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The Role of Cid13 in the G1/S Checkpoint in Fission Yeast 
Taipale, Riikka (Master thesis / Masteroppgave, 2012)
This study was carried out at the Department of Cell Biology at the Institute of Cancer Research at the Oslo University Hospital as a part of my Master’s degree in molecular biosciences at the University of Oslo. Our group ...
Engineering to improve serum half-life modulates classical Fcgamma receptor binding Restricted Access
Grevys, Algirdas (Master thesis / Masteroppgave, 2012)
Summary Antibodies act as adapter molecules that link recognition of foreign substances, such as bacteria and viruses, to elimination mechanisms mediated by cells and molecules of the innate immune system. Cells that express ...
Regulation of the gap junction protein connexin 43 during mitosis Restricted Access
Dahal-Koirala, Shiva (Master thesis / Masteroppgave, 2012)
Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism 
Iversen, Tore G; Frerker, Nadine; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background There is a huge effort in developing ligand-mediated targeting of nanoparticles to diseased cells and tissue. The plant toxin ricin has been shown to enter cells by utilizing both dynamin-dependent ...
Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction 
Mora, Antonio; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Previous studies have noted that drug targets appear to be associated with higher-degree or higher-centrality proteins in interaction networks. These studies explicitly or tacitly make choices ...
Studies of Ribonucleotide Reductase in Crucian Carp-An Oxygen Dependent Enzyme in an Anoxia Tolerant Vertebrate 
Sandvik, Guro Katrine; Tomter, Ane Berg; Bergan, Jonas; Zoppellaro, Giorgio; Barra, Anne-Laure; Røhr, Åsmund Kjendseth; Kolberg, Matthias; Ellefsen, Stian; Andersson, K. Kristoffer; Nilsson, Göran Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The enzyme ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, the precursors for DNA. RNR requires a thiyl radical to activate the substrate. In RNR of eukaryotes (class Ia ...
Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life 
Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor 
Andersen, Jan Terje; Dalhus, Bjørn; Cameron, Jason; Daba, Muluneh Bekele; Plumridge, Andrew; Evans, Leslie; Brennan, Stephen O.; Gunnarsen, Kristin Støen; Bjørås, Magnar; Sleep, Darrell; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Albumin is the most abundant protein in blood where it has a pivotal role as a transporter of fatty acids and drugs. Like IgG, albumin has long serum half-life, protected from degradation by pH-dependent recycling mediated ...
Characterization of oxygen-dependent processes in the anoxia-tolerant crucian carp 
Sandvik, Guro Katrine (Doctoral thesis / Doktoravhandling, 2012)
Most vertebrates die within minutes when exposed to anoxia (no oxygen). However, a few exceptions exist, and a champion among these is the crucian carp, which at low temperatures can survive several months in an active ...
Selective targeting of cancer cells through inhibition of Checkpoint kinase 1 
Hasvold, Grete (Doctoral thesis / Doktoravhandling, 2012)
Investigation of Novel Structures and Functions of Readers and Writers of the Histone Code in Arabidopsis thaliana 
Rahman, Mohummad Aminur (Doctoral thesis / Doktoravhandling, 2012)
Åpent seminar: Fra imaging show til celler og proteinsrukturer 
Bakke, Oddmund; Andersson, K. Kristoffer (Journal article / Tidsskriftartikkel / PublishedVersion, 2012)
I anledning universitetets 200 års jubileum og Mat Nat Fakultetets 150 års jubileum i 2011 fikk vi i oppdrag å fylle en dag med cellebiologi/strukturbiologi og lage en kortfilm med moderne mikroskopi som tema. Den 12. ...
DeltaPhage-a novel helper phage for high-valence pIX phagemid display 
Nilssen, Nicolay Rustad; Frigstad, Terje; Pollmann, Sylvie; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades. We recently reported a novel pIX phagemid display system that is characterized by a strong preference ...
