein Gunnar; Taylor, Myra; Kjetland, Eyrun F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract. Women with female genital schistosomiasis (FGS) have been found to have genital symptoms and a three-fold higher risk of HIV infection. Despite WHO recommendations, regular antischistosomal mass drug administration ...
  • Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation 
    Lachota, Mieszko; Zielniok, Katarzyna; Palacios Orellana, Daniel Alfredo; Kanaya, Minoru; Peena, Leena; Hoel, Hanna Julie; Wiiger, Merete Thune; Kveberg, Lise; Hautz, Wojciech; Zagożdżon, Radosław; Malmberg, Karl-Johan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Natural killer (NK) cells have a unique capability of spontaneous cytotoxicity against malignant cells and hold promise for off-the-shelf cell therapy against cancer. One of the key challenges in the field ...
  • Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain 
    Holmgren, Asbjørn; Hansson, Lars; Bjerkaas-Kjeldal, Kristine; Impellizzeri, Agata Antonia Rita; Gilfillan, Gregor; Djurovic, Srdjan; Hughes, Timothy (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain ...
  • Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives 
    van der Meer, Dennis; Kaufmann, Tobias (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Cortical morphology is a key determinant of cognitive ability and mental health. Its development is a highly intricate process spanning decades, involving the coordinated, localized expression of thousands of ...
  • Mapping the human genetic architecture of COVID-19 
    Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...
  • Mapping, assessing and promoting multiple psychological senses of community (MPSOC) through clinical pathways for treating substance use problems 
    Bahl, Nina Kavita Heggen; Landheim, Anne; Nafstad, Hilde Eileen; Blakar, Rolv Mikkel; Brodahl, Morten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Aim: The recent nationally implemented clinical pathways for the treatment of substance use problems in Norway require mapping and assessing of patients’ needs, challenges, and resources. However, there is a lack of ...
  • Marfan Syndrome - A Diagnostic Challenge : aspects of a Norwegian cohort study 
    Rand-Hendriksen, Svend (Doctoral thesis / Doktoravhandling, 2010)
    Marfan syndrom (MFS) er en sjelden arvelig tilstand, som oftest skyldes feil i genet FBN1 som koder for bindevevsproteinet fibrillin 1. Ved et nasjonalt kompetansesenter for sju sjeldne diagnosegrupper (TRS), erfarte vi ...
  • Marfan syndrome in adults: re-investigations in a Norwegian cohort after 10 years 
    Vanem, Thy Thy (Doctoral thesis / Doktoravhandling, 2021)
    Marfan syndrome (MFS) is a heritable connective tissue disorder (HCTD), caused by mutations in the fibrillin-1 gene, FBN1. The syndrome can affect many organ systems, and is difficult to diagnose, due to overlapping features ...
  • Marfan syndrome: Evolving organ manifestations-A 10-year follow-up study. 
    Böker, Tordis; Vanem, Thy Thy; Lundby, Rigmor; Smith, Hans-Jørgen; Sandvik, Gunhild Falleth; Kirkhus, Eva Astrid; Andersen, Kai; Drolsum, Liv; Røe, Cecilie; Krohg-Sørensen, Kirsten; Geiran, Odd; Paus, Benedicte; Rand-Hendriksen, Svend (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The age‐dependent penetrance of organ manifestations in Marfan syndrome (MFS) is not known. The aims of this follow‐up study were to explore how clinical features change over a 10‐year period in the same Norwegian MFS ...
  • Marine n-3 fatty acid consumption in a Norwegian renal transplant cohort: Comparison of a food frequency questionnaire with plasma phospholipid marine n-3 levels 
    Chan, Wai Joe; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Schmidt, Erik B.; Eide, Ivar Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background High levels of plasma marine n-3 fatty acids (n-3FAs) are associated with improved patient and graft survival in renal transplant recipients (RTRs). The aim of this study was to evaluate the utility of a new ...
  • Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant 
    Aasebø, Willy; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Eide, Ivar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after ...
