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Small Incisions, Big Benefits? A Randomized Controlled Trial Comparing Laparoscopic and Open Nissen Fundoplication in Children 
Fyhn, Thomas Johan (Doctoral thesis / Doktoravhandling, 2022)
Since its introduction in the 1990s, laparoscopic fundoplication has gradually replaced open fundoplication as the gold standard for surgical treatment of gastroesophageal reflux disease in children. Despite its widespread ...
Compliance with recommended cancer patient pathway timeframes and choice of treatment differed by cancer type and place of residence among cancer patients in Norway in 2015–2016 
Nilssen, Yngvar; Brustugun, Odd T.; Eriksen, Morten T.; Guren, Marianne G.; Haug, Erik S.; Naume, Bjørn; Schlichting, Ellen; Møller, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Cancer patient pathways (CPPs) were implemented in Norway to reduce unnecessary waiting times, regional variations, and to increase the predictability of cancer care for the patients. This study ...
HIV-infected immunological nonresponders: a characterization of gut immunity and the effects of a probiotic supplement 
Meyer-Myklestad, Malin Holm (Doctoral thesis / Doktoravhandling, 2022)
Worldwide today, 38 million people live with HIV and in 2020 700.000 died of HIV related disease. HIV infects CD4 T cells and causes a gradual decline in these cells. Antiretroviral treatment (ART) will in most people ...
Engaging with EPIO, a digital pain self-management program: a qualitative study 
Bostrøm, Katrine; Varsi, Cecilie; Eide, Hilde; Børøsund, Elin; Kristjansdottir, Ólöf B.; Schreurs, Karlein M. G.; Waxenberg, Lori B.; Weiss, Karen E.; Morrison, Eleshia J.; Nordang, Elise F.; Stubhaug, Audun; Nes, Lise S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Chronic pain conditions entail significant personal and societal burdens and improved outreach of evidence-based pain self-management programs are needed. Digital cognitive-behavioral self-management ...
Substance abuse, clinical characteristics and mortality in a mixed intensive care population in Oslo: a one-year cross sectional study 
Tollisen, Karen S. Hunting (Doctoral thesis / Doktoravhandling, 2022)
Alcohol and drug abuse is associated with a variety of medical conditions in intensive care (ICU) patients. However, although substance abuse represents a potentially modifiable risk factor for critical illness, the scope ...
Age at menopause: Associated factors and temporal trends 
Gottschalk, Marthe Sørli (Doctoral thesis / Doktoravhandling, 2022)
The timing of menopause influences the length of the period when reproduction is possible, and also the risk of disease and early death. The aims of the thesis were to study if age at natural menopause has changed over ...
Connective tissue disorders and cardiac fibrosis: Genetic substrate and roles of ADAMTSL2 and ADAMTSL3 in the failing heart 
Rypdal, Karoline Bjarnesdatter (Doctoral thesis / Doktoravhandling, 2022)
Genetic variants in connective tissue proteins can cause heritable disorders, often affecting the cardiovascular system, and heart failure is a frequent cause of death in these patients. In the present work, Rypdal and ...
Effects of treatment with lower extremity intermittent negative pressure for peripheral artery disease 
Hoel, Henrik (Doctoral thesis / Doktoravhandling, 2022)
In peripheral artery disease (PAD), arterial blood flow to the extremities is impeded. Exposure of the extremity to cyclic pressure changes increases the macro- and micro circulation. This has recently become a treatment ...
One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study 
Uhlig, Till; Karoliussen, Lars F.; Sexton, Joe; Kvien, Tore K.; Haavardsholm, Espen A.; Perez-Ruiz, Fernando; Hammer, Hilde B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objectives To explore the frequency and predictors of flares over 2 years during a treat-to-target strategy with urate-lowering therapy (ULT) in patients with gout. ...
Experiences of shared decision making among patients with psychotic disorders in Norway: a qualitative study 
Haugom, Espen W.; Stensrud, Bjørn; Beston, Gro; Ruud, Torleif; Landheim, Anne S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Shared decision making (SDM) is a process where the patient and the health professional collaborate to make decisions based on both the patient’s preferences and the best available evidence. ...
Stroke unit demand in Norway – present and future estimates 
Dahl, Fredrik A.; Barra, Mathias; Faiz, Kashif W.; Ihle-Hansen, Hege; Næss, Halvor; Rand, Kim; Rønning, Ole M.; Simonsen, Tone B.; Thommessen, Bente; Labberton, Angela S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background All stroke patients should receive timely admission to a stroke unit (SU). Consequently, most patients with suspected strokes – including stroke mimics (SM) are admitted. The aim of this study ...
Improvements in Hypertension Care: Serum drug measurements to detect non-adherence to standard treatment and effects of renal denervation following directly observed therapy 
Bergland, Ola Undrum (Doctoral thesis / Doktoravhandling, 2022)
As many as 40% of hypertensive patients are unable to reach their blood pressure target despite treatment with antihypertensive drugs. Over the last years, medication non-adherence have emerged as one of the most important ...
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers 
Lemma, Roza B.; Fleischer, Thomas; Martinsen, Emily; Ledsaak, Marit; Kristensen, Vessela; Eskeland, Ragnhild; Gabrielsen, Odd S.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methylation patterns have recurrently been linked to dysregulation of the regulatory program in cancer ...
Emergency response team to critically ill medical patients in the Emergency Department: Evaluation of patient characteristics, calling criteria and effect 
Engebretsen, Stine (Doctoral thesis / Doktoravhandling, 2022)
Critically ill and injured patients need lifesaving measures immediately. Emergency response teams are therefore commonly used to manage these patients in the emergency department (ED). There are few reports on the use ...
Targeted Interdisciplinary Model for Evaluation and Treatment of Neuropsychiatric Symptoms (TIME) in home care services: a cluster randomized feasibility trial 
Hoel, Kari-Anne; Lichtwarck, Bjørn; Væringstad, Anette; Feiring, Ingvild H.; Rokstad, Anne M. M.; Selbæk, Geir; Benth, Jūratė Š.; Bergh, Sverre (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Behavioral and psychological symptoms of dementia (BPSD) occur frequently in people with dementia and can contribute to an increased need for help and a reduced quality of life, but also predict ...
Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial 
Berge, Jarle; Hjelmesæth, Jøran; Kolotkin, Ronette L.; Støren, Øyvind; Bratland-Sanda, Solfrid; Hertel, Jens K.; Gjevestad, Espen; Småstuen, Milada C.; Helgerud, Jan; Bernklev, Tomm (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Aerobic exercise is an important part of obesity treatment and may improve health-related quality of life (HRQOL). The objective of this study was to compare the effect of two different exercise ...