Metagenomic and geochemical characterization of pockmarked sediments overlaying the Troll petroleum reservoir in the North Sea 
Håvelsrud, Othilde E; Haverkamp, Thomas H; Kristensen, Tom; Jakobsen, Kjetill S; Rike, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Pockmarks (depressions in the seabed) have been discovered throughout the world’s oceans and are often related to hydrocarbon seepage. Although high concentrations of pockmarks are present in ...
Human ALKBH4 Interacts with Proteins Associated with Transcription 
Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ...
Transcriptome profiling of LH-producing gonadotropes in female medaka - with special emphasis on calcium-activated potassium channels 
Moen, Line Victoria (Master thesis / Masteroppgave, 2012)
The brain-pituitary-gonad axis regulates puberty and reproduction in all vertebrates. The two gonadotropins, FSH and LH are released from the pituitary and initiates maturing and growth of the gonads. To understand more ...
Investigating BEACH domain containing proteins for a role in autophagy 
Holland, Petter (Master thesis / Masteroppgave, 2012)
The BEACH domain is common for a protein family that has expanded through eukaryotic evolution and contains eight human proteins. These proteins are generally very large and at their C-terminal ends contain a conserved set ...
Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage 
Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor ...
Cell-Cycle Analysis of Fission Yeast Cells by Flow Cytometry 
Knutsen, Jon Halvor Jonsrud; Rein, Idun Dale; Rothe, Christiane; Stokke, Trond; Grallert, Beáta; Boye, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The cell cycle of the fission yeast, Schizosaccharomyces pombe, does not easily lend itself to analysis by flow cytometry, mainly because cells in G1 and G2 phase contain the same amount of DNA. This occurs because fission ...
Study of FcRn binding and FcRn mediated transport of IgGs, Fc fragments and fusions Restricted Access
Foss, Stian (Master thesis / Masteroppgave, 2011)
The genome sequence of Atlantic cod reveals a unique immune system 
Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex ...
Proposal of a new method to measure FRET quantitatively in living or fixed biomedical specimens on a laser microscope 
Helm, Paul Johannes; Ottersen, Ole Petter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Förster Resonance Energy Transfer , abbreviated FRET , is a fluorescence phenomenon, which can be used to study and map co-localizations and dynamics of co-localizations at nanometer precision on a light microscope. FRET ...
The Possible Role of STAMP1 in Breast Cancer Cell Proliferation 
Fosslie, Madeleine Lystad (Master thesis / Masteroppgave, 2011)
iRefScape. A Cytoscape plug-in for visualization and data mining of protein interaction data from iRefIndex 
Razick, Sabry; Mora, Antonio; Michalickova, Katerina; Boddie, Paul; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The iRefIndex consolidates protein interaction data from ten databases in a rigorous manner using sequence-based hash keys. Working with consolidated interaction data comes with distinct challenges: ...
Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage 
Løset, Geir Åge; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein ...
Polymeric human Fc-fusion proteins with modified effector functions 
Mekhaiel, David N. A.; Czajkowsky, Daniel M.; Andersen, Jan Terje; Shi, Jianguo; El-Faham, Marwa; Doenhoff, Michael; McIntosh, Richard S.; Sandlie, Inger; He, Jianfeng; Hu, Jun; Shao, Zhifeng; Pleass, Richard J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The success of Fc-fusion bio-therapeutics has spurred the development of other Fc-fusion products for treating and/or vaccinating against a range of diseases. We describe a method to modulate their function by converting ...
Synthesis and transport of glycoproteins and proteoglycans in the apical and basolateral secretory pathways of epithelial MDCK cells 
Hafte, Tilahun Tolesa (Doctoral thesis / Doktoravhandling, 2011)
Sorting of newly synthesized proteins in the secretory pathway of polarized cells is governed by signals of proteinacous nature or post-translationally added structures such as glycans. Among all polarized cell types, ...
MHC II and the endocytic pathway; Regulation by Invariant Chain 
Landsverk, Ole Jørgen Bjarnason (Doctoral thesis / Doktoravhandling, 2011)
A Practical Approach to T-Cell Receptor Cloning and Expression 
Wälchli, Sebastien; Løset, Geir Åge; Kumari, Shraddha; Johansen, Jorunn; Yang, Weiwen; Sandlie, Inger; Olweus, Johanna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Although cloning and expression of T-cell Receptors (TcRs) has been performed for almost two decades, these procedures are still challenging. For example, the use of T-cell clones that have undergone limited expansion as ...
