Browsing Det medisinske fakultet by Title

Now showing items 306-325 of 598

  • The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells 
    Luhr, Morten; Szalai, Paula; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Bulk autophagy is characterized by the sequestration of large portions of cytoplasm into double/multi-membrane structures termed autophagosomes. Here a simple protocol to monitor this process is described. Moreover, typical ...
  • Lactobacillus plantarum displaying CCL3 chemokine in fusion with HIV-1 Gag derived antigen causes increased recruitment of T cells 
    Kuczkowska, Katarzyna; Mathiesen, Geir; Eijsink, Vincent; Øynebråten, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Chemokines are attractive candidates for vaccine adjuvants due to their ability to recruit the immune cells. Lactic acid bacteria (LAB)-based delivery vehicles have potential to be used as a cheap and safe option ...
  • Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study 
    Huncikova, Zuzana; Vatne, Anlaug; Stensvold, Hans Jørgen; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Salvesen, Bodil; Øymar, Knut Asbjørn Alexander; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Objective To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Design Cohort study using a nationwide, population-based ...
  • Legitimacy in clinical practice: How patients with chronic muscle pain position themselves in the physiotherapy encounter 
    Ahlsen, Birgitte; Mengshoel, Anne Marit; Engebretsen, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Rationale, Aims & Objective Patients who seek healthcare for long-lasting pain and symptoms without a detectable disease must put in extra work to be taken seriously and gain recognition as a patient. However, little ...
  • The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction 
    Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Pedersen, Hilde Røgeberg; Aass, Hans Christian Dalsbotten; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was ...
  • Levels of mental distress over 18 years after entering treatment for substance use disorders: A longitudinal cohort study 
    Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Skeie, Ivar; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Aims: The aims were to investigate whether baseline characteristics and problematic substance use were related to change in mental distress over time in patients with substance use disorders during an 18-year period. ...
  • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 
    Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune ...
  • The link between autophagy and secretion: A story of multitasking proteins 
    Farhan, Hesso; Kundu, Mondira; Ferro-Novick, Susan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    The secretory and autophagy pathways can be thought of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembrane system. In analogy to anabolic and catabolic pathways in metabolism, ...
  • Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger? 
    van Oost, Siddh; Meijer, Debora; Kuijjer, Marieke; Bovée, Judith V.M.G.; de Miranda, Noel F.C.C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Sarcomas comprise a collection of highly heterogeneous malignancies that can be grossly grouped in the categories of sarcomas with simple or complex genomes. Since the outcome for most sarcoma patients has barely improved ...
  • lionessR: single sample network inference in R 
    Kuijjer, Marieke L; Hsieh, Ping-Han; Quackenbush, John; Glass, Kimberly (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background In biomedical research, network inference algorithms are typically used to infer complex association patterns between biological entities, such as between genes or proteins, using data from a ...
  • Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions 
    Hiller, John Kim; Jangmo, Andreas; Tesli, Martin Steen; Jaholkowski, Piotr Pawel; Hoseth, Eva Zsuzsanna; Steen, Nils Eiel; Haram, Marit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Bipolar disorder (BD) is a disabling disorder with heterogeneous symptom profiles and trajectories. Like many other neuropsychiatric disorders, clinical decision making related to diagnoses and choice of treatment is based ...
  • Lipids in exosomes: Current knowledge and the way forward 
    Skotland, Tore; Sandvig, Kirsten; Llorente, Alicia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Lipids are essential components of exosomal membranes, and it is well-known that specific lipids are enriched in exosomes compared to their parent cells. In this review we discuss current knowledge about the lipid composition ...