Diagnosis of Chronic Fatigue Syndrome in Adolescents 
Asprusten, Tarjei Tørre (Doctoral thesis / Doktoravhandling, 2022)
Diagnostic labels as Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME) and Systemic Exertion Intolerance Disease (SEID) represent different approaches to the enigmatic phenomenon of long-lasting unexplained ...
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 
Helland, Åslaug; Russnes, Hege G.; Fagereng, Gro L.; Al-Shibli, Khalid; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil; Bjerkehagen, Bodil; Brabrand, Sigmund; Cameron, Marte G.; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn T.; Grønberg, Bjørn H.; Grønås, Kari; Guren, Tormod; Hamre, Hanne; Haug, Åse; Heinrich, Daniel; Hjortland, Geir O.; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A.; von der Lippe Gythfeldt, Hedda; Lothe, Ragnhild; Lund, Jo-Åsmund; Meza-Zepeda, Leonardo; Munthe-Kaas, Monica C.; Nguyen, Olav T. D.; Niehusmann, Pitt; NilsenPuco, Hilde K.; Ree, Anne H.; Riste, Tonje B.; Semb, Karin; Steinskog, Eli S. S.; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind; Tjønnfjord, Geir E.; Vassbotn, Liv J.; Aas, Eline; Aasebø, Kristine; Tasken, Kjetil; Smeland, Sigbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old ...
Therapeutic drug monitoring of tumour necrosis factor alpha inhibitors in inflammatory joint diseases 
Gehin, Johanna Elin (Doctoral thesis / Doktoravhandling, 2022)
Antibody-based biopharmaceuticals have revolutionised treatment of inflammatory joint diseases in the last two decades. However, a considerable proportion of patients fail to achieve, or lose response. Individualised dosing ...
Sleep and energy drink consumption among Norwegian adolescents – a cross-sectional study 
Kaldenbach, Siri; Leonhardt, Marja; Lien, Lars; Bjærtnes, Asborg A.; Strand, Tor A.; Holten-Andersen, Mads N. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Adolescents are recommended to get 8–10 h of sleep at night, yet more than 80% fail to obtain this goal. Energy drink (ED) consumption has been linked to later bedtime in adolescents. Therefore, ...
Epidemiology of traumatic cervical spinal fractures in a general Norwegian population 
Utheim, Nils C.; Helseth, Eirik; Stroem, Mona; Rydning, Paal; Mejlænder-Evjensvold, Magnus; Glott, Thomas; Hoestmaelingen, Christina T.; Aarhus, Mads; Roenning, Paal A.; Linnerud, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background In Western countries, the typical cervical spine fracture (CS-Fx) patient has historically been a young male injured in a road traffic accident. Recent reports and daily clinical practice clearly ...
Gene expression of fibrinolytic markers in coronary thrombi 
Nordeng, Jostein; Solheim, Svein; Åkra, Sissel; Schandiz, Hossein; Hoffmann, Pavel; Roald, Borghild; Bendz, Bjørn; Arnesen, Harald; Helseth, Ragnhild; Seljeflot, Ingebjørg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background The fibrinolytic system plays an important role in coronary artery atherothrombosis, and especially circulating plasminogen-activator inhibitor (PAI) type 1 (PAI-1) associates with increased ...
Measuring and Understanding Maternal Mortality in Georgia 
Berdzuli, Nino (Doctoral thesis / Doktoravhandling, 2022)
Understanding the level and causes of maternal death is a key for averting preventable death. Most of the major causes of maternal deaths can be prevented or treated with effective and timely clinical interventions, however, ...
Association between statin use and physical performance in home-dwelling older patients receiving polypharmacy: cross-sectional study 
Veddeng, Sigbjørn; Madland, Håkon; Molden, Espen; Wyller, Torgeir B.; Romskaug, Rita (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background In older patients with polypharmacy and multiple comorbidities, even low grades of statin-associated muscle symptoms may have clinical implications. The aim of this study was therefore to ...
Hospital physicians’ experiences and reflections on their work and role in relation to older patients’ pathways - a qualitative study in two Norwegian hospitals 
Leonardsen, Ann-Chatrin L.; Werner, Anne; Lurås, Hilde; Johannessen, Anne-Kari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Older patients are the most frequent users of initial hospital admissions and readmissions. Both hospital admission and discharge require communication and coordination between healthcare ...
Performance of two screening tests and barriers to colorectal cancer screening 
Schult, Anna Lisa (Doctoral thesis / Doktoravhandling, 2022)
Colorectal cancer (CRC) is a major health burden. Screening can reduce both incidence and mortality of CRC. Endoscopic screening with sigmoidoscopy or colonoscopy and testing for occult blood in stool are the most frequently ...
Right Colectomy with Extended D3- Mesenterectomy: What can we say about the extent and the consequences of the injury to the superior mesenteric plexus? 
Thorsen, Yngve (Doctoral thesis / Doktoravhandling, 2022)
The extended D3-mesenterectomy during right colectomy for cancer aims for improved cancer survival by removing the draining lymph nodes around the superior mesenteric vessels. The procedure, however, causes an injury to a ...
Colorectal cancer in Ulcerative Colitis: A prospective study of clinical and biological markers in population based cohorts 
Klepp, Pasquale (Doctoral thesis / Doktoravhandling, 2022)
A significant number of IBD patients still develop colitis associated colorectal cancer (CACRC). Guidelines, therefore, recommend colonoscopic surveillance at intervals based on a patient´s individual risk determined by ...
Prednisolone and prednisone pharmacokinetics in renal transplant recipients 
Skauby, Ragnhild Kristine Heier (Doctoral thesis / Doktoravhandling, 2022)
The main findings of this study was the large variability in prednisolone and prednisone plasma concentrations between patients, even after adjusting for dose and bodyweight. Glucocorticoids remain cornerstones in ...
Application of drug sensitivity screening in B-cell malignancies for informing precision medicine strategies 
Giliberto, Mariaserena (Doctoral thesis / Doktoravhandling, 2022)
Cancer is still in many cases an incurable disease in urgent need for effective therapies and personalized treatment protocols. The work in this Thesis presents a drug sensitivity screening approach to test a number of ...
Accessibility and interventions of crisis resolution teams: a multicenter study of team practices and team differences in Norway 
Ruud, Torleif; Holgersen, Katrine H.; Hasselberg, Nina; Siqveland, Johan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Components of crisis resolution teams’ (CRTs) practices have been defined in recommendations and a fidelity scale, and surveys have reported how team leaders describe CRT practices. However, ...
Advancements in Total Hip Arthroplasty: - polyethylene, articulation and factors associated with dislocation 
Thoen, Peder Svenkerud (Doctoral thesis / Doktoravhandling, 2022)
Total hip arthroplasty (THA) is one of the most successful treatments offered within the field of orthopedic surgery. There is considerable patient satisfaction, pain reduction and increased activity level for patients ...
