Browsing Det medisinske fakultet by Issue Date
Now showing items 1-20 of 548
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 1995)The recently cloned murine flt3 ligand (FL) was studied for its ability to stimulate the growth of primitive (Lin-Sca-1+) and more committed (Lin-Sca-1-) murine bone marrow progenitor cells, alone and in combination with ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)To identify phosphoproteins that might play a role in naringin-sensitive hepatocellular cytoskeletal disruption and apoptosis induced by algal toxins, hepatocyte extracts were separated by gel electrophoresis and immunostained ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify the genomic mechanisms for specific traits is becoming more important in breeding and management of the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background The behaviour of children with Attention-Deficit / Hyperactivity Disorder is often described as highly variable, in addition to being hyperactive, impulsive and inattentive. One reason might be ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background The Atlantic salmon is an important aquaculture species and a very interesting species biologically, since it spawns in fresh water and develops through several stages before becoming a smolt, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)Background Trace or chromatogram files (raw data) are produced by automatic nucleic acid sequencing equipment or sequencers. Each file contains information which can be interpreted by specialised software ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)Soil bacteria are heavily exposed to environmental methylating agents such as methylchloride and may have special requirements for repair of alkylation damage on DNA. We have used functional complementation of an Escherichia ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs). ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian carcinomas (n = 52) ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Rapid means to discover and enumerate unknown mutations in the exons of human genes on a pangenomic scale are needed to discover the genes carrying inherited risk for common diseases or the genes ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)Background Microarray Comparative Genomic Hybridization (array CGH) provides a means to examine DNA copy number aberrations. Various platforms, brands and underlying technologies are available, facing the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)Background The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal ...
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Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)Background Sequencing of the human genome has led to most genes being available in BAC or PAC vectors. However, limited functional information has been assigned to most of these genes. Techniques for the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)Background TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)Background High-density tiling microarrays are a powerful tool for the characterization of complete genomes. The two major computational challenges associated with custom-made arrays are design and analysis. Firstly, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, ...