Browsing Det medisinske fakultet by Title

Now showing items 380-399 of 598

  • Nucleolin regulates phosphorylation and nuclear export of Fibroblast Growth Factor 1 (FGF1) 
    Sletten, Torunn; Kostas, Michal; Bober, Joanna; Sørensen, Vigdis; Yadollahi, Mandana; Olsnes, Sjur; Tomala, Justyna; Otlewski, Jacek; Zakrzewska, Malgorzata; Wiedlocha, Antoni (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Extracellular fibroblast growth factor 1 (FGF1) acts through cell surface tyrosine kinase receptors, but FGF1 can also act directly in the cell nucleus, as a result of nuclear import of endogenously produced, non-secreted ...
  • Obesity-associated changes in molecular biology of primary breast cancer 
    Nguyen, Ha-Linh; Geukens, Tatjana; Maetens, Marion; Aparicio, Samuel; Bassez, Ayse; Borg, Ake; Brock, Jane; Broeks, Annegien; Caldas, Carlos; Cardoso, Fatima; De Schepper, Maxim; Delorenzi, Mauro; Drukker, Caroline A.; Glas, Annuska M.; Green, Andrew R.; Isnaldi, Edoardo; Eyfjörð, Jórunn; Khout, Hazem; Knappskog, Stian; Krishnamurthy, Savitri; Lakhani, Sunil R.; Langerød, Anita; Martens, John W. M.; McCart Reed, Amy E.; Murphy, Leigh; Naulaerts, Stefan; Nik-Zainal, Serena; Nevelsteen, Ines; Neven, Patrick; Piccart, Martine; Poncet, Coralie; Punie, Kevin; Purdie, Colin; Rakha, Emad A.; Richardson, Andrea; Rutgers, Emiel; Vincent-Salomon, Anne; Simpson, Peter T.; Schmidt, Marjanka K.; Sotiriou, Christos; Span, Paul N.; Tan, Kiat Tee Benita; Thompson, Alastair; Tommasi, Stefania; Van Baelen, Karen; Van de Vijver, Marc; Van Laere, Steven; van’t Veer, Laura; Viale, Giuseppe; Viari, Alain; Vos, Hanne; Witteveen, Anke T.; Wildiers, Hans; Floris, Giuseppe; Garg, Abhishek D.; Smeets, Ann; Lambrechts, Diether; Biganzoli, Elia; Richard, François; Desmedt, Christine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology ...
  • Off-label uses of drugs for depression 
    Skånland, Sigrid Strand; Cieslar-Pobuda, Artur (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The prescription of drugs for depression is rising rapidly. One of the reasons for this trend is their many off-label uses. Up to one third of all prescriptions are for non-indicated use, which in addition to drug repurposing ...
  • OikoBase: a genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica 
    Danks, Gemma Barbara; Campsteijn, Coen; Parida, Mruyunjaya; Butcher, Stephen; Doddapaneni, Harsha; Fu, Bolei; Petrin, Raul; Metpally, Raghu; Lenhard, Boris; Wincker, Patrick; Chourrout, Daniel; Thompson, Eric; Manak, J Robert (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    We report the development of OikoBase (http://oikoarrays.biology.uiowa.edu/Oiko/), a tiling array-based genome browser resource for Oikopleura dioica, a metazoan belonging to the urochordates, the closest extant group to ...
  • On Becoming Microbes and People with Texts. Moving Academic Writing Toward Responsible Agency 
    Borges Rau Steuernagel, Carolina; Resløkken, Åmund Norum; Lillehagen, Ida (Chapter / Bokkapittel / PublishedVersion; Peer reviewed, 2024)
    This chapter explores how academic textual production may be understood as a practice of responsible agency, through a dialogue between two scholarly texts about microbes. The first emphasizes the discovery of bacteria, ...
  • ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma 
    Jackson, Evangeline R.; Duchatel, Ryan J.; Staudt, Dilana E.; Persson, Mika L.; Mannan, Abdul; Yadavilli, Sridevi; Parackal, Sarah; Game, Shaye; Chong, Wai Chin; Jayasekara, W.N. Samantha; Le Grand, Marion; Kearney, Padraic S.; Douglas, Alicia M.; Findlay, Izac J.; Germon, Zacary P.; McEwen, Holly P.; Beitaki, Tyrone S.; Patabendige, Adjanie; Skerrett-Byrne, David A.; Nixon, Brett; Smith, Nathan D.; Day, Bryan; Manoharan, Neevika; Nagabushan, Sumanth; Hansford, Jordan R.; Govender, Dinisha; McCowage, Geoff B.; Firestein, Ron; Howlett, Meegan; Endersby, Raelene; Gottardo, Nicholas G.; Alvaro, Frank; Waszak, Sebastian Martin; Larsen, Martin R.; Colino-Sanguino, Yolanda; Valdes-Mora, Fatima; Rakotomalala, Andria; Meignan, Samuel; Pasquier, Eddy; André, Nicolas; Hulleman, Esther; Eisenstat, David D.; Vitanza, Nicholas A.; Nazarian, Javad; Koschmann, Carl; Mueller, Sabine; Cain, Jason E.; Dun, Matthew D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to ...
  • "Once Upon a Time" Fairytales and the Translation of Mindfulness in Whereever you go, There You Are 
    Resløkken, Åmund Norum; Henrichsen, Gina Fraas; Ødemark, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
  • OnTarget: In silico design of MiniPromoters for targeted delivery of expression 
    Fornes, Oriol; Av-Shalom, Tamar V; Korecki, Andrea J; Farkas, Rachelle A; Arenillas, David J; Mathelier, Anthony; Simpson, Elizabeth M; Wasserman, Wyeth W (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract MiniPromoters, or compact promoters, are short DNA sequences that can drive expression in specific cells and tissues. While broadly useful, they are of high relevance to gene therapy due to their role ...
  • OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells 
    Rogne, Marie; Chu, Dinh Toi; Küntziger, Thomas M.; Mylonakou, Maria-Niki; Collas, Philippe; Tasken, Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Optic atrophy 1 (OPA1) is the A-kinase anchoring protein targeting the pool of protein kinase A (PKA) responsible for perilipin 1 phosphorylation, a gatekeeper for lipolysis. However, the involvement of OPA1-bound PKA in ...
  • Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation 
    Caglayan, Safak; Hashim, Adnan; Cieslar-Pobuda, Artur; Jensen, Vidar; Behringer, Sidney; Talug, Burcu; Chu, Dinh Toi; Pecquet, Christian; Rogne, Marie; Brech, Andreas; Brorson, Sverre Henning; Nagelhus, Erlend Arnulf; Hannibal, Luciana; Boschi, Antonella; Tasken, Kjetil; Staerk, Judith (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Optic atrophy 1 (OPA1), a GTPase at the inner mitochondrial membrane involved in regulating mitochondrial fusion, stability, and energy output, is known to be crucial for neural development: Opa1 heterozygous mice show ...
  • Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers 
    Hoei-Hansen, Christina E; Kraggerud, Sigrid M; Abeler, Vera M; Kærn, Janne; Rajpert-De Meyts, Ewa; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events ...
  • Pan-cancer atlas of somatic core and linker histone mutations 
    Bonner, Erin R.; Dawood, Adam; Gordish-Dressman, Heather; Eze, Augustine; Bhattacharya, Surajit; Yadavilli, Sridevi; Mueller, Sabine; Waszak, Sebastian Martin; Nazarian, Javad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone ...
  • Parvalbumin interneuron dendrites enhance gamma oscillations 
    Kriener, Birgit; Hu, Hua; Vervaeke, Koen Gerard Alois (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Dendrites are essential determinants of the input-output relationship of single neurons, but their role in network computations is not well understood. Here, we use a combination of dendritic patch-clamp recordings and in ...