“Psychometric properties of the Norwegian foot function index revised short form” 
Mørk, Marianne; Hoksrud, Aasne F.; Soberg, Helene L.; Zucknick, Manuela; Heide, Marte; Groven, Karen S.; Røe, Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Foot disorders affect up to one quarter of the adult population. Plantar fasciopathy is a common cause of foot pain associated with decreased activity level and quality of life. Patient-reported ...
Breast cancer risks associated with missense variants in breast cancer susceptibility genes 
Dorling, Leila; Carvalho, Sara; Allen, Jamie; Parsons, Michael T.; Fortuno, Cristina; González-Neira, Anna; Heijl, Stephan M.; Adank, Muriel A.; Ahearn, Thomas U.; Andrulis, Irene L.; Auvinen, Päivi; Becher, Heiko; Beckmann, Matthias W.; Behrens, Sabine; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Bremer, Michael; Briceno, Ignacio; Camp, Nicola J.; Campbell, Archie; Castelao, Jose E.; Chang-Claude, Jenny; Chanock, Stephen J.; Chenevix-Trench, Georgia; Collée, J. M.; Czene, Kamila; Dennis, Joe; Dörk, Thilo; Eriksson, Mikael; Evans, D. G.; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; Gabrielson, Marike; Gago-Dominguez, Manuela; García-Closas, Montserrat; Giles, Graham G.; Glendon, Gord; Guénel, Pascal; Gündert, Melanie; Hadjisavvas, Andreas; Hahnen, Eric; Hall, Per; Hamann, Ute; Harkness, Elaine F.; Hartman, Mikael; Hogervorst, Frans B. L.; Hollestelle, Antoinette; Hoppe, Reiner; Howell, Anthony; Jakubowska, Anna; Jung, Audrey; Khusnutdinova, Elza; Kim, Sung-Won; Ko, Yon-Dschun; Kristensen, Vessela N.; Lakeman, Inge M. M.; Li, Jingmei; Lindblom, Annika; Loizidou, Maria A.; Lophatananon, Artitaya; Lubiński, Jan; Luccarini, Craig; Madsen, Michael J.; Mannermaa, Arto; Manoochehri, Mehdi; Margolin, Sara; Mavroudis, Dimitrios; Milne, Roger L.; Mohd Taib, Nur A.; Muir, Kenneth; Nevanlinna, Heli; Newman, William G.; Oosterwijk, Jan C.; Park, Sue K.; Peterlongo, Paolo; Radice, Paolo; Saloustros, Emmanouil; Sawyer, Elinor J.; Schmutzler, Rita K.; Shah, Mitul; Sim, Xueling; Southey, Melissa C.; Surowy, Harald; Suvanto, Maija; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; van Asperen, Christi J.; Waltes, Regina; Wang, Qin; Yang, Xiaohong R.; Pharoah, Paul D. P.; Schmidt, Marjanka K.; Benitez, Javier; Vroling, Bas; Dunning, Alison M.; Teo, Soo H.; Kvist, Anders; de la Hoya, Miguel; Devilee, Peter; Spurdle, Amanda B.; Vreeswijk, Maaike P. G.; Easton, Douglas F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk, but risks associated with missense variants in these genes are uncertain. ...
Suicidal ideation in patients with mental illness and concurrent substance use: analyses of national census data in Norway 
Andersson, Helle W.; Lilleeng, Solfrid E.; Ruud, Torleif; Ose, Solveig O. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Suicidal ideation may signal potential risk for future suicidal behaviors and death. We examined the prevalence of recent suicidal ideation in patients with mental illness and concurrent substance ...
Is age of self-harm onset associated with increased frequency of non-suicidal self-injury and suicide attempts in adolescent outpatients? 
Brager-Larsen, Anne; Zeiner, Pål; Klungsøyr, Ole; Mehlum, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Self-harm in adolescents is an increasing public health concern and an important risk factor for suicide. We aimed to examine how age of self-harm onset in adolescents was associated with frequency ...
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping 
Belloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent; Ahmad, Shahzad; Ikram, M. A.; Ramirez, Alfredo; Tsolaki, Anthoula C.; Rossi, Giacomina; Jansen, Iris E.; de Rojas, Itziar; Parveen, Kayenat; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Amin, Najaf; Andreassen, Ole; Sánchez-Juan, Pascual; Kehoe, Patrick; Amouyel, Philippe; Sims, Rebecca; Frikke-Schmidt, Ruth; van der Flier, Wiesje M.; Lambert, Jean-Charles; He, Zihuai; Han, Summer S.; Napolioni, Valerio; Greicius, Michael D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly ...
Patients’ and relatives’ perspectives on best possible care in the context of developing a multidisciplinary center for endometriosis and adenomyosis: findings from a national survey 
Omtvedt, Marianne; Bean, Elisabeth; Hald, Kirsten; Larby, Elisabeth R.; Majak, Guri B.; Tellum, Tina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Endometriosis and adenomyosis are common benign conditions compromising both physical and psychological health, with a negative impact on quality of life. This survey aimed to establish what the ...
Exploring drug cost and disease outcome in rheumatoid arthritis patients treated with biologic and targeted synthetic DMARDs in Norway in 2010–2019 – a country with a national tender system for prescription of costly drugs 
Brkic, Alen; Diamantopoulos, Andreas P.; Haavardsholm, Espen A.; Fevang, Bjørg T. S.; Brekke, Lene K.; Loli, Liz; Zettel, Camilla; Rødevand, Erik; Bakland, Gunnstein; Mielnik, Pawel; Haugeberg, Glenn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background In Norway, an annual tender system for the prescription of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) has been used since 2007. This study aimed to explore ...
Clinical outcomes and their Determinants in Fibrotic Interstitial Lung Disease 
Durheim, Michael (Doctoral thesis / Doktoravhandling, 2022)
Idiopathic pulmonary fibrosis (IPF) and other fibrotic interstitial lung diseases (ILDs) are associated with substantial mortality, symptoms, and impairment in health-related quality of life (HRQL). Questions remain about ...
Assessment of preoperative axillary nodal disease burden: breast MRI in locally advanced breast cancer before, during and after neoadjuvant endocrine therapy 
Reis, Joana; Boavida, Joao; Tran, Hang T.; Lyngra, Marianne; Reitsma, Laurens C.; Schandiz, Hossein; Melles, Woldegabriel A.; Gjesdal, Kjell-Inge; Geisler, Jürgen; Geitung, Jonn T. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Axillary lymph node (LN) metastasis is one of the most important predictors of recurrence and survival in breast cancer, and accurate assessment of LN involvement is crucial. Determining extent ...
