Browsing Det medisinske fakultet by Title

Now showing items 566-585 of 599

  • Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface 
    Yang, Menglu; Lennikov, Anton; Chang, Karen; Ashok, Ajay; Lee, Cherin; Cho, Kin-Sang; Utheim, Tor P.; Dartt, Darlene A.; Chen, Dong F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Purpose Transcorneal electrical stimulation (TcES) is increasingly applied as a therapy for preserving and improving vision in retinal neurodegenerative and ischemic disorders. However, a common complaint ...
  • Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival 
    Sveen, Anita; Ågesen, Trude H; Nesbakken, Arild; Rognum, Torleiv O; Lothe, Ragnhild A; Skotheim, Rolf I (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Colorectal cancer (CRC) is a heterogeneous disease that, on the molecular level, can be characterized by inherent genomic instabilities; chromosome instability and microsatellite instability. In ...
  • Transposable elements as tissue-specific enhancers in cancers of endodermal lineage 
    Karttunen, Konsta; Patel, Divyesh; Xia, Jihan; Fei, Liangru; Palin, Kimmo; Aaltonen, Lauri; Sahu, Biswajyoti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Transposable elements (TE) are repetitive genomic elements that harbor binding sites for human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal development and diseases such ...
  • Treating equivalent cases differently: A comparative analysis of substance use disorder and type 2 diabetes in Norwegian treatment guidelines 
    Moe, Fredrik Dreyer; Berg, Henrik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Substance use disorder (SUD) is often understood as a chronic illness. Aims: This paper investigates whether SUD is treated as a chronic illness. Method To this aim, we have used World Health Organizations ...
  • Treatment response to tumor necrosis factor inhibitors and methotrexate monotherapy in adults with juvenile idiopathic arthritis: Data from NORDMARD 
    Bardan, Imane; Fagerli, Karen Minde; Sexton, Joseph; Kvien, Tore Kristian Aaserud; Bakland, Gunnstein; Pawel, Mielnik; Lien, Gunhild; Flatø, Berit; Molberg, Øyvind; Kristianslund, Eirik; Aga, Anna-Birgitte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Objective To compare the effectiveness of tumor necrosis factor inhibitors (TNFi) ± comedication and methotrexate (MTX) monotherapy between patients with adult juvenile idiopathic arthritis (JIA) and patients with rheumatoid ...
  • Trends in transfusion of trauma victims - evaluation of changes in clinical practice 
    Nakstad, Anders R; Skaga, Nils O; Pillgram-Larsen, Johan; Gran, Berit; Heier, Hans E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background The present study was performed to compare blood product consumption and clinical results in consecutive, unselected trauma patients during the first 6 months of year 2002, 2004 and 2007. ...
  • Trigeminal neuralgia and genetics: A systematic review 
    Mannerak, Mari Aaroe; Lashkarivand, Aslan; Eide, Per Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear genetic background. To examine the existing knowledge about genetics in TN, we performed a systematic study asking about the prevalence ...
  • TRIM21: A cytosolic Fc receptor with broad antibody isotype specificity 
    Foss, Stian; Watkinson, Ruth; Sandlie, Inger; James, Leo C.; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Antibodies are key molecules in the fight against infections. Although previously thought to mediate protection solely in the extracellular environment, recent research has revealed that antibody-mediated protection extends ...
