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  • Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas 
    van IJzendoorn, David G.P.; Szuhai, Karoly; Briaire-De Bruijn, Inge H; Kostine, Marie; Kuijjer, Marieke Lydia; Bovée, Judith V.M.G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Based on morphology it is often challenging to distinguish between the many different soft tissue sarcoma subtypes. Moreover, outcome of disease is highly variable even between patients with the same disease. Machine ...
  • Major Increase in Incidence of Pediatric ACL Reconstructions From 2005 to 2021: A Study From the Norwegian Knee Ligament Register 
    Tveiten, Caroline Emilie Van Woensel Ko; Jakobsen, Rune Bruhn; Fenstad, Anne Marie; Persson, Andreas; Visnes, Håvard; Engebretsen, Lars; Ekås, Guri Ranum (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: The incidence of pediatric and adolescent anterior cruciate ligament reconstruction (ACLR) is increasing in several countries. It is uncertain whether this trend applies to countries that traditionally prefer ...
  • Making genome browsers portable and personal 
    Khan, Aziz; Zhang, Xuegong (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    GIVE is a framework and library for creating portable and personalized genome browsers. It makes visualizing genomic data as easy as building a laboratory homepage.
  • Making sustainable healthcare decisions: Three turns towards sustainable guidelines 
    Wieringa, Cornelis Hermannus Sietse; McGuire, Hugh; Wang, Qi; Van Der Wees, Philip; Shaw, Beth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
  • Mammalian target of rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts 
    Torp, May-Kristin; Yang, Kuan; Ranheim, Trine; Lauritzen, Knut Husø; Alfsnes, Katrine; Vinge, Leif Erik; Aukrust, Pål; Stensløkken, Kåre-Olav; Yndestad, Arne; Sandanger, Øystein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background: IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune receptors activating NFκB. If tissue damage occurs, ...
  • MANTA2, update of the Mongo database for the analysis of transcription factor binding site alterations 
    Fornes, Oriol; Gheorghe, Marius; Richmond, Phillip A.; Arenillas, David J.; Wasserman, Wyeth W.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Interpreting the functional impact of noncoding variants is an ongoing challenge in the field of genome analysis. With most noncoding variants associated with complex traits and disease residing in regulatory regions, ...
  • A map of direct TF–DNA interactions in the human genome 
    Gheorghe, Marius; Sandve, Geir Kjetil; Khan, Aziz; Cheneby, Jeanne; Ballester, Benoit; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most popular assay to identify genomic regions, called ChIP-seq peaks, that are bound in vivo by transcription factors (TFs). These regions are derived ...
  • Mapping the global mRNA transcriptome during development of the murine first molar 
    Landin, Maria Augusta Dos S Silva; Nygård, Ståle; Shabestari, Maziar; Babaie, Eshrat; Reseland, Janne Elin; Osmundsen, Harald (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The main objective of this study was to map global geneexpression in order to provide information about the populations of mRNA species participating in murine tooth development at 24 h intervals, starting at the eleventh ...
  • Marine n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Kidney Transplant Recipients: A Randomized, Placebo-Controlled Trial 
    Jørgensen, Hanne; Eide, Ivar Anders; Jenssen, Trond Geir; Åsberg, Anders; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders; Schmidt, Erik Berg; Svensson, My Hanna Sofia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Kidney transplant recipients are at high risk of progressive bone loss and low-energy fractures in the years following transplantation. Marine n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation may have beneficial ...
  • Maternal human papillomavirus infection during pregnancy and preterm delivery: A mother–child cohort study in Norway and Sweden 
    Wiik, Johanna; Værnesbranden, Caren Magdalena Rydland; Jonassen, Christine M; Staff, Anne Cathrine; Carlsen, Karin Cecilie Lødrup; Granum, Berit; Haugen, Guttorm Nils; Hedlin, Gunilla; Hilde, Katarina; Jacobsson, Bo; Nilsson, Staffan; Nordlund, Bjørn Kristian; Rangberg, Anbjørg; Rehbinder, Eva Maria; Sengpiel, Verena; Skjerven, Håvard Ove; Sundet, Birgitte Kordt; Söderhäll, Cilla; Vettukattil, Muhammad Riyas; Sjøborg, Katrine Dønvold (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Introduction Human papillomavirus (HPV) infection is common in women of reproductive age. Infection and inflammation are leading causes for preterm delivery (PTD), but the role of HPV infection in PTD and prelabor rupture ...
  • Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study 
    Skytte, Hege; Roland, Marie Cecilie; Christensen, Jacob J.; Holven, Kirsten Bjørklund; Lekva, Tove; Gunnes, Nina; Michelsen, Trond Melbye (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Introduction Increased BMI has been identified as a risk factor for most pregnancy complications, but the underlying metabolic factors mediating the detrimental effects of BMI are largely unknown. We aimed to ...
  • Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study 
    Mitlid-Mork, Birgitte; Bowe, Sophie; Gran, Jon Michael; Bolstad, Nils; Berg, Jens Petter; Redman, Christopher W.G.; Staff, Anne Cathrine; Sugulle, Meryam (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Post-term pregnancies have increased risks for adverse fetal and maternal outcomes. Maternal concentrations of the placenta-associated proteins placental growth factor (PlGF) and soluble fms-like tyrosine ...
  • Maternal Stress, Early Life Factors and Infant Salivary Cortisol Levels 
    Mägi, Caroline-Aleksi Olsson; Despriee, Åshild; Småstuen, Milada Cvancarova; Almqvist, Catarina; Bahram, Fuad; Bakkeheim, Egil; Bjerg, Anders; Glavin, Kari; Granum, Berit; Haugen, Guttorm Nils; Hedlin, Gunilla; Jonassen, Christine M; Carlsen, Karin Cecilie Lødrup; Rehbinder, Eva Maria; Rolfsjord, Leif Bjarte; Staff, Anne Cathrine; Skjerven, Håvard Ove; Vettukattil, Riyas; Nordlund, Björn; Söderhäll, Cilla (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background: Salivary cortisol (SC), a commonly used biomarker for stress, may be disrupted by negative events in pregnancy, at birth and in infancy. We aimed to explore if maternal perceived stress (PSS) in or after pregnancy ...
  • MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines 
    Ohnstad, Hege O; Paulsen, Erik B; Noordhuis, Paul; Berg, Marianne; Lothe, Ragnhild A; Vassilev, Lyubomir T; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
  • Measurement precision at the cut score in medical multiple choice exams: Theory matters 
    Felicitas-Maria, Lahner; Schauber, Stefan Kilian; Andrea Carolin, Lövald; Roger, Kropf; Sissel, Guttormsen; Martin R., Fischer; Sören, Huwendiek (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Introduction In high-stakes assessment, the measurement precision of pass-fail decisions is of great importance. A concept for analyzing the measurement precision at the cut score is conditional reliability, which ...
  • Mental health disorders, functioning and health-related quality of life among extensively hospitalized patients due to severe self-harm – results from the Extreme Challenges project 
    Langjord, Tuva; Pedersen, Geir Arild Feigum; Bovim, Tone; Christensen, Tore Buer; Eikenæs, Ingeborg Helene Ulltveit-Moe; Hove, Oddbjørn; Kildahl, Arvid Nikolai; Mork, Erlend; Norheim, Astrid Berge; Ramleth, Ruth-Kari; Ringen, Petter Andreas; Romm, Kristin Lie; Siqveland, Johan; Schønning, Thea; Stänicke, Line Indrevoll; Torgersen, Terje; Pettersen, Mona; Tveit, Tone; Urnes, Øyvind; Walby, Fredrik A; Kvarstein, Elfrida Hartveit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Severe self-harm leading to extensive hospitalization generates extreme challenges for patients, families, and health services. Controversies regarding diagnoses and health care often follow. Most evidence-based ...
  • Microfoundations of Data-Driven Antimicrobial Stewardship Policy (ASP) 
    Thakral, Yogita; Mukherjee, Arunima Sehgal; Sahay, Sundeep (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    This paper introduces a comprehensive framework that elucidates the microfoundations of data-driven antimicrobial stewardship programs (ASPs), specifically focusing on resource-constrained settings. Such settings necessitate ...
  • MirGeneDB 2.0: the metazoan microRNA complement 
    Fromm, Bastian; Domanska, Diana Ewa; Høye, Eirik; Ovchinnikov, Vladimir; Kang, Wenjing; Aparicio-Puerta, Ernesto; Johansen, Morten; Flatmark, Kjersti; Mathelier, Anthony; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R.; Peterson, Kevin J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Small non-coding RNAs have gained substantial attention due to their roles in animal development and human disorders. Among them, microRNAs are special because individual gene sequences are conserved across the animal ...
  • Mixed electrical-chemical synapses in adult rat hippocampus are primarily glutamatergic and coupled by connexin-36 
    Hamzei-Sichani, Farid; Davidson, Kimberly G.V.; Yasumura, Thomas; Janssen, William G.M.; Wearne, Susan L.; Hof, Patrick R.; Traub, Roger D.; Gutiérrez, Rafael; Ottersen, Ole Petter; Rash, John E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Dendrodendritic electrical signaling via gap junctions is now an accepted feature of neuronal communication in mammalian brain, whereas axodendritic and axosomatic gap junctions have rarely been described. We present ...
  • Mixed fatty acid-phospholipid protocell networks 
    Põldsalu, Inga; Köksal, Elif; Gözen, Irep (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Self-assembled membranes composed of both fatty acids and phospholipids are permeable for solutes and structurally stable, which was likely an advantageous combination for the development of primitive cells on the early ...