  • Long-term follow up of families with pathogenic NFKB1 variants reveals incomplete penetrance and frequent inflammatory sequelae 
    Tuovinen, Elina A.; Kuismin, Outi; Soikkonen, Leila; Martelius, Timi; Kaustio, Meri; Hamalainen, Sari; Viskari, Hanna; Syrjänen, Jaana; Wartionvaara-Kauttu, U; Eklund, Kari K.; Saarela, Janna Saija; Varjosalo, Markku; Kere, Juha; Hautala, Timo; Seppanen, Mkko (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Nuclear factor κ light-chain enhancer of activated B cells (NF-κB) family of evolutionarily conserved transcription factors are involved in key cellular signaling pathways. Previously, hypogammaglobulinemia and common ...
  • Long-Term Language Development in Children With Early Simultaneous Bilateral Cochlear Implants 
    Wie, Ona Bø; Torkildsen, Janne von Koss; Schauber, Stefan Kilian; Busch, Tobias; Litovsky, Ruth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Objectives: This longitudinal study followed the language development of children who received the combination of early (5 to 18 months) and simultaneous bilateral cochlear implants (CIs) throughout the first 6 years ...
  • Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes 
    Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Zucknick, Manuela; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Selmer, Kaja Kristine; Lie, Benedicte Alexandra; Gervin, Kristina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and ...
  • Longitudinal Covid-19 effects on child mental health: vulnerability and age dependent trajectories 
    Larsen, Linda; Schauber, Stefan K.; Holt, Tonje; Helland, Maren S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Few longitudinal studies have investigated the extended long-term impact of the Covid-19 pandemic for children’s and adolescents’ mental health, and a lack of uniform findings suggest heterogeneity ...
  • Longitudinal kidney function outcome in aging testicular cancer survivors 
    Nome, Ragnhild Veline; Småstuen, Milada Cvancarova; Bjøro, Trine; Kiserud, Cecilie E.; Fosså, Sophie Dorothea (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Purpose: Testicular cancer survivors (TCSs) have increased risk of reduced kidney function related to treatment burden, but longitudinal studies of renal outcome in aging TCSs have been lacking. This longitudinal study ...
  • Loss of DIAPH1 causes SCBMS, combined immunodeficiency, and mitochondrial dysfunction 
    Kaustio, Meri; Nayebzadeh, Naemeh; Hinttala, Reetta; Tapiainen, Terhi; Åström, Pirjo; Mamia, Katariina Aino Inkeri; Pernaa, Nora; Lehtonen, Johanna Marianna; Glumoff, Virpi; Rahikkala, Elisa; Honkila, Minna; Olsén, Päivi; Hassinen, Antti; Polso, Minttu; Al Sukati, Nashat; Al Shekaili, Jalila; Al Kindi, Mahmood; Al Hashmi, Nadia; Almusa, Henrikki; Bulanova, Daria; Haapaniemi, Emma Maria; Chen, Pu; Suo-Palosaari, Maria; Vieira, Paivi; Tuominen, Hannu; Kokkonen, Hannaleena; Al Macki, Nabil; Al Habsi, Huda; Löppönen, Tuija; Rantala, Heikki; Pietiäinen, Vilja; Zhang, Shen-Ying; Renko, Marjo; Hautala, Timo; Al Farsi, Tariq; Uusimaa, Johanna; Saarela, Janna Saija (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied 5 Finnish and 2 Omani patients with loss of DIAPH1 presenting with SCBMS, mitochondrial ...
  • LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction 
    Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin; Vekterud, Kristin; Soedling, Helen; Matthews, Jason; Lemma, Roza Berhanu; Gabrielsen, Odd Stokke; Bindesbøll, Christian; Ulven, Stine Marie; Nebb, Hilde Irene; Grønning-Wang, Line Mariann; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid ...
  • Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas 
    van IJzendoorn, David G.P.; Szuhai, Karoly; Briaire-De Bruijn, Inge H; Kostine, Marie; Kuijjer, Marieke Lydia; Bovée, Judith V.M.G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Based on morphology it is often challenging to distinguish between the many different soft tissue sarcoma subtypes. Moreover, outcome of disease is highly variable even between patients with the same disease. Machine ...