Browsing Det medisinske fakultet by Title
Now showing items 1-20 of 225
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric ACL injuries. Representatives ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify the genomic mechanisms for specific traits is becoming more important in breeding and management of the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)Background Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)Background The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)Context The ability to self‐monitor one's performance in clinical settings is a critical determinant of safe and effective practice. Various studies have shown this form of self‐regulation to be more trustworthy than ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Alcohol use is increasing among women in Africa, and comparable information about women's current alcohol use is needed to inform national and international health policies relevant to the entire ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)Intercellular communication is pivotal in optimizing and synchronizing cellular responses to keep homeostasis and to respond adequately to external stimuli. In the central nervous system (CNS), glutamatergic and GABAergic ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background The Atlantic salmon is an important aquaculture species and a very interesting species biologically, since it spawns in fresh water and develops through several stages before becoming a smolt, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ...
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Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability of PTE to cross the blood–brain barrier raised the possibility that this compound may modulate ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs). ...