Studies on c-type cytochromes exhibiting "large g-max"/HALS EPR behaviour 
Harbitz, Espen (Doctoral thesis / Doktoravhandling, 2011)
Små vannløselige c cytokrommer finnes i elektrontransportkjeder i alle livets domener, og har essensielle roller i metabolismen. De inneholder jernatomer bundet i den plane kofaktoren hem. Disse jernatomene er koordinert ...
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential 
Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC; Gerritsen, J.; Zhao, Y; Kleijer, M; Sandlie, Inger; de Haas, Masja; Jonsdottir, I; van der Schoot, CE; Vidarsson, G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and ...
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines 
Ohnstad, Hege O; Paulsen, Erik B; Noordhuis, Paul; Berg, Marianne; Lothe, Ragnhild A; Vassilev, Lyubomir T; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
Identification of surface proteins in Enterococcus faecalis V583 
Bøhle, Liv A; Riaz, Tahira; Egge-Jacobsen, Wolfgang; Skaugen, Morten; Busk, Øyvind L; Eijsink, Vincent G; Mathiesen, Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Surface proteins are a key to a deeper understanding of the behaviour of Gram-positive bacteria interacting with the human gastro-intestinal tract. Such proteins contribute to cell wall synthesis ...
A metagenomic study of methanotrophic microorganisms in Coal Oil Point seep sediments 
Håvelsrud, Elise O; Haverkamp, Thomas H; Kristensen, Tom; Jakobsen, Kjetill S; Rike, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Methane oxidizing prokaryotes in marine sediments are believed to function as a methane filter reducing the oceanic contribution to the global methane emission. In the anoxic parts of the sediments, ...
Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential 
Stratford, Eva W; Castro, Russell; Wennerstrøm, Anna; Holm, Ruth; Munthe, Else; Lauvrak, Silje; Bjerkehagen, Bodil; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
PIAS1 interacts with FLASH and enhances its co-activation of c-Myb 
Alm-Kristiansen, Anne H; Lorenzo, Petra I; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit; Sæther, Thomas; Gabrielsen, Odd S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background FLASH is a huge nuclear protein involved in various cellular functions such as apoptosis signalling, NF-κB activation, S-phase regulation, processing of histone pre-mRNAs, and co-regulation of ...
Patients Referred to a Norwegian Trauma Centre: effect of transfer distance on injury patterns, use of resources and outcomes 
Kristiansen, Thomas; Lossius, Hans M; Søreide, Kjetil; Steen, Petter A; Gaarder, Christine; Næss, Pål A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Triage and interhospital transfer are central to trauma systems. Few studies have addressed transferred trauma patients. This study investigated transfers of variable distances to OUH (Oslo ...
iRefR: an R package to manipulate the iRefIndex consolidated protein interaction database 
Mora, Antonio; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The iRefIndex addresses the need to consolidate protein interaction data into a single uniform data resource. iRefR provides the user with access to this data source from an R environment. ...
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts 
Kuijjer, Marieke L; Namløs, Heidi M; Hauben, Esther I; Machado, Isidro; Kresse, Stine H; Serra, Massimo; Llombart-Bosch, Antonio; Hogendoorn, Pancras C; Meza-Zepeda, Leonardo A; Myklebost, Ola; Cleton-Jansen, Anne-Marie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last ...
Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins 
Lunde, Elin; Løset, Geir Å; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection ...
Regulation of the gap junction protein connexin43 by members of the Nedd4 E3 ubiquitin ligase family Restricted Access
Fykerud, Tone Aase (Master thesis / Masteroppgave, 2010)
Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding 
Andersen, Jan Terje; Daba, Muluneh Bekele; Berntzen, Gøril; Michaelsen, Terje Einar; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, ...
Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours 
Kresse, Stine H; Szuhai, Karoly; Barragan-Polania, Ana H; Rydbeck, Halfdan; Cleton-Jansen, Anne-Marie; Myklebost, Ola; Meza-Zepeda, Leonardo A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Several high-density oligonucleotide microarray platforms are available for genome-wide single nucleotide polymorphism (SNP) detection and microarray-based comparative genomic hybridisation (array ...
Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells 
Henriksen, Jørn; Stabell, Marianne; Meza-Zepeda, Leonardo A; Lauvrak, Silje A; Kassem, Moustapha; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background The HMGA2 gene, coding for an architectural transcription factor involved in mesenchymal embryogenesis, is frequently deranged by translocation and/or amplification in mesenchymal tumours, generally ...
Single-cell qPCR on dispersed primary pituitary cells -an optimized protocol 
Hodne, Kjetil; Haug, Trude M; Weltzien, Finn-Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background The incidence of false positives is a potential problem in single-cell PCR experiments. This paper describes an optimized protocol for single-cell qPCR measurements in primary pituitary cell ...
Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective 
Dittami, Simon M; Michel, Gurvan; Collén, Jonas; Boyen, Catherine; Tonon, Thierry (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Chlorophyll-binding proteins (CBPs) constitute a large family of proteins with diverse functions in both light-harvesting and photoprotection. The evolution of CBPs has been debated, especially ...
Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA 
Gunnarsen, Kristin S; Lunde, Elin; Kristiansen, Per E; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Å (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...
Molecular Mechanisms of Adipogenesis and Adipocyte Biology : Possible role of MKPs and STAMPs 
Lindstad, Torstein (Doctoral thesis / Doktoravhandling, 2010)
Adipogenesis is the developmental process that upon appropriate stimuli differentiates progenitor cells into specialized fat storing adipocytes. We studied this process and the potential involvement of two different protein ...
Polymorphic residues of HLA-DQ2.2 and HLA-DQ2.5 that affect CLIP presentation and stability 
Berg-Larsen, Axel (Master thesis / Masteroppgave, 2009)
Celiac disease is an autoimmune disease driven by an immune response to gluten peptides. The disease is strongly associated with the MHC class II molecule HLA-DQ2.5. The similar molecule HLA-DQ2.2 is not associated with ...
The role of HMGA2 in mesenchymal biology 
Abrha, Biruk Luelseged (Master thesis / Masteroppgave, 2009)
The human HMGA2 gene is located at chromosomal band 12q14-15. In normal cells it encodes for the HMGA2 protein (109 amino acids). HMGA2 is a transcription factor that binds to the AT rich sequences on DNA and thereby ...
Development of microbiological molecular diagnostic techniques for the rapid screening and identification of selected human bacterial pathogens and indicators 
Anglès d Auriac, Marc B. (Doctoral thesis / Doktoravhandling, 2009)
This work, we believe, is a significant contribution to the development of molecular methods for the rapid detection of microorganism interacting with humans. Prevention, through the implementation of effective water ...
Endocytosis and retrograde transport of Shiga toxin and ricin 
Utskarpen, Audrun (Doctoral thesis / Doktoravhandling, 2009)
The plant toxin ricin and the bacterial toxin Shiga toxin are not only a threat to human health but may also be used in cancer treatment and to gain new insight into the mechanisms of intracellular transport. Ricin and ...
Identification of a High Affinity Fc gamma RIIA-binding Peptide That Distinguishes Fc gamma RIIA from Fc gamma RIIB and Exploits Fc gamma RIIA-mediated Phagocytosis and Degradation 
Berntzen, Gøril; Andersen, Jan Terje; Ustgård, Kristine; Ustgård, Kristine; Michaelsen, Terje Einar; Mousavi, Darbi Seyed Ali; Mousavi, Seyed Ali; Qian, Julie Dee; Qian, Julie Dee; Kristiansen, Per Eugen; Kristiansen, Per Eugen; Lauvrak, Vigdis; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
Global transcriptional response after exposure of fission yeast cells to ultraviolet light 
Skjølberg, Henriette C; Fensgård, Øyvind; Nilsen, Hilde; Grallert, Beáta; Boye, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background In many cell types, including the fission yeast Schizosaccharomyces pombe, a set of checkpoints are induced by perturbations of the cell cycle or by DNA damage. Many of the checkpoint responses ...
