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Achieving objective response in treatment of non-resectable neuroendocrine tumors does not predict longer time to progression compared to achieving stable disease 
Thiis-Evensen, Espen; Poole, Amalie C; Nguyen, Hong-Thien T; Sponheim, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis ...
Integrative approaches to study TF-DNA interactions 
Gheorghe, Marius (Doctoral thesis / Doktoravhandling, 2020)
Transcriptional regulation is a crucial process for cell differentiation and development. This process is tightly coordinated by the binding of key proteins, called transcription factors (TFs), to the DNA in a sequence-specific ...
Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms 
Thonon, Bénédicte; Van Aubel, Evelyne; Lafit, Ginette; Della Libera, Clara; Larøi, Frank (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative ...
JASPAR 2020: update of the open-access database of transcription factor binding profiles 
Fornes, Oriol; Castro Mondragón, Jaime Abraham; Khan, Aziz; Robin van der, Lee; Zhang, Xi; A. Richmond, Phillip; P. Modi, Bhavi; Correard, Solenne; Gheorghe, Marius; Baranasic, Damir; Santana-Garcia, Walter; Tan, Ge; Cheneby, Jeanne; Ballester, Benoit; Parcy, François; Sandelin, Albin; Lenhard, Boris; Wasserman, Wyeth W.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) for TFs across multiple species in six taxonomic ...
How sure can we be that a student really failed? On the measurement precision of individual pass-fail decisions from the perspective of Item Response Theory 
Schauber, Stefan Kilian; Hecht, Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background In high-stakes assessments in medical education, the decision to let a particular participant pass or fail has far-reaching consequences. Reliability coefficients are usually used to support the trustworthiness ...
Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function 
Fagny, Maud; Platig, John; Kuijjer, Marieke Lydia; Lin, Xihong; Quackenbush, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs ...
ESCRT-mediated phagophore sealing during mitophagy 
Zhen, Yan; Spangenberg, Helene; Munson, Michael Joseph; Brech, Andreas; Schink, Kay Oliver; Tan, Kia Wee; Sørensen, Vigdis; Wenzel, Eva; Radulovic, Maja; Engedal, Nikolai; Simonsen, Anne; Raiborg, Camilla; Stenmark, Harald (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in macroautophagy/autophagy remain incompletely ...
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene 
Gawel, Kinga Aurelia; Turski, Waldemar A.; van der Ent, Wietske; Mathai, Benan John; Kirstein-Smardzewska, Karolina Joanna; Simonsen, Anne; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug 
Kamiński, Krzysztof; Esguerra, Camila V.; Gawel, Kinga Aurelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure ...
Predicting skin barrier dysfunction and atopic dermatitis in early infancy 
Rehbinder, Eva Maria; Endre, Kim Magnus Advocaat; Carlsen, Karin C. Lødrup; Asarnoj, Anna; Bains, Karen Eline Stensby; Berents, Teresa Løvold; Carlsen, Kai-Håkon; Gudmundsdóttir, Hrefna Katrín; Haugen, Guttorm; Hedlin, Gunilla; Kreyberg, Ina; Nordhagen, Live Solveig; Nordlund, Björn; Schinagl, Carina Madelen; Sandvik, Leiv; Skjerven, Håvard Ove; Söderhäll, Cilla; Staff, Anne Cathrine; Vettukattil, Muhammad Riyas; Værnesbranden, Caren Magdalena Rydland; Landrø, Linn Aina Ysland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Dry skin is associated with increased transepidermal water loss (TEWL), which has been found to precede atopic dermatitis (AD) in childhood. Objective We aimed to identify parental, prenatal, and perinatal predictive factors ...
Measurement precision at the cut score in medical multiple choice exams: Theory matters 
Felicitas-Maria, Lahner; Schauber, Stefan Kilian; Andrea Carolin, Lövald; Roger, Kropf; Sissel, Guttormsen; Martin R., Fischer; Sören, Huwendiek (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction In high-stakes assessment, the measurement precision of pass-fail decisions is of great importance. A concept for analyzing the measurement precision at the cut score is conditional reliability, which ...
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components 
Lindner, Paula; Christensen, Søren B; Nissen, Poul; Møller, Jesper V; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. ...
A Short Series of Laparoscopic Mesenteric Bypasses for Chronic Mesenteric Ischemia 
Kazmi, Syed Sajid Hussain; Berge, Simen Tveten; Sahba, Mehdi; Medhus, Asle Wilhelm; Sundhagen, Jon Otto (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Laparoscopic aortomesenteric bypass may be performed to treat the chronic mesenteric ischemia patients who are not suitable for endovascular treatment. This study presents an initial experience with a limited ...
Long-Term Language Development in Children With Early Simultaneous Bilateral Cochlear Implants 
Wie, Ona Bø; Torkildsen, Janne von Koss; Schauber, Stefan Kilian; Busch, Tobias; Litovsky, Ruth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objectives: This longitudinal study followed the language development of children who received the combination of early (5 to 18 months) and simultaneous bilateral cochlear implants (CIs) throughout the first 6 years ...
Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy 
Larsson, Christopher; Groote, Inge Rasmus; Vardal, Jonas; Kleppestø, Magne Mørk; Odland, Audun; Brandal, Petter; Due-Tønnessen, Paulina; Holme, Sigrun Skaar; Hope, Tuva Roaldsdatter; Meling, Torstein Ragnar; Fosse, Erik; Emblem, Kyrre E; Bjørnerud, Atle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The aim of this study was to investigate changes in structural magnetic resonance imaging (MRI) according to the RANO criteria and perfusion- and permeability related metrics derived from dynamic contrast-enhanced ...
Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy 
Gonzalez, Alba; Nome, Cecilie; Bendiksen, Bård Andre; Sjaastad, Ivar; Zhang, Lili; Aleksandersen, Mona; Taubøll, Erik; Aurlien, Dag; Heuser, Kjell (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature seizure-related death. An association between SUDEP and cardiac remodeling has been suggested. However, whether SUDEP is a direct consequence ...
Quantification of ocular surface microcirculation by computer assisted video microscopy and diffuse reflectance spectroscopy 
Kvernebo, Anne Kari; Miyamoto, Takuma; Sporastøyl, Ane Halse; Wikslund, Liv Kristin; Måsøy, Svein-Erik; Drolsum, Liv; Moe, Morten Carsten; Salerud, Göran; Fukamachi, Kiyotaka; Kvernebo, Knut (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In piglets we tested the applicability of digital video microscopy and diffuse reflectance spectroscopy for non-invasive assessments of limbal and bulbar conjunctival microcirculation. A priori we postulated that the ...
Evidence of validity for the Norwegian version of the interprofessional collaborative competency attainment survey (ICCAS) 
Lunde, Lene; Baerheim, Anders; Johannessen, Ane; Aase, Ingunn; Almendingen, Kari; Andersen, Irene Aasen; Bengtsson, Rutt Venke; Brenna, Sissel Johansson; Hauksdottir, Nanna; Steinsbekk, Aslak; Rosvold, Elin Olaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
This was a validation study of the Norwegian version of The Interprofessional Collaborative Competency Attainment Survey (ICCAS). ICCAS consists of 20 retrospective pre- and post-questions, where respondents rate their ...
DNA copy number motifs are strong and independent predictors of survival in breast cancer 
Pladsen, Arne Valebjørg; Nilsen, Gro; Rueda, Oscar M.; Aure, Miriam Ragle; Borgan, Ørnulf; Liestøl, Knut; Vitelli, Valeria; Frigessi Di Rattalma, Arnoldo; Langerød, Anita; Mathelier, Anthony; Engebråten, Olav; Kristensen, Vessela N.; Wedge, David C.; Van Loo, Peter; Caldas, Carlos; Børresen-Dale, Anne-Lise; Russnes, Hege Elisabeth Giercksky; Lingjærde, Ole Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome ...
Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples 
Napoli, Elisa; Stenberg, Vilde Yuli; Juzeniene, Asta; Hjellum, Gro E.; Bruland, Øyvind; Larsen, Roy H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Lead-212 is a promising radionuclide for cancer therapy, but no primary 212Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of 212Pb activity in equilibrium ...
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells 
Barkovskaya, Anna; Seip, Kotryna; Prasmickaite, Lina; Mills, Ian Geoffrey; Moestue, Siver Andreas; Itkonen, Harri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of ...
Stage‑specific survival has improved for young breast cancer patients since 2000: but not equally 
Trewin, Cassia Bree; Johansson, Anna Louise Viktoria; Hjerkind, Kirsti Vik; Strand, Bjørn Heine; Kiserud, Cecilie E.; Ursin, Giske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose The stage-specific survival of young breast cancer patients has improved, likely due to diagnostic and treatment advances. We addressed whether survival improvements have reached all socioeconomic groups in a country ...
Behavioral effects of sub-anesthetic ketamine in a go/no-go task 
Nilsen, Andre Sevenius; Juel, Bjørn Erik; Farnes, Nadine; Romundstad, Luis Georg; Storm, Johan Frederik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims While psychedelic agents are known to have powerful, but largely unexplained, effects on contents of consciousness, there is an increasing interest in the potential clinical usefulness of such drugs ...
Longitudinal kidney function outcome in aging testicular cancer survivors 
Nome, Ragnhild Veline; Småstuen, Milada Cvancarova; Bjøro, Trine; Kiserud, Cecilie E.; Fosså, Sophie Dorothea (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose: Testicular cancer survivors (TCSs) have increased risk of reduced kidney function related to treatment burden, but longitudinal studies of renal outcome in aging TCSs have been lacking. This longitudinal study ...
Basic self-disturbances are associated with Sense of Coherence in patients with psychotic disorders 
Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Melle, Ingrid; Haug, Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The Sense of Coherence (SOC) theory gives a possible explanation of how people can experience subjective good health despite severe illness. Basic self-disturbances (BSDs) are subtle non-psychotic disturbances ...
Progress testing anytime and anywhere – Does a mobile-learning approach enhance the utility of a large-scale formative assessment tool? 
Karay, Yassin; Reiss, Birger; Schauber, Stefan Kilian (Journal article / Tidsskriftartikkel / SubmittedVersion, 2020)
Background The widespread use of mobile devices among students favors the use of mobile learning scenarios at universities. In this study, we explore whether a time- and location-independent variant of a formative ...
Data quality of Glasgow Coma Scale and Systolic Blood Pressure in scientific studies involving physician-staffed emergency medical services: Systematic review 
Tønsager, Kristin; Krüger, Andreas; Ringdal, Kjetil G.; Rehn, Marius (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Emergency physicians on‐scene provide highly specialized care to severely sick or injured patients. High‐quality research relies on the quality of data, but no commonly accepted definition of EMS data quality ...
Towards a translational medical humanities: introducing the cultural crossings of care 
Engebretsen, Eivind; Henrichsen, Gina Fraas; Ødemark, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
n this introductory essay, we will present a translational medical humanities approach where the humanities are not only an auxiliary to medical science and practice, but also an interdisciplinary space where both medicine ...