  • Marine n-3 Polyunsaturated Fatty Acids and Cellular Senescence Markers in Incident Kidney Transplant Recipients: The Omega-3 Fatty Acids in Renal Transplantation (ORENTRA) Randomized Clinical Trial 
    Chan, Joe; Eide, Ivar A.; Tannæs, Tone M.; Waldum-Grevbo, Bård; Jenssen, Trond; Svensson, My Hanna Sofia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Rationale & Objective Deterioration of kidney graft function is associated with accelerated cellular senescence. Marine n-3 polyunsaturated fatty acids (PUFAs) have favorable properties that may counteract cellular ...
  • Marine n-3 polyunsaturated fatty acids in renal transplantation 
    Eide, Ivar Anders (Doctoral thesis / Doktoravhandling, 2016)
    Background. Cardiovascular disease is the leading cause of death following renal transplantation. Marine n-3 polyunsaturated fatty acids (PUFAs) exert cardio-protective metabolic effects that may lower mortality risk after ...
  • Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in Norway 
    Skirbekk, Vegard Fykse; Bowen, Catherine E; Håberg, Asta; Jugessur, Astanand; Engdahl, Bo Lars; Bratsberg, Bernt Magne; Zotcheva, Ekaterina; Selbæk, Geir; Kohler, Hans-Peter; Weiss, Jordan; Harris, Jennifer Ruth; Tom, Sarah; Krokstad, Steinar; Stern, Yaakov; Strand, Bjørn Heine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Objectives: Earlier studies suggest that being married in later life protects against dementia, and that being single in old age increases the risk of dementia. In this study, we examine midlife marital status trajectories ...
  • Marital status and suicide risk: Temporal effect of marital breakdown and contextual difference by socioeconomic status 
    Næss, Erik Oftedahl; Mehlum, Lars; Qin, Ping (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Research has shown that people who have never been married, divorced, or widowed are at an increased risk of suicide compared with those who are married, but we have little knowledge as to how this elevated risk is modified ...
  • Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection 
    Lekva, Tove; Ueland, Thor; Halvorsen, Bente; Murphy, Sarah Louise Mikalsen; Dyrhol-Riise, Anne Ma; Tveita, Anders Aune; Finbråten, Ane-Kristine; Mathiessen, Alexander; Muller, Karl Erik; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; Lerum, Tøri Vigeland; Aukrust, Pål; Dahl, Tuva Børresdatter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19). However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have ...
  • Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin reseptor agonists 
    Garabet, Lamya Samir Noori; Henriksson, Carola; Lozano, Maria Luisa; Ghanima, Waleed Khalid; Bussel, James; Brodin, Ellen Elisabeth; Fernández-Pérez, Maria Piedad; Martinez, Constantino; Gónzález-Conejero, Rocío; Mowinckel, Marie-Christine; Sandset, Per Morten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Introduction Patients with immune thrombocytopenia (ITP) are at increased risk of thrombosis, which seems to be further enhanced by treatment with thrombopoietin-receptor-agonists (TPO-RAs). The underlying mechanisms of ...
  • Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases 
    Seim, Bjørn Edvard; Holt, Margrethe Flesvig; Ratajska, Aleksandra; Michelsen, Annika Elisabet; Ringseth, Monica Myklebust; Halvorsen, Bente; Skjelland, Mona; Kvitting, John-Peder; Lundblad, Runar; Krohg-Sørensen, Kirsten; Osnes, Liv T. N.; Aukrust, Pål; Paus, Benedicte; Ueland, Thor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background In approximately 20% of patients with thoracic aortic aneurysms or dissections a heritable thoracic aortic disease (HTAD) is suspected. Several monogenic connective tissue diseases imply high risk of aortic ...
  • Markers of hypercoagulability in CAD patients. Effects of single aspirin and clopidogrel treatment 
    Bratseth, Vibeke; Pettersen, Alf-Åge; Opstad, Trine B; Arnesen, Harald; Seljeflot, Ingebjørg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background Cardiovascular disease with disturbances in the haemostatic system, might lead to thrombotic complications with clinical manifestations like acute myocardial infarction (AMI) and stroke. Activation ...