A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain 
Rounge, Trine B; Rohrlack, Thomas; Nederbragt, Alexander J; Kristensen, Tom; Jakobsen, Kjetill S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background Cyanobacteria often produce several different oligopeptides, with unknown biological functions, by nonribosomal peptide synthetases (NRPS). Although some cyanobacterial NRPS gene cluster types ...
Characterization of unknown genetic modifications using high throughput sequencing and computational subtraction 
Tengs, Torstein; Zhang, Haibo; Holst-Jensen, Arne; Bohlin, Jon; Butenko, Melinka A; Bråthen Kristoffersen, Anja; Opsahl Sorteberg, Hilde-Gunn; Berdal, Knut G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background When generating a genetically modified organism (GMO), the primary goal is to give a target organism one or several novel traits by using biotechnology techniques. A GMO will differ from its ...
Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species 
Mousavi, Seyed A; Fønhus, Marita S; Berg, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background The urokinase plasminogen activator receptor associated protein (uPARAP)/Endo180 is a novel endocytic receptor that mediates collagen uptake and is implicated to play a role in physiological and ...
Periplasmic targeting of fluorobodies 
Øieren, Lise Mirja (Master thesis / Masteroppgave, 2009)
Molecular evolution is a key strategy in the development of novel diagnostics and therapeutics. Libraries of mutant variants are generated and those with desired properties selected after screening. However, large scale ...
Cell-cycle-dependent trafficking in the endocytic pathway 
Bergeland, Trygve (Doctoral thesis / Doktoravhandling, 2008)
In the endocytic pathway, many components are degraded. This is essential for cells in many ways, like uptake of nutrients, defense against pathogens, receptor downregulation, and antigen processing. In interphase, the ...
Olfactory processing of sex and alarm cues in the crucian carp Carassius carassius 
Lastein, Stine (Doctoral thesis / Doktoravhandling, 2008)
Hvordan fiskene lukter sex og fare Fisker har en meget god luktesans og bruker den blant annet til å oppfatte farer, for eksempel når andre individer blir skadet eller spist av rovfisk. Noen av substansene fra fiskenes ...
Proteomic studies of hepatocytic autophagosomes 
Øverbye, Anders (Doctoral thesis / Doktoravhandling, 2008)
Doktorand Anders Øverbye har jobbet ved Institutt for kreftforskning ved Radiumhospitalet med sin avhandling innenfor de raskt voksende fagfeltene proteomikk og autofagi. Proteomikk innebærer utforskning av komplekse ...
Pro-inflammatory potential of particles from residential wood smoke and traffic : importance of physicochemical characteristics 
Kocbach, Anette (Doctoral thesis / Doktoravhandling, 2008)
Exposure to particulate matter (PM) has been associated with increased cardiopulmonary morbidity and mortality, and inflammation has been suggested as a mechanistic link between PM exposure and adverse health effects. ...
Gene expression in anoxic crucian carp brain 
Ellefsen, Stian (Doctoral thesis / Doktoravhandling, 2008)
Crucian carp, Carassius carassius, survives days to months without oxygen (anoxia). Still, during anoxia, it needs to keep the energy expenditure low, particularly in the brain, which has a high rate of ATP use mainly ...
Effects of UV light on cell cycle regulation in fission yeast 
Tvegård, Tonje (Doctoral thesis / Doktoravhandling, 2008)
Cancer cells are growing without control and it is therefore important to understand the mechanisms limiting the growth of normal cells. Before a cell can divide it must make a new set of chromosomes, so that both ...
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers 
Ahlquist, Terje; Lind, Guro E; Costa, Vera L; Meling, Gunn I; Vatn, Morten; Hoff, Geir S; Rognum, Torleiv O; Skotheim, Rolf I; Thiis-Evensen, Espen; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers that can discriminate between ...
Salmon louse (Lepeophtheirus salmonis) transcriptomes during post molting maturation and egg production, revealed using EST-sequencing and microarray analysis 
Eichner, Christiane; Frost, Petter; Dysvik, Bjarte; Jonassen, Inge; Kristiansen, Bjørn; Nilsen, Frank (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Lepeophtheirus salmonis is an ectoparasitic copepod feeding on skin, mucus and blood from salmonid hosts. Initial analysis of EST sequences from pre adult and adult stages of L. salmonis revealed ...
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data 
Lyng, Heidi; Lando, Malin; Brøvig, Runar S; Svendsrud, Debbie H; Johansen, Morten; Galteland, Eivind; Brustugun, Odd T; Meza-Zepeda, Leonardo A; Myklebost, Ola; Kristensen, Gunnar B; Hovig, Eivind; Stokke, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers ...
Recombination and selectional forces in cyanopeptolin NRPS operons from highly similar, but geographically remote Planktothrix strains 
Rounge, Trine B; Rohrlack, Thomas; Kristensen, Tom; Jakobsen, Kjetill S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Cyanopeptolins are nonribosomally produced heptapetides showing a highly variable composition. The cyanopeptolin synthetase operon has previously been investigated in three strains from the genera ...
iRefIndex: A consolidated protein interaction database with provenance 
Razick, Sabry; Magklaras, George; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Interaction data for a given protein may be spread across multiple databases. We set out to create a unifying index that would facilitate searching for these data and that would group together ...
Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera 
Tooming-Klunderud, Ave; Fewer, David P; Rohrlack, Thomas; Jokela, Jouni; Rouhiainen, Leo; Sivonen, Kaarina; Kristensen, Tom; Jakobsen, Kjetill S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Cyanobacteria produce a wealth of secondary metabolites, including the group of small cyclic heptapeptide hepatotoxins that constitutes the microcystin family. The enzyme complex that directs the ...
Hypermethylated MAL gene – a silent marker of early colon tumorigenesis 
Lind, Guro E; Ahlquist, Terje; Kolberg, Matthias; Berg, Marianne; Eknæs, Mette; Alonso, Miguel A; Kallioniemi, Anne; Meling, Gunn I; Skotheim, Rolf I; Rognum, Torleiv O; Thiis-Evensen, Espen; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the present study was to investigate the ...
Positive and negative modulation of the transactivation potential of the transcription factor c-Myb : novel regulatory mechanisms for a classical proto-oncoprotein 
Sæther, Thomas (Doctoral thesis / Doktoravhandling, 2008)
Mechanisms in Intracellular Transport of Toxins 
Skånland, Sigrid (Doctoral thesis / Doktoravhandling, 2008)
Ricin and Shiga toxin are protein toxins able to enter target cells by endocytosis. They can be transported via early endosomes to the Golgi apparatus and the endoplasmic reticulum. From this compartment, they are translocated ...
Destabilization of chimeric rbcL 5`UTR:GUS transcripts by changing nucleotides in the second half of the UTR sequence 
Hussain, Frazia (Master thesis / Hovedoppgave, 2007)
The Clamydomonas chloroplast rbcL gene encodes the large subunit of ribulose-bisphosphate carboxylase (RUBISCO). The 5`untranslated region (5`UTR) of the rbcL gene is crucial for its transcripts stability. Previous studies ...
Molecular Mechanisms of Androgen Action : Characterization of the Androgen Regulated Gene KLK4 and the Role of Nuclear Dynamics in Androgen Receptor-Mediated Transcription 
Klokk, Tove Irene (Doctoral thesis / Doktoravhandling, 2007)
Androgens are important for the normal development of the male sexual characteristics, but are also involved in pathological conditions such as prostate cancer. The biological effects of androgens are mediated by the ...
Microchips for Isothermal Amplification of RNA : Development of microsystems for analysis of bacteria, virii and cells 
Gulliksen, Anja (Doctoral thesis / Doktoravhandling, 2007)
The goal of the present work was to develop a microchip for amplification and detection of mRNA by employing nucleic acid sequence-based amplification (NASBA) technology. The technology platform should in principle be ...
