Browsing Det medisinske fakultet by Title

Now showing items 3-22 of 598

  • A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity 
    Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren; Fure, Hilde; Landsem, Anne; Bergseth, Grete; Schjalm, Camilla; Haugaard-Kedström, Linda M.; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ...
  • A four‐group urine risk classifier for predicting outcomes in patients with prostate cancer 
    Connell, Shea P; Yazbek-Hanna, Marcelino; McCarthy, Frank; Hurst, Rachel; Webb, Martyn; Curley, Helen; Walker, Helen; Mills, Rob; Ball, Richard Y; Sanda, Martin G.; Pellegrini, Kathryn L; Patil, Dattatraya; Perry, Antoinette; Schalken, Jack A.; Pandha, Hardev; Whitaker, Hayley; Dennis, Nening; Stuttle, Christine; Mills, Ian Geoffrey; Guldvik, Ingrid; Parker, Chris; Brewer, Daniel; Cooper, Colin S.; Clark, Jeremy P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objectives To develop a risk classifier using urine‐derived extracellular vesicle (EV )‐RNA capable of providing diagnostic information on disease status prior to biopsy, and prognostic information for men on active ...
  • A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase 
    Sommer, Theis; Bjerregaard-Andersen, Kaare; Uribe, Lalita; Etzerodt, Michael; Diezemann, Gregor; Gauss, Jürgen; Cascella, Michele; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
  • A highly redundant BAC library of Atlantic salmon (Salmo salar): an important tool for salmon projects 
    Thorsen, Jim; Zhu, Baoli; Frengen, Eirik; Osoegawa, Kazutoyo; de Jong, Pieter J; Koop, Ben F; Davidson, William S; Høyheim, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Background As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify the genomic mechanisms for specific traits is becoming more important in breeding and management of the ...
  • A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation 
    Llimos, Gerard; Gardeux, Vincent; Koch, Ute; Kribelbauer, Judith F.; Hafner, Antonina; Alpern, Daniel; Pezoldt, Joern; Litovchenko, Maria; Russeil, Julie; Dainese, Riccardo; Moia, Riccardo; Mahmoud, Abdurraouf Mokhtar; Rossi, Davide; Gaidano, Gianluca; Plass, Christoph; Lutsik, Pavlo; Gerhauser, Clarissa; Waszak, Sebastian Martin; Boettiger, Alistair; Radtke, Freddy; Deplancke, Bart (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named “variable chromatin modules” ...
  • A longitudinal investigation of letter-name knowledge in a semi-transparent orthography 
    Larsen, Linda; Hjetland, Hanne Næss; Schauber, Stefan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Children's ability to correctly name letters is a key predictor of later reading abilities and skills, but research on letter naming from Scandinavian orthographies is scarce. The aim of this study is to explore how child- ...
  • A nationwide study of patients operated for cervical degenerative disorders in public and private hospitals 
    Danielsen, elisabeth; Mjåset, Christer; Ingebrigtsen, Tor; Gulati, Sasha; Grotle, Margreth; Rudolfsen, Jan Håkon; Nygaard, Øystein Petter; Solberg, Tore (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract During the last decades, there has been an increase in the rate of surgery for degenerative disorders of the cervical spine and in the use of supplementary private health insurance. Still, there is limited knowledge ...
  • A novel desmoplakin mutation causes dilated cardiomyopathy with palmoplantar keratoderma as an early clinical sign 
    Karvonen, V.; Harjama, L.; Heliö, K.; Kettunen, K.; Elomaa, O.; Koskenvuo, J.W.; Kere, J.; Weckström, S.; Holmström, M.; Saarela, Janna Saija; Ranki, A.; Heliö, T.; Hannula-Jouppi, K. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background PPKs represent a heterogeneous group of disorders with hyperkeratosis of palmar and/or plantar skin. PPK, hair shaft abnormalities, cardiomyopathy and arrhythmias can be caused by mutations in desmosomal ...