Health-related quality of life in patients with COVID-19; international development of a patient-reported outcome measure 
Amdal, Cecilie D.; Taylor, Katherine; Kuliś, Dagmara; Falk, Ragnhild S.; Bottomley, Andrew; Arraras, Juan I.; Barte, James H.; Darlington, Anne S.; Hofsø, Kristin; Holzner, Bernard; Jørgensen, Nina M. H.; Mariano, Melissa P.; Pe, Madeline; Piccinin, Claire; Riccetti, Nicola; Schranz, Melanie; Wheelwright, Sally; Bjordal, Kristin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background We aimed to create a questionnaire to assess the health-related quality of life including functioning, symptoms, and general health status of adult patients with current or previous COVID-19. ...
Common variants in breast cancer risk loci predispose to distinct tumor subtypes 
Ahearn, Thomas U.; Zhang, Haoyu; Michailidou, Kyriaki; Milne, Roger L.; Bolla, Manjeet K.; Dennis, Joe; Dunning, Alison M.; Lush, Michael; Wang, Qin; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J.; Auer, Paul L.; Augustinsson, Annelie; Baten, Adinda; Becher, Heiko; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bojesen, Stig E.; Bonanni, Bernardo; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brooks-Wilson, Angela; Brüning, Thomas; Burwinkel, Barbara; Buys, Saundra S.; Canzian, Federico; Castelao, Jose E.; Chang-Claude, Jenny; Chanock, Stephen J.; Chenevix-Trench, Georgia; Clarke, Christine L.; Collée, J. M.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Devilee, Peter; Dörk, Thilo; Dwek, Miriam; Eccles, Diana M.; Evans, D. G.; Fasching, Peter A.; Figueroa, Jonine; Floris, Giuseppe; Gago-Dominguez, Manuela; Gapstur, Susan M.; García-Sáenz, José A.; Gaudet, Mia M.; Giles, Graham G.; Goldberg, Mark S.; González-Neira, Anna; Alnæs, Grethe I. G.; Grip, Mervi; Guénel, Pascal; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Harkness, Elaine F.; Heemskerk-Gerritsen, Bernadette A. M.; Holleczek, Bernd; Hollestelle, Antoinette; Hooning, Maartje J.; Hoover, Robert N.; Hopper, John L.; Howell, Anthony; Jakimovska, Milena; Jakubowska, Anna; John, Esther M.; Jones, Michael E.; Jung, Audrey; Kaaks, Rudolf; Kauppila, Saila; Keeman, Renske; Khusnutdinova, Elza; Kitahara, Cari M.; Ko, Yon-Dschun; Koutros, Stella; Kristensen, Vessela N.; Krüger, Ute; Kubelka-Sabit, Katerina; Kurian, Allison W.; Kyriacou, Kyriacos; Lambrechts, Diether; Lee, Derrick G.; Lindblom, Annika; Linet, Martha; Lissowska, Jolanta; Llaneza, Ana; Lo, Wing-Yee; MacInnis, Robert J.; Mannermaa, Arto; Manoochehri, Mehdi; Margolin, Sara; Martinez, Maria E.; McLean, Catriona; Meindl, Alfons; Menon, Usha; Nevanlinna, Heli; Newman, William G.; Nodora, Jesse; Offit, Kenneth; Olsson, Håkan; Orr, Nick; Park-Simon, Tjoung-Won; Patel, Alpa V.; Peto, Julian; Pita, Guillermo; Plaseska-Karanfilska, Dijana; Prentice, Ross; Punie, Kevin; Pylkäs, Katri; Radice, Paolo; Rennert, Gad; Romero, Atocha; Rüdiger, Thomas; Saloustros, Emmanouil; Sampson, Sarah; Sandler, Dale P.; Sawyer, Elinor J.; Schmutzler, Rita K.; Schoemaker, Minouk J.; Schöttker, Ben; Sherman, Mark E.; Shu, Xiao-Ou; Smichkoska, Snezhana; Southey, Melissa C.; Spinelli, John J.; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Taylor, Jack A.; Teras, Lauren R.; Terry, Mary B.; Torres, Diana; Troester, Melissa A.; Vachon, Celine M.; van Deurzen, Carolien H. M.; van Veen, Elke M.; Wagner, Philippe; Weinberg, Clarice R.; Wendt, Camilla; Wesseling, Jelle; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R.; Zheng, Wei; Couch, Fergus J.; Simard, Jacques; Kraft, Peter; Easton, Douglas F.; Pharoah, Paul D. P.; Schmidt, Marjanka K.; García-Closas, Montserrat; Chatterjee, Nilanjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) ...
Impact of tobacco on circulating troponin concentrations and cardiovascular risk 
Skranes, Julia Brox (Doctoral thesis / Doktoravhandling, 2022)
Cardiac troponin is the preferred biomarker of myocardial injury and is essential in the diagnosis of acute myocardial infarction. In the general population and in patients with chronic coronary syndromes concentrations ...
“It was an important part of my treatment”: a qualitative study of Norwegian breast Cancer patients’ experiences with mainstreamed genetic testing 
Strømsvik, Nina; Olsson, Pernilla; Gravdehaug, Berit; Lurås, Hilde; Schlichting, Ellen; Jørgensen, Kjersti; Wangensteen, Teresia; Vamre, Tone; Heramb, Cecilie; Mæhle, Lovise; Grindedal, Eli M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background In South-Eastern Norway, genetic testing for BRCA1 and BRCA2 is offered to breast cancer patients by their treating surgeon or oncologist. Genetic counselling from a geneticist or a genetic ...
Characterizing the bioburden of ESBL-producing organisms in a neonatal unit using chromogenic culture media: a feasible and efficient environmental sampling method 
Vurayai, Moses; Strysko, Jonathan; Kgomanyane, Kgomotso; Bayani, One; Mokomane, Margaret; Machiya, Tichaona; Arscott-Mills, Tonya; Goldfarb, David M.; Steenhoff, Andrew P.; McGann, Carolyn; Nakstad, Britt; Gezmu, Alemayehu; Richard-Greenblatt, Melissa; Coffin, Susan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Introduction Infections due to extended spectrum beta-lactamase producing organisms (ESBL) have emerged as the leading cause of sepsis among hospitalized neonates in Botswana and much of sub-Saharan Africa ...
Associations between personal recovery and service user-rated versus clinician-rated clinical recovery, a cross-sectional study 
Skar-Fröding, Regina; Clausen, Hanne; Šaltytė Benth, Jūratė; Ruud, Torleif; Slade, Mike; S. Heiervang, Kristin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background This study examined the relationship between service user-rated personal recovery and clinician-rated and service user-rated clinical recovery. The relationships between different subdomains of ...
