Now showing items 28-47 of 119

  • Nygaard, Vigdis; Løland, Anders; Holden, Marit; Langaas, Mette; Rue, Håvard; Liu, Fang; Myklebost, Ola; Fodstad, Øystein; Hovig, Eivind; Smith-Sørensen, Birgitte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)
    Background A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically ...
  • Mora, Antonio; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background Previous studies have noted that drug targets appear to be associated with higher-degree or higher-centrality proteins in interaction networks. These studies explicitly or tacitly make choices ...
  • Tvegård, Tonje (Doctoral thesis / Doktoravhandling, 2008)
    Cancer cells are growing without control and it is therefore important to understand the mechanisms limiting the growth of normal cells. Before a cell can divide it must make a new set of chromosomes, so that both ...
  • Hagen, Bjarne (Master thesis / Hovedoppgave, 2005)
    De to formene av den polymorfe ciliaten Tetrahymena vorax er svært ulike med hensyn på morfologi, atferd og næringspreferanser. Den mikrostome formen lever av blant annet bakterier og råtnende biologisk materiale som taes ...
  • Utskarpen, Audrun (Doctoral thesis / Doktoravhandling, 2009)
    The plant toxin ricin and the bacterial toxin Shiga toxin are not only a threat to human health but may also be used in cancer treatment and to gain new insight into the mechanisms of intracellular transport. Ricin and ...
  • Grevys, Algirdas (Master thesis / Masteroppgave, 2012)
    Summary Antibodies act as adapter molecules that link recognition of foreign substances, such as bacteria and viruses, to elimination mechanisms mediated by cells and molecules of the innate immune system. Cells that express ...
  • Olsen, Vibeke Murberg (Master thesis / Hovedoppgave, 2005)
    Despite continuous improvement in gene delivery vector technology, development of methods for efficient and specific delivery of therapeutic genes to target cells still remains an important issue in the development of ...
  • Kresse, Stine H; Szuhai, Karoly; Barragan-Polania, Ana H; Rydbeck, Halfdan; Cleton-Jansen, Anne-Marie; Myklebost, Ola; Meza-Zepeda, Leonardo A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Several high-density oligonucleotide microarray platforms are available for genome-wide single nucleotide polymorphism (SNP) detection and microarray-based comparative genomic hybridisation (array ...
  • Tooming-Klunderud, Ave; Fewer, David P; Rohrlack, Thomas; Jokela, Jouni; Rouhiainen, Leo; Sivonen, Kaarina; Kristensen, Tom; Jakobsen, Kjetill S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Background Cyanobacteria produce a wealth of secondary metabolites, including the group of small cyclic heptapeptide hepatotoxins that constitutes the microcystin family. The enzyme complex that directs the ...
  • Løset, Geir Åge; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background: Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein ...
  • Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background: Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor ...
  • Ellefsen, Stian (Doctoral thesis / Doktoravhandling, 2008)
    Crucian carp, Carassius carassius, survives days to months without oxygen (anoxia). Still, during anoxia, it needs to keep the energy expenditure low, particularly in the brain, which has a high rate of ATP use mainly ...
  • Kleivi, Kristine; Lind, Guro E; Diep, Chieu B; Meling, Gunn I; Brandal, Lin T; Nesland, Jahn M; Myklebost, Ola; Rognum, Torleiv O; Giercksky, Karl-Erik; Skotheim, Rolf I; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...
  • Ahlquist, Terje; Lind, Guro E; Costa, Vera L; Meling, Gunn I; Vatn, Morten; Hoff, Geir S; Rognum, Torleiv O; Skotheim, Rolf I; Thiis-Evensen, Espen; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Background Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers that can discriminate between ...
  • Lyng, Heidi; Lando, Malin; Brøvig, Runar S; Svendsrud, Debbie H; Johansen, Morten; Galteland, Eivind; Brustugun, Odd T; Meza-Zepeda, Leonardo A; Myklebost, Ola; Kristensen, Gunnar B; Hovig, Eivind; Stokke, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers ...
  • Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex ...
  • Skjølberg, Henriette C; Fensgård, Øyvind; Nilsen, Hilde; Grallert, Beáta; Boye, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Background In many cell types, including the fission yeast Schizosaccharomyces pombe, a set of checkpoints are induced by perturbations of the cell cycle or by DNA damage. Many of the checkpoint responses ...
  • Robertsen, Ine (Master thesis / Masteroppgave, 2005)
    Bacillus cereus ATCC 14579 was grown under different conditions, in different growth media, and the following parameters were investigated; cell number, pH,oxygen levels, glucose levels, cell morphology, proportions of ...
  • Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ...
  • Steffensen, Knut R; Bouzga, Mariam; Skjeldal, Frode; Kasi, Cecilie; Karahasan, Almira; Matre, Vilborg; Bakke, Oddmund; Guérin, Sylvain; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, ...