Browsing Det medisinske fakultet by Title

Now showing items 391-410 of 598

  • Pan-cancer atlas of somatic core and linker histone mutations 
    Bonner, Erin R.; Dawood, Adam; Gordish-Dressman, Heather; Eze, Augustine; Bhattacharya, Surajit; Yadavilli, Sridevi; Mueller, Sabine; Waszak, Sebastian Martin; Nazarian, Javad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone ...
  • Parvalbumin interneuron dendrites enhance gamma oscillations 
    Kriener, Birgit; Hu, Hua; Vervaeke, Koen Gerard Alois (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Dendrites are essential determinants of the input-output relationship of single neurons, but their role in network computations is not well understood. Here, we use a combination of dendritic patch-clamp recordings and in ...
  • Pathologic Blood Samples Tolerate Exposure to Vibration and High Turbulence in Simulated Drone Flights, but Plasma Samples Should be Centrifuged after Flight 
    Johannessen, Karl Arne; Wear, Nina Kristin Steen; Toska, Karin; Hansbø, Morten; Berg, Jens Petter; Fosse, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Objective. Most of the previous studies of drone transport of blood samples examined normal blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone flights using random vibration ...
  • Patient safety in remote primary care encounters: Multimethod qualitative study combining Safety i and Safety II analysis 
    Payne, Rebecca; Clarke, Aileen; Swann, Nadia; Van Dael, Jackie; Brenman, Natassia; Rosen, Rebecca; Mackridge, Adam; Moore, Lucy; Kalin, Asli; Ladds, Emma; Hemmings, Nina; Rybczynska-Bunt, Sarah; Faulkner, Stuart; Hanson, Isabel; Spitters, Sophie; Wieringa, Cornelis Hermannus Sietse; Dakin, Francesca H.; Shaw, Sara E.; Wherton, Joseph; Byng, Richard; Husain, Laiba; Greenhalgh, Trisha (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Triage and clinical consultations increasingly occur remotely. We aimed to learn why safety incidents occur in remote encounters and how to prevent them. Setting and sample UK primary care. 95 safety incidents ...
  • Patients´ and GPs´ expectations regarding healthcare-seeking behavior: a Norwegian comparative study. 
    Eide, Torunn Bjerve; Straand, Jørund; Rosvold, Elin Olaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background GPs are Norwegian patients' first contact point with the healthcare system for most medical problems. However, little is known regarding GPs' expectations towards their patients' healthcare-seeking behaviour, ...
  • Penile Cancers Attributed to Human Papillomavirus Are Associated with Improved Survival for Node-positive Patients. Findings from a Norwegian Cohort Study Spanning 50 Years 
    Moen, Christian Arvei; Falkenthal, Thea Eline Hetland; Torkelsen, Tor Kristian; Hopland, Andreas; Rio, Oline Eriksen; Honore, Alfred; Juliebø-Jones, Patrick; Dongre, Harsh Nitin; Costea, Daniela Elena; Bostad, Leif Henry; Brennan, Paul; Johansson, Mattias; Feirrero-Iglesias, Aida; Brenner, Nicole; Waterboer, Tim; Nygård, Mari; Beisland, Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: Human papillomavirus (HPV) infection is a risk factor for the development of penile squamous cell carcinoma (PSCC). It remains inconclusive whether HPV-related PSCC has a different prognosis from non-HPV-related ...
  • Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase 
    Sørensen, Henrik Vinther; Montserrat-Canals, Mateu; Loose, Jennifer Sarah Maria; Fisher, S. Zoë; Moulin, Martine; Blakeley, Matthew P.; Cordara, Gabriele; Bjerregaard-Andersen, Kaare; Krengel, Ute (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Lytic polysaccharide monooxygenases (LPMOs) are surface-active redox enzymes that catalyze the degradation of recalcitrant polysaccharides, making them important tools for energy production from renewable sources. In ...
  • Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies 
    Desalegn, Anteneh Assefa; van der Ent, Wietske; Lenters, Virissa; Torcelino-Iszatt, Nina Louise; Stigum, Hein; Lyche, Jan Ludvig; Berg, Vidar; Kirstein-Smardzewska, Karolina Joanna; Esguerra, Camila Vicencio; Eggesbø, Merete Åse (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background The etiology of autism spectrum disorder (ASD) is multifactorial, involving genetic and environmental contributors such as endocrine-disrupting chemicals (EDCs). Objective To evaluate the association ...
  • Perineuronal nets stabilize the grid cell network 
    Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Sutterud, Hallvard; Blackstad, Jan Sigurd; Fyhn, Marianne; Hafting, Torkel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) ...
  • Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA 
    Gunnarsen, Kristin S; Lunde, Elin; Kristiansen, Per E; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Å (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...
  • Personal strengths reported by people with chronic illness: A qualitative study 
    Kristjansdottir, Olöf Birna; Stenberg, Una; Mirkovic, Jelena; Krogseth, Tonje; Ljoså, Tone Marte; Stange, Kurt; Ruland, Cornelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Self‐management of chronic illness can be highly demanding and people need to mobilize their personal strengths to live well with their condition. More knowledge is needed about how people with chronic illness ...
  • Phage display engineered T cell receptors as tools for the study of tumor peptide–MHC interactions 
    Løset, Geir Åge; Berntzen, Gøril; Frigstad, Terje; Pollmann, Sylvie; Gunnarsen, Kristin Støen; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Cancer immunotherapy has finally come of age, demonstrated by recent progress in strategies that engage the endogenous adaptive immune response in tumor killing. Occasionally, significant and durable tumor regression has ...
  • Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies 
    Findlay, Izac J.; De Iuliis, Geoffry N.; Duchatel, Ryan J.; Jackson, Evangeline R.; Vitanza, Nicholas A.; Cain, Jason E.; Waszak, Sebastian Martin; Dun, Matthew D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall survival (OS) ...
  • Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software 
    Banono, Nancy Saana; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    While there is an abundance of commercial and standardized automated systems and software for performing the prepulse inhibition (PPI) assay in rodents, to the best of our knowledge, all PPI assays performed in the zebrafish ...
  • Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects 
    Schwab, Charlotte; Gabrysch, Annemarie; Olbrich, Peter; Patiño, Virginia; Warnatz, Klaus; Wolff, Daniel; Hoshino, Akihiro; Kobayashi, Masao; Imai, Kohsuke; Takagi, Masatoshi; Dybedal, Ingunn; Haddock, Jamanda A.; Sansom, David M.; Lucena, Jose M.; Seidl, Maximilian; Schmitt-Graeff, Annette; Reiser, Veronika; Emmerich, Florian; Frede, Natalie; Bulashevska, Alla; Salzer, Ulrich; Schubert, Desirée; Hayakawa, Seiichi; Okada, Satoshi; Kanariou, Maria; Kucuk, Zeynep Yesim; Chapdelaine, Hugo; Petruzelkova, Lenka; Sumnik, Zdenek; Sediva, Anna; Slatter, Mary; Arkwright, Peter D.; Cant, Andrew; Lorenz, Hanns-Martin; Giese, Thomas; Lougaris, Vassilios; Plebani, Alessandro; Price, Christina; Sullivan, Kathleen E.; Moutschen, Michel; Litzman, Jiří; Freiberger, Tomas; van de Veerdonk, Frank L.; Recher, Mike; Albert, Michael H.; Hauck, Fabian; Seneviratne, Suranjith; Pachlopnik Schmid, Jana; Kolios, Antonios; Unglik, Gary; Klemann, Christian; Speckmann, Carsten; Ehl, Stephan; Leichtner, Alan; Blumberg, Richard; Franke, Andre; Snapper, Scott; Zeissig, Sebastian; Cunningham-Rundles, Charlotte; Giulino-Roth, Lisa; Elemento, Olivier; Dückers, Gregor; Niehues, Tim; Fronkova, Eva; Kanderová, Veronika; Platt, Craig D.; Chou, Janet; Chatila, Talal A.; Geha, Raif; McDermott, Elizabeth; Bunn, Su; Kurzai, Monika; Schulz, Ansgar; Alsina, Laia; Casals, Ferran; Deyà-Martinez, Angela; Hambleton, Sophie; Kanegane, Hirokazu; Tasken, Kjetil; Neth, Olaf; Grimbacher, Bodo (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Objective: We sought to characterize the penetrance, clinical features, and best treatment options in 133 CTLA4 mutation carriers. Methods: Genetics, clinical features, laboratory values, and outcomes of treatment options ...
  • Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene 
    Gawel, Kinga Aurelia; Turski, Waldemar A.; van der Ent, Wietske; Mathai, Benan John; Kirstein-Smardzewska, Karolina Joanna; Simonsen, Anne; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
  • Phenotypic Variability with SLURP1 Mutations and Diffuse Palmoplantar Keratoderma 
    Harjama, Liisa; Kettunen, Kaisa; Elomaa, Outi; Einarsdottir, Elisabet; Heikkilä, Hannele; Kivirikko, Sirpa; Lappalainen, Katriina; Saarela, Janna; Alby, Caroline; Ranki, Annamari; Kere, Juha; Hadj-Rabia, Smaïl; Hannula-Jouppi, Katariina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
  • Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5 
    Merklinger, Lisa; Bauer, Johannes; Pedersen, Per A.; Damgaard, Rune Busk; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Mitochondrial homeostasis is tightly controlled by ubiquitination. The mitochondrial integral membrane ubiquitin ligase MARCH5 is a crucial regulator of mitochondrial membrane fission, fusion, and disposal through mitophagy. ...
  • Photodynamic effects with 5-aminolevulinic acid on cytokines and exosomes in human peripheral blood mononuclear cells from patients with Crohn’s disease 
    Espeland, Kristian; Kleinauskas, Andrius; Juzenas, Petras; Darvekar, Sagar Ramesh; Vasovic, Vlada; Warloe, Trond; Christensen, Eidi; Jahnsen, Jørgen; Qian, Peng (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) which is the precursor of the photosensitizer protoporphyrin IX (PpIX) is an available treatment for several diseases. ALA-PDT induces the apoptosis and necrosis ...
  • Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): a feasibility study for a randomized controlled trial 
    Sirevåg, Kristine; Stavestrand, S. H.; Sjøbø, T.; Endal, T. B.; Nordahl, H. M.; Andersson, E.; Nordhus, I. H. K.; Rekdal; Specht, K.; Hammar; Halmøy, A.; Mohlman, J.; Hjelmervik, H.; Thayer, J. F.; Hovland, A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Generalised anxiety disorder (GAD) is a frequent and severe disorder among older adults. For older adults with GAD the effect of the recommended treatment, cognitive behaviour therapy (CBT), is ...