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JASPAR 2022: the 9th release of the open-acess database of transcription factor binding profiles 
Castro Mondragon, Jaime Abraham; Riudavets Puig, Rafael; Rauluseviciute, Ieva; Lemma, Roza Berhanu; Turchi, Laura; Blanc-Mathieu, Romain; Lucas, Jeremy; Boddie, Paul; Khan, Aziz; Manosalva Perez, Nicolas; Fornes, Oriol; Leung, Tiffany; Aguirre, Alejandro; Hammal, Fayrouz; Schmelter, Daniel; Baranasic, Damir; Ballester, Benoit; Sandelin, Albin; Lenhard, Boris; Vandepoele, Klaas; Wasserman, Wyeth W.; Parcy, François; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract JASPAR (http://jaspar.genereg.net/) is an open-access database containing manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic groups. In this 9th ...
rPanglaoDB: an R package to download and merge labeled single-cell RNA-seq data from the PanglaoDB database 
Osorio, Daniel; Kuijjer, Marieke; Cai, James (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Motivation Characterizing cells with rare molecular phenotypes is one of the promises of high throughput single-cell RNA sequencing (scRNA-seq) techniques. However, collecting ...
vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding 
Tran, Vi Ngoc-Nha; Shams, Alireza; Ascioglu, Sinan; Martinecz, Antal; Liang, Jingyi; Clarelli, Fabrizio; Mostowy, Rafal; Cohen, Ted; Abel zur Wiesch, Pia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background As antibiotic resistance creates a significant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs ...
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies 
Findlay, Izac J.; De Iuliis, Geoffry N.; Duchatel, Ryan J.; Jackson, Evangeline R.; Vitanza, Nicholas A.; Cain, Jason E.; Waszak, Sebastian Martin; Dun, Matthew D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall survival (OS) ...
Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts 
Walhovd, Kristine Beate; Fjell, Anders Martin; Wang, Yunpeng; Amlien, Inge; Mowinckel, Athanasia Monika; Lindenberger, Ulman; Düzel, Sandra; Bartrés-Faz, David; Ebmeier, Klaus P; Drevon, Christian A; Baaré, William F.C.; Ghisletta, Paolo; Johansen, Louise Baruël; Kievit, Rogier A.; Henson, Richard N.; Madsen, Kathrine Skak; Nyberg, Lars; Harris, Jennifer Ruth; Solé-Padullés, Cristina; Pudas, Sara; Sørensen, Øystein; Westerhausen, Rene; Zsoldos, Eniko; Nawijn, Laura; Lyngstad, Torkild Hovde; Suri, Sana; Penninx, Brenda; Røgeberg, Ole Jørgen; Brandmaier, Andreas M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Higher socio-economic status (SES) has been proposed to have facilitating and protective effects on brain and cognition. We ask whether relationships between SES, brain volumes and cognitive ability ...
Use of Drugs With Risk of Heart Rate-Related Problems is Common in Norwegian Dementia Patients Treated With Acetylcholinesterase Inhibitors: A Prevalence Study Based on the Norwegian Prescription Database 
Efjestad, Anne Sverdrup; Ihle-Hansen, Hege; Hjellvik, Vidar; Engedal, Knut; Blix, Hege Salvesen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background: Drugs commonly prescribed for heart rate control may induce adverse drug reactions in Alzheimer patients treated with acetylcholinesterase inhibitors (AChEIs). We have studied use of drugs with a known risk of ...
Associations of pain sensitisation with tender and painful joint counts in people with hand osteoarthritis: results from the Nor-Hand study 
Gløersen, Marthe; Pettersen, Pernille Steen; Neogi, Tuhina; Slatkowsky-Christensen, Barbara; Kvien, Tore Kristian; Magnusson, Karin; Hammer, Hilde Berner; Bos-Haugen, Ida Kristin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective: To examine associations of pain sensitisation with tender and painful joint counts and presence of widespread pain in people with hand osteoarthritis (OA). Methods: Pressure pain thresholds (PPT) at a painful ...
Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia 
Malani, Disha; Adish Kumar, Kumar; Brück, Oscar; Kontro, Mika; Yadav, Bhagwan; Hellesøy, Monica; Kuusanmäki, Heikki; Dufva, Olli; Kankainen, Matti; Eldfors, Samuli; Potdar, Swapnil; Saarela, Jani; Turunen, Laura; Parsons, Alun; Västrik, Imre; Kivinen, Katja; Saarela, Janna Saija; Räty, Riikka; Mooij, Wolf M.; Lehto, M; Gjertsen, Bjørn Tore; Mustjoki, Satu; Aittokallio, Tero Antero; Wennerberg, Krister; Heckman, Caroline Akemi; Kallioniemi, Olli; Porkka, Kimmo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated ...
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment 
Holten, Karen; Sundlisæter, Nina Beate Paulshus; Lillegraven, Siri; Sexton, Joseph; Nordberg, Lena Kristine Bugge; Moholt, Ellen; Hammer, Hilde Berner; Uhlig, Till; Kvien, Tore Kristian; Haavardsholm, Espen A.; Aga, Anna-Birgitte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objectives: Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity and fatigue in patients with early RA during the initial 24 ...
GRAND: a database of gene regulatory network models across human conditions 
Ben Guebila, Marouen; Lopes-Ramos, Camila; Weighill, Deborah; Sonawane, Abhijeet; Burkholz, Rebekka; Shamsaei, Behrouz; Platig, John; Glass, Kimberly; Kuijjer, Marieke; Quackenbush, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Gene regulation plays a fundamental role in shaping tissue identity, function, and response to perturbation. Regulatory processes are controlled by complex networks of interacting elements, including ...
