Browsing Institutt for klinisk medisin by Issue Date
Now showing items 1-20 of 10716
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Background Activation of the extracellular signal-regulated kinases ERK1 and ERK2 in hepatocytes by prostaglandin (PG)F2α was recently found to be inhibited by pertussis toxin (PTX) suggesting a role for ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Treatment to prevent progression of heart failure has been targeted to reverse the consequences of heart failure and to a lesser extent the cause – the atherosclerotic plaque itself. Less than 50% of patients with heart ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Inflammatory cytokines may negatively influence contractility and contribute to the remodelling process in the failing myocardium. Traditional cardiovascular drugs appear to have little influence on the overall cytokine ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Backround Laparoscopic adrenalectomy is a promising alternative to open surgery although concerns exist in regard to laparoscopic treatment of pheocromocytoma. This report compares the outcome of laparoscopic ...
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(Doctoral thesis / Doktoravhandling, 2001)The efforts by the international genome sequencing projects have resulted in huge and exponentially growing databases of public DNA and protein sequence information. The complete genome sequence of many organisms has already ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Type-B T cells raised against the immunodominant peptide in hen egg lysozyme (HEL(48-62)) do not respond to whole lysozyme, and this has been thought to indicate that peptide can bind to I-A(k) in different conformations. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Mucosal surfaces are protected by polymeric immunoglobulins that are transported across the epithelium by the polymeric immunoglobulin receptor (pIgR). Only polymeric IgA and IgM containing a small polypeptide called the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background T7 based linear amplification of RNA is used to obtain sufficient antisense RNA for microarray expression profiling. We optimized and systematically evaluated the fidelity and reproducibility ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background A method to evaluate and analyze the massive data generated by series of microarray experiments is of utmost importance to reveal the hidden patterns of gene expression. Because of the complexity ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background The ability to react early to possible outbreaks of Escherichia coli O157:H7 and to trace possible sources relies on the availability of highly discriminatory and reliable techniques. The ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Introduction The expression of the oestrogen receptor (ER) is one of the more important clinical parameters of breast cancer. However, the relationship between the ER and its ligand, oestradiol, and the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background There are three major B-cell compartments in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of B-cells reside in these ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background RSV is recognized as the most important cause of serious lower respiratory tract illness in infants and young children worldwide leading to hospitalisation in a great number of cases, especially ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background High throughput gene expression data from spotted cDNA microarrays are collected by scanning the signal intensities of the corresponding spots by dedicated fluorescence scanners. The major scanner ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Checkpoint mechanisms prevent cell cycle transitions until previous events have been completed or damaged DNA has been repaired. In fission yeast, checkpoint mechanisms are known to regulate ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background The Lp(a) lipoprotein (Lp(a)) consists of the polymorphic glycoprotein apolipoprotein(a) (apo(a)), which is attached by a disulfide bond to apolipoprotein B (apoB). Apo(a), which has high homology ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Class 1 integrons contain genetic elements for site-specific recombination, capture and mobilization of resistance genes. Studies investigating the prevalence, distribution and types of integron ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Between November 2 and 10, 2002 several patients with psoriasis and personnel staying in the health centre in Gran Canaria, Spain fell ill with diarrhoea, vomiting or both. Patient original came ...