Browsing Det medisinske fakultet by Title

Now showing items 1-20 of 371

  • 2018 International Olympic Committee consensus statement on prevention, diagnosis and management of pediatric anterior cruciate ligament (ACL) injuries 
    Ardern, Clare L.; Ekås, Guri Ranum; Grindem, Hege; Moksnes, Håvard; Anderson, Allen F.; Chotel, Franck; Cohen, Moises; Forssblad, Magnus; Ganley, Theodore J.; Feller, Julian A.; Karlsson, Jón; Kocher, Minider S.; LaPrade, Robert F.; McNamee, Michael; Mandelbaum, Bert; Micheli, Lyle; Mohtadi, Nicholas; Reider, Bruce; Roe, Justin; Seil, Romain; Siebold, Rainer; Silvers-Granelli, Holly J.; Soligard, Torbjørn; Witvrouw, Erik; Engebretsen, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric ACL injuries. Representatives ...
  • 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish 
    Gawel, Kinga Aurelia; Kukula-Koch, Wirginia; Banono, Nancy Saana; Nieoczym, Dorota; Targowska-Duda, Katarzyna M; Czernicka, Lidia; Parada-Turska, Jolanta; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts antiseizure activity, but the ...
  • A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity 
    Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren; Fure, Hilde; Landsem, Anne; Bergseth, Grete; Schjalm, Camilla; Haugaard-Kedström, Linda M.; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ...
  • A four‐group urine risk classifier for predicting outcomes in patients with prostate cancer 
    Connell, Shea P; Yazbek-Hanna, Marcelino; McCarthy, Frank; Hurst, Rachel; Webb, Martyn; Curley, Helen; Walker, Helen; Mills, Rob; Ball, Richard Y; Sanda, Martin G.; Pellegrini, Kathryn L; Patil, Dattatraya; Perry, Antoinette; Schalken, Jack A.; Pandha, Hardev; Whitaker, Hayley; Dennis, Nening; Stuttle, Christine; Mills, Ian Geoffrey; Guldvik, Ingrid; Parker, Chris; Brewer, Daniel; Cooper, Colin S.; Clark, Jeremy P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objectives To develop a risk classifier using urine‐derived extracellular vesicle (EV )‐RNA capable of providing diagnostic information on disease status prior to biopsy, and prognostic information for men on active ...
  • A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase 
    Sommer, Theis; Bjerregaard-Andersen, Kaare; Uribe, Lalita; Etzerodt, Michael; Diezemann, Gregor; Gauss, Jürgen; Cascella, Michele; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
  • A highly redundant BAC library of Atlantic salmon (Salmo salar): an important tool for salmon projects 
    Thorsen, Jim; Zhu, Baoli; Frengen, Eirik; Osoegawa, Kazutoyo; de Jong, Pieter J; Koop, Ben F; Davidson, William S; Høyheim, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Background As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify the genomic mechanisms for specific traits is becoming more important in breeding and management of the ...
  • A single step three-strain in vivo Gateway reaction 
    Gillman, Aaron Nicholas; Helleux, Alexandra; Abel, Sören (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    We developed a simplified, highly efficient Gateway reaction that recombines target DNA to expression (destination) plasmids in vivo and subsequently conjugates the final vector into a recipient strain, all in a single ...
  • A survey of protein interaction data and multigenic inherited disorders 
    Mora, Antonio; Michalickova, Katerina; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein ...
  • A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways 
    Fensgård, Øyvind; Kassahun, Henok; Izabela Agnieszka, Bombik; Rognes, Torbjørn; Lindvall, Jessica Margareta; Nilsen, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response ...
  • A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis 
    Skotheim, Rolf I; Thomassen, Gard O; Eken, Marthe; Lind, Guro E; Micci, Francesca; Ribeiro, Franclim R; Cerveira, Nuno; Teixeira, Manuel R; Heim, Sverre; Rognes, Torbjørn; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Background The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal ...
  • Accuracy of self‐monitoring: does experience, ability or case difficulty matter? 
    Hautz, Wolf E.; Schubert, Sebastian; Schauber, Stefan Kilian; Kunina-Habenicht, Olga; Hautz, Stefanie C.; Kämmer, Juliane E.; Eva, Kevin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Context The ability to self‐monitor one's performance in clinical settings is a critical determinant of safe and effective practice. Various studies have shown this form of self‐regulation to be more trustworthy than ...
  • Achieving objective response in treatment of non-resectable neuroendocrine tumors does not predict longer time to progression compared to achieving stable disease 
    Thiis-Evensen, Espen; Poole, Amalie C; Nguyen, Hong-Thien T; Sponheim, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis ...
  • Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 
    Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, ...
  • Active antibiotic discontinuation in suspected but not confirmed early‐onset neonatal sepsis—A quality improvement initiative 
    Dretvik, Thomas Bruvoll; Solevåg, Anne Lee; Finvåg, Andreas; Størdal, Eline Hasselgård; Størdal, Ketil; Klingenberg, Claus (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Aim To study whether a simple targeted intervention could reduce unwarranted antibiotic treatment in near‐term and term neonates with suspected, but not confirmed early‐onset sepsis. Methods A quality improvement ...
  • Advanced in developmental organic and inorganic nanomaterial: a review 
    Khalid, Khalisanni; Tan, Xuefei; Mohd Zaid, Hayyiratul Fatimah; Tao, Yang; Lye Chew, Chien; Chu, Dinh Toi; Lam, Man Kee; Ho, Yeek-Chia; Lim, Jun Wei; Chin Wei, Lai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    With the unique properties such as high surface area to volume ratio, stability, inertness, ease of functionalization, as well as novel optical, electrical, and magnetic behaviors, nanomaterials have a wide range of ...
  • Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience 
    Brudvik, Kristoffer Watten; Bains, Simer Jit; Seeberg, Lars Thomas; Labori, Knut Jørgen; Waage, Anne; Tasken, Kjetil; Aandahl, Einar Martin; Bjørnbeth, Bjørn Atle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. ...
  • Akutt forgiftning ved rusrelatert bruk av benzodiazepiner 
    Andersson, Jon Andreas; Brekke, Mette; Vallersnes, Odd Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    BAKGRUNN Benzodiazepiner brukes også som rusmidler. Dette kan være farlig, særlig ved blandingsrus. Vi beskriver akutte forgiftninger ved rusrelatert bruk av benzodiazepiner hos pasienter på Legevakten i Oslo. MATERIALE ...
  • Alcohol abstinence and drinking among African women: data from the World Health Surveys 
    Martinez, Priscilla; Røislien, Jo; Naidoo, Nirmala; Clausen, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Alcohol use is increasing among women in Africa, and comparable information about women's current alcohol use is needed to inform national and international health policies relevant to the entire ...
  • ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells 
    Schläfli, Anna M.; Tokarchuk, Igor; Parejo, Sarah; Jutzi, Susanne; Berezowska, Sabina; Engedal, Nikolai; Tschan, Mario P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract ALK inhibitors effectively target EML4-ALK positive non-small cell lung cancer, but their effects are hampered by treatment resistance. In the present study, we asked whether ALK inhibition affects autophagy, and ...
  • The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon Secretion 
    Jenstad, Monica; Chaudhry, Farrukh Abbas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Intercellular communication is pivotal in optimizing and synchronizing cellular responses to keep homeostasis and to respond adequately to external stimuli. In the central nervous system (CNS), glutamatergic and GABAergic ...