Browsing Institutt for klinisk medisin by Title
Now showing items 717-736 of 7899
-
B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)The B cell receptor (BCR) is a master regulator of B cells, controlling cellular processes such as proliferation, migration and survival. Cell signalling downstream of the BCR is aberrantly activated in the B cell malignancy ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac ...
-
(Doctoral thesis / Doktoravhandling, 2020)The role of B cells in pathophysiology of multiple sclerosis has been of great interest to wide array of researchers after the introduction of B cell depleting therapies demonstrated significant effects on central nervous ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)Background B cells may contribute to the immunopathogenesis of multiple sclerosis (MS). Dimethyl fumarate (DMF) has recently been shown to reduce the frequency of memory B cells in blood, but it is not known whether the ...
-
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)Background Natriuretic peptides are substrates of neprilysin; hence, B-type natriuretic peptide (BNP) concentrations rise with neprilysin inhibition. Thus, the clinical validity of measuring BNP in sacubitril/valsartan-treated ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Abstract Background Concentrations of B-type natriuretic peptide (BNP) reflect myocardial distension and stress, and are associated with poor prognosis in patients with cardiovascular ...
-
B-type natriuretic peptide trumps other prognostic markers in patients assessed for coronary disease (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background: Risk prediction for patients with suspected coronary artery disease is complex due to the common occurrence of prior cardiovascular disease and extensive risk modification in primary care. Numerous markers have ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background We have previously reported overexpression of the immunoregulatory protein B7-H3 in colorectal cancer and that nuclear expression predicted poor outcome in colon cancer patients. The present study ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)B7-H3, a member of the B7 family of immunoregulatory proteins, is overexpressed in cancer and promotes tumor growth, metastasis, and drug resistance. We discuss here the involvement of B7-H3 in cancer that goes beyond its ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background: Several studies have reported an association between chronic periodontitis (CP) and cardiovascular diseases. Detection of periodontopathogens, including red complex bacteria (RCB), in vascular lesions has ...
-
BAFF predicts immunogenicity in older patients with rheumatoid arthritis treated with TNF inhibitors (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Immunogenicity related to treatment with TNF inhibitors (TNFi) is one of the causes for the decreased attainment of clinical response in patients with rheumatoid arthritis (RA). The B-cell activating factor (BAFF) may be ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)BACKGROUND: Two-thirds of patients with stroke experience only mild impairments in the acute phase, and the proportion of patients <70 years is increasing. Knowledge about balance and gait and predictive factors are scarce ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)Balloon Eustachian tuboplasty (BET) aims to improve the function of the Eustachian tube (ET). The objective of this study was to review the longterm outcome of BET and present the process and results of outlining indications ...
-
(Doctoral thesis / Doktoravhandling, 2018)Treatment seeking patients with severe obesity might choose between specialized medical treatment and surgical treatment. Knowledge of what distinguishes patients that choose either treatment is sparse, with greater ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)Background: Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Et økende antall barn og unge kontakter Røde Kors sitt nettsamtaletilbud «Kors på halsen», for å snakke om selvmordstanker. Gjennom analyse av 200 chat-samtaler med Kors på halsen fra barn og unge mellom 11 og 20 år, har ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background Clinical research in severely ill or injured patients is required to improve healthcare but may be challenging to perform in practice. The aim of this study was to analyse barriers and challenges in the process ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background The uptake of family involvement in health care services for patients with psychotic disorders is poor, despite a clear evidence base, socio-economic and moral justifications, policy, and guideline ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Diabetes in pregnancy contributes to maternal mortality and morbidity though it receives little attention in developing countries. The purpose of the study was to explore the barriers to adherence and possible solutions ...