  • A novel SERPINA12 variant and first European patients with diffuse palmoplantar keratoderma 
    Brandt, E.; Harjama, L.; Elomaa, O.; Saarela, Janna Saija; Donner, K.; Lappalainen, K.; Kivirikko, S.; Ranki, A.; Kere, J.; Kettunen, K.; Hannula-Jouppi, K. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
    Abstract Background Hereditary palmoplantar keratodermas (hPPKs) comprise a heterogeneous group of skin disorders characterized by persistent palmoplantar hyperkeratosis. Loss‐of‐function variants in a serine peptidase ...
  • A pilot study of implementation of endoscopic sleeve gastroplasty (ESG) in Norway 
    Tønnesen, Christer Julseth; Hjelmesæth, Jøran Sture; Aabakken, Lars; Lund, Randi Størdal; Johnson, Line Kristin; Hertel, Jens Kristoffer; Kalager, Mette; Løberg, Magnus; Bretthauer, Michael (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background and aim Bariatric surgery is the most effective treatment for obesity but is invasive and associated with serious complications. Endoscopic sleeve gastroplasty (ESG) is a less invasive weight loss procedure ...
  • A single step three-strain in vivo Gateway reaction 
    Gillman, Aaron Nicholas; Helleux, Alexandra; Abel, Sören (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    We developed a simplified, highly efficient Gateway reaction that recombines target DNA to expression (destination) plasmids in vivo and subsequently conjugates the final vector into a recipient strain, all in a single ...
  • A survey of protein interaction data and multigenic inherited disorders 
    Mora, Antonio; Michalickova, Katerina; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein ...
  • A systematic review of measurement uncertainty visualizations in the context of standardized assessments 
    Heltne, Aleksander; Frans, Niek; Hummelen, Benjamin; Falkum, Erik; Selvik, Sara Germans; Paap, Muirne C. S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    This systematic review summarized findings of 29 studies evaluating visual presentation formats appropriate for communicating measurement uncertainty associated with standardized clinical assessment instruments. Studies ...
  • A transdiagnostic approach to negative symptoms: Exploring factor structure and negative symptoms in bipolar disorders. 
    Ihler, Henrik Myhre; Lyngstad, Siv Hege; Mørch-Johnsen, Lynn Egeland; Lagerberg, Trine Vik; Melle, Ingrid; Romm, Kristin Lie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Negative symptoms are increasingly recognized as transdiagnostic phenomena, linked to reduced quality of life and functioning, and often caused or worsened by amendable external factors such as depression, social ...
  • A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways 
    Fensgård, Øyvind; Kassahun, Henok; Izabela Agnieszka, Bombik; Rognes, Torbjørn; Lindvall, Jessica Margareta; Nilsen, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response ...
  • A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis 
    Skotheim, Rolf I; Thomassen, Gard O; Eken, Marthe; Lind, Guro E; Micci, Francesca; Ribeiro, Franclim R; Cerveira, Nuno; Teixeira, Manuel R; Heim, Sverre; Rognes, Torbjørn; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Background The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal ...
  • Accuracy of self‐monitoring: does experience, ability or case difficulty matter? 
    Hautz, Wolf E.; Schubert, Sebastian; Schauber, Stefan Kilian; Kunina-Habenicht, Olga; Hautz, Stefanie C.; Kämmer, Juliane E.; Eva, Kevin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Context The ability to self‐monitor one's performance in clinical settings is a critical determinant of safe and effective practice. Various studies have shown this form of self‐regulation to be more trustworthy than ...
  • Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine 
    Umu, Sinan Ugur; Paynter, Vanessa Molin; Trondsen, Håvard; Buschmann, Tilo; Rounge, Trine Ballestad; Peterson, Kevin J.; Fromm, Bastian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    The annotation of microRNAs depends on the availability of transcriptomics data and expert knowledge. This has led to a gap between the availability of novel genomes and high-quality microRNA complements. Using >16,000 ...
  • Achieving objective response in treatment of non-resectable neuroendocrine tumors does not predict longer time to progression compared to achieving stable disease 
    Thiis-Evensen, Espen; Poole, Amalie C; Nguyen, Hong-Thien T; Sponheim, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis ...
  • Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 
    Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, ...