On the Evolution of Nonribosomal Peptide Synthetase Gene Clusters in Cyanobacteria 
Tooming-Klunderud, Ave (Doctoral thesis / Doktoravhandling, 2007)
Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins. Nonribosomal peptides are produced by peptide synthetases or polyketide ...
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses 
Kleivi, Kristine; Lind, Guro E; Diep, Chieu B; Meling, Gunn I; Brandal, Lin T; Nesland, Jahn M; Myklebost, Ola; Rognum, Torleiv O; Giercksky, Karl-Erik; Skotheim, Rolf I; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...
Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator 
Steffensen, Knut R; Bouzga, Mariam; Skjeldal, Frode; Kasi, Cecilie; Karahasan, Almira; Matre, Vilborg; Bakke, Oddmund; Guérin, Sylvain; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, ...
Microarray-based method for detection of unknown genetic modifications 
Tengs, Torstein; Kristoffersen, Anja B; Berdal, Knut G; Thorstensen, Tage; Butenko, Melinka A; Nesvold, Håvard; Holst-Jensen, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Due to the increased use of genetic modifications in crop improvement, there is a need to develop effective methods for the detection of both known and unknown transgene constructs in plants. We ...
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential 
Francis, Princy; Maria Namløs, Heidi; Müller, Christoph; Edén, Patrik; Fernebro, Josefin; Berner, Jeanne-Marie; Bjerkehagen, Bodil; Åkerman, Måns; Bendahl, Pär-Ola; Isinger, Anna; Rydholm, Anders; Myklebost, Ola; Nilbert, Mef (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of ...
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate 
Cekaite, Lina; Peng, Qian; Reiner, Andrew; Shahzidi, Susan; Tveito, Siri; Furre, Ingegerd E; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
Wellness through a comprehensive Yogic breathing program – A controlled pilot trial 
Kjellgren, Anette; Bood, Sven Å; Axelsson, Kajsa; Norlander, Torsten; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Increasing rates of psychosocial disturbances give rise to increased risks and vulnerability for a wide variety of stress-related chronic pain and other illnesses. Relaxation exercises aim at ...
ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines 
Sporstøl, Marita; Mousavi, Seyed A; Eskild, Winnie; Roos, Norbert; Berg, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport. Reverse cholesterol transport is a mechanism ...
The ribosomal protein genes and Minute loci of Drosophila melanogaster 
Marygold, Steven J; Roote, John; Reuter, Gunter; Lambertsson, Andrew; Ashburner, Michael; Millburn, Gillian H; Harrison, Paul M; Yu, Zhan; Kenmochi, Naoya; Kaufman, Thomas C; Leevers, Sally J; Cook, Kevin R (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
preAssemble: a tool for automatic sequencer trace data processing 
Adzhubei, Alexei A; Laerdahl, Jon K; Vlasova, Anna V (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background Trace or chromatogram files (raw data) are produced by automatic nucleic acid sequencing equipment or sequencers. Each file contains information which can be interpreted by specialised software ...
Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas 
Ribeiro, Franclim R; Henrique, Rui; Hektoen, Merete; Berg, Marianne; Jerónimo, Carmen; Teixeira, Manuel R; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46 primary prostate ...
Diskriminering av gallesalter i luktelappen hos karuss Carassius carassius 
Bohmann, Kurt Halim (Master thesis / Masteroppgave, 2005)
Det er vist at gallesubstanser er potente luktestimuli og induserer ulike typer adferdsmønstre hos fisk. Det er også flere egenskaper ved gallesaltene som gjør dem spesielt interessante i det akvatiske miljø som eksempel ...
Identification of endothelial Weibel-Palade bodies by single organelle flow cytometry 
Joel, Mrinal (Master thesis / Masteroppgave, 2005)
Abstract Vascular endothelial cells contain typical, elongated vesicles called Weibel-Palade bodies (WPBs), which serve as a storage compartment for biologically active factors involved in hemostasis and inflammation. ...
