Browsing Institutt for klinisk medisin by Title
Now showing items 10295-10314 of 10751
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Given a tropical line L and a smooth tropical surface X, we look at the position of L on X. We introduce its primal and dual motifs which are respectively a decorated graph and a subcomplex of the dual triangulation of X. ...
-
TRP channels as interior designers: Remodeling the endolysosomal compartment in natural killer cells (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Cytotoxic lymphocytes, including natural killer (NK) cells and T cells are distinguished by their ability to eliminate target cells through release of secretory lysosomes. Conventional lysosomes and secretory lysosomes are ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Different dopaminergic (DA) neuronal subgroups exhibit distinct vulnerability to stress, while the underlying mechanisms are elusive. Here we report that the transient receptor potential melastatin 2 (TRPM2) channel is ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)Rationale and Objectives To explore radiological aspects of interval breast cancer in a population-based screening program. Materials and Methods We performed a consensus-based informed review of mammograms from diagnosis ...
-
Trunk Muscle Impairment and Pain in Myotonic Dystrophy type 1: Association to CTG size and Function (Doctoral thesis / Doktoravhandling, 2021)Myotonic Dystrophy 1 (DM1) is a progressive, hereditary neuromuscular disorder with multi-organ involvement. The genetic cause is an unstable CTG trinucleotide expansion in the DMPK gene at chromosome 19. Muscle involvement ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)In the aftermath of terrorist attacks and disasters, public institutions play an important role in re-establishing safety and justice. However, little is known about the importance of institutional trust for victims’ ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Abstract Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme 1–4 . Here we show that despite tryptophan depletion, in-frame ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Background T cell infiltration around dying motor neurons is a hallmark of amyotrophic lateral sclerosis (ALS). It is not known if this immune response represents a cause or a consequence of the disease. We aimed to ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background Globally, tuberculosis (TB) lasts a major public health concern. Using feasible strategies to estimate TB infectious periods is crucial. The aim of this study was to determine the magnitude of TB infectious ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)Background Screening for tuberculosis (TB) and providing TB preventive treatment (TPT) along with antiretroviral therapy is key components of human immune deficiency virus (HIV) care. The uptake of TPT ...
-
Tubulator: an automated approach to analysis of t-tubule and dyadic organization in cardiomyocytes (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)During cardiac disease, t-tubules and dyads are remodelled and disrupted within cardiomyocytes, thereby reducing cardiac performance. Given the pathological implications of such dyadic remodelling, robust and versatile ...
-
(Doctoral thesis / Doktoravhandling, 2012)
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Introduction Hypercoagulability in malignancy increases the risk of thrombosis, but is also involved in cancer progression. Experimental studies suggest that tissue factor (TF) and tissue factor pathway ...
-
(Doctoral thesis / Doktoravhandling, 2020)Prostate cancer is the most frequently diagnosed cancer among Norwegian men. Currently available risk stratification tools are inadequate for differentiating between men who will develop a life-threatening disease that ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)CD4+ T cells can induce potent anti-tumor immune responses. Due to the lack of MHC class II expression in most cancer cells, antigen recognition occurs indirectly via uptake and presentation on tumor-infiltrating ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background The complement system is involved in pathogenesis of cardiovascular disease, and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, we examined complement activation in SpA, and ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Secretion of matrix metalloproteinases (MMPs) enables cancer cells to degrade extracellular matrix, thus promoting tumor invasion and metastasis. We have recently found that the endosomal protein WDFY2 serves as a gatekeeper ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ...
-
(Doctoral thesis / Doktoravhandling, 2017)
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)In the eighth edition of the TNM classification for pancreatic ductal adenocarcinoma (PDAC), stages T1 to T3 are defined by tumour size, size measurement being deemed objective and accurate. This study investigated whether ...