Levels of mental distress over 18 years after entering treatment for substance use disorders: A longitudinal cohort study 
Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Skeie, Ivar; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Aims: The aims were to investigate whether baseline characteristics and problematic substance use were related to change in mental distress over time in patients with substance use disorders during an 18-year period. ...
Multiple Mutuality. Positions and Storylines in Adolescent Psychodynamic Psychotherapy 
Løvgren, André; Røssberg, Jan Ivar; Engebretsen, Eivind; Ulberg, Randi (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
In the psychodynamic psychotherapy of adolescents, a mutual relationship is a central and often reoccurring theme. However, what this mutuality consists of and how adolescents experience this seems to have been the subject ...
LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction 
Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin; Vekterud, Kristin; Soedling, Helen; Matthews, Jason; Lemma, Roza Berhanu; Gabrielsen, Odd Stokke; Bindesbøll, Christian; Ulven, Stine Marie; Nebb, Hilde Irene; Grønning-Wang, Line Mariann; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid ...
Reproduction and the welfare state: Notes on Norwegian biopolitics 
Shammas, Victor Lund; Sandset, Tony Joakim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Norway has long been considered to be a bastion of social democracy due to its strong, protective, decommodifying welfare state. However, with the recent rise of neoliberalism and right-wing populist politics across the ...
Akutt forgiftning ved rusrelatert bruk av benzodiazepiner 
Andersson, Jon Andreas; Brekke, Mette; Vallersnes, Odd Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
BAKGRUNN Benzodiazepiner brukes også som rusmidler. Dette kan være farlig, særlig ved blandingsrus. Vi beskriver akutte forgiftninger ved rusrelatert bruk av benzodiazepiner hos pasienter på Legevakten i Oslo. MATERIALE ...
Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software 
Banono, Nancy Saana; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While there is an abundance of commercial and standardized automated systems and software for performing the prepulse inhibition (PPI) assay in rodents, to the best of our knowledge, all PPI assays performed in the zebrafish ...
The impact of surgical simulation on patient outcomes: a systematic review and meta-analysis 
Meling, Trym R.; Meling, Torstein Ragnar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The use of simulation in surgical training is ever growing. Evidence suggests such training may have beneficial clinically relevant effects. The objective of this research is to investigate the effects of surgical simulation ...
Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns 
Pålhaugen, Lene; Sudre, Carole H; Teceläo, Sandra Raquel Ramos; Nakling, Arne; Almdahl, Ina Selseth; Kalheim, Lisa Flem; Cardoso, M Jorge; Johnsen, Stein Harald; Rongve, Arvid; Aarsland, Dag; Bjørnerud, Atle; Selnes, Per; Fladby, Tormod (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer’s disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls ...
Trajectories and risk factors of dementia progression: a memory clinic cohort followed up to 3 years from diagnosis 
Edwin, Trine Holt; Strand, Bjørn Heine; Persson, Karin Ester Torun; Engedal, Knut; Selbæk, Geir; Knapskog, Anne-Brita (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objectives: Patients with dementia follow different trajectories of progression. We aimed to investigate which factors at the time of diagnosis could predict trajectory group membership. Design: Longitudinal ...
Post-stroke health-related quality of life at 3 and 12 months and predictors of change in a Danish and Arctic Norwegian Region 
Heiberg, Guri Anita; Friborg, Oddgeir; Pedersen, Synne Garder; Thrane, Gyrd; Stabell, Henriette Holm; Nielsen, Jørgen Feldbæk; Anke, Audny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objectives: To investigate changes in health-related quality of life between 3- and 12-months post-stroke in a north Norwegian and a Danish region that organize their rehabilitation services differently, and to identify ...
PUMA: PANDA Using MicroRNA Associations 
Kuijjer, Marieke Lydia; Fagny, Maud; Marin, Alessandro; Quackenbush, John; Glass, Kimberly (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Motivation Conventional methods to analyze genomic data do not make use of the interplay between multiple factors, such as between microRNAs (miRNAs) and the messenger RNA (mRNA) ...
Clustering Sparse Data with Feature Correlation with Application to Discover Subtypes in Cancer 
Qiang, Jipeng; Ding, Wei; Kuijjer, Marieke Lydia; Quackenbush, John; Chen, Ping (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In this paper, given data with high-dimensional features, we study this problem of how to calculate the similarity between two samples by considering feature interaction network, where a feature interaction network represents ...
Active antibiotic discontinuation in suspected but not confirmed early‐onset neonatal sepsis—A quality improvement initiative 
Dretvik, Thomas Bruvoll; Solevåg, Anne Lee; Finvåg, Andreas; Størdal, Eline Hasselgård; Størdal, Ketil; Klingenberg, Claus (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Aim To study whether a simple targeted intervention could reduce unwarranted antibiotic treatment in near‐term and term neonates with suspected, but not confirmed early‐onset sepsis. Methods A quality improvement ...
Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues 
Lopes-ramos, Camila; Chen, Cho-Yi; Kuijjer, Marieke Lydia; Paulson, Joseph N.; Sonawane, Abhijeet; Fagny, Maud; Platig, John; Glass, Kimberly; Quackenbush, John; DeMeo, Dawn L. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific gene ...