Needs for information about lifestyle and rehabilitation in long-term young adult cancer survivors 
Thorsen, Lene; Bøhn, Synne-Kristin H.; Lie, Hanne C.; Fosså, Sophie Dorothea; Kiserud, Cecilie E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Background Healthy lifestyle and rehabilitation may mitigate late effects after cancer treatment, but knowledge about lifestyle and rehabilitation information needs among long-term young adult ...
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial 
Baksaas-Aasen, Kjersti; Gall, Lewis; Stensballe, Jakob; Juffermans, Nicole P.; Curry, Nicola; Maegele, Marc; Brooks, A.; Rourke, Claire; Gillespie, Scarlett; Murphy, J.; Maroni, R.; Vulliamy, Paul; Henriksen, H.H.; Pedersen, K. Holst; Kolstadbråten, Knut Magne; Wirtz, M.R.; Kleinveld, D.J.B.; Schäfer, N.; Chinna, S.; Davenport, Ross; Næss, Pål Aksel; Goslings, J. Carel; Eaglestone, Simon; Stanworth, Simon; Johansson, Pär I.; Gaarder, Christine; Brohi, Karim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Purpose Contemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine whether augmenting MHPs with Viscoelastic ...
Cost-effectiveness of meningococcal vaccination of Norwegian teenagers with a quadrivalent ACWY conjugate vaccine 
Watle, Sara Sofie Viksmoen; Næss, Lisbeth Meyer; Tunheim, Gro; Caugant, Dominique A; Wisløff, Torbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
n Norway, the incidence of invasive meningococcal disease (IMD) is higher among 16–19-year-olds than in the general population. Most IMD cases among teenagers are caused by serogroup Y. Since 2011, one dose of meningococcal ...
Perineuronal nets stabilize the grid cell network 
Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Sutterud, Hallvard; Blackstad, Jan Sigurd; Fyhn, Marianne; Hafting, Torkel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) ...
Gastro- or Duodenojejunostomy Leaks After Pancreatoduodenectomy: Single Center Experience and Narrative Literature Review 
Labori, Knut Jørgen; Tholfsen, Tore; Yaqub, Sheraz; Lassen, Kristoffer; Kleive, Dyre; Waage, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Background and Methods Gastro- or duodenojejunostomy leaks after pancreatoduodenectomy is rare. This study aims to analyze the incidence, management, and outcome of gastro- or duodenojejunostomy ...
Pathologic Blood Samples Tolerate Exposure to Vibration and High Turbulence in Simulated Drone Flights, but Plasma Samples Should be Centrifuged after Flight 
Johannessen, Karl Arne; Wear, Nina Kristin Steen; Toska, Karin; Hansbø, Morten; Berg, Jens Petter; Fosse, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective. Most of the previous studies of drone transport of blood samples examined normal blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone flights using random vibration ...
Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? 
Banono, Nancy Saana; Gawel, Kinga Aurelia; De Witte, Linus; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Persons with certain single nucleotide polymorphisms (SNPs) in the CACNA1D gene (encoding voltage-gated calcium channel subunit alpha 1-D) have increased risk of developing neuropsychiatric disorders such as ...
Do different response formats affect how test takers approach a clinical reasoning task? An experimental study on antecedents of diagnostic accuracy using a constructed response and a selected response format 
Schauber, Stefan Kilian; Hautz, Stefanie C.; Kämmer, Juliane E.; Stroben, Fabian; Hautz, Wolf E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract The use of response formats in assessments of medical knowledge and clinical reasoning continues to be the focus of both research and debate. In this article, we report on an experimental study in which we address ...
Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening 
Grad, Iwona; Hanes, Robert; Ayuda-Durán, Pilar; Kuijjer, Marieke Lydia; Enserink, Jorrit; Meza-Zepeda, Leonardo A; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ...
The association between physical complications following female genital cutting and the mental health of 12-year-old Gambian girls: A community-based crosssectional study 
Bendiksen, Bothild; Heir, Trond; Minteh, Fabakary; Ziyada, Mai Mahgoub; Kuye, Rex A.; Lien, Inger-Lise (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Female genital cutting (FGC) involve an acute physical trauma that hold a potential risk for immediate and long-term complications and mental health problems. The aim of this study was to examine the prediction ...
Preclinical and clinical status of psma-targeted alpha therapy for metastatic castration-resistant prostate cancer 
Juzeniene, Asta; Stenberg, Vilde Yuli; Bruland, Øyvind; Larsen, Roy Hartvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Bone, lymph node, and visceral metastases are frequent in castrate-resistant prostate cancer patients. Since such patients have only a few months’ survival benefit from standard therapies, there is an urgent need for new ...
UniBind: maps of high-confidence direct TF-DNA interactions across nine species 
Puig, Rafael R.; Boddie, Paul; Khan, Aziz; Castro-Mondragon, Jaime A.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Transcription factors (TFs) bind specifically to TF binding sites (TFBSs) at cis-regulatory regions to control transcription. It is critical to locate these TF-DNA interactions to understand ...
The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI 
Nordeng, Jostein; Schandiz, Hossein; Solheim, Svein; Åkra, Sissel; Hoffmann, Pavel; Roald, Borghild; Bendz, Bjørn; Arnesen, Harald; Helseth, Ragnhild; Seljeflot, Ingebjørg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background. The Nod-Like-Receptor-Protein-3 (NLRP3) inflammasome and the Interleukin-6 (IL-6) pathways are central mechanisms of the inflammatory response in myocardial reperfusion injury. Expanding our knowledge about the ...
Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death 
Hestad, Knut; Engedal, Knut; Selbæk, Geir; Strand, Bjørn Heine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective: It is unknown whether systolic blood pressure (SBP) drop is part of the normal aging process or due to the onset of dementia for some people. SBP drop is referring to the decrease in blood pressure often seen ...
