Browsing Det medisinske fakultet by Title

Now showing items 69-88 of 598

  • C57BL/6J mice as a polygenic developmental model of diet-induced obesity 
    Chu, Dinh Toi; Malinowska, Elzbieta; Jura, Magdalena; Kozak, Leslie P (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Susceptibility to obesity changes during the course of life. We utilized theC57BL/6J (B6) and 129S mouse as a genetic model for variation in diet-induced obesity to define the adiposity phenotypes from birth to maturity ...
  • Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples 
    Napoli, Elisa; Stenberg, Vilde Yuli; Juzeniene, Asta; Hjellum, Gro E.; Bruland, Øyvind; Larsen, Roy H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Lead-212 is a promising radionuclide for cancer therapy, but no primary 212Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of 212Pb activity in equilibrium ...
  • Cancer risk and tumour spectrum in 172 patients with a germline SUFU pathogenic variation: A collaborative study of the SIOPE Host Genome Working Group 
    Guerrini-Rousseau, Lea; Masliah-Planchon, Julien; Waszak, Sebastian Martin; Alhopuro, Pia; Benusiglio, Patrick R; Bourdeaut, Franck; Brecht, Ines B; Del Baldo, Giada; Dhanda, Sandeep Kumar; Garre, Maria Luisa; Gidding, Corrie E M; Hirsch, Steffen; Hoarau, Pauline; Jorgensen, Mette; Kratz, Christian; Lafay-Cousin, Lucie; Mastronuzzi, Angela; Pastorino, Lorenza; Pfister, Stefan M; Schroeder, Christopher; Smith, Miriam Jane; Vahteristo, Pia; Vibert, Roseline; Vilain, Catheline; Waespe, Nicolas; Winship, Ingrid M; Evans, D Gareth; Brugieres, Laurence (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Little is known about risks associated with germline SUFU pathogenic variants (PVs) known as a cancer predisposition syndrome. Methods To study tumour risks, we have analysed data of a large cohort of 45 ...
  • Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN 
    Borge, Kaja Sverdrup; Nord, Silje; Van Loo, Peter; Lingjærde, Ole Christian; Gunnes, Gjermund; Alnæs, Grethe I Grenaker; Solvang, Hiroko Kato; Luders, Torben; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Lingaas, Frode (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, ...
  • Cardiac Structure and Function in Epilepsy Patients with Drug-Resistant Convulsive Seizures 
    Gonzalez, Alba; Haugaa, Kristina Ingrid Helena Hermann; Brekke, Pål Haugar; Hopp, Einar; Ørn, Stein; Alvestad, Silje; Taubøll, Erik; Aurlien, Dag (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    High frequency of convulsive seizures and long-lasting epilepsy are associated with an increased risk of sudden unexpected death in epilepsy (SUDEP). Structural changes in the myocardium have been described in SUDEP victims. ...
  • The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure 
    Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise; Birkeland, Jon Arne; Skomedal, Tor; Osnes, Jan-Bjørn; Sjaastad, Ivar; Levy, Finn Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    A positive inotropic responsiveness to serotonin, mediated by 5-HT4 and 5-HT2A receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A ...
  • Care as intertextuality—from human condition to holistic device 
    Askheim, Clemet; Engebretsen, Eivind; Ødemark, John (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Since the Roman mythographer Hyginus composed the fable of Cura in the second century AD, it has been cited and reemployed in literary and philosophical texts by authors like Augustin, Herder, Goethe, Heidegger, Blumenberg ...
  • CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation 
    Itkonen, Harri; Poulose, Ninu; Walker, Suzanne; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Cyclin-dependent kinase 9 (CDK9), a key regulator of RNA-polymerase II, is a candidate drug target for cancers driven by transcriptional deregulation. Here we report a multi-omics-profiling of prostate cancer cell responses ...
  • Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components 
    Lindner, Paula; Christensen, Søren B; Nissen, Poul; Møller, Jesper V; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. ...