Guide on Diabetes and COVID-19 for Healthcare Professionals in Bangladesh 
Bhowmik, Bishwajit; Ahmed, Tareen; Afsana, Faria; Qureshi, Nazmul Kabir; Siddiquee, Tasnima; Pathan, Faruque; Amin, F; Do Vale Moreira, Nayla Cristina; Samad, M. A.; Ashrafuzzaman, S. M.; Ahmed, Tofail; Latif, Zafar Ahmed; Bhuiyan, Abul Majid; Alim, Abdul; Munir, Sanjida Binte; Karmokar, Rajat Kanti; Choudhury, Kaiser Alam; Zabeen, Bedowra; Islam, Khaleda; Rahman, Mohammad Mahbubur; Rahman, Mofizur; Milon, Sarowar Uddin; Ozaki, Rie; Alam, Md Abdur Razzakul; Huda, Tabassum; Rahman, Md. Habibur; Hossain, AHM Enayat; Mahtab, Hajera; Hussain, Akhtar; Khan, AK Azad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The world is suffering from a pandemic of coronavirus disease-2019 (COVID-19), and people with diabetes mellitus (DM) are more vulnerable to the serious effects of the COVID-19. This interaction is alarming, considering ...
Climate change and epilepsy: Time to take action 
Sisodiya, Sanjay M.; Fowler, Hayley J.; Lake, Iain; Nanji, Rosemary O.; Gawel, Kinga Aurelia; Esguerra, Camila Vicencio; Newton, Charles; Foley, Aideen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Climate change is the biggest challenge facing humanity today. The associated global warming and humidification, increases in the severity and frequency of extreme climate events, extension of the ranges of vector‐borne ...
Sex Differences in Quality of Life in Patients With Atrial Fibrillation: A Systematic Review 
Strømnes, Linn Arvidsson; Ree, Helene; Gjesdal, Knut; Ariansen, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The goal of this literature review was to assess sex differences in the quality of life (QoL) in patients with atrial fibrillation (AF) and, if possible, to determine if these are due to AF. Methods and ...
EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology 
Brennecke, Philip; Rasina, Dace; Aubi Catevilla, Oscar; Herzog, Katja; Landskron, Johannes; Cautain, Bastien; Vicente, Francisca; Quintana, Jordi; Mestres, Jordi; Stechmann, Bahne; Ellinger, Bernhard; Brea, Jose; Kolanowski, Jacek L.; Pilarski, Radosław; Orzáez, Mar; Pineda-Lucena, Antonio; Laraia, Luca; Nami, Faranak; Zielenkiewicz, Piotr; Paruch, Kamil; Hansen, Espen; von Kries, Jens P.; Neuenschwander, Martin; Specker, Edgar; Bartunek, Petr; Šímová, Šárka; Leśnikowski, Zbigniew; Krauss, Stefan; Lehtiö, Lari; Bilitewski, Ursula; Brönstrup, Mark; Tasken, Kjetil; Jirgensons, Aigars; Lickert, Heiko; Clausen, Mads H.; Andersen, Jeanette hammer; Vicent, Maria J.; Genilloud, Olga; Martinez, Aurora; Nazaré, Marc; Fecke, Wolfgang; Gribbon, Philip (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research ...
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 
Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, ...
Mammalian target of rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts 
Torp, May-Kristin; Yang, Kuan; Ranheim, Trine; Lauritzen, Knut Husø; Alfsnes, Katrine; Vinge, Leif Erik; Aukrust, Pål; Stensløkken, Kåre-Olav; Yndestad, Arne; Sandanger, Øystein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background: IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune receptors activating NFκB. If tissue damage occurs, ...
Styrene maleic acid copolymer induces pores in biomembranes 
Rydmark, Marcella Orwick; Christensen, Mikkel Killingmoe; Köksal, Elif; Kantarci, Ilayda; Yantchev, Ventsislav; Jesorka, Aldo; Gözen, Irep (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
We investigated the interactions between styrene–maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally ...
Diagnostic error increases mortality and length of hospital stay in patients presenting through the emergency room 
Hautz, Wolf E; Kämmer, Juliane E; Hautz, Stefanie C; Sauter, Thomas C; Zwaan, Laura; Exadaktylos, Aristomenis K; Birrenbach, Tanja; Maier, Volker; Müller, Martin; Schauber, Stefan K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Diagnostic errors occur frequently, especially in the emergency room. Estimates about the consequences of diagnostic error vary widely and little is known about the factors predicting error. Our ...
Remodeling of secretory lysosomes during education tunes functional potential in NK cells 
Goodridge, Jodie; Jacobs, Benedikt Marcel; Sætersmoen, Michelle Lu; Clement, Dennis; Hammer, Quirin; Clancy, Trevor; Skarpen, Ellen; Brech, Andreas; Landskron, Johannes; Grimm, Christian; Pfefferle, Aline; Meza, Leonardo Zepeda; Lorenz, Susanne; Wiiger, Merete Thune; Louch, William Edward; Ask, Eivind Heggernes; Liu, Lisa L.; Oei, Vincent Yi Sheng; Kjällquist, Una; Linnarsson, Sten; Patel, Sandip; Tasken, Kjetil; Stenmark, Harald; Malmberg, Karl-Johan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Inhibitory signaling during natural killer (NK) cell education translates into increased responsiveness to activation; however, the intracellular mechanism for functional tuning by inhibitory receptors remains unclear. ...
Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis 
Ha, Thomas J; Zhang, Peter G Y; Robert, Remi; Yeung, Joanna; Swanson, Douglas J; Mathelier, Anthony; Wasserman, Wyeth W; Im, Sujin; Itoh, Masayoshi; Kawaji, Hideya; Lassmann, Timo; Daub, Carsten O; Arner, Erik; Carninci, Piero; Hayashizaki, Yoshihide; Forrest, Alistair R R; Goldowitz, Daniel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The work of the FANTOM5 Consortium has brought forth a new level of understanding of the regulation of gene transcription and the cellular processes involved in creating diversity of cell types. ...
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling 
Subbannayya, Yashwanth; Pinto, Sneha M.; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members ...
