Browsing Det medisinske fakultet by Title

Now showing items 258-277 of 598

  • Identification of a High Affinity Fc gamma RIIA-binding Peptide That Distinguishes Fc gamma RIIA from Fc gamma RIIB and Exploits Fc gamma RIIA-mediated Phagocytosis and Degradation 
    Berntzen, Gøril; Andersen, Jan Terje; Ustgård, Kristine; Ustgård, Kristine; Michaelsen, Terje Einar; Mousavi, Darbi Seyed Ali; Mousavi, Seyed Ali; Qian, Julie Dee; Qian, Julie Dee; Kristiansen, Per Eugen; Kristiansen, Per Eugen; Lauvrak, Vigdis; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
  • Identification of DHX40 as a candidate susceptibility gene for colorectal and hematological neoplasia 
    Olkinuora, Alisa; Nieminen, Taina T.; Douglas, Suvi; Kauppinen, Anni; Kontro, Mika; Väänänen, Juho; Kankainen, Matti; Ristimäki, Ari; Mäkinen, Markus; Lahermo, Päivi; Heckman, Caroline; Saarela, Janna Saija; Salonen, Milla; Lepistö, Anna; Järvinen, Heikki; Mecklin, Jukka-Pekka; Kilpivaara, Outi; Wartiovaara-Kautto, Ulla; Porkka, Kimmo; Peltomäki, Päivi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
  • Identification of gluten T cell epitopes driving celiac disease 
    Chlubnova, Marketa; Christophersen, Asbjørn Otto; Sandve, Geir Kjetil Ferkingstad; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Dahal-Koirala, Shiva; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    CD4+ T cells specific for cereal gluten proteins are key players in celiac disease (CeD) pathogenesis. While several CeD-relevant gluten T cell epitopes have been identified, epitopes recognized by a substantial proportion ...
  • Identification of Key Tissue-Specific, Biological Processes by Integrating Enhancer Information in Maize Gene Regulatory Networks 
    Fagny, Maud; Kuijjer, Marieke Lydia; Stam, Maike; Joets, Johann; Turc, Olivier; Rozière, Julien; Pateyron, Stéphanie; Venon, Anthony; Vitte, Clémentine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Enhancers are key players in the spatio-temporal coordination of gene expression during numerous crucial processes, including tissue differentiation across development. Characterizing the transcription factors (TFs) and ...
  • Identification of mammalian transcription factors that bind to inaccessible chromatin 
    Pop, Romana Tabita; Pisante, Alessandra; Nagy, Dorka; Martin, Patrick C. N.; Mikheeva, Liudmila A.; Hayat, Ateequllah; Ficz, Gabriella; Zabet, Nicolae Radu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Transcription factors (TFs) are proteins that affect gene expression by binding to regulatory regions of DNA in a sequence specific manner. The binding of TFs to DNA is controlled by many factors, including ...
  • Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis 
    Ha, Thomas J; Zhang, Peter G Y; Robert, Remi; Yeung, Joanna; Swanson, Douglas J; Mathelier, Anthony; Wasserman, Wyeth W; Im, Sujin; Itoh, Masayoshi; Kawaji, Hideya; Lassmann, Timo; Daub, Carsten O; Arner, Erik; Carninci, Piero; Hayashizaki, Yoshihide; Forrest, Alistair R R; Goldowitz, Daniel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background The work of the FANTOM5 Consortium has brought forth a new level of understanding of the regulation of gene transcription and the cellular processes involved in creating diversity of cell types. ...
  • Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer 
    Puvirajesinghe, Tania M.; Bertucci, François; Jain, Ashish; Scerbo, Pierluigi; Belotti, Edwige; Audebert, Stéphane; Sebbagh, Michael; Lopez, Marc; Brech, Andreas; Finetti, Pascal; Charafe-Jauffret, Emmanuelle; Chaffanet, Max; Castellano, Rémy; Restouin, Audrey; Marchetto, Sylvie; Collette, Yves; Gonçalvès, Anthony; Macara, Ian; Birnbaum, Daniel; Kodjabachian, Laurent; Johansen, Terje; Borg, Jean-Paul (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as ...
  • Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data 
    Yang, Mingyi; Ali, Omer; Bjørås, Magnar; Wang, Junbai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases. We propose a non-encoding SNVs analysis tool bpb3, BayesPI-BAR ...
  • Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms 
    Thonon, Bénédicte; Van Aubel, Evelyne; Lafit, Ginette; Della Libera, Clara; Larøi, Frank (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative ...
  • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 
    Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...
  • Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice 
    Tønnessen, Theis; Melleby, Arne Olav; Hauge-Iversen, Ida Marie; Espe, Emil Knut Stenersen; Ahmed, Muhammad Shakil; Ueland, Thor; Haavardsholm, Espen A.; Atkinson, Sara Marie; Melum, Espen; Attramadal, Håvard; Sjaastad, Ivar; Vinge, Leif Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Aims Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the ...
  • Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia 
    Malani, Disha; Adish Kumar, Kumar; Brück, Oscar; Kontro, Mika; Yadav, Bhagwan; Hellesøy, Monica; Kuusanmäki, Heikki; Dufva, Olli; Kankainen, Matti; Eldfors, Samuli; Potdar, Swapnil; Saarela, Jani; Turunen, Laura; Parsons, Alun; Västrik, Imre; Kivinen, Katja; Saarela, Janna Saija; Räty, Riikka; Mooij, Wolf M.; Lehto, M; Gjertsen, Bjørn Tore; Mustjoki, Satu; Aittokallio, Tero Antero; Wennerberg, Krister; Heckman, Caroline Akemi; Kallioniemi, Olli; Porkka, Kimmo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated ...
  • In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice 
    Nieoczym, Dorota; Banono, Nancy Saana; Stępnik, Katarzyna; Kaczor, Agnieszka A.; Szybkowski, Przemysław; Esguerra, Camila; Kukula-Koch, Wirginia; Gawel, Kinga Aurelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    The aim of this study is to evaluate the anticonvulsant potential of schisandrin B, a main ingredient of Schisandra chinensis extracts. Schisandrin B showed anticonvulsant activity in the zebrafish larva pentylenetetrazole ...
  • In-office thermal systems for the treatment of dry eye disease 
    Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...
  • Increased default-mode variability is related to reduced task-performance and is evident in adults with ADHD 
    Mowinckel, Athanasia Monika; Pedersen, Mads Lund; Ziegler, Sigurd; Fredriksen, Mats; Kaufmann, Tobias; Sonuga-Barke, Edmund J.S.; Endestad, Tor; Westlye, Lars Tjelta; Biele, Guido (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Insufficient suppression and connectivity of the default mode network (DMN) is a potential mediator of cognitive dysfunctions across various disorders, including attention deficit/hyperactivity disorder (ADHD). However, ...
  • Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma 
    Gao, Jian; Zhao, Sen; Halstensen, Trond Sundby (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Increased expression of interleukin 6 (IL-6) is associated with poor prognosis and chemoresistance in many different carcinomas, but its role in head and neck squamous cell carcinoma (HNSCC) is still unsettled. Analyzing ...
  • Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings 
    Viste, Rannveig; Follin, Louise Frøstrup; Kornum, Birgitte R.; Lie, Benedicte Alexandra; Viken, Marte Kathrine; Thorsby, Per Medbøe; Rootwelt-Revheim, Terje; Christensen, Julie Anja Engelhard; Knudsen, Stine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 ...
  • Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency 
    Macpherson, Magnhild Eide; Skarpengland, Tonje; Hov, Johannes Espolin Roksund; Ranheim, Trine; Vestad, Beate; Dahl, Tuva Børresdatter; Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Holven, Kirsten Bjørklund; Fevang, Børre; Berge, Rolf Kristian; Aukrust, Pål; Halvorsen, Bente; Jørgensen, Silje Fjellgård (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Purpose Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have ...
  • Increased thromboinflammatory load in hereditary angioedema 
    Gramstad, Olav Rogde; Schjalm, Camilla; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract C1 inhibitor (C1Inh) is a serine protease inhibitor involved in the kallikrein-kinin system, the complement system, the coagulation system, and the fibrinolytic system. In addition to the plasma leakage ...
  • Inflammation and Neutrophil Oxidative Burst in a Family with NFKB1 p.R157X LOF and Sterile Necrotizing Fasciitis 
    Santaniemi, Wenny; Åström, Pirjo; Glumoff, Virpi; Pernaa, Nora; Tallgren, Ella-Noora; Palosaari, Sanna; Nissinen, Antti; Kaustio, Meri; Kuismin, Outi; Saarela, Janna Saija; Nurmi, Katariina; Eklund, Kari K.; Seppänen, Mikko R. J.; Hautala, Timo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Loss-of-function (LOF) mutations in NFKB1 , coding for p105, may cause common variable immunodeficiency due to dysregulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κΒ) pathway. ...