The PI 3-kinase hVps34 modulates endosome to Golgi transport of ricin 
Skånland, Sigrid Strand (Master thesis / Masteroppgave, 2005)
The protein toxin ricin is found in the plant Ricinus communis, and is a useful tool in studies of intracellular traffic. It consists of an enzymatically active A chain and a B chain with lectin properties, joined together ...
Isolering, kloning og ekspresjon av groESL2-operonet fra den termofile bakterien Chloroflexus aurantiacus 
Benestad, Ingun (Master thesis / Hovedoppgave, 2005)
Chaperoninene GroEL og GroES er en gruppe molekylære chaperoner som hittil er funnet i alle bakterier. Genene som koder for chaperoniner er vanligvis organisert i operoner på genomet. Den moderat termofile grønne glidende ...
Karakterisering av regulatoriske regioner oppstrøms for WWOX 
Lindeberg, Mona Mari (Master thesis / Hovedoppgave, 2005)
Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter av kromosom 16q i ulike krefttyper. Dette genet er lokalisert innenfor kromosom ...
Enhancement of delivery of therapeutic genes by photochemical internalization 
Olsen, Vibeke Murberg (Master thesis / Hovedoppgave, 2005)
Despite continuous improvement in gene delivery vector technology, development of methods for efficient and specific delivery of therapeutic genes to target cells still remains an important issue in the development of ...
Intracellular transport of Fc-receptors in J774- and liver endothelial- cells, studied by electron microscopy. 
Kjær, Marte Avranden (Master thesis / Hovedoppgave, 2005)
In this study we have investigated by means of electron microscopy the uptake of the fragment crystallisable gamma receptor (FcãR) and its ligands (aggregated immunoglobulin G (AgIgG)) in J774 cells, a mouse macrophage ...
Stressful social interaction reduces telencephalic cell proliferation in rainbow trout 
Sørensen, Christina (Master thesis / Masteroppgave, 2005)
When housed together, juvenile rainbow trout (Oncorhynchus mykiss) form social hierarchies in which subordinate animals show stress-related changes in behaviour, endocrine function and neurochemistry. Similar changes are ...
Does MRF4 play a role in regulation of adult muscle phenotype? 
Sjåland, Cecilie (Master thesis / Masteroppgave, 2005)
Abstract Skeletal muscle fibre types are determined by the activity of motor neurons, hormones, stretch and probably cell lineage. The electrical activity of the motor neurons might, through an unknown pathway, influence ...
Chromalveolate evolution: chloroplast replacements in dinoflagellates and the deep phylogeny of Telonema 
Minge, Marianne Aastebøl (Master thesis / Hovedoppgave, 2005)
The eukaryotic supergroup chromalveolates, as defined in the chromalveolate hypothesis, comprise the chromists (haptophytes, heterokonts and cryptophytes) and the alveolates (dinoflagellates, ciliates and apicomplexa). The ...
En sammenligning av responser på kjemiske og mekaniske stimuli hos de to formene av den polymorfe ciliaten Tetrahymena vorax 
Hagen, Bjarne (Master thesis / Hovedoppgave, 2005)
De to formene av den polymorfe ciliaten Tetrahymena vorax er svært ulike med hensyn på morfologi, atferd og næringspreferanser. Den mikrostome formen lever av blant annet bakterier og råtnende biologisk materiale som taes ...
"Induction of long-term potentiation in dorsal horn neurons and expression of immediate early genes Zif and Arc 
Lien, Guro Flor (Master thesis / Masteroppgave, 2005)
Abstract Increased pain response following injury is an important step in the process of protecting the injured site from further damage. However, pain can often be a more serious problem than the injury or disease process ...
5'UTR sequence requirements for stability of rbcL transcripts in the chloroplast of Chlamydomonas reinhardtii 
Gershuny, Rachel (Master thesis / Hovedoppgave, 2005)
A reporter gene was constructed of the Chlamydomonas reinhardtii rbcL 5 f region from position -70 to +47, relative to the transcription start point (+1), followed by the E. coli uidA (GUS) gene and the Chlamydomonas psaB ...
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