Nanotube-Mediated Path to Protocell Formation 
Köksal, Elif; Liese, Susanne; Kantarci, Ilayda; Olsson, Ragni; Carlson, Andreas; Gözen, Irep (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Off-label uses of drugs for depression 
Skånland, Sigrid Strand; Cieslar-Pobuda, Artur (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The prescription of drugs for depression is rising rapidly. One of the reasons for this trend is their many off-label uses. Up to one third of all prescriptions are for non-indicated use, which in addition to drug repurposing ...
Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas 
van IJzendoorn, David G.P.; Szuhai, Karoly; Briaire-De Bruijn, Inge H; Kostine, Marie; Kuijjer, Marieke Lydia; Bovée, Judith V.M.G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Based on morphology it is often challenging to distinguish between the many different soft tissue sarcoma subtypes. Moreover, outcome of disease is highly variable even between patients with the same disease. Machine ...
Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests 
Nieoczym, Dorota; Socala, Katarzyna; Gawel, Kamila; Esguerra, Camila Vicencio; Wyska, Elzbieta; Wlaz, Piotr (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability of PTE to cross the blood–brain barrier raised the possibility that this compound may modulate ...
Characterization of the Enzymatic Activity of the Serine Protease Domain of Factor VII Activating Protease (FSAP) 
Nielsen, Nis Valentin; Roedel, Elfie; Manna, Dipankar; Etscheid, Michael; Morth, Jens Preben; Kanse, Sandip (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Factor VII (FVII) activating protease (FSAP) is a circulating serine protease. Human genetic studies, based on the Marburg I (MI) (Gly221Glu, chymotrypsin numbering system) polymorphism, implicate FSAP in the pathogenesis ...
Diet quality on days without breakfast or lunch - Identifying targets to improve adolescents' diet. 
Medin, Anine Christine; Myhre, Jannicke Borch; Diep, Lien My; Andersen, Lene Frost (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Dietary intake in adolescents does often not align with the recommended dietary guidelines. Excess intakes of added sugar and saturated fat, and insufficient vegetable intake are among the identified challenges, which can ...
lionessR: single sample network inference in R 
Kuijjer, Marieke L; Hsieh, Ping-Han; Quackenbush, John; Glass, Kimberly (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background In biomedical research, network inference algorithms are typically used to infer complex association patterns between biological entities, such as between genes or proteins, using data from a ...
Common nodes of virus–host interaction revealed through an integrated network analysis 
Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...
MirGeneDB 2.0: the metazoan microRNA complement 
Fromm, Bastian; Domanska, Diana Ewa; Høye, Eirik; Ovchinnikov, Vladimir; Kang, Wenjing; Aparicio-Puerta, Ernesto; Johansen, Morten; Flatmark, Kjersti; Mathelier, Anthony; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R.; Peterson, Kevin J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Small non-coding RNAs have gained substantial attention due to their roles in animal development and human disorders. Among them, microRNAs are special because individual gene sequences are conserved across the animal ...
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy 
Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their ...
CENP‐C unwraps the human CENP‐A nucleosome through the H2A C‐terminal tail 
Ali Ahmad, Ahmad; Bilokapic, Silvija; Schafer, Ingmar B; Halic, Mario; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP ‐A, upon which the constitutive centromere‐associated network of proteins (CCAN ) is built. CENP ‐C is considered to be a central ...
High intraocular pressure in eyes with late in-the-bag intraocular lens dislocation 
Kristianslund, Olav; Dalby, Marius; Drolsum, Liv (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The frequency of late in-the-bag intraocular lens (IOL) dislocation has increased over the past decades. Important predisposing factors are pseudoexfoliation syndrome (PXF), myopia, previous vitreoretinal surgery, and ...
Evaluation of dental arch dimensions in 12 year-old Vietnamese children - A cross-sectional study of 4565 subjects 
Dung, Truong Manh; Ngoc, Vo Truong Nhu; Hiep, Nguyen Hung; Khoi, Truong Dinh; Xiem, Vu Van; Chu-Dinh, Thien; Cieslar-Pobuda, Artur; Stoufi, Eleana; Show, Pau Loke; Tao, Yang; Bac, Nguyen Duy; Van Ba, Nguyen; Le, Quynh-Anh; Pham, Van-Huy; Chu, Dinh Toi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
This study aimed to define the width and length of the dental arch in 12-year-old Vietnamese children, and to elucidate differences between genders and among ethnic groups. A cross-sectional study was conducted in 4565 12 ...
Estimating Sample-Specific Regulatory Networks 
Kuijjer, Marieke Lydia; Tung, Matthew George; Yuan, GuoCheng; Quackenbush, John; Glass, Kimberly (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Biological systems are driven by intricate interactions among molecules. Many methods have been developed that draw on large numbers of expression samples to infer connections between genes (or their products). The result ...
A four‐group urine risk classifier for predicting outcomes in patients with prostate cancer 
Connell, Shea P; Yazbek-Hanna, Marcelino; McCarthy, Frank; Hurst, Rachel; Webb, Martyn; Curley, Helen; Walker, Helen; Mills, Rob; Ball, Richard Y; Sanda, Martin G.; Pellegrini, Kathryn L; Patil, Dattatraya; Perry, Antoinette; Schalken, Jack A.; Pandha, Hardev; Whitaker, Hayley; Dennis, Nening; Stuttle, Christine; Mills, Ian Geoffrey; Guldvik, Ingrid; Parker, Chris; Brewer, Daniel; Cooper, Colin S.; Clark, Jeremy P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To develop a risk classifier using urine‐derived extracellular vesicle (EV )‐RNA capable of providing diagnostic information on disease status prior to biopsy, and prognostic information for men on active ...
