Browsing Det medisinske fakultet by Title
Now showing items 131-150 of 598
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background Emergency physicians on‐scene provide highly specialized care to severely sick or injured patients. High‐quality research relies on the quality of data, but no commonly accepted definition of EMS data quality ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Rab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late endosome seems to be regulated through an endosomal ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Abstract Mutations in POLG , the gene encoding the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol‐γ), lead to diseases driven by defective mtDNA maintenance. Despite being the most prevalent cause ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Background Bladder cancer (BLCA) is a common and deadly disease that results in a reduced quality of life for the patients and a significant economic burden on society. A better understanding of tumorigenesis is needed to ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Understanding the underlying determinants of maternal knowledge and attitude towards breastfeeding guides the development of context-specific interventions to improve breastfeeding practices. This study aimed to assess the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Simple Summary In the present study, we addressed the unmet need for a molecular antibody (mAb) with high affinity and specificity against a truncated hyperactive isoform of human epidermal growth factor receptor 2 (HER2), ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Background. Task shifting is a systematic delegation of tasks in order to make more efficient use of the available human resources for health. Training programs and the quality of these are sparsely studied and specially ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background Diagnostic errors occur frequently, especially in the emergency room. Estimates about the consequences of diagnostic error vary widely and little is known about the factors predicting error. Our ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)In this perspective article, I discuss whether and how solid surfaces could have played a key role in the formation of membranous primitive cells on the early Earth. I argue why surface energy could have been used by ...
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Diet quality on days without breakfast or lunch - Identifying targets to improve adolescents' diet. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Dietary intake in adolescents does often not align with the recommended dietary guidelines. Excess intakes of added sugar and saturated fat, and insufficient vegetable intake are among the identified challenges, which can ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Wnt signalling is prevented by the proteosomal degradation of β-catenin, which occurs in a destruction complex containing adenomatous polyposis coli (APC), APC-like (APCL), Axin and Axin2. Truncating mutations of the APC ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Introduction Wrong and missed diagnoses contribute substantially to medical error. Can a prompt to generate alternative diagnoses (prompt) or a differential diagnosis checklist (DDXC) increase diagnostic accuracy? How ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Inhibition of the tankyrase enzymes (TNKS1 and TNKS2) has recently been shown to induce highly dynamic assemblies of β-catenin destruction complex components known as degradasomes, which promote degradation of β-catenin ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Introduction Digital health offers the potential to strengthen health systems in low- and middle-income countries. However, experts have warned about threats to human rights. Methods We used qualitative methods to ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Abstract Objectives MTX, LEF and SSZ are conventional synthetic DMARDs (csDMARDs) with a well-established role in the treatment of RA. We aimed to estimate and compare the relative risks ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wide range of molecules such as fatty acids, metabolites, hormones, and toxins. In addition, it binds a variety of drugs. ...