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses 
Høydahl, Lene; Frigstad, Terje; Rasmussen, Ingunn B; Øynebråten, Inger; Schjetne, Karoline W; Andersen, Jan Terje; Michaelsen, Terje Einar; Lunde, Elin; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Targeted delivery of antigen to antigen-presenting cells (APCs) enhances antigen presentation and thus, is a potent strategy for making more efficacious vaccines. This can be achieved by use of antibodies with specificity ...
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft 
Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Øy, Geir Frode; Kildal, Wanja; Engebråten, Olav; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl ...
Marine n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Kidney Transplant Recipients: A Randomized, Placebo-Controlled Trial 
Jørgensen, Hanne; Eide, Ivar Anders; Jenssen, Trond Geir; Åsberg, Anders; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders; Schmidt, Erik Berg; Svensson, My Hanna Sofia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Kidney transplant recipients are at high risk of progressive bone loss and low-energy fractures in the years following transplantation. Marine n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation may have beneficial ...
Exploring the triggering process of a cancer care reform in three Scandinavian countries 
Mæhle, Per Magnus; Hajdarevic, Senada; Håland, Erna; Aarhus, Rikke; Smeland, Sigbjørn; Mørk, Bjørn Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Cancer incidence is increasing, and cancer is a leading cause of death in the Scandinavian countries, and at the same time more efficient but very expensive new treatment options are available. Based on the increasing ...
Innate Immune Invisible Ultrasmall Gold Nanoparticles - Framework for Synthesis and Evaluation 
Zhu, Geyunjian Harry; Azharuddin, Mohammad; Islam, Rakibul; Rahmoune, Hassan; Deb, Suryyani; Kanji, Upasona; Das, Jyotirmoy; Osterrieth, Johannes; Aulakh, Parminder; Ibrahim-Hashi, Hashi; Manchanda, Raghav; Nilsson, Per; Mollnes, Tom Eirik; Bhattacharyya, Maitreyee; Islam, Mohammad Mirazul; Hinkula, Jorma; Slater, Nigel K. H.; Patra, Hirak K. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Nanomedicine is seen as a potential central player in the delivery of personalized medicine. Biocompatibility issues of nanoparticles have largely been resolved over the past decade. Despite their tremendous progress, less ...
Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 
Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to ...
Intervening on health literacy by knowledge translation processes in kidney transplantation: A feasibility study 
Andersen, Marit Helen; Urstad, Kristin Hjorthaug; Larsen, Marie Hamilton; Henrichsen, Gina Fraas; Engebretsen, Eivind; Ødemark, John; Stenehjem, Aud Eldrid; Reisæter, Anna Varberg; Nordlie, Arve; Wahl, Astrid Klopstad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Patients awaiting kidney transplantation need to be prepared ahead of the upcoming transplantation by developing targeted pre- and post-transplant knowledge. On this background, we designed a new health literacy ...
Teaching critical thinking about health using digital technology in lower secondary schools in Rwanda: A qualitative context analysis 
Mugisha, Michael; Uwitonze, Anne-Marie; Chesire, Faith; Senyonga, Ronald; Oxman, Matt; Nsangi, Allen; Semakula, Daniel; Kaseje, Margaret; Lewin, Simon Arnold; Sewankambo, Nelson; Nyirazinyoye, Laetitia; Oxman, Andrew David; Rosenbaum, Sarah Ellen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Introduction Adolescents encounter misleading claims about health interventions that can affect their health. Young people need to develop critical thinking skills to enable them to verify health claims and make informed ...
A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity 
Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren; Fure, Hilde; Landsem, Anne; Bergseth, Grete; Schjalm, Camilla; Haugaard-Kedström, Linda M.; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ...
Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: Study protocol for the randomised controlled phase II ReSScue trial 
Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Sarna, Vikas Kumar; Barua, Imon Shoumitra; Carstens, Maylen N.; Distler, Oliver; Khanna, Dinesh; Volkmann, Elizabeth R.; Midtvedt, Øyvind; Didriksen, Henriette; Dhainaut, Alvilde; Halse, Anne Kristine Hjorteseth; Bakland, Gunnstein; Pesonen, Maiju; Olsen, Inge Christoffer; Molberg, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Introduction In the multisystem inflammatory disorder systemic sclerosis (SSc), gastrointestinal tract (GIT) affliction is highly prevalent. There are no known disease modifying therapies and the negative impact is ...
Fetal Thoracic Circumference and Lung Volume and Their Relation to Fetal Size and Pulmonary Artery Blood Flow 
Hilde, Katarina; Lødrup Carlsen, Karin C.; Bains, Karen Eline Stensby; Gudmundsdóttir, Hrefna Katrín; Jonassen, Christine Monceyron; Kreyberg, Ina; LeBlanc, Marissa; Nordhagen, Live Solveig; Nordlund, Björn; Rehbinder, Eva Maria; Sjøborg, Katrine Dønvold; Skjerven, Håvard Ove; Staff, Anne Cathrine; Sundet, Birgitte Kordt; Vettukattil, Riyas; Værnesbranden, Magdalena R.; Wiik, Johanna; Haugen, Guttorm Nils (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective Research on early origins of lung disease suggests the need for studying the relationships of thoracic and lung size with fetal size and pulmonary circulation. The primary aim of this study is therefore to ...
Sealing holes in cellular membranes 
Zhen, Yan; Radulovic, Maja; Vietri, Marina; Stenmark, Harald (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The compartmentalization of eukaryotic cells, which is essential for their viability and functions, is ensured by single or double bilayer membranes that separate the cell from the exterior and form boundaries between the ...
Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression 
Siafarikas, Nikias Ioannis; Kirsebom, Bjørn-Eivind; Srivastava, Deepak P; Eriksson, Cecilia Magdalena; Auning, Eirik; Hessen, Erik; Selbæk, Geir; Blennow, Kaj; Aarsland, Dag; Fladby, Tormod (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) ...
