Browsing Institutt for klinisk medisin by Title

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  • High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1 
    Viste, Rannveig; Viken, Marte Kathrine; Lie, Benedicte Alexandra; Juvodden, Hilde Therese; Nordstrand, Sebjørg E. H.; Thorsby, Per M.; Rootwelt, Terje; Kornum, Birgitte Rahbek; Knudsen, Stine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Study Objectives Narcolepsy type 1 (NT1) is associated with hypocretin neuron loss. However, there are still unexplained phenotypic NT1 features. We investigated the associations ...
  • High number of hypoglycaemic episodes identified by CGM among home-dwelling older people with diabetes: an observational study in Norway 
    Fløde, Mari; Hermann, Monica; Haugstvedt, Anne; Søfteland, Eirik; Igland, Jannicke; Åsberg, Anders; Jenssen, Trond G.; Graue, Marit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background A scoping review from 2021 identified a lack of studies on the incidence, prevention and management of hypoglycaemia in home-dwelling older people with diabetes. The aim of this study was to ...
  • High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival 
    Helland, Å; Brustugun, O.T; Nakken, S; Halvorsen, A.R; Dønnem, Tom; Bremnes, R.; Busund, Lill-Tove; Sun, J; Lorenz, S; Solberg, S; Jørgensen, LH; Vodak, Daniel; Myklebost, Ola; Hovig, Eivind; Meza-Zepeda, Leonardo A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several ...
  • High penetrance and similar disease progression in probands and in family members with arrhythmogenic cardiomyopathy 
    Chivulescu, Ana Monica; Lie, Øyvind Haugen; Popescu, Bogdan A.; Skulstad, Helge; Edvardsen, Thor; Jurcut, Ruxandra; Haugaa, Kristina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Aims We aimed to assess structural progression in arrhythmogenic cardiomyopathy (AC) patients and mutation-positive family members and its impact on arrhythmic outcome in a longitudinal cohort study. Methods and ...
  • High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting 
    Xu, Kaiqi; Chatzitakis, Athanasios Eleftherios; Risbakk, Sanne; Yang, Mingyi; Backe, Paul Hoff; Grandcolas, Mathieu; Bjørås, Magnar; Norby, Truls Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    In this work, Co-based cocatalysts are electrodeposited on mesoporous Ta3N5 nanotubes. The electrodeposition time is varied and the optimized photoelectrode reaches a photocurrent density of 6.3 mA/cm2 at 1.23 V vs. SHE, ...
  • High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism 
    Grover, Steven P.; Snir, Omri; Hindberg, Kristian Dalsbø; Englebert, Tatianna M.; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Jensen, Søren Beck; Wolberg, Alisa S.; Mollnes, Tom Eirik; Ueland, Thor; Mackman, Nigel; Hansen, John Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) ...
  • High Plasma Oxalate Levels Early After Kidney Transplantation Are Associated With Impaired Long-Term Outcomes 
    Krogstad, Veronica; Elgstøen, Katja B. Prestø; Johnsen, Linda Flaa; Hartmann, Anders; Mørkrid, Lars; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background: Elevated levels of oxalate are common in renal failure patients and non-hyperoxaluria disease, and may cause damage after transplantation. We examined outcomes after 15 years for 167 kidney transplant recipients ...
  • High prevalence and increasing incidence of multiple sclerosis in the Norwegian county of Buskerud 
    Simonsen, Cecilia Smith; Edland, Astrid; Berg-Hansen, Pål; Celius, Elisabeth Gulowsen (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Objectives The objective was to investigate the incidence of multiple sclerosis (MS) as well as estimate the prevalence as of 1 January 2014 in the southeastern Norwegian county of Buskerud. Materials and Methods All ...
  • High Prevalence and Persistence of Escherichia coli Strains Producing Shiga Toxin Subtype 2k in Goat Herds 
    Yang, Xi; Liu, Qian; Bai, Xiangning; Hu, Bin; Jiang, Deshui; Jiao, Hongbo; Lu, Liangmei; Fan, Ruyue; Hou, Peibin; Matussek, Andreas Albert; Xiong, Yanwen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Shiga toxin (Stx)-producing Escherichia coli (STEC) is a zoonotic pathogen with the ability to cause severe diseases like hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Shiga toxin (Stx) is the key virulence ...
  • High prevalence and significant ethnic differences in actionable HbA1C after gestational diabetes mellitus in women living in Norway 
    Sharma, Archana; Nermoen, Ingrid; Qvigstad, Elisabeth; Tran, Anh T.; Sommer, Christine; Sattar, Naveed; Gill, Jason M. R.; Gulseth, Hanne L.; Sollid, Stina T.; Birkeland, Kåre I. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background The type 2 diabetes risk after gestational diabetes mellitus (GDM) is twice as high in South Asian compared to European women. Current guidelines differ regarding which test to use as a screening-tool ...
