Browsing Institutt for molekylær biovitenskap by Title
Now showing items 60-79 of 121
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The iRefIndex addresses the need to consolidate protein interaction data into a single uniform data resource. iRefR provides the user with access to this data source from an R environment. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The iRefIndex consolidates protein interaction data from ten databases in a rigorous manner using sequence-based hash keys. Working with consolidated interaction data comes with distinct challenges: ...
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(Master thesis / Hovedoppgave, 2005)Genet som koder for chaperoninet GroESL1 i C. aurantiacus ble isolert fra et genomisk bibliotek av bakterien. Genet som koder for GroESL2 var tidligere isolert fra det samme biblioteket (Vanberg, Hovedfagsoppgave UiO, 2001) ...
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(Master thesis / Hovedoppgave, 2005)Chaperoninene GroEL og GroES er en gruppe molekylære chaperoner som hittil er funnet i alle bakterier. Genene som koder for chaperoniner er vanligvis organisert i operoner på genomet. Den moderat termofile grønne glidende ...
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(Master thesis / Hovedoppgave, 2005)Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter av kromosom 16q i ulike krefttyper. Dette genet er lokalisert innenfor kromosom ...
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(Master thesis / Hovedoppgave, 2004)In order to assess the biological role of the flap endonuclease 1 (Fen1), RNA interference (RNAi) was chosen as a method for FEN1 down-regulation in this study. Knock down of FEN1 was achieved both in stable transfected ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers between two genomes can be analysed by competitive hybridisation to DNA ...
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(Master thesis / Hovedoppgave, 2004)Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant inherited disorders, and carriers are at greatly increased risk of developing malignant peripheral nerve sheath tumours (MPNST). The NF1 patients ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
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MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
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(Doctoral thesis / Doktoravhandling, 2008)Ricin and Shiga toxin are protein toxins able to enter target cells by endocytosis. They can be transported via early endosomes to the Golgi apparatus and the endoplasmic reticulum. From this compartment, they are translocated ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Background Pockmarks (depressions in the seabed) have been discovered throughout the world’s oceans and are often related to hydrocarbon seepage. Although high concentrations of pockmarks are present in ...
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(Doctoral thesis / Doktoravhandling, 2011)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Due to the increased use of genetic modifications in crop improvement, there is a need to develop effective methods for the detection of both known and unknown transgene constructs in plants. We ...
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(Doctoral thesis / Doktoravhandling, 2007)The goal of the present work was to develop a microchip for amplification and detection of mRNA by employing nucleic acid sequence-based amplification (NASBA) technology. The technology platform should in principle be ...
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(Doctoral thesis / Doktoravhandling, 2010)Adipogenesis is the developmental process that upon appropriate stimuli differentiates progenitor cells into specialized fat storing adipocytes. We studied this process and the potential involvement of two different protein ...
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(Doctoral thesis / Doktoravhandling, 2007)Androgens are important for the normal development of the male sexual characteristics, but are also involved in pathological conditions such as prostate cancer. The biological effects of androgens are mediated by the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last ...