Browsing Det medisinske fakultet by Title

Now showing items 474-493 of 598

  • Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: Study protocol for the randomised controlled phase II ReSScue trial 
    Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Sarna, Vikas Kumar; Barua, Imon Shoumitra; Carstens, Maylen N.; Distler, Oliver; Khanna, Dinesh; Volkmann, Elizabeth R.; Midtvedt, Øyvind; Didriksen, Henriette; Dhainaut, Alvilde; Halse, Anne Kristine Hjorteseth; Bakland, Gunnstein; Pesonen, Maiju; Olsen, Inge Christoffer; Molberg, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Introduction In the multisystem inflammatory disorder systemic sclerosis (SSc), gastrointestinal tract (GIT) affliction is highly prevalent. There are no known disease modifying therapies and the negative impact is ...
  • Scaling up cell-counting efforts in neuroscience through semi-automated methods 
    Bjerke, Ingvild Elise; Yates, Sharon Christine; Carey, Harry; Bjaalie, Jan G.; Leergaard, Trygve B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Quantifying how the cellular composition of brain regions vary across development, aging, sex, and disease, is crucial in experimental neuroscience, and the accuracy of different counting methods is continuously debated. ...
  • SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility 
    Silvennoinen, Katri; Gawel, Kinga Aurelia; Tsortouktzidis, Despina; Pitsch, Julika; Alhusaini, Saud; van Loo, Karen M. J.; Picardo, Richard; Michalak, Zuzanna; Pagni, Susanna; Martins Custodio, Helena; Mills, James; Whelan, Christopher D.; de Zubicaray, Greig I.; McMahon, Katie L.; van der Ent, Wietske; Kirstein-Smardzewska, Karolina Joanna; Tiraboschi, Ettore; Mudge, Jonathan M.; Frankish, Adam; Thom, Maria; Wright, Margaret J.; Thompson, Paul M.; Schoch, Susanne; Becker, Albert J.; Esguerra, Camila; Sisodiya, Sanjay M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Mesial temporal lobe epilepsy with hippocampal sclerosis and a history of febrile seizures is associated with common variation at rs7587026, located in the promoter region of SCN1A. We sought to explore possible ...
  • Sealing holes in cellular membranes 
    Zhen, Yan; Radulovic, Maja; Vietri, Marina; Stenmark, Harald (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The compartmentalization of eukaryotic cells, which is essential for their viability and functions, is ensured by single or double bilayer membranes that separate the cell from the exterior and form boundaries between the ...
  • Seizing the moment: Zebrafish epilepsy models 
    Gawel, Kinga Aurelia; Langlois, Melanie; Martins, Teresa G.; van der Ent, Wietske; Tiraboschi, Ettore; Jacmin, Maxime; Crawford, Alexander Dettmar; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Zebrafish are now widely accepted as a valuable animal model for a number of different central nervous system (CNS) diseases. They are suitable both for elucidating the origin of these disorders and the sequence of events ...
  • Selection of Nanobodies that Target Human Neonatal Fc Receptor 
    Andersen, Jan Terje; Gonzalez-Pajuelo, Maria; Foss, Stian; Landsverk, Ole J. B.; Pinto, Debora; Szyroki, Alexander; de Haard, Hans J.; Saunders, Michael; Vanlandschoot, Peter; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different ...
  • Self-reported symptoms experienced by intensive care unit patients: a prospective observational multicenter study 
    Saltnes-Lillegård, Christin; Rustøen, Tone; Beitland, Sigrid; Puntillo, Kathleen; Hagen, Milada; Lerdal, Anners; Hofsø, Kristin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Purpose The purpose of this study is to describe the prevalence, intensity and distress of five symptoms in intensive care unit (ICU) patients and to investigate possible predictive factors associated with symptom ...
  • Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues 
    Lopes-ramos, Camila; Chen, Cho-Yi; Kuijjer, Marieke Lydia; Paulson, Joseph N.; Sonawane, Abhijeet; Fagny, Maud; Platig, John; Glass, Kimberly; Quackenbush, John; DeMeo, Dawn L. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific gene ...
  • Sex Differences in Quality of Life in Patients With Atrial Fibrillation: A Systematic Review 
    Strømnes, Linn Arvidsson; Ree, Helene; Gjesdal, Knut; Ariansen, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background The goal of this literature review was to assess sex differences in the quality of life (QoL) in patients with atrial fibrillation (AF) and, if possible, to determine if these are due to AF. Methods and ...
