Browsing Institutt for klinisk medisin by Title
Now showing items 4041-4060 of 4583
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(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)Background Activated leukocytes may contribute to the development and progression of heart failure (HF). We investigated the predictive value of circulating levels of stable and readily detectable markers reflecting ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Type-B T cells raised against the immunodominant peptide in hen egg lysozyme (HEL(48-62)) do not respond to whole lysozyme, and this has been thought to indicate that peptide can bind to I-A(k) in different conformations. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defence mechanism. In this study, we ...
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(Doctoral thesis / Doktoravhandling, 2017)
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T2 weighted MRI and Histopathology as Markers for Response to Somatostatin Analogues in Acromegaly (Doctoral thesis / Doktoravhandling, 2016)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. To uncover these genomic events in an HPV infection, we have developed an innovative and cost-effective sequencing ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)Background: The tapering of methadone or buprenorphine during pregnancy is an understudied and controversial issue. The aim of this study was to determine to what extent women tapered their opioid medication dose during ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)The quantification of illicit drug and pharmaceutical residues in sewage has been shown to be a valuable tool that complements existing approaches in monitoring the patterns and trends of drug use. The present work delineates ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background & Aims Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background Therapeutic idiotypic (Id) vaccination is an experimental treatment for selected B cell malignancies. A broader use of Id-based vaccination, however, is hampered by the complexity and costs due ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Background: Idiotypes (Id) are antigenic determinants localized in variable (V) regions of Ig. Id-specific T and B cells (antibodies) play a role in immunotherapy of Id+ tumors. However, vaccine strategies that enhance ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Hereditary ataxia and spastic paraplegia are heterogeneous monogenic neurodegenerative disorders. To date, a large number of individuals with such disorders remain undiagnosed. Here, we have assessed molecular diagnosis ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)Objective To determine the effectiveness of the Targeted Interdisciplinary Model for Evaluation and Treatment of Neuropsychiatric Symptoms (TIME) for treatment of moderate to severe agitation in people with dementia. Methods ...
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(Doctoral thesis / Doktoravhandling, 2017)
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)Receptor tyrosine kinase AXL is found upregulated in various types of cancer, including melanoma, and correlates with an aggressive cancer phenotype, inducing cell proliferation and epithelial-to-mesenchymal transition. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Purpose The aim of this study was to explore the β-emitting lutetium-177 labelled anti-CD37 antibody NNV003 (177Lu-NNV003, Humalutin®) for the treatment of non-Hodgkin’s lymphoma in in vitro studies and in animal ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the ...
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(Doctoral thesis / Doktoravhandling, 2017)The complement system is part of the immediate innate immune response to pending danger. However, uncontrolled activation contributes to the pathophysiology of many human diseases. Complement inhibitory therapy is approved ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Efficient influenza vaccination of pigs can reduce disease burdens for the swine industry, but also represents an important measure for reducing the risk from novel viral reassortments that pose pandemic threats to the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Monoclonal antibodies (mAbs) are valuable as research reagents, in diagnosis and in therapy. Their high specificity, the ease in production, favorable biophysical properties and the opportunity to engineer different ...