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma 
Wong, Kim; van der Weyden, Louise; Schott, Courtney R.; Foote, Alastair; Constantino-Casas, Fernando; Smith, Sionagh; Dobson, Jane M.; Murchison, Elizabeth P.; Wu, Hong; Yeh, Iwei; Fullen, Douglas R.; Joseph, Nancy; Bastian, Boris C.; Patel, Rajiv M.; Martincorena, Inigo; Robles-Espinoza, Carla Daniela; Iyer, Vivek; Kuijjer, Marieke Lydia; Arends, Mark J.; Brenn, Thomas; Harms, Paul W.; Wood, Geoffrey A.; Adams, David J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary ...
Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum 
Köksal, Elif; Belletati, Patrícia Fernandes; Reint, Ganna; Olsson, Ragni; Leitl, Kira; Kantarci, Ilayda; Gözen, Irep (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
We present a convenient method to form a bottom-up structural organelle model for the endoplasmic reticulum (ER). The model consists of highly dense lipidic nanotubes that are, in terms of morphology and dynamics, reminiscent ...
Drivers of AR indifferent anti-androgen resistance in prostate cancer cells 
Handle, Florian; Prekovic, Stefan; Helsen, Christine; van den Broeck, Thomas; Smeets, Elien; Moris, Lisa; Eerlings, Roy; El Kharraz, Sarah; Urbanucci, Alfonso; Mills, Ian Geoffrey; Joniau, Steven; Attard, Gerhardt; Claessens, Frank (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance. ...
Targeted metabolic profiling of methionine cycle metabolites and redox thiol pools in mammalian plasma, cells and urine 
Behringer, Sidney; Wingert, Victoria; Oria, Victor; Schumann, Anke; Grünert, Sarah; Cieslar-Pobuda, Artur; Kölker, Stefan; Lederer, Ann-Kathrin; Jacobsen, Donald W.; Stärk, Judith; Schilling, Oliver; Spiekerkoetter, Ute; Hannibal, Luciana (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The concentration of thiol and thioether metabolites in plasma has diagnostic value in genetic diseases of B-vitamin metabolism linked to methionine utilization. Among these, cysteine/cystine (Cys/CSSC) and glutathione/oxidized ...
Hip Structure Analyses in Acromegaly: Decrease of Cortical Bone Thickness After Treatment: A Longitudinal Cohort Study 
Godang, Kristin; Lekva, Tove; Normann, Kjersti Ringvoll; Olarescu, Nicoleta Cristina; Øystese, Kristin Astrid; Kolnes, Anders Jensen; Ueland, Thor; Bollerslev, Jens; Heck, Ansgar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Long‐standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry, including increased cortical bone thickness (CBT). However, a high prevalence and incidence ...
Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B 
Copmans, Daniëlle; Kildgaard, Sara; Rasmussen, Silas A.; Ślęzak, Monika; Dirkx, Nina; Partoens, Michèle; Esguerra, Camila Vicencio; Crawford, Alexander Dettmar; Larsen, Thomas O.; de Witte, Peter A.M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the ...
Two truncating variants in FANCC and breast cancer risk 
Dörk, Thilo; Peterlongo, Paolo; Mannermaa, Arto; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Ahearn, Thomas; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristian J.; Augustinsson, Annelie; Freeman, Laura E. Beane; Beckmann, Matthias W.; Beeghly-Fadiel, Alicia; Behrens, Sabine; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Canzian, Federico; Chan, Tsun L.; Chang-Claude, Jenny; Chanock, Stephen J.; Choi, Ji-Yeob; Christiansen, Hans; Clarke, Christine L.; Couch, Fergus J.; Czene, Kamila; Daly, Mary B.; dos-Santos-Silva, Isabel; Dwek, Miriam; Eccles, Diana M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; Fritschi, Lin; Gabrielson, Marike; Gago-Dominguez, Manuela; Gao, Chi; Gapstur, Susan M.; García-Closas, Montserrat; García-Sáenz, José A.; Gaudet, Mia M.; Giles, Graham G.; Goldberg, Mark S.; Goldgar, David E.; Guenel, Pascal; Haeberle, Lothar; Haiman, Christopher A.; Håkansson, Niclas; Hall, Per; Hamann, Ute; Hartman, Mikael; Hauke, Jan; Hein, Alexander; Hillemanns, Peter; Hogervorst, Frans B.L.; Hooning, Maartje J.; Hopper, John L.; Howell, Tony; Huo, Dezheng; Ito, Hidemi; Iwasaki, Motoki; Jakubowska, Anna; Janni, Wolfgang; John, Esther M.; Jung, Audrey; Kaaks, Rudolf; Kang, Daehee; Kapoor, Pooja Middha; Khusnutdinova, Elza; Kim, Sung-Won; Kitahara, Cari M.; Koutros, Stella; Kraft, Peter; Kristensen, Vessela N.; Kwong, Ava; Lambrechts, Diether; Le Marchand, Loïc; Li, Jingmei; Lindström, Sara; Linet, Martha; Lo, Wing-Yee; Long, Jirong; Lophatananon, Artitaya; Lubiński, Jan; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Elena; Matsuo, Keitaro; Mavroudis, Dimitris; Meindl, Alfons; Menon, Usha; Milne, Roger L.; Mohd Taib, Nur Aishah; Muir, Kenneth; Mulligan, Anna Marie; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Newman, William G.; Offit, Kenneth; Olopade, Olufunmilayo I.; Olshan, Andrew F.; Olson, Janet E.; Olsson, Håkan; Park, Sue K.; Park-Simon, Tjoung-Won; Peto, Julian; Plaseska-Karanfilska, Dijana; Pohl-Rescigno, Esther; Presneau, Nadege; Rack, Brigitte; Radice, Paolo; Rashid, Muhammad Usman; Rennert, Gad; Rennert, Hedy S.; Romero, Atocha; Ruebner, Matthias; Saloustros, Emmanouil; Schmidt, Marjanka K.; Schmutzler, Rita K.; Schneider, Michael O.; Schoemaker, Minouk J.; Scott, Christopher; Shen, Chen-Yang; Shu, Xiao-Ou; Simard, Jacques; Slager, Susan; Smichkoska, Snezhana; Southey, Melissa C.; Spinelli, John J.; Stone, Jennifer; Surowy, Harald; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Teo, Soo H.; Terry, Mary Beth; Toland, Amanda E.; Tollenaar, Robert A.E.M.; Torres, Diana; Torres-Mejía, Gabriela; Troester, Melissa A.; Truong, Thérèse; Tsugane, Shoichiro; Untch, Michael; Vachon, Celine M.; van den Ouweland, Ans M.W.; van Veen, Elke M.; Vijai, Joseph; Wendt, Camilla; Wolk, Alicja; Yu, Jyh-Cherng; Zheng, Wei; Ziogas, Argyrios; Ziv, Elad; Dunning, Alison M.; Pharoah, Paul D.P.; Schindler, Detlev; Devilee, Peter; Easton, Douglas F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk ...
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress 
Luhr, Morten; Torgersen, Maria Lyngaas; Szalai, Paula; Hashim, Adnan; Brech, Andreas; Stärk, Judith; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Endoplasmic reticulum (ER) stress is thought to activate autophagy via unfolded protein response (UPR)-mediated transcriptional up-regulation of autophagy machinery components and modulation of microtubule-associated protein ...
CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation 
Itkonen, Harri; Poulose, Ninu; Walker, Suzanne; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Cyclin-dependent kinase 9 (CDK9), a key regulator of RNA-polymerase II, is a candidate drug target for cancers driven by transcriptional deregulation. Here we report a multi-omics-profiling of prostate cancer cell responses ...
Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease 
Keskitalo, Salla; Haapaniemi, Emma M.; Glumoff, Virpi; Liu, Xiaonan; Lehtinen, Ville; Fogarty, Christopher; Rajala, Hanna; Chiang, Samuel C.; Mustjoki, Satu; Kovanen, Panu; Lohi, Jouko; Bryceson, Yenan; Seppänen, Mikko; Kere, Juha; Heiskanen, Kaarina; Varjosalo, Markku (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Mutations in several proteins functioning as endolysosomal components cause monogenic autoimmune diseases, of which pathogenesis is linked to increased endoplasmic reticulum stress, inefficient autophagy, and defective ...
Waste to bioenergy: a review on the recent conversion technologies 
Lee, Sze Y; Sankaran, Revathy; Chew, Kit W; Tan, Chung H; Krishnamoorthy, Rambabu; Chu, Dinh-Toi; Show, Pau-Loke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Scientific studies have demonstrated that it is possible to generate a wide variety of bioenergy from biomass residues and waste, and however its cost is not competitive with petro-fuels and other renewable energy. On-going ...
Rating the quality of teamwork—a comparison of novice and expert ratings using the Team Emergency Assessment Measure (TEAM) in simulated emergencies 
Freytag, Julia; Stroben, Fabian; Hautz, Wolf E; Schauber, Stefan K; Kämmer, Juliane E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Training in teamwork behaviour improves technical resuscitation performance. However, its effect on patient outcome is less clear, partly because teamwork behaviour is difficult to measure. ...
The singular patient in patient-centred care. Physiotherapists' accounts of treatment of patients with chronic muscle pain 
Ahlsen, Birgitte; Engebretsen, Eivind; Nicholls, David; Mengshoel, Anne Marit (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
A patient-centred approach has gained increasing interest in medicine and other health sciences. Whereas there are discussions about the meaning of a patient-centred approach and what the concept entails, little is known ...
Accuracy of self‐monitoring: does experience, ability or case difficulty matter? 
Hautz, Wolf E.; Schubert, Sebastian; Schauber, Stefan Kilian; Kunina-Habenicht, Olga; Hautz, Stefanie C.; Kämmer, Juliane E.; Eva, Kevin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Context The ability to self‐monitor one's performance in clinical settings is a critical determinant of safe and effective practice. Various studies have shown this form of self‐regulation to be more trustworthy than ...
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells 
Itkonen, Harri; Urbanucci, Alfonso; Sara ES, Martin; Khan, Aziz; Mathelier, Anthony; Thiede, Bernd; Walker, Suzanne; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
O-GlcNAc transferase (OGT) is overexpressed in aggressive prostate cancer. OGT modifies intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity. We recently discovered the first ...
A cellular automaton for modeling non-trivial biomembrane ruptures 
Gupta, Abhay; Gözen, Irep; Taylor, Michael (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models ...
Integrative modeling reveals key chromatin and sequence signatures predicting super-enhancers 
Khan, Aziz; Zhang, Xuegong (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Super-enhancers (SEs) are clusters of transcriptional enhancers which control the expression of cell identity and disease-associated genes. Current studies demonstrated the role of multiple factors in SE formation; however, ...
Characterization of the human RFX transcription factor family by regulatory and target gene analysis 
Sugiaman-Trapman, Debora; Vitezic, Morana; Jouhilahti, Eeva-Mari; Mathelier, Anthony; Lauter, Gilbert; Misra, Sougat; Daub, Carsten O; Kere, Juha; Swoboda, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal ...
A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase 
Sommer, Theis; Bjerregaard-Andersen, Kaare; Uribe, Lalita; Etzerodt, Michael; Diezemann, Gregor; Gauss, Jürgen; Cascella, Michele; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
Making genome browsers portable and personal 
Khan, Aziz; Zhang, Xuegong (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
GIVE is a framework and library for creating portable and personalized genome browsers. It makes visualizing genomic data as easy as building a laboratory homepage.
The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells 
Luhr, Morten; Szalai, Paula; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Bulk autophagy is characterized by the sequestration of large portions of cytoplasm into double/multi-membrane structures termed autophagosomes. Here a simple protocol to monitor this process is described. Moreover, typical ...
Bromodomain-containing proteins in prostate cancer 
Urbanucci, Alfonso; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Several oncogenic factors have been involved in prostate cancer progression. However, therapeutic approaches still focus on suppression of androgen receptor (AR) signaling. In fact, whereas the full-length AR incorporates ...
Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia 
Rogne, Marie; Svärd, Oksana; Madsen-Østerbye, Julia-Kristina Jensen; Hashim, Adnan; Tjønnfjord, Geir Erland; Staerk, Judith (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Cytokinesis failure leads to the emergence of tetraploid cells and multiple centrosomes. Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in adults and is characterized by clonal B cell ...
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells 
Rogne, Marie; Chu, Dinh Toi; Küntziger, Thomas M.; Mylonakou, Maria-Niki; Collas, Philippe; Tasken, Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Optic atrophy 1 (OPA1) is the A-kinase anchoring protein targeting the pool of protein kinase A (PKA) responsible for perilipin 1 phosphorylation, a gatekeeper for lipolysis. However, the involvement of OPA1-bound PKA in ...
From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs 
Engedal, Nikolai; Žerovnik, Eva; Rudov, Alexander; Galli, Francesco; Olivieri, Fabiola; Procopio, Antonio Domenico; Rippo, Maria Rita; Monsurrò, Vladia; Betti, Michele; Albertini, Maria Cristina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Oxidative stress can alter the expression level of many microRNAs (miRNAs), but how these changes are integrated and related to oxidative stress responses is poorly understood. In this article, we addressed this question ...
Survival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norway 
Strand, Bjørn Heine; Knapskog, Anne Brita; Edwin, Trine Holt; Amland, Rachel; Mjørud, Marit; Bjertness, Espen; Engedal, Knut; Selbæk, Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Introduction: Alzheimer’s disease patients are reported to have higher survival rate compared to patients with vascular dementia or dementia with Lewy bodies. There is a paucity of studies investigating survival including ...
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts 
Seibert, TM; Fan, CC; Wang, Yan; Zuber, W; Karunamuni, R; Parsons, JK; Eeles, RA; Easton, DF; Kote-Jarai, Z; Al Olama, Ali Amin; Garcia, SB; Muir, K; Gronberg, Henrik; Wiklund, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeki, C; Tammela, TM; Nordestgaard, BG; Nielsen, SF; Weischer, Maren; Bisbjerg, R; Røder, MA; Iversen, P; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharaoa, P; Pashayan, Nora; Khaw, KT; Maier, C.; Vogel, Walther; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Vokolorzcyk, D; Klusniak, W; Cannon-Albright, D; Brenner, H.; Cuk, K; Saum, KU; Park, JY; Sellers, TA; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Clements, JA; Spurdle, A; Teixeira, MR; Paulo, P; Maia, S; Phanda, H; Michael, A; Kierzek, A; Karow, DS; Mills, Ian Geoffrey; Andreassen, Ole Andreas; Dale, AM (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Objectives: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. Design: Analysis of genotype, PCa status, and age ...
The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction 
Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Pedersen, Hilde Røgeberg; Aass, Hans Christian Dalsbotten; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was ...
Shared and independent functions of aPKC? and Par3 in skin tumorigenesis 
Vorhagen, Susanne; Kleefisch, Dominik; Persa, Oana-Diana; Graband, Annika; Schwickert, Alexandra; Saynisch, Michael; Leitges, Michael; Niessen, Carien M.; Iden, Sandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The polarity proteins Par3 and aPKC are key regulators of processes altered in cancer. Par3/aPKC are thought to dynamically interact with Par6 but increasing evidence suggests that aPKC and Par3 also exert complex-independent ...
Updates on old and weary haematopoiesis 
Konieczny, Joanna; Arranz, Lorena (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow ...
A map of direct TF–DNA interactions in the human genome 
Gheorghe, Marius; Sandve, Geir Kjetil; Khan, Aziz; Cheneby, Jeanne; Ballester, Benoit; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most popular assay to identify genomic regions, called ChIP-seq peaks, that are bound in vivo by transcription factors (TFs). These regions are derived ...
MANTA2, update of the Mongo database for the analysis of transcription factor binding site alterations 
Fornes, Oriol; Gheorghe, Marius; Richmond, Phillip A.; Arenillas, David J.; Wasserman, Wyeth W.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Interpreting the functional impact of noncoding variants is an ongoing challenge in the field of genome analysis. With most noncoding variants associated with complex traits and disease residing in regulatory regions, ...
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Date Issued2010 - 2020 (242)2000 - 2009 (17)1995 - 1999 (1)Document TypeTidsskriftartikkel (257)Doktoravhandling (3)AuthorMills, Ian Geoffrey (16)Mathelier, Anthony (15)Sandlie, Inger (15)Tasken, Kjetil (15)Andersen, Jan Terje (12)... View MorePeer ReviewedPeer reviewed (251)
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