Pegs not superior to screws for fixation of fractures of the proximal humerus 
Bønes, Ingrid; Karlberg, Anna C.; Liljeholm, Maria; Fraser, Alexander N.; Madsen, Jan E.; Fjalestad, Tore (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Angular stable plates were introduced two decades ago as a promising treatment for fixation of displaced fractures of the proximal humerus (PHF). However, high rates of adverse events and ...
Impact of a dementia-friendly program on detection and management of patients with cognitive impairment and delirium in acute-care hospital units: a controlled clinical trial design 
Weldingh, NM; Mellingsæter, MR; Hegna, BW; Benth, J Saltyte; Einvik, G; Juliebø, V; Thommessen, B; Kirkevold, M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Frail older persons with cognitive impairment (CI) are at special risk of experiencing delirium during acute hospitalisation. The purpose of this study was to investigate whether a dementia-friendly ...
Immunogenetic studies in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) 
Hajdarevic, Riad (Doctoral thesis / Doktoravhandling, 2022)
Myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease that affects about 0.1-0.2% of the general population. The core symptoms are persistent debilitating fatigue, post-exertional ...
Center experience and other determinants of patient radiation exposure during prostatic artery embolization: a retrospective study in three Scandinavian centers 
Svarc, Petra; Hagen, Thijs; Waltenburg, Hanne; Andersson, Christian; Bläckberg, Mats; Baco, Eduard; Taudorf, Mikkel; Røder, Martin Andreas; Lindgren, Hans; Kløw, Nils-Einar; Lönn, Lars (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
Objectives To evaluate the effects of center experience and a variety of patient- and procedure-related factors on patient radiation exposure during prostatic artery embolization (PAE) in three Scandinavian centers with ...
Physiological changes following swimming in cold water in triathlon and military operations: Temperaturephysiology and cold water swimming with wetsuit or drysuit 
Melau, Jørgen (Doctoral thesis / Doktoravhandling, 2022)
Cold water activities have evolved increasingly popular. However, how this affects the body is relatively heterogeneous among individuals. For some, cold water swimming can be harmful. In his dissertation "Physiological ...
The relationship of acute delirium with cognitive and psychiatric symptoms after stroke: a longitudinal study 
Nerdal, Vilde; Gjestad, Elise; Saltvedt, Ingvild; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege; Ryum, Truls; Lydersen, Stian; Grambaite, Ramune (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective Delirium, a common complication after stroke, is often overlooked, and long-term consequences are poorly understood. This study aims to explore whether delirium in the acute phase of stroke predicts ...
Incidence of emergency neurosurgical TBI procedures: a population-based study 
Tverdal, Cathrine; Aarhus, Mads; Rønning, Pål; Skaansar, Ola; Skogen, Karoline; Andelic, Nada; Helseth, Eirik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background The rates of emergency neurosurgery in traumatic brain injury (TBI) patients vary between populations and trauma centers. In planning acute TBI treatment, knowledge about rates and incidence of ...
Joint effect of particulate matter and cigarette smoke on women’s sex hormones 
Merklinger-Gruchala, Anna; Jasienska, Grazyna; Thune, Inger; Kapiszewska, Maria (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Although relationships between exposure to air pollution and reproductive health are broadly studied, mechanisms behind these phenomena are still unknown. The aim of the study was to assess whether ...
Modifiable and non-modifiable risk factors for obstetric anal sphincter injury in a Norwegian Region: a case–control study 
Klokk, Ragnhild; Bakken, Kjersti S.; Markestad, Trond; Holten-Andersen, Mads N. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Obstetric anal sphincter injury (OASI) is a common and severe complication of vaginal delivery and may have short- and long-term consequences, including anal incontinence, sexual dysfunction and ...
Visual impairment and employment in Norway 
Brunes, Audun; Heir, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Past studies have suggested lower employment of people with visual impairment. Reasons for this are less known. This study aimed to examine the employment rates among people with visual impairment, ...
Improved breast cancer screening for women and society: A radiological approach 
Hovda, Tone (Doctoral thesis / Doktoravhandling, 2022)
Breast cancer is the most common cancer in women, and early detection by mammographic screening is demonstrated to reduce mortality from the disease. BreastScreen Norway offers women aged 50-69 biennial mammographic ...
The Norwegian Adult Achondroplasia Study: A population-based study of medical complications, physical functioning, cardiovascular risk factors, and body composition in adults with achondroplasia 
Fredwall, Svein Otto (Doctoral thesis / Doktoravhandling, 2022)
While medical complications are well described in children with achondroplasia, our scoping review found few studies concerning adults. The Norwegian Adult Achondroplasia Study included 50 Norwegian adults, aged 16–87 ...
Improving the diagnostic workup of deep vein thrombosis: Findings from the Ri-Schedule study 
Vikum, Synne Frønæs (Doctoral thesis / Doktoravhandling, 2022)
In the Rivaroxaban for Scheduled Workup of Deep Vein Thrombosis (the Ri-Schedule) study, we identified patients with suspected deep vein thrombosis (DVT) of the leg in whom diagnostic workup could be deferred while receiving ...
Road traffic injuries in Lilongwe, Malawi 
Sundet, Mads (Doctoral thesis / Doktoravhandling, 2022)
Malawi has one of the highest rates of deaths due to road traffic injuries in the world. Despite this, the knowledge about road traffic injuries in this country is sparse. This thesis aimed to provide detailed information ...
Reliability of preoperative MRI findings in patients with lumbar spinal stenosis 
Banitalebi, Hasan; Espeland, Ansgar; Anvar, Masoud; Hermansen, Erland; Hellum, Christian; Brox, Jens I.; Myklebust, Tor Å.; Indrekvam, Kari; Brisby, Helena; Weber, Clemens; Aaen, Jørn; Austevoll, Ivar M.; Grundnes, Oliver; Negård, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Magnetic Resonance Imaging (MRI) is an important tool in preoperative evaluation of patients with lumbar spinal stenosis (LSS). Reported reliability of various MRI findings in LSS varies from ...
Similarities and differences between service users’ and carers’ experiences of crisis resolution teams in Norway: a survey 
Hasselberg, Nina; Klevan, Trude G.; Weimand, Bente; Uverud, Gunn-Marit; Holgersen, Katrine H.; Siqveland, Johan; Ruud, Torleif (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Crisis resolution team (CRT) care in adult mental health services is intended to provide accessible and flexible short-term, intensive crisis intervention to service users experiencing a mental ...
