• English
    • Norsk
  • English 
    • English
    • Norsk
  • Administration
View Item 
  •   Home
  • Det matematisk-naturvitenskapelige fakultet
  • Institutt for molekylær biovitenskap ( -2012)
  • Institutt for molekylær biovitenskap
  • View Item
  •   Home
  • Det matematisk-naturvitenskapelige fakultet
  • Institutt for molekylær biovitenskap ( -2012)
  • Institutt for molekylær biovitenskap
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Mechanisms in Intracellular Transport of Toxins

Skånland, Sigrid
Doctoral thesis
View/Open
88811_Skaanland_DUO_Publ.pdf (3.247Mb)
Year
2008
Permanent link
http://urn.nb.no/URN:NBN:no-22029

Metadata
Show metadata
Appears in the following Collection
  • Institutt for molekylær biovitenskap [119]
Abstract
Ricin and Shiga toxin are protein toxins able to enter target cells by endocytosis. They can be transported via early endosomes to the Golgi apparatus and the endoplasmic reticulum. From this compartment, they are translocated to the cytosol where they inactivate ribosomes and thus kill the cell.

We have studied mechanisms involved in endosome to Golgi transport of ricin and Shiga toxin. We have found that Shiga toxin can induce signaling events which promote the toxin transport, and identified effectors of this pathway. When it comes to ricin, we have characterized several proteins important for its endosome to Golgi transport, and show how they act together to regulate endosome motility. These findings provide new knowledge on how molecules travel inside cells.
List of papers
I Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (2007): Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Traffic, 8, 297-309. (2007). The paper is removed from the thesis in DUO. The published version is available at: https://doi.org/10.1111/j.1600-0854.2006.00527.x
II Wälchli S, Skånland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K (2008): The Mitogen-activated Protein Kinase p38 Links Shiga Toxin-dependent Signaling and Trafficking. Mol Biol Cell, 19, 95-104. (2008). https://doi.org/10.1091/mbc.E07-06-0565
III Skånland SS, Wälchli S, Brech A, Sandvig K: SNX4 in complex with and dynein: implications for endosome movement. PLoS ONE, 4, e5935. (2009). The paper is removed from the thesis in DUO. The published version is available at: https://doi.org/10.1371/journal.pone.0005935
IV Skånland SS, Wälchli S, Sandvig K: beta-arrestins attenuate p38 mediated endosome to Golgi transport. Cell Microbiol, 11, 796-807. (2009). The paper is removed from the thesis in DUO. The published version is available at: https://doi.org/10.1111/j.1462-5822.2009.01292.x
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy
 

 

For students / employeesSubmit master thesisAccess to restricted material

Browse

All of DUOCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

For library staff

Login

Statistics

View Usage Statistics
RSS Feeds
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy