Browsing Det medisinske fakultet by Title

Now showing items 298-317 of 598

  • JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework 
    Khan, Aziz; Fornes, O; Stigliani, A; Gheorghe, Marius; Castro-Mondragon, J; van der Lee, R; Bessy, A; Cheneby, J; Kulkarni, SR; Tan, G; Baranasic, D; Arenillas, DJ; Sandelin, A; Vandepoele, K; Lenhard, B; Ballester, B; Wassermann, WW; Parcy, F; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across ...
  • JASPAR 2020: update of the open-access database of transcription factor binding profiles 
    Fornes, Oriol; Castro Mondragón, Jaime Abraham; Khan, Aziz; Robin van der, Lee; Zhang, Xi; A. Richmond, Phillip; P. Modi, Bhavi; Correard, Solenne; Gheorghe, Marius; Baranasic, Damir; Santana-Garcia, Walter; Tan, Ge; Cheneby, Jeanne; Ballester, Benoit; Parcy, François; Sandelin, Albin; Lenhard, Boris; Wasserman, Wyeth W.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) for TFs across multiple species in six taxonomic ...
  • JASPAR 2022: the 9th release of the open-acess database of transcription factor binding profiles 
    Castro Mondragon, Jaime Abraham; Riudavets Puig, Rafael; Rauluseviciute, Ieva; Lemma, Roza Berhanu; Turchi, Laura; Blanc-Mathieu, Romain; Lucas, Jeremy; Boddie, Paul; Khan, Aziz; Manosalva Perez, Nicolas; Fornes, Oriol; Leung, Tiffany; Aguirre, Alejandro; Hammal, Fayrouz; Schmelter, Daniel; Baranasic, Damir; Ballester, Benoit; Sandelin, Albin; Lenhard, Boris; Vandepoele, Klaas; Wasserman, Wyeth W.; Parcy, François; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract JASPAR (http://jaspar.genereg.net/) is an open-access database containing manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic groups. In this 9th ...
  • JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles 
    Rauluseviciute, Ieva; Riudavets-Puig, Rafael; Blanc-Mathieu, Romain; Castro-Mondragon, Jaime Abraham; Ferenc, Katalin Terezia; Kumar, Vipin; Lemma, Roza Berhanu; Lucas, Jeremy; Cheneby, Jeanne; Baranasic, Damir; Khan, Aziz; Fornes, Oriol; Gundersen, Sveinung; Johansen, Morten; Hovig, Eivind; Lenhard, Boris; Sandelin, Albin; Wasserman, Wyeth W.; Parcy, François; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    JASPAR (https://jaspar.elixir.no/) is a widely-used open-access database presenting manually curated high-quality and non-redundant DNA-binding profiles for transcription factors (TFs) across taxa. In this 10th release and ...
  • JASPAR RESTful API: accessing JASPAR data from any programming language 
    Khan, Aziz; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    JASPAR is a widely used open-access database of curated, non-redundant transcription factor binding profiles. Currently, data from JASPAR can be retrieved as flat files or by using programming language-specific interfaces. ...
  • Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses 
    Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate ...
  • Ketamine for the treatment of prehospital acute pain: a systematic review of benefit and harm 
    Sandberg, Mårten; Hyldmo, Per Kristian; Kongstad, Poul; Friesgaard, Kristian D.; Raatiniemi, Lasse; Larsen, Robert; Magnusson, Vidar; Rognås, Leif Kåre; Kurola, Jouni; Rehn, Marius; Vist, Gunn Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Few publications have addressed prehospital use of ketamine in analgesic doses. We aimed to assess the effect and safety profile of ketamine compared with other analgesic drugs (or no drug) in adult prehospital ...
  • Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging 
    Solvang, Stein-Erik Hafstad; Hodge, Allison; Watne, Leiv; Cabral-Marques, Otavio; Nordrehaug, Jan Erik; Giles, Graham G.; Dugué, Pierre-Antoine; Nygård, Ottar Kjell; Ueland, Per Magne; McCann, Adrian; Idland, Ane-Victoria; Midttun, Øivind; Ulvik, Arve; Halaas, Nathalie Bodd; Tell, Grethe S.; Melvær, Giil Lasse (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ...
  • The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells 
    Luhr, Morten; Szalai, Paula; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Bulk autophagy is characterized by the sequestration of large portions of cytoplasm into double/multi-membrane structures termed autophagosomes. Here a simple protocol to monitor this process is described. Moreover, typical ...
  • Lactobacillus plantarum displaying CCL3 chemokine in fusion with HIV-1 Gag derived antigen causes increased recruitment of T cells 
    Kuczkowska, Katarzyna; Mathiesen, Geir; Eijsink, Vincent; Øynebråten, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Chemokines are attractive candidates for vaccine adjuvants due to their ability to recruit the immune cells. Lactic acid bacteria (LAB)-based delivery vehicles have potential to be used as a cheap and safe option ...
  • Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study 
    Huncikova, Zuzana; Vatne, Anlaug; Stensvold, Hans Jørgen; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Salvesen, Bodil; Øymar, Knut Asbjørn Alexander; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Objective To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Design Cohort study using a nationwide, population-based ...
  • Legitimacy in clinical practice: How patients with chronic muscle pain position themselves in the physiotherapy encounter 
    Ahlsen, Birgitte; Mengshoel, Anne Marit; Engebretsen, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Rationale, Aims & Objective Patients who seek healthcare for long-lasting pain and symptoms without a detectable disease must put in extra work to be taken seriously and gain recognition as a patient. However, little ...
  • The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction 
    Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Pedersen, Hilde Røgeberg; Aass, Hans Christian Dalsbotten; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was ...
  • Levels of mental distress over 18 years after entering treatment for substance use disorders: A longitudinal cohort study 
    Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Skeie, Ivar; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Aims: The aims were to investigate whether baseline characteristics and problematic substance use were related to change in mental distress over time in patients with substance use disorders during an 18-year period. ...
  • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 
    Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune ...
  • The link between autophagy and secretion: A story of multitasking proteins 
    Farhan, Hesso; Kundu, Mondira; Ferro-Novick, Susan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    The secretory and autophagy pathways can be thought of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembrane system. In analogy to anabolic and catabolic pathways in metabolism, ...
  • Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger? 
    van Oost, Siddh; Meijer, Debora; Kuijjer, Marieke; Bovée, Judith V.M.G.; de Miranda, Noel F.C.C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Sarcomas comprise a collection of highly heterogeneous malignancies that can be grossly grouped in the categories of sarcomas with simple or complex genomes. Since the outcome for most sarcoma patients has barely improved ...
  • lionessR: single sample network inference in R 
    Kuijjer, Marieke L; Hsieh, Ping-Han; Quackenbush, John; Glass, Kimberly (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background In biomedical research, network inference algorithms are typically used to infer complex association patterns between biological entities, such as between genes or proteins, using data from a ...
  • Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions 
    Hiller, John Kim; Jangmo, Andreas; Tesli, Martin Steen; Jaholkowski, Piotr Pawel; Hoseth, Eva Zsuzsanna; Steen, Nils Eiel; Haram, Marit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Bipolar disorder (BD) is a disabling disorder with heterogeneous symptom profiles and trajectories. Like many other neuropsychiatric disorders, clinical decision making related to diagnoses and choice of treatment is based ...
  • Lipids in exosomes: Current knowledge and the way forward 
    Skotland, Tore; Sandvig, Kirsten; Llorente, Alicia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Lipids are essential components of exosomal membranes, and it is well-known that specific lipids are enriched in exosomes compared to their parent cells. In this review we discuss current knowledge about the lipid composition ...