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors 
Dahlberg, Daniel; Rummel, Jutta; Distante, Sonia; De Souza, Gustavo A.; Stensland, Maria E.; Mariussen, Espen; Rootwelt, Helge; Voie, Øyvind; Hassel, Bjørnar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background The growth of malignant tumors is influenced by their microenvironment. Glioblastoma, an aggressive primary brain tumor, may have cysts containing fluid that represents the tumor microenvironment. ...
Investigating functional phenotypes of PARP inhibitor treatment by advanced flow cytometry 
Rein, Idun Dale (Doctoral thesis / Doktoravhandling, 2022)
PARP inhibitors are clinically approved for cancer treatment, and the side effects are in general tolerable and transient. Tumor cells with defects in homologous recombination repair (HR), like BRCA1/2 mutations, are ...
The Impact of Childbirth before and after Mid-Urethral Sling Surgery: New Knowledge derived from Norwegian Health Registries 
Dyrkorn, Ole Aleksander (Doctoral thesis / Doktoravhandling, 2022)
Stress urinary incontinence (SUI) is a common pelvic floor disorder, substantially impacting women's quality of life. Mid-urethral slings (MUS) have been established as the standard surgical treatment for SUI. Women, who ...
Proximal Hamstring Tendon Avulsions: A Survey of Orthopaedic Surgeons’ Current Practices in the Nordic Countries 
Laszlo, Sofia; Nilsson, Martin; Pihl, Elsa; Mattila, Ville M.; Schilcher, Jörg; Sköldenberg, Olof; Frihagen, Frede; Jonsson, Kenneth B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background and purpose Evidence guiding the decision on whether to treat proximal hamstring tendon avulsions (PHA) operatively or non-operatively is very limited. The aim of this study was to identify the ...
Vitamin D deficiency in Inflammatory Bowel Disease - prevalence, predictors and associations with fatigue and pain: The Vitality Study 
Frigstad, Svein Oskar (Doctoral thesis / Doktoravhandling, 2022)
Vitamin D deficiency in inflammatory Bowel Disease Inflammatory bowel disease (IBD) consists mainly of Crohn’s disease and ulcerative colitis, which are chronic inflammatory disorders of the gastrointestinal tract. Patients ...
Nanoparticles in Targeted Cancer Therapy 
Pandya, Abhilash Dipakbhai (Doctoral thesis / Doktoravhandling, 2022)
According to the world health organization, breast cancer is the most common type of cancer in women. Among other subtypes, triple-negative breast cancer is one of the most aggressive subtypes and presents challenges in ...
Mortality in nursing home residents stratified according to subtype of dementia: a longitudinal study over three years 
Vossius, Corinna; Bergh, Sverre; Selbæk, Geir; Benth, Jūratė Š.; Myhre, Janne; Aakhus, Eivind; Lichtwarck, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background There are several subtypes of dementia caused by different pathophysiology and with different clinical characteristics. Irrespective subtype, the disease is progressive, eventually leading to the ...
Emergency cricothyroidotomy in difficult airway simulation – a national observational study of Air Ambulance crew performance 
Andresen, Åke E. L.; Kramer-Johansen, Jo; Kristiansen, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Advanced prehospital airway management includes complex procedures carried out in challenging environments, necessitating a high level of technical and non-technical skills. We aimed to describe ...
Shifts in the Skin Microbiota after UVB Treatment in Adult Atopic Dermatitis 
Lossius, Astrid Haaskjold; Sundnes, Olav; Ingham, Anna Cäcilia; Edslev, Sofie Marie; Bjørnholt, Jørgen Vildershøj; Lilje, Berit; Bradley, Maria; Asad, Samina; Haraldsen, Guttorm; Skytt-Andersen, Paal; Holm, Jan Øyvind; Berents, Teresa Løvold (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
<b><i>Background:</i></b> The pathophysiology in atopic dermatitis (AD) is not fully understood, but immune dysfunction, skin barrier defects, and alterations of the skin microbiota are thought to ...
RFU derived LRs for activity level assignments using Bayesian Networks 
Gill, Peter; Bleka, Øyvind; Fonneløp, Ane Elida (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
A comparative study has been carried out, comparing two different methods to estimate activity level likelihood ratios (𝐿𝑅𝑎) using Bayesian Networks. The first method uses the sub-source likelihood ratio (𝑙𝑜𝑔10𝐿𝑅𝜙) ...
Skogholt’s disease—A tauopathy precipitated by iron and copper? 
Aspli, Klaus Thanke; Holmøy, Trygve; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background It has been suggested that Skogholt’s disease is a new neurological disease entity. The disease, confined to a family line in Hedmark county, Norway, usually affects both the brain and peripheral nerves. ...
The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality 
Karlsen, Tom Hemming; Sheron, Nick; Zelber-Sagi, Shira; Carrieri, Patrizia; Dusheiko, Geoffery; Bugianesi, Elisabetta; Pryke, Rachel; Hutchinson, Sharon; Sangro, Bruno; Martin, Natasha K; Cecchini, Michele; Ashworth Dirac, Mae; Belloni, Annalisa; Serra-Burriel, Miquel; Ponsioen, Cyriel Y; Sheena, Brittney; Lerouge, Alienor; Devaux, Marion; Scott, Nick; Hellard, Margaret; Verkade, Henkjan J; Sturm, Ekkehard; Marchesini, Guilio; Yki-Järvinen, Hennele; Byrne, Chris D; Targher, Giovanni; Tur-Sinai, Aviad; Barret, Damon; Ninburg, Michael; Reic, Tatjana; Taylor, Alison; Rhodes, Tim; Treloar, Carla; Petersen, Claus; Schramm, Christoph; Flisiak, Robert; Simonova, Marieta Y; Pares, Albert; Johnson, Philip; Cucchetti, Alessandro; Graupera, Isabel; Lionis, Christos; Pose, Elisa; Fabrellas, Nuria; Ma, Ann T; Mendive, Juan M; Mazzaferro, Vincenzo; Rutter, Harry; Cortez-Pinto, Helena; Kelly, Deirdre; Burton, Robyn; Lazarus, Jeffrey V.; Gines, Pere; Buti, Maria; Newsome, Philip N.; Burra, Patrizia; Manns, Michael P. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study 
Kostov, Konstantin Hrisimirov; Kostov, Hrisimir; Larsson, Pål Gunnar; Henning, Oliver Johannes; Eckmann, Christian Alexander Cornelius; Lossius, Morten Ingvar; Peltola, Jukka (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective This study was undertaken to evaluate the efficacy of vagus nerve stimulation (VNS) over time, and to determine which patient groups derive the most benefit. Methods Long-term outcomes are reported in 436 ...
Impaired Neurocognitive Performance in Children After Liver Transplantation 
Østensen, Inger Anniken Bjørnstad; Skarbø, Anne-Britt; Sanengen, Truls; Line, Pål Dag; Almaas, Runar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objectives To assess longitudinal neurocognitive development after liver transplantation and evaluate factors associated with neurocognitive performance. Study design Data from neurocognitive testing of 65 children ...
Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study 
Trickey, Jeanette; Sahbudin, Ilfita; Ammitzbøll-Danielsen, Mads; Azzolin, Irene; Borst, Carina; Bortoluzzi, Alessandra; Bruyn, George AW; Carron, Philippe; Ciurtin, Coziana; Filippou, Georgios; Fliciński, Jacek; Fodor, Daniela; Gouze, Hélène; Gutierrez, Marwin; Hammer, Hilde Berner; Hauge, Ellen-Margrethe; Iagnocco, Annamaria; Ikeda, Kei; Karalilova, Rositsa; Keen, Helen Isobel; Kortekaas, Marion C.; La Paglia, Giuliana; Leon, Gustavo; Mandl, Peter; Maruseac, Mihaela; Milchert, Marcin; Mortada, Mohamed Atia; Naredo, Esperanza; Ohrndorf, Sarah; Pineda, Carlos; Rasch, Mads Nyhuus Bendix; Reátegui-Sokolova, Cristina; Sakellariou, Garifallia; Serban, Teodora; Sifuentes-Cantú, Cesar A; Stoenoiu, Maria S.; Suzuk, Takeshi; Terslev, Lene; Tinazzi, Ilaria; Vreju, Florentin Ananu; Wittoek, Ruth; d’Agostino, Maria-Antonietta; Filer, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objectives: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Methods: Adult HS (age 18-80 years) were recruited in 23 international ...
Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature 
Masina, Riccardo; Ansaripour, Ali; Beneš, Vladimír; Berhouma, Moncef; Choque-Velasquez, Joham; Eide, Per Kristian; Fedorko, Stepan; Fleck, Steffen; Hernesniemi, Juha; Koziarski, Andrzej; Májovský, Martin; Podgorski, Andrzej; Schroeder, Henry; Teo, Charles; Unterberg, Andreas W.; Yeung, Jacky T.; Kolias, Angelos; Santarius, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract    Background To examine published data and assess evidence relating to safety and efficacy of surgical management of symptomatic pineal cysts without hydrocephalus (nhSPC), we performed a ...
Needs for information about lifestyle and rehabilitation in long-term young adult cancer survivors 
Thorsen, Lene; Bøhn, Synne-Kristin H.; Lie, Hanne C.; Fosså, Sophie Dorothea; Kiserud, Cecilie E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Background Healthy lifestyle and rehabilitation may mitigate late effects after cancer treatment, but knowledge about lifestyle and rehabilitation information needs among long-term young adult ...
Cost-effectiveness analysis of combined cognitive and vocational rehabilitation in patients with mild-to-moderate TBI: results from a randomized controlled trial 
Howe, Emilie I.; Andelic, Nada; Fure, Silje C R.; Røe, Cecilie; Søberg, Helene L.; Hellstrøm, Torgeir; Spjelkavik, Øystein; Enehaug, Heidi; Lu, Juan; Ugelstad, Helene; Løvstad, Marianne; Aas, Eline (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Traumatic brain injury (TBI) represents a financial burden to the healthcare system, patients, their families and society. Rehabilitation interventions with the potential for reducing costs ...
Sepsis treatment options identified by 10-year study of microbial isolates and antibiotic susceptibility in a level-four neonatal intensive care unit 
Størdal, Eline Hasselgård; Solevåg, Anne Lee; Bjørnholt, Jørgen; Rønnestad, Arild Erland; Stensvold, Hans Jørgen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Aim: This observational study investigated the microbiology of blood culture-positive sepsis episodes and susceptibility to empiric antibiotics in early-onset sepsis (EOS) and late-onset sepsis (LOS) in a level-four neonatal ...
Genetic studies of sporadic Parkinson’s disease: On the identification of genetic risk factors and the path towards a better understanding of underlying pathogenic mechanisms 
Berge-Seidl, Victoria (Doctoral thesis / Doktoravhandling, 2022)
Parkinson’s disease (PD) is a common neurological movement disorder that mainly affects individuals in higher age groups. While treatment exists that alleviates some symptoms, there is currently no curative therapy that ...
Stress, pain, and work affiliation are strongly associated with health-related quality of life in parents of 14-15-year-old adolescents 
Rohde, Gudrun E.; Helseth, Sølvi; Mikkelsen, Hilde Elisabeth Timenes; Skarstein, Siv; Småstuen, Milada Cvancarova; Haraldstad, Kristin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Background For many adults, their role as a parent is a vital part of their lives. This role is likely to be associated with a parent’s health-related quality of life (HRQOL). The aim of this ...
Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health 
Wang, Geng; Bhatta, Laxmi; Moen, Gunn-Helen; Hwang, Liang-Dar; Kemp, John P.; Bond, Tom A.; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M.; Warrington, Nicole M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether ...
Comparative efficacy and safety of infliximab and vedolizumab therapy in patients with inflammatory bowel disease: a systematic review and meta-analysis 
Peyrin-Biroulet, Laurent; Arkkila, Perttu; Armuzzi, Alessandro; Danese, Silvio; Guardiola, Jordi; Jahnsen, Jørgen; Lees, Charles; Louis, Edouard; Lukáš, Milan; Reinisch, Walter; Roblin, Xavier; Jang, Minyoung; Byun, Han G.; Kim, Dong-Hyeon; Lee, Sung J.; Atreya, Raja (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background and aims There are limited comparative data for infliximab and vedolizumab in inflammatory bowel disease patients. Methods We conducted ...
Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss 
Simeone, Paola; Tripaldi, Romina; Michelsen, Annika; Ueland, Thor; Liani, Rossella; Ciotti, Sonia; Birkeland, Kåre I.; Gulseth, Hanne L.; Di Castelnuovo, Augusto; Cipollone, Francesco; Aukrust, Pål; Consoli, Agostino; Halvorsen, Bente; Santilli, Francesca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Soluble suppression of tumorigenesis-2 (sST2) and galectin (Gal)-3 are two biomarkers related to inflammation, metabolic disturbances and to myocardial fibrosis that characterize several cardiac ...