Rapid genome editing by CRISPR-Cas9-POLD3 fusion 
Reint, Ganna; Li, Zhuokun; Labun, Kornel; Keskitalo, Salla; Soppa, Inkeri; Mamia, Katariina Aino Inkeri; Tolo, Eero; Szymanska, Monika; Meza-Zepeda, Leonardo A.; Lorenz, Susanne; Cieslar-Pobuda, Artur Grzegorz; Hu, Xian; Bodin, Diana L; Staerk, Judith; Valen, Eivind Dale; Schmierer, Bernhard; Varjosalo, Markku; Taipale, Jussi; Haapaniemi, Emma Maria (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the ...
Using process indicators to monitor documentation of patient-centred variables in an integrated oncology and palliative care pathway—results from a cluster randomized trial 
Hjermstad, Marianne Jensen; Hamfjord, Julian; Aass, Nina Kathrine; Dajani, Olav; Lundeby, Tonje; Wester, Torunn Elin; Kaasa, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background. Despite robust evidence from randomized controlled trials (RCTs) demonstrating clinical and patient-reported benefits of integrated oncology and palliative care, the tumour-centred focus is predominant. This ...
Structure prediction of honey bee vitellogenin: a multi-domain protein important for insect immunity 
Leipart, Vilde; Montserrat Canals, Mateu; Cunha, Eva S.; Luecke, Hartmut; Herrero-Galán, Elías; Halskau, Øyvind; Amdam, Gro Vang (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Vitellogenin (Vg) has been implicated as a central protein in the immunity of egg-laying animals. Studies on a diverse set of species suggest that Vg supports health and longevity through binding to pathogens. Specific ...
Regulatory network of PD1 signaling is associated with prognosis in glioblastoma multiforme 
Lopes-Ramos, Camila; Belova, Tatiana; Brunner, Tess; Ben Guebila, Marouen; Osorio, Daniel; Quackenbush, John; Kuijjer, Marieke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Glioblastoma is an aggressive cancer of the brain and spine. While analysis of glioblastoma ‘omics data has somewhat improved our understanding of the disease, it has not led to direct improvement in patient survival. ...
Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger? 
van Oost, Siddh; Meijer, Debora; Kuijjer, Marieke; Bovée, Judith V.M.G.; de Miranda, Noel F.C.C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Sarcomas comprise a collection of highly heterogeneous malignancies that can be grossly grouped in the categories of sarcomas with simple or complex genomes. Since the outcome for most sarcoma patients has barely improved ...
Community Detection in Large-Scale Bipartite Biological Networks 
Calderer i Garcia, Genís; Kuijjer, Marieke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Networks are useful tools to represent and analyze interactions on a large, or genome-wide scale and have therefore been widely used in biology. Many biological networks—such as those that represent regulatory interactions, ...
Factors associated with non-completion of and scores on physical capability tests in health surveys: The North Health in Intellectual Disability Study 
Olsen, Monica Isabel Benedikte; Halvorsen, Marianne Berg; Søndenaa, Erik; Strand, Bjørn Heine; Langballe, Ellen Melbye; Årnes, Anders; Michalsen, Henriette; Larsen, Frode Kibsgaard; Gamst, Wenche; Bautz-Holter, Erik; Anke, Audny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background This study investigated the completion rates, scores and factors associated with non-completion and low scores on physical capability tests in a health survey administered to adults with intellectual disabilities. ...
Being sheltered from a demanding everyday life: experiences of the next of kin to people with dementia attending farm-based daycare 
Taranrød, Liv Bjerknes; Pedersen, Ingeborg; Kirkevold, Øyvind; Eriksen, Siren (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Purpose Farm-based daycare (FDC) is a type of daycare service for people with dementia. The aim of the present study was to explore the next of kin’s experiences with FDC and how the service may affect their daily life. ...
Time-Based Decision Making for Reperfusion in Acute Ischemic Stroke 
Grøan, Mathias; Ospel, Johanna; Ajmi, Soffien Chadli; Sandset, Else Charlotte; Kurz, Friedrich Martin Wilhelm; Skjelland, Mona; Advani, Rajiv (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Decision making in the extended time windows for acute ischemic stroke can be a complex and time-consuming process. The process of making the clinical decision to treat has been compounded by the availability of different ...
A single step three-strain in vivo Gateway reaction 
Gillman, Aaron Nicholas; Helleux, Alexandra; Abel, Sören (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
We developed a simplified, highly efficient Gateway reaction that recombines target DNA to expression (destination) plasmids in vivo and subsequently conjugates the final vector into a recipient strain, all in a single ...
Childhood seizures after prenatal exposure to maternal influenza infection: A population-based cohort study from Norway, Australia and Canada 
Oakley, Laura L; Regan, Annette K.; Fell, Deshayne B.; Spruin, Sarah; Bakken, Inger Johanne Landsjøåsen; Kwong, Jeffrey C; Pereira, Gavin; Nassar, Natasha; Aaberg, Kari Modalsli; Wilcox, Allen J.; Håberg, Siri Eldevik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Objective To assess whether clinical and/or laboratory-confirmed diagnosis of maternal influenza during pregnancy increases the risk of seizures in early childhood. Design Analysis of prospectively collected registry data ...
Evaluating a Strengths-Based mHealth Tool (MyStrengths): Explorative Feasibility Trial 
Jessen, Stian; Mirkovic, Jelena; Brendmo, Elanor Halvorsen; Solberg Nes, Lise (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background As the number of people living with chronic illnesses increases, providing wide-reaching and easy-to-use support tools is becoming increasingly important. Supporting people in this group to recognize ...
