Browsing Det medisinske fakultet by Title
Now showing items 566-585 of 599
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Purpose Transcorneal electrical stimulation (TcES) is increasingly applied as a therapy for preserving and improving vision in retinal neurodegenerative and ischemic disorders. However, a common complaint ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Colorectal cancer (CRC) is a heterogeneous disease that, on the molecular level, can be characterized by inherent genomic instabilities; chromosome instability and microsatellite instability. In ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Abstract Transposable elements (TE) are repetitive genomic elements that harbor binding sites for human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal development and diseases such ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background Substance use disorder (SUD) is often understood as a chronic illness. Aims: This paper investigates whether SUD is treated as a chronic illness. Method To this aim, we have used World Health Organizations ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Objective To compare the effectiveness of tumor necrosis factor inhibitors (TNFi) ± comedication and methotrexate (MTX) monotherapy between patients with adult juvenile idiopathic arthritis (JIA) and patients with rheumatoid ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The present study was performed to compare blood product consumption and clinical results in consecutive, unselected trauma patients during the first 6 months of year 2002, 2004 and 2007. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear genetic background. To examine the existing knowledge about genetics in TN, we performed a systematic study asking about the prevalence ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Antibodies are key molecules in the fight against infections. Although previously thought to mediate protection solely in the extracellular environment, recent research has revealed that antibody-mediated protection extends ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)BAKGRUNN Nasjonalt pasientforløp (tidligere kalt pakkeforløp) for oppfølging etter rusmiddeloverdose er en viktig del av nasjonal overdosestrategi og trådte i kraft 1. januar 2022. Fire år forut for dette ble det innledet ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Depletion of the Anaphase-Promoting Complex/Cyclosome (APC/C) activator Cdc20 arrests cells in metaphase with high levels of the mitotic cyclin (Cyclin B) and the Separase inhibitor Securin. In mammalian cells this arrest ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Introduction Antimicrobial resistance (AMR) has a critical global impact, mostly affecting low- and middle-income countries. A major knowledge gap exists in understanding the transmission pathway of the gut colonisation ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Background Transcription factors (TFs) bind specifically to TF binding sites (TFBSs) at cis-regulatory regions to control transcription. It is critical to locate these TF-DNA interactions to understand ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Abstract Purpose: PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG). ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Background There is a huge effort in developing ligand-mediated targeting of nanoparticles to diseased cells and tissue. The plant toxin ricin has been shown to enter cells by utilizing both dynamin-dependent ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background: Drugs commonly prescribed for heart rate control may induce adverse drug reactions in Alzheimer patients treated with acetylcholinesterase inhibitors (AChEIs). We have studied use of drugs with a known risk of ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)AIMS OF THE STUDY: Anaphylaxis is a medical emergency and requires prompt treatment to prevent life-threatening conditions. Epinephrine, considered as the first-line drug, is often not administered. We aimed first to analyse ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Background. Despite robust evidence from randomized controlled trials (RCTs) demonstrating clinical and patient-reported benefits of integrated oncology and palliative care, the tumour-centred focus is predominant. This ...