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs 
Sønderby, Ida Elken; Ching, Christopher R. K.; Thomopoulos, Sophia I.; van der Meer, Dennis; Sun, Daqiang; Villalon-Reina, Julio E.; Agartz, Ingrid; Amunts, Katrin; Arango, Celso; Armstrong, Nicola J.; Ayesa-Arriola, Rosa; Bakker, Geor; Bassett, Anne S.; Boomsma, Dorret I.; Bulow, Robin; Butcher, Nancy J.; Calhoun, Vince D.; Caspers, Svenja; Chow, Eva W. C.; Cichon, Sven; Ciufolini, Simone; Craig, Michael C.; Crespo-Facorro, Benedicto; Cunningham, Adam C.; Dale, Anders M.; Dazzan, Paola; de Zubicaray, Greig I.; Djurovic, Srdjan; Doherty, Joanne L.; Donohoe, Gary; Draganski, Bogdan; Durdle, Courtney A.; Ehrlich, Stefan; Emanuel, Beverly S.; Espeseth, Thomas; Fisher, Simon E.; Ge, Tian; Glahn, David C.; Grabe, Hans J.; Gur, Raquel E.; Gutman, Boris A.; Lundervold, Astri J.; Haavik, Jan; Håberg, Asta; Hansen, Laura A.; Moberget, Torgeir; Sánchez, Jennifer Monereo; Reinbold, Céline Sonja; Tamnes, Christian Krog; Westlye, Lars Tjelta; Andreassen, Ole; et al., , (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors ...
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile 
Vedeld, Hege Marie; Grimsrud, Marit Mæhle; Andresen, Kim; Pharo, Heidi Dietrichson; von Seth, Erik; Karlsen, Tom Hemming; Honne, Hilde; Paulsen, Vemund; Färkkilä, Martti A.; Bergquist, Annika; Jeanmougin, Marine; Aabakken, Lars; Boberg, Kirsten Muri; Folseraas, Trine; Lind, Guro Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background and Aims Primary sclerosing cholangitis (PSC) is associated with increased risk of cholangiocarcinoma (CCA). Early and accurate CCA detection represents an unmet clinical need as the majority of patients with ...
Evaluation of functional magnetic resonance imaging in the diagnosis of brain tumors and other brain lesions for assessment of clinical efficacy 
Due-Tønnessen, Paulina B. (Doctoral thesis / Doktoravhandling, 2022)
Brain lesions, given their location, may have a profound and often life-threatening impact on the patients’ life. An accurate and timely diagnosis of disease is critical for optimal treatment decisions. Magnetic resonance ...
Posttraumatic stress disorder in people with visual impairment compared with the general population 
Bonsaksen, Tore; Brunes, Audun; Heir, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background: People with a visual impairment appear to have an increased risk of experiencing potentially traumatizing life events and possibly also subsequently developing post-traumatic stress disorder (PTSD). This study ...
Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms 
Lund, Martina Jonette; Alnæs, Dag; de Lange, Ann-Marie Glasø; Andreassen, Ole; Westlye, Lars Tjelta; Kaufmann, Tobias (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective Magnetic resonance imaging (MRI) has shown that estimated brain age is deviant from chronological age in various common brain disorders. Brain age estimation could be useful for investigating patterns of brain ...
Survival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study 
Hamfjord, Julian; Myklebust, Tor Åge; Larsen, Inger Kristin; Kure, Elin Wenche Hegland; Glimelius, Bengt; Guren, Tormod Kyrre; Tveit, Magne Kjell; Guren, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background: Patients with right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ clinically and molecularly. The main objective was to investigate stage-stratified survival and recurrence of RCC and LCC ...
A 10-year perspective on apathy development in psychotic disorders: Genetic risk and early predictors, associations with depression, and functional outcome 
Lyngstad, Siv Hege (Doctoral thesis / Doktoravhandling, 2022)
The thesis aims were to explore 1) genetic underpinnings of apathy in schizophrenia spectrum disorders (SZ) and healthy controls (HC), 2) prevalence of persistent apathy (PA), persistent depression (PD) and associations ...
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment 
Pagano, Ester; Elias, Joshua E.; Schneditz, Georg Thomas; Saveljeva, Svetlana; Holland, Lorraine M.; Borrelli, Francesca; Karlsen, Tom Hemming; Kaser, Arthur; Kaneider, Nicole C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective Primary sclerosing cholangitis (PSC) is in 70% of cases associated with inflammatory bowel disease. The hypermorphic T108M variant of the orphan G protein-coupled receptor GPR35 increases risk for PSC and ulcerative ...
Associations between physical activity, left atrial size and incident atrial fibrillation: the Tromsø Study 1994–2016 
Heitmann, Kim Arne; Løchen, Maja-Lisa; Stylidis, Michael; Hopstock, Laila Arnesdatter; Schirmer, Henrik; Morseth, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Aims Left atrial (LA) enlargement is an independent risk factor for atrial fibrillation (AF). Interestingly, some athletes have increased risk of AF, which may be linked to LA enlargement; however, little is known about ...
Does the use of Doppler ultrasound reduce foetal mortality? A population study of all deliveries in Norway 1990-2014 
Grytten, Jostein Ivar; Skau, Irene; Eskild, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Background The aim of the present study was to examine the effect that the introduction of Doppler ultrasound in obstetric care has had on fetal death in Norway. One mechanism by ...
The effect of cognitive function and central nervous system depressant use on mortality—A prospective observational study of previously hospitalised older patients 
Siddiqui, Tahreem Ghazal; Bjelkarøy, Maria Torheim; Cheng, Socheat; Kristoffersen, Espen Saxhaug; Grambaite, Ramune; Lundqvist, Christofer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Older patients are often users of prolonged Central Nervous System Depressants (CNSD) (Z-hypnotics, benzodiazepines and opioids), which may be associated with reduced cognition. The long-term effects of CNSD ...
Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease 
Lindeman, Ida; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
Single-cell analysis is a powerful technology that has found widespread use in recent years. For diseases with involvement of adaptive immunity, single-cell analysis of antigen-specific T cells and B cells is particularly ...
Reconstructing topography and extent of injury to the superior mesenteric artery plexus in right colectomy with extended D3 mesenterectomy: a composite multimodal 3‑dimensional analysis 
Luzon, Javier; Thorsen, Yngve; Parreiras Nogueira, Liebert; Andersen, Solveig Norheim; Edwin, Bjørn von Gohren; Haugen, Håvard Jostein; Ignjatovic, Dejan; Stimec, Bojan Vladimir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Superior mesenteric artery plexus (SMAP) injury is reported to cause postoperative intractable diarrhea after pancreatic/colonic surgery with extended lymphadenectomy. This study aims to describe the SMAP ...
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Date Issued2020 - 2022 (3184)2010 - 2019 (4199)2001 - 2009 (263)Document TypeTidsskriftartikkel (6608)Doktoravhandling (1027)Bokkapittel (6)Bok (1)Forskningsrapport (1)AuthorAndreassen, Ole Andreas (232)Aukrust, Pål (159)Melle, Ingrid (129)Ueland, Thor (123)Westlye, Lars Tjelta (114)... View MorePeer ReviewedPeer reviewed (6438)
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