  • Two truncating variants in FANCC and breast cancer risk 
    Dörk, Thilo; Peterlongo, Paolo; Mannermaa, Arto; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Ahearn, Thomas; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristian J.; Augustinsson, Annelie; Freeman, Laura E. Beane; Beckmann, Matthias W.; Beeghly-Fadiel, Alicia; Behrens, Sabine; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Canzian, Federico; Chan, Tsun L.; Chang-Claude, Jenny; Chanock, Stephen J.; Choi, Ji-Yeob; Christiansen, Hans; Clarke, Christine L.; Couch, Fergus J.; Czene, Kamila; Daly, Mary B.; dos-Santos-Silva, Isabel; Dwek, Miriam; Eccles, Diana M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; Fritschi, Lin; Gabrielson, Marike; Gago-Dominguez, Manuela; Gao, Chi; Gapstur, Susan M.; García-Closas, Montserrat; García-Sáenz, José A.; Gaudet, Mia M.; Giles, Graham G.; Goldberg, Mark S.; Goldgar, David E.; Guenel, Pascal; Haeberle, Lothar; Haiman, Christopher A.; Håkansson, Niclas; Hall, Per; Hamann, Ute; Hartman, Mikael; Hauke, Jan; Hein, Alexander; Hillemanns, Peter; Hogervorst, Frans B.L.; Hooning, Maartje J.; Hopper, John L.; Howell, Tony; Huo, Dezheng; Ito, Hidemi; Iwasaki, Motoki; Jakubowska, Anna; Janni, Wolfgang; John, Esther M.; Jung, Audrey; Kaaks, Rudolf; Kang, Daehee; Kapoor, Pooja Middha; Khusnutdinova, Elza; Kim, Sung-Won; Kitahara, Cari M.; Koutros, Stella; Kraft, Peter; Kristensen, Vessela N.; Kwong, Ava; Lambrechts, Diether; Le Marchand, Loïc; Li, Jingmei; Lindström, Sara; Linet, Martha; Lo, Wing-Yee; Long, Jirong; Lophatananon, Artitaya; Lubiński, Jan; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Elena; Matsuo, Keitaro; Mavroudis, Dimitris; Meindl, Alfons; Menon, Usha; Milne, Roger L.; Mohd Taib, Nur Aishah; Muir, Kenneth; Mulligan, Anna Marie; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Newman, William G.; Offit, Kenneth; Olopade, Olufunmilayo I.; Olshan, Andrew F.; Olson, Janet E.; Olsson, Håkan; Park, Sue K.; Park-Simon, Tjoung-Won; Peto, Julian; Plaseska-Karanfilska, Dijana; Pohl-Rescigno, Esther; Presneau, Nadege; Rack, Brigitte; Radice, Paolo; Rashid, Muhammad Usman; Rennert, Gad; Rennert, Hedy S.; Romero, Atocha; Ruebner, Matthias; Saloustros, Emmanouil; Schmidt, Marjanka K.; Schmutzler, Rita K.; Schneider, Michael O.; Schoemaker, Minouk J.; Scott, Christopher; Shen, Chen-Yang; Shu, Xiao-Ou; Simard, Jacques; Slager, Susan; Smichkoska, Snezhana; Southey, Melissa C.; Spinelli, John J.; Stone, Jennifer; Surowy, Harald; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Teo, Soo H.; Terry, Mary Beth; Toland, Amanda E.; Tollenaar, Robert A.E.M.; Torres, Diana; Torres-Mejía, Gabriela; Troester, Melissa A.; Truong, Thérèse; Tsugane, Shoichiro; Untch, Michael; Vachon, Celine M.; van den Ouweland, Ans M.W.; van Veen, Elke M.; Vijai, Joseph; Wendt, Camilla; Wolk, Alicja; Yu, Jyh-Cherng; Zheng, Wei; Ziogas, Argyrios; Ziv, Elad; Dunning, Alison M.; Pharoah, Paul D.P.; Schindler, Detlev; Devilee, Peter; Easton, Douglas F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk ...
  • Ubenyttet behandlingstilbud ved rusakuttmottak – en kvalitativ studie 
    Rognli, Eline B.; Dalsrud, Martine Kihle; Wüsthoff, Linda Elise; Arnevik, Espen Kristian Ajo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    BAKGRUNN Nasjonalt pasientforløp (tidligere kalt pakkeforløp) for oppfølging etter rusmiddeloverdose er en viktig del av nasjonal overdosestrategi og trådte i kraft 1. januar 2022. Fire år forut for dette ble det innledet ...
  • Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast 
    Chica-Balaguera, Nathalia; Portantier, Marina; Nyquist-Andersen, Mari; Espada Burriel, Silvia; Lopez Aviles, Sandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Depletion of the Anaphase-Promoting Complex/Cyclosome (APC/C) activator Cdc20 arrests cells in metaphase with high levels of the mitotic cyclin (Cyclin B) and the Separase inhibitor Securin. In mammalian cells this arrest ...
