Browsing Institutt for molekylær biovitenskap ( -2012) by Title
Now showing items 21-40 of 225
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(Master thesis / Hovedoppgave, 2005)Production of DNA damage is the basis of cancer treatments, such as radiotherapy. The limitation of the treatment dose tends to be how well the tumor and normal cell within the body can tolerate the therapy. In order to ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)The cell cycle of the fission yeast, Schizosaccharomyces pombe, does not easily lend itself to analysis by flow cytometry, mainly because cells in G1 and G2 phase contain the same amount of DNA. This occurs because fission ...
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Cellular and sub-cellular localization of different N-methyl-D-aspartate receptor subunits in the hippocampal formation of mature and aged mice lacking the Neil3 geneRestricted Access (Master thesis / Masteroppgave, 2009)High levels of oxidative stress are a common aspect of most neurodegenerative disorders. Oxidative stress in the brain causes DNA lesions that are mainly repaired by the base excision repair (BER) pathway. The BER pathway ...
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(Master thesis / Masteroppgave, 2011)Autophagy is an important growth regulatory process in eukaryotic cells. Dysfunctional autophagy can cause tumorigenesis and neurodegenerative diseases due to accumulation of defective cellular substructures and protein ...
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(Master thesis / Hovedoppgave, 2004)Chromosome One Amplified Sequence 2 (COAS2) is a member of the cyclophilin family of proteins (Meza Zepeda et al., 2002). It has 84% amino acid homology to H. sapiens cyclophilin A, also known as Peptidylprolyl Isomerase ...
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(Master thesis / Masteroppgave, 2009)Our group has shown that ultraviolet (UV) irradiation of fission yeast cells in G1 phase induces a delayed entry into S phase. More recently, we found that the cell cycle delay is accompanied by a general depression of ...
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Characterisation of the fish pathogen Francisella in cells and zebrafish : Developing an assay for testing the delivery of drugs and vaccines using the nanoparticle systemRestricted Access (Master thesis / Masteroppgave, 2011)
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Characterisation of the phosphatidylinositol-3-phosphate 5-kinase, Fab1, in Drosophila melanogaster (Master thesis / Hovedoppgave, 2004)Phosphoinositides play important roles in downregulation of growth factor receptors, such as the epidermal growth factor receptor (EGFR), through regulation of membrane transport and multivesicular body (MVB) biogenesis. ...
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(Master thesis / Hovedoppgave, 2004)A total of nine single-copy transgenic Arabidopsis thaliana lines displaying varying degrees of silencing of a nos promoter-nptII marker gene (encoding kanamycin-resistance) have been studied, with emphasis on two of these, ...
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(Master thesis / Masteroppgave, 2008)Mammalian AlkB homologues (ABH) contain a 2-oxoglutarate and iron dependent dioxygenase domain, placing these proteins in the 2OG/Fe2+ dependent dioxygenase superfamily. The mammalian ABH2 and ABH3 proteins are oxidative ...
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(Master thesis / Masteroppgave, 2011)Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades, arguably with most success in the field of drug discovery. Despite being a mature and dominating ...
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(Master thesis / Masteroppgave, 2010)The human 5-HT7 serotonin receptor is a G-protein-coupled receptor that activates adenylyl cyclase constitutively and upon agonist-activation. In previous studies, some inverse agonists induce both homo- and heterologous ...
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(Master thesis / Masteroppgave, 2011)Gene therapy strategies have been intensively studied for over 20 years. However, there are yet no gene therapy protocols in conventional use. In this project, a gene delivery protocol was optimized for the transient ...
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Characterization of LSAMP, a novel candidate tumor suppressor gene in osteosarcomasRestricted Access (Master thesis / Masteroppgave, 2011)Osteosarcomas are the most common primary malignant tumors of bone. They are highly aggressive with poor prognosis, and display complex genomic aberrations. Previously, our group has identified a frequently deleted region ...
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(Master thesis / Masteroppgave, 2011)
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(Master thesis / Masteroppgave, 2007)The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...
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(Master thesis / Masteroppgave, 2008)The human genome encodes 8 homologues of the E.coli protein AlkB, hABH1-8. AlkB, hABH2, and hABH3 repair DNA and RNA by oxidative demetylation in the presence of Fe2+ and 2-oxoglutarate (2OG). The functions of the remaining ...
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(Master thesis / Hovedoppgave, 2005)The eukaryotic supergroup chromalveolates, as defined in the chromalveolate hypothesis, comprise the chromists (haptophytes, heterokonts and cryptophytes) and the alveolates (dinoflagellates, ciliates and apicomplexa). The ...
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(Master thesis / Hovedoppgave, 2004)For evolutionary and medical reasons bacterial classification is an important field within microbiology. Before Carl Woese introduced the use of ribosomal RNA sequences for phylogenetic comparison, bacterial classification ...
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(Master thesis / Hovedoppgave, 2007)The crucian carp survives anoxia with the brain turned on. In such a state it is crucial to lower energy expenditures. This can be achieved by lowering the permeability of ionotropic receptors such as the N-metyl-D-aspartate ...