Browsing Det medisinske fakultet by Title

Now showing items 360-379 of 598

  • N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug 
    Kamiński, Krzysztof; Esguerra, Camila V.; Gawel, Kinga Aurelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure ...
  • N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor 
    Itkonen, Harri; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Prostate cancer is the second most common cause of cancer-associated deaths in men and signalling via a transcription factor called androgen receptor (AR) is an important driver of the disease. Androgen treatment is known ...
  • The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening 
    Bjerregaard-Andersen, Kaare; Perdreau, Harmonie; Guldsten, Hanne; Praetorius, Jeppe; Jensen, Jan K.; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    The sodium dependent bicarbonate transporter NCBE/NBCn2 is predominantly expressed in the central nervous system (CNS). The highest protein concentrations are found in the choroid plexus. The primary function of this ...
  • Nagashima-type palmoplantar keratosis in Finland caused by a SERPINB7 founder mutation 
    Hannula-Jouppi, Katariina; Harjama, Liisa; Einarsdottir, Elisabet; Elomaa, Outi; Kettunen, Kaisa; Saarela, Janna; Soronen, Minna; Bouchard, Laura; Lappalainen, Katriina; Heikkilä, Hannele; Kivirikko, Sirpa; Seppänen, Mikko R J; Kere, Juha; Ranki, Annamari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
  • Nanotube-Mediated Path to Protocell Formation 
    Köksal, Elif; Liese, Susanne; Kantarci, Ilayda; Olsson, Ragni; Carlson, Andreas; Gözen, Irep (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
  • Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes 
    Ruud Larsen, Ann K.; Møller, Michael T. N; Blankson, Henrietta; Samari, Hamid R.; Holden, Lise; Seglen, Per O. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)
    To identify phosphoproteins that might play a role in naringin-sensitive hepatocellular cytoskeletal disruption and apoptosis induced by algal toxins, hepatocyte extracts were separated by gel electrophoresis and immunostained ...
  • Needs for information about lifestyle and rehabilitation in long-term young adult cancer survivors 
    Thorsen, Lene; Bøhn, Synne-Kristin H.; Lie, Hanne C.; Fosså, Sophie Dorothea; Kiserud, Cecilie E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Background Healthy lifestyle and rehabilitation may mitigate late effects after cancer treatment, but knowledge about lifestyle and rehabilitation information needs among long-term young adult ...
  • Nestin-expressing progenitor cells: function, identity and therapeutic implications 
    Bernal Mera, Aurora; Arranz, Lorena (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence ...
  • New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX. 
    Rein, Idun Dale; Stokke, Caroline; Johansen, Maria; Myklebust, June; Patzke, Sebastian; Stokke, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Induction of DNA double strand breaks leads to phosphorylation and focus-formation of H2AX. However, foci of phosphorylated H2AX (γH2AX) appear during DNA replication also in the absence of exogenously applied injury. We ...
  • New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome 
    Tiraboschi, Ettore; Martina, Silvia; van der Ent, Wietske; Grzyb, Kamil; Gawel, Kinga; Cordero-Maldonado, Maria Lorena; Poovathingal, Suresh K.; Heintz, Sarah; Satheesh, Somisetty Venkata; Brattespe, Jarle; Xu, Ju; Suster, Maximiliano; Skupin, Alexander; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Objective: To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period) during perinatal brain development in a new zebrafish model of Dravet syndrome (DS) and to investigate potential ...
  • A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD 
    Alseth, Ingrun; Rognes, Torbjørn; Lindbäck, Toril; Solberg, Inger; Robertsen, Kristin; Kristiansen, Knut Ivan; Mainieri, Davide; Lillehagen, Lucy; Kolstø, Anne-Brit; Bjørås, Magnar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
    Soil bacteria are heavily exposed to environmental methylating agents such as methylchloride and may have special requirements for repair of alkylation damage on DNA. We have used functional complementation of an Escherichia ...
  • Night shift work, chemical coexposures and risk of female breast cancer in the Norwegian Offshore Petroleum Workers (NOPW) cohort: A prospectively recruited case-cohort study 
    Liu, Fei-Chih; Veierød, Marit Bragelien; Kjærheim, Kristina; Robsahm, Trude Eid; Ghiasvand, Reza; Hosgood, H Dean; Samuelsen, Sven Ove; Bråtveit, Magne; Kirkeleit, Jorunn; Rothman, Nathaniel; Lan, Qing; Silverman, Debra T; Friesen, Melissa C; Babigumira, Ronnie; Shala, Nita Kaupang; Grimsrud, Tom Kristian; Stenehjem, Jo S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Objectives This study examined the association between night shift work and risk of breast cancer, overall and by hormone receptor subtype, among females in the Norwegian Offshore Petroleum Workers (NOPW) cohort. We also ...
  • NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy 
    Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their ...
  • No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy 
    Fjell, Anders Martin; Sørensen, Øystein; Wang, Yunpeng; Amlien, Inge; Baaré, William F. C.; Bartrés-Faz, David; Bertram, Lars; Boraxbekk, Carl-Johan; Brandmaier, Andreas M.; Demuth, Ilja; Drevon, Christian André; Ebmeier, Klaus P.; Ghisletta, Paolo; Kievit, Rogier; Kühn, Simone; Madsen, Kathrine Skak; Mowinckel, Athanasia Monika; Nyberg, Lars Erik; Sexton, Claire; Solé-Padullés, Cristina; Vidal-Piñeiro, Didac; Wagner, Gerd; Watne, Leiv; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for ...
  • Non-Coding RNA in Salivary Extracellular Vesicles: A New Frontier in Sjögren's Syndrome Diagnostics? 
    Cross, Tanya; Haug, Kari Bente Foss; Brusletto, Berit; Ommundsen, Stine Kamilla; Trøseid, Anne-Marie Siebke; Aspelin, Trude; Olstad, Ole Kristoffer; Aass, Hans Christian; Galtung, Hilde; Utheim, Tor Paaske; Jensen, Janicke Liaaen; Øvstebø, Reidun (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Sjögren’s syndrome is an autoimmune rheumatic disease characterized by inflammation of the salivary and lacrimal glands, often manifesting as dry mouth and dry eyes. To simplify diagnostics of primary Sjögren’s syndrome ...
  • Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function 
    Fagny, Maud; Platig, John; Kuijjer, Marieke Lydia; Lin, Xihong; Quackenbush, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs ...
  • Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death 
    Szalai, Paula; Parys, Jan B; Bultynck, Geert; Christensen, Søren Brøgger; Nissen, Poul; Møller, Jesper Vuust; Engedal, Nikolai (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Endoplasmic reticulum (ER) Ca2+ depletion activates the unfolded protein response (UPR), inhibits bulk autophagy and eventually induces cell death in mammalian cells. However, the extent and duration of ER Ca2+ depletion ...
  • ‘Not at all what I had expected’: Discontinuing treatment with extended-release naltrexone (XR-NTX): A qualitative study 
    Brenna, Ida Halvorsen; Marciuch, Anne; Birkeland, Bente; Veseth, Marius; Røstad, Bente; Løberg, Else-Marie; Solli, Kristin Klemmetsby; Tanum, Lars Håkon Reiestad; Weimand, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background: Extended-release naltrexone (XR-NTX), an opioid antagonist, has demonstrated equal treatment outcomes, in terms of safety, opioid use, and retention, to the recommended OMT medication buprenorphine. However, ...
  • Novel Compound Heterozygous Splice-Site Variants in TPM3 Revealed by RNA Sequencing in a Patient with an Unusual Form of Nemaline Myopathy: A Case Report 
    Pelin, Katarina; Sagath, Lydia; Lehtonen, Johanna; Kiiski, Kirsi; Tynninen, Olli; Paetau, Anders; Johari, Mridul; Savarese, Marco; Wallgren-Pettersson, Carina; Lehtokari, Vilma-Lotta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: Pathogenic variants in the TPM3 gene, encoding slow skeletal muscle α-tropomyosin account for less than 5% of nemaline myopathy cases. Dominantly inherited or de novo missense variants in TPM3 are more common ...
  • Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency 
    Tuovinen, Elina A.; Grönholm, Juha; Ohman, Tiina; Pöysti, Sakari; Toivonen, Raine; Kreutzman, Anna; Heiskanen, Kaarina; Trotta, Luca; Toiviainen-Salo, Sanna; Routes, John M.; Verbsky, James; Mustjoki, Satu; Saarela, Janna; Kere, Juha; Varjosalo, Markku; Hänninen, Arno; Seppänen, Mikko (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Hypomorphic IL2RG mutations may lead to milder phenotypes than X-SCID, named variably as atypical X-SCID or X-CID. We report an 11-year-old boy with a novel c. 172C>T;p.(Pro58Ser) mutation in IL2RG, presenting with atypical ...