De novo formation of early endosomes during Rab5-to-Rab7a transition. 
Skjeldal, Frode Miltzow; Haugen, Linda Hofstad; Frei, Dominik Michael; Rødseth, Anna Vik; Hu, Xian; Bakke, Oddmund (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Rab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late endosome seems to be regulated through an endosomal ...
Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB 
Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The transcription factor MYB is a master regulator in haematopoietic progenitor cells and a pioneer factor affecting differentiation and proliferation of these cells. Leukaemic transformation may be promoted by high MYB ...
The association between placenta-associated circulating biomarkers and composite adverse delivery outcome of a likely placental cause in healthy post-date pregnancies 
Bowe, Sophie; Mitlid-Mork, Birgitte; Georgieva, Antoniya; Gran, Jon M.; Redman, Christopher W.G.; Staff, Anne Cathrine; Sugulle, Meryam (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Introduction Post-date pregnancies have an increased risk of adverse delivery outcome. Our aim was to explore the association between placenta-associated circulating biomarkers and composite adverse delivery outcome of ...
What is the evidence for abdominal and pelvic floor muscle training to treat diastasis recti abdominis postpartum? A systematic review with meta-analysis 
Gluppe, Sandra L.; Engh, Anna Marie Ellström; Bø, Kari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background: Diastasis recti abdominis (DRA) affects a significant number of women in the postpartum period. Objective: To systematically review whether abdominal and pelvic floor muscle (PFM) exercise programs are effective ...
Recall and Understanding of Discharge Information in Observation Ward Patients: An Explorative Observational Study 
Østen, Kjersti; Menichetti, Julia; Nordfalk, Jenny M.; Ofstad, Eirik Hugaas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Effective communication is essential for understanding and recall of hospital discharge information. This study aimed to explore discharge information, patient recall and patient involvement in discharge encounters. We ...
‘Not at all what I had expected’: Discontinuing treatment with extended-release naltrexone (XR-NTX): A qualitative study 
Brenna, Ida Halvorsen; Marciuch, Anne; Birkeland, Bente; Veseth, Marius; Røstad, Bente; Løberg, Else-Marie; Solli, Kristin Klemmetsby; Tanum, Lars Håkon Reiestad; Weimand, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background: Extended-release naltrexone (XR-NTX), an opioid antagonist, has demonstrated equal treatment outcomes, in terms of safety, opioid use, and retention, to the recommended OMT medication buprenorphine. However, ...
The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy 
Ravussin, Anthony; Brech, Andreas; Tooze, Sharon A.; Stenmark, Harald (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
ABSTRACT Late endosomes and lysosomes (endolysosomes) receive proteins and cargo from the secretory, endocytic and autophagic pathways. Although these pathways and the degradative processes of endolysosomes are ...
Determinants of knowledge and attitude towards breastfeeding in rural pregnant women using validated instruments in Ethiopia 
Ahmed, Misra Abdulahi; Fretheim, Atle; Argaw, Alemayehu; Magnus, Jeanette H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Understanding the underlying determinants of maternal knowledge and attitude towards breastfeeding guides the development of context-specific interventions to improve breastfeeding practices. This study aimed to assess the ...
Versatile workflow for cell type–resolved transcriptional and epigenetic profiles from cryopreserved human lung 
Llamazares-Prada, Maria; Waszak, Sebastian Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Complexity of lung microenvironment and changes in cellular composition during disease make it exceptionally hard to understand molecular mechanisms driving development of chronic lung diseases. Although recent advances ...
Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy 
Hoyer, A.; Rehbinder, Eva Maria; Färdig, Martin; Asad, Samina; Carlsen, Karin Cecilie Lødrup; Endre, Kim Magnus Advocaat; Granum, Berit; Haugen, Guttorm Nils; Hedlin, G.; Jonassen, Christine M; Katayama, S.; Konradsen, Jon R.; Landrø, Linn Aina Ysland; LeBlanc, Marissa Erin; Olsson Mägi, Caroline-Aleksi; Rudi, Knut; Skjerven, Håvard Ove; Staff, Anne Cathrine; Vettukattil, Muhammad Riyas; Bradley, Maria; Nordlund, B.; Söderhäll, Cilla (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Loss-of-function mutations in the skin barrier gene filaggrin (FLG) increase the risk of atopic dermatitis (AD), but their role in skin barrier function, dry skin and eczema in infancy is unclear. Objectives To ...
Loss of DIAPH1 causes SCBMS, combined immunodeficiency, and mitochondrial dysfunction 
Kaustio, Meri; Nayebzadeh, Naemeh; Hinttala, Reetta; Tapiainen, Terhi; Åström, Pirjo; Mamia, Katariina Aino Inkeri; Pernaa, Nora; Lehtonen, Johanna Marianna; Glumoff, Virpi; Rahikkala, Elisa; Honkila, Minna; Olsén, Päivi; Hassinen, Antti; Polso, Minttu; Al Sukati, Nashat; Al Shekaili, Jalila; Al Kindi, Mahmood; Al Hashmi, Nadia; Almusa, Henrikki; Bulanova, Daria; Haapaniemi, Emma Maria; Chen, Pu; Suo-Palosaari, Maria; Vieira, Paivi; Tuominen, Hannu; Kokkonen, Hannaleena; Al Macki, Nabil; Al Habsi, Huda; Löppönen, Tuija; Rantala, Heikki; Pietiäinen, Vilja; Zhang, Shen-Ying; Renko, Marjo; Hautala, Timo; Al Farsi, Tariq; Uusimaa, Johanna; Saarela, Janna Saija (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied 5 Finnish and 2 Omani patients with loss of DIAPH1 presenting with SCBMS, mitochondrial ...