  • Sex-specific factors associated with lifetime suicide attempt among patients with alcohol use disorders 
    Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Walby, Fredrik A; Myhre, Martin Øverlien; Bramness, Jørgen Gustav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Patients with alcohol use disorder (AUD) are at high risk for suicide attempts. Mental health problems along with AUD-related factors may contribute to this increased risk. Studies have shown sex differences ...
  • Sex/gender differences in verbal fluency and verbal-episodic memory: A meta-analysis 
    Hirnstein, Marco; Stuebs, Josephine; Moè, Angelica; Hausmann, Markus (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Women are thought to fare better in verbal abilities, especially in verbal-fluency and verbal-memory tasks. However, the last meta-analysis on sex/gender differences in verbal fluency dates from 1988. Although verbal memory ...
  • Shared and independent functions of aPKC? and Par3 in skin tumorigenesis 
    Vorhagen, Susanne; Kleefisch, Dominik; Persa, Oana-Diana; Graband, Annika; Schwickert, Alexandra; Saynisch, Michael; Leitges, Michael; Niessen, Carien M.; Iden, Sandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The polarity proteins Par3 and aPKC are key regulators of processes altered in cancer. Par3/aPKC are thought to dynamically interact with Par6 but increasing evidence suggests that aPKC and Par3 also exert complex-independent ...
  • Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 
    Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to ...
  • Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system 
    Fominykh, Vera; Shadrin, Alexey; Jaholkowski, Piotr Pawel; Bahrami, Shahram; Athanasiu, Lavinia; Wightman, Douglas P.; Uffelmann, Emil; Posthuma, Danielle; Selbæk, Geir; Dale, Anders; Djurovic, Srdjan; Frei, Oleksandr; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Neuroinflammation is involved in the pathophysiology of Alzheimer's disease (AD), including immune-linked genetic variants and molecular pathways, microglia and astrocytes. Multiple Sclerosis (MS) is a chronic, ...
  • A Short Series of Laparoscopic Mesenteric Bypasses for Chronic Mesenteric Ischemia 
    Kazmi, Syed Sajid Hussain; Berge, Simen Tveten; Sahba, Mehdi; Medhus, Asle Wilhelm; Sundhagen, Jon Otto (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background: Laparoscopic aortomesenteric bypass may be performed to treat the chronic mesenteric ischemia patients who are not suitable for endovascular treatment. This study presents an initial experience with a limited ...
  • Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells 
    Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius; McClymont, David; Skavland, Jørn; Gavasso, Sonia; Gjertsen, Bjørn Tore (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects ...
  • Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells 
    Sahu, Biswajyoti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Cell fate can be reprogrammed by ectopic expression of lineage-specific transcription factors (TFs). However, the exact cell state transitions during transdifferentiation are still poorly understood. Here, we have generated ...
  • Single-chain Variable Fragment Albumin Fusions Bind the Neonatal Fc Receptor (FcRn) in a Species-dependent Manner: IMPLICATIONS FOR IN VIVO HALF-LIFE EVALUATION OF ALBUMIN FUSION THERAPEUTICS 
    Andersen, Jan Terje; Cameron, J; Plumridge, A; Sleep, D; Evans, L; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Albumin has a serum half-life of 3 weeks in humans. This has been utilized to extend the serum persistence of biopharmaceuticals that are fused to albumin. In light of the fact that the neonatal Fc receptor (FcRn) is a key ...
  • Single-sample network modeling on omics data 
    De Marzio, Margherita; Glass, Kimberly; Kuijjer, Marieke L. (Journal article / Tidsskriftartikkel / PublishedVersion, 2023)
    Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an “aggregate” network, i.e., one that merges information across all the samples in an omics data set. ...
  • siRNA screening reveals that SNAP29 contributes to exosome release 
    Hessvik, Nina Pettersen; Sagini, Krizia; Romero, Silvana Angelica Troncoso; Ramirez, Manuel; Rodriguez, Marta; Tutturen, Astrid Elisabeth Voorham; Kvalvaag, Audun Sverre Myrset; Stang, Espen; Brech, Andreas; Sandvig, Kirsten; Llorente, Alicia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Cells release extracellular vesicles (EVs) of different sizes. Small EVs (< 200 nm) can originate from the fusion of multivesicular bodies with the plasma membrane, i.e. exosomes, and from budding of the plasma ...