  • High prevalence of ADHD symptoms in unmedicated youths with post-H1N1 narcolepsy type 1 
    Hansen, Berit M Hjelde; Juvodden, Hilde Therese; Nordstrand, Sebjørg Elizabeth Hesla; Viste, Rannveig; Thorsby, Per Medbøe; Swanson, David; Nilsen, Kristian Bernhard; Nærland, Terje; Knudsen, Stine (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    Objectives To characterize attention deficit-hyperactivity disorder (ADHD) symptoms in unmedicated post-H1N1 narcolepsy type 1 (NT1) youths, and explore associations between ADHD symptoms and the narcolepsy phenotype. ...
  • High prevalence of common human viruses in thyroid tissue 
    Weider, Therese; Genoni, Angelo; Broccolo, Francesco; Paulsen, Trond Harder; Dahl-Jørgensen, Knut; Toniolo, Antonio; Hammerstad, Sara Salehi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Introduction: Evidence points to viral infections as possible triggers of autoimmune thyroid disease (AITD), but little is known about the prevalence of common viruses in the thyroid gland. Using a novel approach based on ...
  • High prevalence of fatigue in contemporary patients with multiple sclerosis 
    Broch, Line; Simonsen, Cecilia Smith; Flemmen, Heidi Øyen; Berg-Hansen, Pål; Skardhamar, Åshild; Ormstad, Heidi; Celius, Elisabeth Gulowsen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Objective: The prevalence of multiple sclerosis (MS)-related fatigue may have changed due to new diagnostic criteria and new disease modifying drugs. We aimed to assess the prevalence of fatigue in a contemporary MS cohort, ...
  • High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients 
    Papp, Janos; Kovacs, Marietta E; Solyom, Szilvia; Kasler, Miklos; Børresen-Dale, Anne-Lise; Olah, Edith (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Peutz-Jeghers syndrome (PJS) is a rare autosomal dominantly inherited disease characterized by gastrointestinal hamartomatous polyposis and mucocutaneous pigmentation. The genetic predisposition ...
  • High prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopia 
    Dembinski, Jennifer Lynn; Mihret, Adane; Yimer, Solomon Abebe; Tessema, Bamlak; Trieu, Mai Chi; Tarekegn, Azeb; Getachew, Nahom; Cox, Rebecca Jane; Oftung, Fredrik; Haneberg, Bjørn; Aseffa, Abraham; Mjaaland, Siri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background: Influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. However, new evidence suggests that it significantly impacts hospitalization and promotes ...
  • High prevalence of pre-eclampsia in women with coarctation of the aorta 
    Grønningsæter, Lasse; Langesæter, Eldrid; Krarup Sørbye, Ingvil; Quattrone, Alessia; Almaas, Vibeke Marie; Skulstad, Helge; Estensen, Mette-Elise (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Aims The aim was to study pregnancy outcomes in women with coarctation of the aorta (CoA) and associations to hypertensive disorders of pregnancy. Maternal morbidity and mortality are higher in women with heart disease ...
  • High prevalence of symptomatic spinal stenosis in Norwegian adults with achondroplasia: a population-based study 
    Fredwall, Svein O; Steen, Unni; de Vries, Olga; Rustad, Cecilie F; Eggesbø, Heidi B; Weedon-Fekjær, Harald; Lidal, Ingeborg B; Savarirayan, Ravi; Månum, Grethe (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Symptomatic spinal stenosis (SSS) is a well-known medical complication in achondroplasia. The reported prevalence of SSS is 10 to 30%, an estimate based on small studies or selected populations. No population-based ...
  • High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT 
    Borgen, Tove Tveitan; Bjørnerem, Åshild; Solberg, Lene Bergendal; Andreasen, Camilla; Brunborg, Cathrine; Stenbro, May-Britt; Hübschle, Lars Michael; Froholdt, Anne; Figved, Wender; Apalset, Ellen M; Gjertsen, Jan-Erik; Basso, Trude; Lund, Ida; Hansen, Ann Kristin; Stutzer, Jens-Meinhard; Dahl, Cecilie; Omsland, Tone Kristin; Nordsletten, Lars; Frihagen, Frede Jon; Eriksen, Erik Fink (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Purpose Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not ...
  • ‘High proliferative cribriform prostate cancer’ defines a patient subgroup with an inferior prognosis 
    Bogaard, Mari; Skotheim, Rolf I.; Maltau, Aase Margrethe Victoria; Kidd, Susanne Gundersen; Lothe, Ragnhild Adelheid; Axcrona, Karol; Axcrona, Ulrika (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Aims A cribriform pattern, reactive stroma (RS), PTEN, Ki67 and ERG are promising prognostic biomarkers in primary prostate cancer (PCa). We aim to determine the relative contribution of these factors and the Cancer of the ...
  • High rate of per oral mecillinam treatment failure in community-acquired urinary tract infections caused by ESBL-producing escherichia coli 
    Søraas, Arne Vasli Lund; Sundsfjord, Arnfinn; Jørgensen, Silje Bakken; Liestøl, Knut; Jenum, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    A population-based study was performed to investigate the efficacy of mecillinam treatment of community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum ß-lactamase (ESBL) producing Escherichia coli. ...