6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish 
Gawel, Kinga Aurelia; Kukula-Koch, Wirginia; Banono, Nancy Saana; Nieoczym, Dorota; Targowska-Duda, Katarzyna M; Czernicka, Lidia; Parada-Turska, Jolanta; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts antiseizure activity, but the ...
Somatic mutations and T-cell clonality in patients with immunodeficiency 
Savola, Paula; Martelius, Timi; Kankainen, Matti; Huuhtanen, Jani; Lundgren, Sofie; Koski, Yrjö; Samuli, Eldfors; Kelkka, Tiina; Keränen, Mikko A I; Ellonen, Pekka; Kovanen, Panu E; Kytölä, Soili; Saarela, Janna Saija; Lähdesmäki, Harri; Seppänen, Mikko R J; Mustjoki, Satu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Common variable immunodeficiency and other late-onset immunodeficiencies often co-manifest with autoimmunity and lymphoproliferation. The pathogenesis of most cases is elusive, as only a minor subset harbors known monogenic ...
Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients 
Hashem, Hasan; Bucciol, Giorgia; Ozen, Seza; Unal, Sule; Ok Bozkaya, Ikbal; Akarsu, Nurten; Taskinen, Mervi; Koskenvuo, Minna; Saarela, Janna Saija; Dimitrova, Dimana; Hickstein, Dennis D; Hsu, Amy P.; Holland, Steven M.; Krance, Robert A.; Sasa, Ghadir; Kumar, Ashish R; Müller, Ingo; de Sousa, Monica Abreu; Delafontaine, Selket; Moens, Leen; Babor, Florian; Barzaghi, Federica; Cicalese, Maria Pia; Bredius, Robbert; van Montfrans, Joris; Baretta, Valentina; Cesaro, Simone; Stepensky, Polina; Benedicte, Nevn; Moshous, Despina; Le Guenno, Guillaume; Boutboul, David; Dalal, Jignesh; Brooks, Joel P; Dokmeci, Elif; Dara, Jasmeen; Lucas, Carrie L; Hambleton, Sophie; Wilson, Keith; Jolles, Stephen; Koc, Yener; Güngör, Tayfun; Schnider, Caroline; Candotti, Fabio; Steinmann, Sandra; Schulz, Ansgar; Chambers, Chip; Hershfield, Michael S; Ombrello, Amanda; Kanakry, Jennifer A; Meyts, Isabelle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis ...
Differential diagnosis checklists reduce diagnostic error differentially: a randomized experiment 
Kämmer, Juliane E.; Schauber, Stefan Kilian; Hautz, Stefanie C.; Stroben, Fabian; Hautz, Wolf E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Introduction Wrong and missed diagnoses contribute substantially to medical error. Can a prompt to generate alternative diagnoses (prompt) or a differential diagnosis checklist (DDXC) increase diagnostic accuracy? How ...
Prenatal insomnia and childbirth-related PTSD symptoms: A prospective population-based cohort study 
Deforges, Camille; Noël, Yvonnick; Eberhard-Gran, Malin; Garthus-Niegel, Susan; Horsch, Antje (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Certain populations are at high risk of experiencing a traumatic event and developing post-traumatic stress disorder (PTSD). Yet, primary preventive interventions against PTSD are lacking. It is therefore ...
Trigeminal neuralgia and genetics: A systematic review 
Mannerak, Mari Aaroe; Lashkarivand, Aslan; Eide, Per Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear genetic background. To examine the existing knowledge about genetics in TN, we performed a systematic study asking about the prevalence ...
Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells 
Korecki, Andrea J; Cueva-Vargas, Jorge; Fornes, Oriol; Agostinone, Jessica; Farkas, Rachelle; Hickmott, Jack W; Ling Lam, Siu; Mathelier, Anthony; Zhou, Michelle; Wasserman, Wyeth W.; Di Polo, Adriana; Simpson, Elizabeth M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Small and cell-type restricted promoters are important tools for basic and preclinical research, and clinical delivery of gene therapies. In clinical gene therapy, ophthalmic trials have been leading the field, ...
Did Solid Surfaces Enable the Origin of Life? 
Gözen, Irep (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
In this perspective article, I discuss whether and how solid surfaces could have played a key role in the formation of membranous primitive cells on the early Earth. I argue why surface energy could have been used by ...
Mixed fatty acid-phospholipid protocell networks 
Põldsalu, Inga; Köksal, Elif; Gözen, Irep (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Self-assembled membranes composed of both fatty acids and phospholipids are permeable for solutes and structurally stable, which was likely an advantageous combination for the development of primitive cells on the early ...
Prevalence and perinatal risk factors of parent-reported colic, abdominal pain and other pain or discomforts in infants until 3 months of age - A prospective cohort study in PreventADALL 
Despriee, Åshild; Mägi, Caroline-Aleksi Olsson; Småstuen, Milada Cvancarova; Glavin, Kari; Nordhagen, Live Solveig; Jonassen, Christine M; Rehbinder, Eva Maria; Nordlund, Björn; Söderhäll, Cilla; Carlsen, Karin Cecilie Lødrup; Skjerven, Håvard Ove (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Aims and objectives To estimate the prevalence and perinatal risk factors associated with parent reported colic, abdominal pain and pain or other discomforts in infants until 3 months of age. Background Infant colic ...
Family involvement practices for persons with psychotic disorders in community mental health centres – a cross-sectional fidelity-based study 
Hestmark, Lars; Heiervang, Kristin S.; Pedersen, Reidar; Hansson, Kristiane M.; Ruud, Torleif; Romøren, Maria (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Family involvement for persons with psychotic disorders is supported by scientific evidence, as well as legal and ethical considerations, and recommended in clinical practice guidelines. This ...
Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle 
Bengtsen, Mads; Winje, Ivan Myhre; Eftestøl, Einar; Landskron, Johannes; Sun, Chengyi; Nygård, Kamilla Børve; Domanska, Diana Ewa; Millay, Douglas P.; Meza, Leonardo Zepeda; Gundersen, Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Muscle cells have different phenotypes adapted to different usage, and can be grossly divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of such fiber types, we aimed at providing ...
TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial 
Olafsson, Jonatan; Lai, Xiaoran; Landsend, Erlend Christoffer Sommer; Olafsson, Snorri; Parissi, Eric; Utheim, Øygunn Aass; Ræder, Sten; Badian, Reza A.; Lagali, Neil Satish; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare the effects of eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, ...
Gendered vulnerabilities and the blind spots of the 2030 Agenda’s ‘leave no one behind’ pledge 
Vandeskog, Hilde Ousland; Heggen, Kristin; Engebretsen, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Agenda 2030 with the Sustainable Development Goals makes the transformative pledge to ‘leave no one behind.’ This paper asks how Agenda 2030 bring certain gendered vulnerabilities to light and make others invisible, and ...
Epistemic injustice in the age of evidence-based practice: The case of fibromyalgia 
Heggen, Kristin Margrethe; Berg, Henrik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract The aim of this paper is to analyze epistemic interactions in healthcare practices. In clinical encounters, participants exchange and interpret knowledge. Patients suffering from fibromyalgia often report that ...
Why Only Efficiency, and Not Efficacy, Matters in Psychotherapy Practice 
Berg, Henrik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Evidence-based practice in psychology consists of two quality parameters. One of these quality parameters is efficacy and the other is efficiency. In this article, it is argued that the only relevant parameter for determining ...
ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells 
Schläfli, Anna M.; Tokarchuk, Igor; Parejo, Sarah; Jutzi, Susanne; Berezowska, Sabina; Engedal, Nikolai; Tschan, Mario P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract ALK inhibitors effectively target EML4-ALK positive non-small cell lung cancer, but their effects are hampered by treatment resistance. In the present study, we asked whether ALK inhibition affects autophagy, and ...
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components 
Lindner, Paula; Christensen, Søren B; Nissen, Poul; Møller, Jesper V; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. ...
Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms 
Thonon, Bénédicte; Van Aubel, Evelyne; Lafit, Ginette; Della Libera, Clara; Larøi, Frank (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative ...
A Short Series of Laparoscopic Mesenteric Bypasses for Chronic Mesenteric Ischemia 
Kazmi, Syed Sajid Hussain; Berge, Simen Tveten; Sahba, Mehdi; Medhus, Asle Wilhelm; Sundhagen, Jon Otto (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Laparoscopic aortomesenteric bypass may be performed to treat the chronic mesenteric ischemia patients who are not suitable for endovascular treatment. This study presents an initial experience with a limited ...
Long-Term Language Development in Children With Early Simultaneous Bilateral Cochlear Implants 
Wie, Ona Bø; Torkildsen, Janne von Koss; Schauber, Stefan Kilian; Busch, Tobias; Litovsky, Ruth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objectives: This longitudinal study followed the language development of children who received the combination of early (5 to 18 months) and simultaneous bilateral cochlear implants (CIs) throughout the first 6 years ...
Evidence of validity for the Norwegian version of the interprofessional collaborative competency attainment survey (ICCAS) 
Lunde, Lene; Baerheim, Anders; Johannessen, Ane; Aase, Ingunn; Almendingen, Kari; Andersen, Irene Aasen; Bengtsson, Rutt Venke; Brenna, Sissel Johansson; Hauksdottir, Nanna; Steinsbekk, Aslak; Rosvold, Elin Olaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
This was a validation study of the Norwegian version of The Interprofessional Collaborative Competency Attainment Survey (ICCAS). ICCAS consists of 20 retrospective pre- and post-questions, where respondents rate their ...
Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy 
Gonzalez, Alba; Nome, Cecilie; Bendiksen, Bård Andre; Sjaastad, Ivar; Zhang, Lili; Aleksandersen, Mona; Taubøll, Erik; Aurlien, Dag; Heuser, Kjell (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature seizure-related death. An association between SUDEP and cardiac remodeling has been suggested. However, whether SUDEP is a direct consequence ...
Stage‑specific survival has improved for young breast cancer patients since 2000: but not equally 
Trewin, Cassia Bree; Johansson, Anna Louise Viktoria; Hjerkind, Kirsti Vik; Strand, Bjørn Heine; Kiserud, Cecilie E.; Ursin, Giske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose The stage-specific survival of young breast cancer patients has improved, likely due to diagnostic and treatment advances. We addressed whether survival improvements have reached all socioeconomic groups in a country ...
Behavioral effects of sub-anesthetic ketamine in a go/no-go task 
Nilsen, Andre Sevenius; Juel, Bjørn Erik; Farnes, Nadine; Romundstad, Luis Georg; Storm, Johan Frederik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims While psychedelic agents are known to have powerful, but largely unexplained, effects on contents of consciousness, there is an increasing interest in the potential clinical usefulness of such drugs ...
DNA copy number motifs are strong and independent predictors of survival in breast cancer 
Pladsen, Arne Valebjørg; Nilsen, Gro; Rueda, Oscar M.; Aure, Miriam Ragle; Borgan, Ørnulf; Liestøl, Knut; Vitelli, Valeria; Frigessi Di Rattalma, Arnoldo; Langerød, Anita; Mathelier, Anthony; Engebråten, Olav; Kristensen, Vessela N.; Wedge, David C.; Van Loo, Peter; Caldas, Carlos; Børresen-Dale, Anne-Lise; Russnes, Hege Elisabeth Giercksky; Lingjærde, Ole Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome ...
LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction 
Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin; Vekterud, Kristin; Soedling, Helen; Matthews, Jason; Lemma, Roza Berhanu; Gabrielsen, Odd Stokke; Bindesbøll, Christian; Ulven, Stine Marie; Nebb, Hilde Irene; Grønning-Wang, Line Mariann; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid ...
Data quality of Glasgow Coma Scale and Systolic Blood Pressure in scientific studies involving physician-staffed emergency medical services: Systematic review 
Tønsager, Kristin; Krüger, Andreas; Ringdal, Kjetil G.; Rehn, Marius (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Emergency physicians on‐scene provide highly specialized care to severely sick or injured patients. High‐quality research relies on the quality of data, but no commonly accepted definition of EMS data quality ...
Longitudinal kidney function outcome in aging testicular cancer survivors 
Nome, Ragnhild Veline; Småstuen, Milada Cvancarova; Bjøro, Trine; Kiserud, Cecilie E.; Fosså, Sophie Dorothea (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose: Testicular cancer survivors (TCSs) have increased risk of reduced kidney function related to treatment burden, but longitudinal studies of renal outcome in aging TCSs have been lacking. This longitudinal study ...
Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples 
Napoli, Elisa; Stenberg, Vilde Yuli; Juzeniene, Asta; Hjellum, Gro E.; Bruland, Øyvind; Larsen, Roy H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Lead-212 is a promising radionuclide for cancer therapy, but no primary 212Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of 212Pb activity in equilibrium ...
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells 
Barkovskaya, Anna; Seip, Kotryna; Prasmickaite, Lina; Mills, Ian Geoffrey; Moestue, Siver Andreas; Itkonen, Harri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of ...
JASPAR 2020: update of the open-access database of transcription factor binding profiles 
Fornes, Oriol; Castro Mondragón, Jaime Abraham; Khan, Aziz; Robin van der, Lee; Zhang, Xi; A. Richmond, Phillip; P. Modi, Bhavi; Correard, Solenne; Gheorghe, Marius; Baranasic, Damir; Santana-Garcia, Walter; Tan, Ge; Cheneby, Jeanne; Ballester, Benoit; Parcy, François; Sandelin, Albin; Lenhard, Boris; Wasserman, Wyeth W.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) for TFs across multiple species in six taxonomic ...
Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function 
Fagny, Maud; Platig, John; Kuijjer, Marieke Lydia; Lin, Xihong; Quackenbush, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs ...
ESCRT-mediated phagophore sealing during mitophagy 
Zhen, Yan; Spangenberg, Helene; Munson, Michael Joseph; Brech, Andreas; Schink, Kay Oliver; Tan, Kia Wee; Sørensen, Vigdis; Wenzel, Eva; Radulovic, Maja; Engedal, Nikolai; Simonsen, Anne; Raiborg, Camilla; Stenmark, Harald (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in macroautophagy/autophagy remain incompletely ...
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug 
Kamiński, Krzysztof; Esguerra, Camila V.; Gawel, Kinga Aurelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure ...
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene 
Gawel, Kinga Aurelia; Turski, Waldemar A.; van der Ent, Wietske; Mathai, Benan John; Kirstein-Smardzewska, Karolina Joanna; Simonsen, Anne; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
Measurement precision at the cut score in medical multiple choice exams: Theory matters 
Felicitas-Maria, Lahner; Schauber, Stefan Kilian; Andrea Carolin, Lövald; Roger, Kropf; Sissel, Guttormsen; Martin R., Fischer; Sören, Huwendiek (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction In high-stakes assessment, the measurement precision of pass-fail decisions is of great importance. A concept for analyzing the measurement precision at the cut score is conditional reliability, which ...
Predicting skin barrier dysfunction and atopic dermatitis in early infancy 
Rehbinder, Eva Maria; Endre, Kim Magnus Advocaat; Carlsen, Karin C. Lødrup; Asarnoj, Anna; Bains, Karen Eline Stensby; Berents, Teresa Løvold; Carlsen, Kai-Håkon; Gudmundsdóttir, Hrefna Katrín; Haugen, Guttorm; Hedlin, Gunilla; Kreyberg, Ina; Nordhagen, Live Solveig; Nordlund, Björn; Schinagl, Carina Madelen; Sandvik, Leiv; Skjerven, Håvard Ove; Söderhäll, Cilla; Staff, Anne Cathrine; Vettukattil, Muhammad Riyas; Værnesbranden, Caren Magdalena Rydland; Landrø, Linn Aina Ysland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Dry skin is associated with increased transepidermal water loss (TEWL), which has been found to precede atopic dermatitis (AD) in childhood. Objective We aimed to identify parental, prenatal, and perinatal predictive factors ...
Reproduction and the welfare state: Notes on Norwegian biopolitics 
Shammas, Victor Lund; Sandset, Tony Joakim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Norway has long been considered to be a bastion of social democracy due to its strong, protective, decommodifying welfare state. However, with the recent rise of neoliberalism and right-wing populist politics across the ...
Akutt forgiftning ved rusrelatert bruk av benzodiazepiner 
Andersson, Jon Andreas; Brekke, Mette; Vallersnes, Odd Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
BAKGRUNN Benzodiazepiner brukes også som rusmidler. Dette kan være farlig, særlig ved blandingsrus. Vi beskriver akutte forgiftninger ved rusrelatert bruk av benzodiazepiner hos pasienter på Legevakten i Oslo. MATERIALE ...
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Date Issued2020 - 2022 (151)2010 - 2019 (202)2000 - 2009 (17)1995 - 1999 (1)Document TypeTidsskriftartikkel (368)Doktoravhandling (3)AuthorMathelier, Anthony (19)Mills, Ian Geoffrey (16)Sandlie, Inger (16)Tasken, Kjetil (16)Andersen, Jan Terje (13)... View MorePeer ReviewedPeer reviewed (362)
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