Browsing Det medisinske fakultet by Title

Now showing items 1-20 of 249

  • 2018 International Olympic Committee consensus statement on prevention, diagnosis and management of pediatric anterior cruciate ligament (ACL) injuries 
    Ardern, Clare L.; Ekås, Guri Ranum; Grindem, Hege; Moksnes, Håvard; Anderson, Allen F.; Chotel, Franck; Cohen, Moises; Forssblad, Magnus; Ganley, Theodore J.; Feller, Julian A.; Karlsson, Jón; Kocher, Minider S.; LaPrade, Robert F.; McNamee, Michael; Mandelbaum, Bert; Micheli, Lyle; Mohtadi, Nicholas; Reider, Bruce; Roe, Justin; Seil, Romain; Siebold, Rainer; Silvers-Granelli, Holly J.; Soligard, Torbjørn; Witvrouw, Erik; Engebretsen, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric ACL injuries. Representatives ...
  • A four‐group urine risk classifier for predicting outcomes in patients with prostate cancer 
    Connell, Shea P; Yazbek-Hanna, Marcelino; McCarthy, Frank; Hurst, Rachel; Webb, Martyn; Curley, Helen; Walker, Helen; Mills, Rob; Ball, Richard Y; Sanda, Martin G.; Pellegrini, Kathryn L; Patil, Dattatraya; Perry, Antoinette; Schalken, Jack A.; Pandha, Hardev; Whitaker, Hayley; Dennis, Nening; Stuttle, Christine; Mills, Ian Geoffrey; Guldvik, Ingrid; Parker, Chris; Brewer, Daniel; Cooper, Colin S.; Clark, Jeremy P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objectives To develop a risk classifier using urine‐derived extracellular vesicle (EV )‐RNA capable of providing diagnostic information on disease status prior to biopsy, and prognostic information for men on active ...
  • A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase 
    Sommer, Theis; Bjerregaard-Andersen, Kaare; Uribe, Lalita; Etzerodt, Michael; Diezemann, Gregor; Gauss, Jürgen; Cascella, Michele; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
  • A highly redundant BAC library of Atlantic salmon (Salmo salar): an important tool for salmon projects 
    Thorsen, Jim; Zhu, Baoli; Frengen, Eirik; Osoegawa, Kazutoyo; de Jong, Pieter J; Koop, Ben F; Davidson, William S; Høyheim, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Background As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify the genomic mechanisms for specific traits is becoming more important in breeding and management of the ...
  • A survey of protein interaction data and multigenic inherited disorders 
    Mora, Antonio; Michalickova, Katerina; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein ...
  • A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways 
    Fensgård, Øyvind; Kassahun, Henok; Izabela Agnieszka, Bombik; Rognes, Torbjørn; Lindvall, Jessica Margareta; Nilsen, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response ...
  • A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis 
    Skotheim, Rolf I; Thomassen, Gard O; Eken, Marthe; Lind, Guro E; Micci, Francesca; Ribeiro, Franclim R; Cerveira, Nuno; Teixeira, Manuel R; Heim, Sverre; Rognes, Torbjørn; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Background The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal ...
  • Accuracy of self‐monitoring: does experience, ability or case difficulty matter? 
    Hautz, Wolf E.; Schubert, Sebastian; Schauber, Stefan Kilian; Kunina-Habenicht, Olga; Hautz, Stefanie C.; Kämmer, Juliane E.; Eva, Kevin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Context The ability to self‐monitor one's performance in clinical settings is a critical determinant of safe and effective practice. Various studies have shown this form of self‐regulation to be more trustworthy than ...
  • Achieving objective response in treatment of non-resectable neuroendocrine tumors does not predict longer time to progression compared to achieving stable disease 
    Thiis-Evensen, Espen; Poole, Amalie C; Nguyen, Hong-Thien T; Sponheim, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis ...
  • Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 
    Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, ...
  • Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience 
    Brudvik, Kristoffer Watten; Bains, Simer Jit; Seeberg, Lars Thomas; Labori, Knut Jørgen; Waage, Anne; Tasken, Kjetil; Aandahl, Einar Martin; Bjørnbeth, Bjørn Atle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. ...
  • Akutt forgiftning ved rusrelatert bruk av benzodiazepiner 
    Andersson, Jon Andreas; Brekke, Mette; Vallersnes, Odd Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    BAKGRUNN Benzodiazepiner brukes også som rusmidler. Dette kan være farlig, særlig ved blandingsrus. Vi beskriver akutte forgiftninger ved rusrelatert bruk av benzodiazepiner hos pasienter på Legevakten i Oslo. MATERIALE ...
  • Alcohol abstinence and drinking among African women: data from the World Health Surveys 
    Martinez, Priscilla; Røislien, Jo; Naidoo, Nirmala; Clausen, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Alcohol use is increasing among women in Africa, and comparable information about women's current alcohol use is needed to inform national and international health policies relevant to the entire ...
  • The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon Secretion 
    Jenstad, Monica; Chaudhry, Farrukh Abbas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Intercellular communication is pivotal in optimizing and synchronizing cellular responses to keep homeostasis and to respond adequately to external stimuli. In the central nervous system (CNS), glutamatergic and GABAergic ...
  • An EST-based approach for identifying genes expressed in the intestine and gills of pre-smolt Atlantic salmon (Salmo salar) 
    Hagen-Larsen, Heidi; Laerdahl, Jon K; Panitz, Frank; Adzhubei, Alexei; Høyheim, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Background The Atlantic salmon is an important aquaculture species and a very interesting species biologically, since it spawns in fresh water and develops through several stages before becoming a smolt, ...
  • The androgen receptor controls expression of the cancerassociated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer 
    Munkley, Jennifer; Oltean, Sebastian; Vodak, Daniel; Wilson, Brian T.; Livermore, Karen E.; Zhou, Yan; Star, Eleanor; Floros, Vasileios I.; Johannessen, Bjarne; Knight, Bridget; McCullagh, Paul; McGrath, John; Crundwell, Malcolm; Skotheim, Rolf Inge; Robson, Craig N.; Leung, Hing Y.; Harries, Lorna W.; Rajan, Prabhakar; Mills, Ian Geoffrey; Elliott, David J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ...
  • Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer 
    Urbanucci, Alfonso; Barfeld, Stefan Jörg; Kytölä, Ville; Itkonen, Harri; Coleman, Ilsa M.; Vodák, Daniel; Sjöblom, Liisa; Sheng, Xia; Minner, Sarah; Burdelski, Christoph; Kivinummi, Kati K.; Kohvakka, Annika; Kregel, Steven; Takhar, Mandeep; Alshalalfa, Mohammed; Davicioni, Elai; Erho, Nicholas; Lloyd, Paul; Karnes, R. Jeffrey; Ross, Ashley E.; Schaeffer, Edward M.; Vander Griend, Donald J; Knapp, Stefan; Corey, Eva; Feng, Felix Y.; Nelson, Peter S.; Saatcioglu, Fahri; Knudsen, Karen E.; Tammela, Teuvo L.J.; Sauter, Guido; Schlomm, Thorsten; Nykter, Matti; Visakorpi, Tapio; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been ...
  • Annotated Expressed Sequence Tags (ESTs) from pre-smolt Atlantic salmon (Salmo salar) in a searchable data resource 
    Adzhubei, Alexei A; Vlasova, Anna V; Hagen-Larsen, Heidi; Ruden, Torgeir A; Laerdahl, Jon K; Høyheim, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their ...
  • Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life 
    Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
  • Antibody-antigen kinetics constrain intracellular humoral immunity 
    Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E; Foss, Stian; Sandlie, Inger; Andersen, Jan Terje; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching ...