Browsing Institutt for klinisk medisin by Title
Now showing items 3967-3986 of 10751
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Transient potential (TRP) ion channels expressed in primary sensory neurons act as the initial detectors of environmental cold and heat, information which controls muscle energy expenditure. We hypothesize that non-neuronal ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Climate changes the geographic range of both species as well as pathogens, causing a potential increase in the vulnerability of populations or species with limited genetic diversity. With advances in high throughput ...
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(Doctoral thesis / Doktoravhandling, 2018)
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)Background To compare the long-term functional outcomes of patients surgically treated for Weber B ankle fractures with or without syndesmotic fixation. Methods In total, 959 adult patients with previous treatment ...
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(Doctoral thesis / Doktoravhandling, 2024)A displaced femoral neck fracture (FNF) is a severe injury and will require hospitalization and surgery. The most common treatment options in Norway for FNFs are closed reduction and internal fixation (IF), hemiarthroplasty ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Abstract Introduction The induced membrane technique (IMT), frequently called Masquelet technique, is an operative, two-staged technique for treatment of segmental bone loss. Previous studies mainly ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)This study aims to evaluate the global functional outcomes after moderate-to-severe traumatic injury at 6 and 12 months and to examine the sociodemographic and injury-related factors that predict these outcomes. A prospective ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)Functional precision medicine is a new, emerging area that can guide cancer treatment by capturing information from direct perturbations of tumor-derived, living cells, such as by drug sensitivity screening. Precision ...
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(Doctoral thesis / Doktoravhandling, 2014)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Purpose To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Significance Our results provide evidence that functional pre-existing SARS-CoV-2-reactive memory CD4+ T cells are elicited in early childhood and linked to seroconversion with the seasonal coronavirus OC43 but not many ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Serum-free culturing of patient-derived glioblastoma biopsies enrich for glioblastoma stem cells (GSCs) and is recognized as a disease-relevant model system in glioblastoma (GBM). We hypothesized that the temozolomide (TMZ) ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)Abstract Purpose: PI3K inhibitors (PI3Ki) are approved for relapsed chronic lymphocytic leukemia (CLL). Although patients may show an initial response to these therapies, development of ...
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(Doctoral thesis / Doktoravhandling, 2020)Telomeres are nucleoprotein structures located at the end of chromosomes. Telomere length and the enzyme responsible for their elongation, telomerase, are essential for genome integrity by protecting chromosomal ends. ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)Background: Early confirmation of the effect of brachytherapy for choroidal melanoma showing that tumour coverage is valuable. The irradiated retinal pigment epithelium (RPE) commonly develops atrophy. This study compares ...
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Fusion of engineered albumin with factor IX Padua extends half-life and improves coagulant activity (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)The short half-life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)-mediated recycling of the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background/Aim: Aggressive angiomyxomas are mostly found in the pelvic and perineal region and are prone to recur after surgery. Cytogenetic information is available on only nine such tumors. Herein, we report the cytogenetic ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)The HEARO cochlear implantation surgery aims to replace the conventional wide mastoidectomy approach with a minimally invasive direct cochlear access. The main advantage of the HEARO access would be that the trajectory ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background/Aim: Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features. Materials and Methods: Cytogenetic, RNA sequencing, reverse ...