Browsing Institutt for klinisk medisin by Title
Now showing items 2917-2936 of 10751
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background Therapeutic cancer vaccines represent a promising approach to improve clinical outcomes with immune checkpoint inhibition. UV1 is a second generation telomerase-targeting therapeutic cancer vaccine being ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)BACKGROUND CONTEXT Dural ectasia is widening of the dural sac often seen in patients with Marfan syndrome and other hereditary connective tissue disorders. Dural ectasia can cause specific symptoms and is associated ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Objective Our main objective was to investigate the association between duration of active labor and severe postpartum hemorrhage. We examined the effect of the total duration of active labor, the effect of each stage of ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)Objective: The objective of this study was to examine the duration of mechanical ventilation (MV) in days until the first successful extubation and the cumulative duration of MV until discharge of infants with gestational ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where invaginations of the surface membrane (t-tubules) form functional junctions with the sarcoplasmic reticulum (SR). Within each dyad, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background and aims Pupil size and reaction are influenced by opioids, an effect that is not considered to be affected by opioid tolerance. As clinicians have observed patients on high-dose opioids who exhibited seemingly ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)In healthy humans, cerebral blood flow (CBF) is autoregulated against changes in arterial blood pressure. Spontaneous fluctuations in mean arterial pressure (MAP) and CBF can be used to assess cerebral autoregulation. We ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Previous studies have indicated a synergistic effect between radiotherapy and immunotherapy. A better understanding of how this combination affects the immune system can help to clarify its role in the treatment of metastatic ...
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(Doctoral thesis / Doktoravhandling, 2021)This work investigates several underlying assumptions that is made in the acquisition and analysis of dynamic contrast-enhanced MRI images applied to monitoring of brain cancer patients, and how these affect the derived ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Background Main aim was assessment of regional blood–brain barrier (BBB) function by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with neuroborreliosis. Secondary aim was to ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal ...
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(Doctoral thesis / Doktoravhandling, 2014)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Purpose: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of rectal cancer and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)Purpose According to the revised World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) of 2016, oligodendrogliomas are now defined primarily by a specific molecular signature (presence ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities and cognitive deficits ...
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(Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)Atrial switch operation in patients with transposition of the great arteries (TGA) leads to leftward shift and changes the geometry of the interventricular septum. By including the implications of regional work and septal ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Background: Dyslipidemia is a major risk factor for cardiovascular events. The prognostic importance of lipoproteins in patients with atrial fibrillation is not well understood. We aimed to explore the association between ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Dysphotopsias are unwanted visual phenomena that occur after cataract surgery. They represent some of the most common reasons for patient dissatisfaction after uncomplicated surgery for cataract phacoemulsification with ...