  • Pathologic Blood Samples Tolerate Exposure to Vibration and High Turbulence in Simulated Drone Flights, but Plasma Samples Should be Centrifuged after Flight 
    Johannessen, Karl Arne; Wear, Nina Kristin Steen; Toska, Karin; Hansbø, Morten; Berg, Jens Petter; Fosse, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Objective. Most of the previous studies of drone transport of blood samples examined normal blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone flights using random vibration ...
  • Patient safety in remote primary care encounters: Multimethod qualitative study combining Safety i and Safety II analysis 
    Payne, Rebecca; Clarke, Aileen; Swann, Nadia; Van Dael, Jackie; Brenman, Natassia; Rosen, Rebecca; Mackridge, Adam; Moore, Lucy; Kalin, Asli; Ladds, Emma; Hemmings, Nina; Rybczynska-Bunt, Sarah; Faulkner, Stuart; Hanson, Isabel; Spitters, Sophie; Wieringa, Cornelis Hermannus Sietse; Dakin, Francesca H.; Shaw, Sara E.; Wherton, Joseph; Byng, Richard; Husain, Laiba; Greenhalgh, Trisha (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Triage and clinical consultations increasingly occur remotely. We aimed to learn why safety incidents occur in remote encounters and how to prevent them. Setting and sample UK primary care. 95 safety incidents ...
  • Patients´ and GPs´ expectations regarding healthcare-seeking behavior: a Norwegian comparative study. 
    Eide, Torunn Bjerve; Straand, Jørund; Rosvold, Elin Olaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background GPs are Norwegian patients' first contact point with the healthcare system for most medical problems. However, little is known regarding GPs' expectations towards their patients' healthcare-seeking behaviour, ...
  • Penile Cancers Attributed to Human Papillomavirus Are Associated with Improved Survival for Node-positive Patients. Findings from a Norwegian Cohort Study Spanning 50 Years 
    Moen, Christian Arvei; Falkenthal, Thea Eline Hetland; Torkelsen, Tor Kristian; Hopland, Andreas; Rio, Oline Eriksen; Honore, Alfred; Juliebø-Jones, Patrick; Dongre, Harsh Nitin; Costea, Daniela Elena; Bostad, Leif Henry; Brennan, Paul; Johansson, Mattias; Feirrero-Iglesias, Aida; Brenner, Nicole; Waterboer, Tim; Nygård, Mari; Beisland, Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: Human papillomavirus (HPV) infection is a risk factor for the development of penile squamous cell carcinoma (PSCC). It remains inconclusive whether HPV-related PSCC has a different prognosis from non-HPV-related ...
  • Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase 
    Sørensen, Henrik Vinther; Montserrat-Canals, Mateu; Loose, Jennifer Sarah Maria; Fisher, S. Zoë; Moulin, Martine; Blakeley, Matthew P.; Cordara, Gabriele; Bjerregaard-Andersen, Kaare; Krengel, Ute (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Lytic polysaccharide monooxygenases (LPMOs) are surface-active redox enzymes that catalyze the degradation of recalcitrant polysaccharides, making them important tools for energy production from renewable sources. In ...
  • Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies 
    Desalegn, Anteneh Assefa; van der Ent, Wietske; Lenters, Virissa; Torcelino-Iszatt, Nina Louise; Stigum, Hein; Lyche, Jan Ludvig; Berg, Vidar; Kirstein-Smardzewska, Karolina Joanna; Esguerra, Camila Vicencio; Eggesbø, Merete Åse (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background The etiology of autism spectrum disorder (ASD) is multifactorial, involving genetic and environmental contributors such as endocrine-disrupting chemicals (EDCs). Objective To evaluate the association ...
  • Perineuronal nets stabilize the grid cell network 
    Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Sutterud, Hallvard; Blackstad, Jan Sigurd; Fyhn, Marianne; Hafting, Torkel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) ...