  • Understanding transmission pathways and integrated digital surveillance potential of antimicrobial resistance in Ethiopia in a One Health approach: a mixed-method study protocol 
    Asaduzzaman, Muhammad; Rødland, Ernst Kristian; Mekonnen, Zeleke; Gradmann, Christoph; Winkler, Andrea Sylvia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Introduction Antimicrobial resistance (AMR) has a critical global impact, mostly affecting low- and middle-income countries. A major knowledge gap exists in understanding the transmission pathway of the gut colonisation ...
  • UniBind: maps of high-confidence direct TF-DNA interactions across nine species 
    Puig, Rafael R.; Boddie, Paul; Khan, Aziz; Castro-Mondragon, Jaime A.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Transcription factors (TFs) bind specifically to TF binding sites (TFBSs) at cis-regulatory regions to control transcription. It is critical to locate these TF-DNA interactions to understand ...
  • Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals 
    Lizio, Marina; Harshbarger, Jayson; Abugessaisa, Imad; Noguchi, Shuei; Kondo, Atsushi; Severin, Jessica; Mungall, Chris; Arenillas, David; Mathelier, Anthony; Medvedeva, Yulia; Lennartsson, Andreas; Drabløs, Finn Sverre; Ramilowski, Jordan; Rackham, Owen; Gough, Julian; Andersson, Robin; Sandelin, Albin; Ienasescu, Hans; Ono, Hiromasa; Bono, Hidemasa; Hayashizaki, Yoshihide; Carninci, Piero; Forrest, Alistair R.R.; Kasukawa, Takeya; Kawaji, Hideya (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ...
  • Updates on old and weary haematopoiesis 
    Konieczny, Joanna; Arranz, Lorena (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow ...
  • Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003 
    Kline, Cassie; Jain, Payal; Kilburn, Lindsay; Bonner, Erin R.; Gupta, Nalin; Crawford, John R.; Banerjee, Anu; Packer, Roger J.; Villanueva-Meyer, Javier; Luks, Tracy; Zhang, Yalan; Kambhampati, Madhuri; Zhang, Jie; Yadavilli, Sridevi; Zhang, Bo; Gaonkar, Krutika S.; Rokita, Jo Lynne; Kraya, Adam; Kuhn, John; Liang, Winnie; Byron, Sara; Berens, Michael; Molinaro, Annette; Prados, Michael; Resnick, Adam; Waszak, Sebastian Martin; Nazarian, Javad; Mueller, Sabine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Purpose: PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG). ...
  • Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism 
    Iversen, Tore G; Frerker, Nadine; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background There is a huge effort in developing ligand-mediated targeting of nanoparticles to diseased cells and tissue. The plant toxin ricin has been shown to enter cells by utilizing both dynamin-dependent ...
  • Use of Drugs With Risk of Heart Rate-Related Problems is Common in Norwegian Dementia Patients Treated With Acetylcholinesterase Inhibitors: A Prevalence Study Based on the Norwegian Prescription Database 
    Efjestad, Anne Sverdrup; Ihle-Hansen, Hege; Hjellvik, Vidar; Engedal, Knut; Blix, Hege Salvesen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background: Drugs commonly prescribed for heart rate control may induce adverse drug reactions in Alzheimer patients treated with acetylcholinesterase inhibitors (AChEIs). We have studied use of drugs with a known risk of ...
  • Use of epinephrine in anaphylaxis: a retrospective cohort study at a Swiss university emergency department 
    Ehrhard, Simone; Gautschi, Dominic; Eyb, Vicky; Schauber, Stefan; Ricklin, Meret E.; Klukowska-Rötzler, Jolanta; Exadaktylos, Aristomenis K.; Helbling, Arthur (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    AIMS OF THE STUDY: Anaphylaxis is a medical emergency and requires prompt treatment to prevent life-threatening conditions. Epinephrine, considered as the first-line drug, is often not administered. We aimed first to analyse ...
  • Using process indicators to monitor documentation of patient-centred variables in an integrated oncology and palliative care pathway—results from a cluster randomized trial 
    Hjermstad, Marianne Jensen; Hamfjord, Julian; Aass, Nina Kathrine; Dajani, Olav; Lundeby, Tonje; Wester, Torunn Elin; Kaasa, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background. Despite robust evidence from randomized controlled trials (RCTs) demonstrating clinical and patient-reported benefits of integrated oncology and palliative care, the tumour-centred focus is predominant. This ...