  • A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM 
    Dukic, Aleksandra; McClymont, David; Tasken, Kjetil (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Connexin 43 (Cx43), the predominant gap junction (GJ) protein, directly interacts with the A-kinase-anchoring protein (AKAP) Ezrin in human cytotrophoblasts and a rat liver epithelial cells (IAR20). The Cx43-Ezrin–protein ...
  • A cellular automaton for modeling non-trivial biomembrane ruptures 
    Gupta, Abhay; Gözen, Irep; Taylor, Michael (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models ...
  • CENP-A and CENP-B collaborate to create an open centromeric chromatin state 
    Nagpal, Harsh; Ali Ahmad, Ahmad; Hirano, Yasuhiro; Cai, Wei; Halic, Mario; Fukagawa, Tatsuo; Sekulic, Nikolina; Fierz, Beat (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the ...
  • CENP-A nucleosome-a chromatin-embedded pedestal for the centromere: lessons learned from structural biology 
    Ali-Ahmad, Ahmad; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract The centromere is a chromosome locus that directs equal segregation of chromosomes during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically defines the centromere. Here, ...
  • CENP‐C unwraps the human CENP‐A nucleosome through the H2A C‐terminal tail 
    Ali Ahmad, Ahmad; Bilokapic, Silvija; Schafer, Ingmar B; Halic, Mario; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP ‐A, upon which the constitutive centromere‐associated network of proteins (CCAN ) is built. CENP ‐C is considered to be a central ...
  • Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression 
    Siafarikas, Nikias Ioannis; Kirsebom, Bjørn-Eivind; Srivastava, Deepak P; Eriksson, Cecilia Magdalena; Auning, Eirik; Hessen, Erik; Selbæk, Geir; Blennow, Kaj; Aarsland, Dag; Fladby, Tormod (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) ...
  • Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells 
    Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine B; Lyle, Robert; Kringen, Marianne K; Staff, Anne C; Dybedal, Ingunn; Mills, Ian G; Klungland, Arne; Staerk, Judith (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background Hematopoietic stem cell renewal and differentiation are regulated through epigenetic processes. The conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC) by ten-eleven-translocation ...
  • Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display 
    Gunnarsen, Kristin Støen; Kristinsson, Solveig Gunn; Justesen, Sune; Frigstad, Terje; Buus, Søren; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    We here report a novel phage display selection strategy enabling fast and easy selection of thermostabilized proteins. The approach is illustrated with stabilization of an aggregation-prone soluble single chain T cell ...
  • Characterization of degradation and heterozygote balance by simulation of the forensic DNA analysis process 
    Hansson, Nils Oskar Gunnar; Egeland, Thore; Gill, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Simulation experiments were used to show the impact of varying extraction efficiency, aliquot proportion, and PCR efficiency on the heterozygote balance of a range of diploid and haploid cells. Reducing either parameters ...
  • Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity 
    Gomez, Alvin; Bindesbøll, Christian; Venkata, Satheesh; Grimaldi, Giulia; Hutin, David; MacPherson, Laura; Ahmed, Shaimaa; Tamblyn, Laura; Cho, Tiffany; Nebb, Hilde Irene; Moen, Anders; Anonsen, Jan Haug; Grant, Denis M; Matthews, Jason (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Here, we report the biochemical characterization of the mono-ADP-ribosyltransferase 2,3,7,8-tetrachlorodibenzo-p-dioxin poly-ADP-ribose polymerase (TIPARP/ARTD14/PARP7), which is known to repress aryl hydrocarbon receptor ...
  • Characterization of the Enzymatic Activity of the Serine Protease Domain of Factor VII Activating Protease (FSAP) 
    Nielsen, Nis Valentin; Roedel, Elfie; Manna, Dipankar; Etscheid, Michael; Morth, Jens Preben; Kanse, Sandip (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Factor VII (FVII) activating protease (FSAP) is a circulating serine protease. Human genetic studies, based on the Marburg I (MI) (Gly221Glu, chymotrypsin numbering system) polymorphism, implicate FSAP in the pathogenesis ...