Browsing Institutt for molekylær biovitenskap by Title
Now showing items 64-83 of 121
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(Master thesis / Hovedoppgave, 2005)Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter av kromosom 16q i ulike krefttyper. Dette genet er lokalisert innenfor kromosom ...
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(Master thesis / Hovedoppgave, 2004)In order to assess the biological role of the flap endonuclease 1 (Fen1), RNA interference (RNAi) was chosen as a method for FEN1 down-regulation in this study. Knock down of FEN1 was achieved both in stable transfected ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers between two genomes can be analysed by competitive hybridisation to DNA ...
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(Master thesis / Hovedoppgave, 2004)Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant inherited disorders, and carriers are at greatly increased risk of developing malignant peripheral nerve sheath tumours (MPNST). The NF1 patients ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
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MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
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(Doctoral thesis / Doktoravhandling, 2008)Ricin and Shiga toxin are protein toxins able to enter target cells by endocytosis. They can be transported via early endosomes to the Golgi apparatus and the endoplasmic reticulum. From this compartment, they are translocated ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Background Pockmarks (depressions in the seabed) have been discovered throughout the world’s oceans and are often related to hydrocarbon seepage. Although high concentrations of pockmarks are present in ...
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(Doctoral thesis / Doktoravhandling, 2011)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Due to the increased use of genetic modifications in crop improvement, there is a need to develop effective methods for the detection of both known and unknown transgene constructs in plants. We ...
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(Doctoral thesis / Doktoravhandling, 2007)The goal of the present work was to develop a microchip for amplification and detection of mRNA by employing nucleic acid sequence-based amplification (NASBA) technology. The technology platform should in principle be ...
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(Doctoral thesis / Doktoravhandling, 2010)Adipogenesis is the developmental process that upon appropriate stimuli differentiates progenitor cells into specialized fat storing adipocytes. We studied this process and the potential involvement of two different protein ...
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(Doctoral thesis / Doktoravhandling, 2007)Androgens are important for the normal development of the male sexual characteristics, but are also involved in pathological conditions such as prostate cancer. The biological effects of androgens are mediated by the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last ...
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(Doctoral thesis / Doktoravhandling, 2008)Hvordan fiskene lukter sex og fare Fisker har en meget god luktesans og bruker den blant annet til å oppfatte farer, for eksempel når andre individer blir skadet eller spist av rovfisk. Noen av substansene fra fiskenes ...
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(Doctoral thesis / Doktoravhandling, 2007)Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins. Nonribosomal peptides are produced by peptide synthetases or polyketide ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Triage and interhospital transfer are central to trauma systems. Few studies have addressed transferred trauma patients. This study investigated transfers of variable distances to OUH (Oslo ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...