Browsing Institutt for molekylær biovitenskap by Title
Now showing items 20-39 of 121
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and ...
-
(Master thesis / Hovedoppgave, 2003)TCF11 is a regulatory transcription factor belonging to the CNC-bZIP family. The specific biological function of this protein is still unknown. However, knockout studies in mice have revealed its importance during embryo ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades. We recently reported a novel pIX phagemid display system that is characterized by a strong preference ...
-
(Master thesis / Hovedoppgave, 2007)The Clamydomonas chloroplast rbcL gene encodes the large subunit of ribulose-bisphosphate carboxylase (RUBISCO). The 5`untranslated region (5`UTR) of the rbcL gene is crucial for its transcripts stability. Previous studies ...
-
(Doctoral thesis / Doktoravhandling, 2009)This work, we believe, is a significant contribution to the development of molecular methods for the rapid detection of microorganism interacting with humans. Prevention, through the implementation of effective water ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of ...
-
(Master thesis / Masteroppgave, 2005)Det er vist at gallesubstanser er potente luktestimuli og induserer ulike typer adferdsmønstre hos fisk. Det er også flere egenskaper ved gallesaltene som gjør dem spesielt interessante i det akvatiske miljø som eksempel ...
-
(Master thesis / Masteroppgave, 2005)Abstract Skeletal muscle fibre types are determined by the activity of motor neurons, hormones, stretch and probably cell lineage. The electrical activity of the motor neurons might, through an unknown pathway, influence ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Background Previous studies have noted that drug targets appear to be associated with higher-degree or higher-centrality proteins in interaction networks. These studies explicitly or tacitly make choices ...
-
(Doctoral thesis / Doktoravhandling, 2008)Cancer cells are growing without control and it is therefore important to understand the mechanisms limiting the growth of normal cells. Before a cell can divide it must make a new set of chromosomes, so that both ...
-
(Master thesis / Hovedoppgave, 2005)De to formene av den polymorfe ciliaten Tetrahymena vorax er svært ulike med hensyn på morfologi, atferd og næringspreferanser. Den mikrostome formen lever av blant annet bakterier og råtnende biologisk materiale som taes ...
-
(Doctoral thesis / Doktoravhandling, 2009)The plant toxin ricin and the bacterial toxin Shiga toxin are not only a threat to human health but may also be used in cancer treatment and to gain new insight into the mechanisms of intracellular transport. Ricin and ...
-
Engineering to improve serum half-life modulates classical Fcgamma receptor bindingRestricted Access (Master thesis / Masteroppgave, 2012)Summary Antibodies act as adapter molecules that link recognition of foreign substances, such as bacteria and viruses, to elimination mechanisms mediated by cells and molecules of the innate immune system. Cells that express ...
-
(Master thesis / Hovedoppgave, 2005)Despite continuous improvement in gene delivery vector technology, development of methods for efficient and specific delivery of therapeutic genes to target cells still remains an important issue in the development of ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background Several high-density oligonucleotide microarray platforms are available for genome-wide single nucleotide polymorphism (SNP) detection and microarray-based comparative genomic hybridisation (array ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)Background Cyanobacteria produce a wealth of secondary metabolites, including the group of small cyclic heptapeptide hepatotoxins that constitutes the microcystin family. The enzyme complex that directs the ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background: Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background: Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor ...