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Pain mechanisms and the genetic influence of 5-HTT and OPRM1 polymorphisms Restricted Access
Olsen, Maria Belland (Master thesis / Masteroppgave, 2012)
Previous studies indicate that central sensitization may be an underlying mechanism of hyperalgesia and development of persistent pain. However, some individuals may have a higher risk of long lasting pain than others, ...
An unbalanced (X;22) translocation in a neurodevelopmentally delayed girl : Does the X-inactivation spread to chr22? Restricted Access
Gabrielsen, Ingvild (Master thesis / Masteroppgave, 2012)
Intellectual disability/mental retardation occur in 2-3% of newborns in the general population. In 80% of the cases, the causes remain elusive. Improved molecular and cytogenetic techniques have enabled the detection of ...
Structure of Thermotoga maritima endonuclease V binding to DNA Restricted Access
Karki, Sudeep (Master thesis / Prosjektoppgave, 2012)
Abstract Endonuclease V (EndoV) is highly conserved from prokaryotes to eukaryotes. Endonuclease V in E. coli functions in repair of DNA damages caused by deamination of adenine and guanine in particular. E. coli EndoV ...
Expression of the bacterial ectA gene in the chloroplast of Chlamydomonas reinhardtii 
Lunde, Anders (Master thesis / Masteroppgave, 2012)
Ectoine is a small molecule that confers salt tolerance to organisms. It is synthesized in bacteria by the gene products of ectA, ectB, and ectC. Ectoine is used in medical, biotechnological, and cosmetic products. The ...
Development of a reporter gene construct that can be used for the localization of RNA pyrophosphohydrolase (rppH) in cells of Chlamydomonas reinhardtii cells. 
Abrha, Biruk Luelseged (Master thesis / Masteroppgave, 2012)
Abstract The concept that messenger RNA (mRNA) degradation in E. coli begins with endonucleolytic cleavage has been challenged by the recent discovery that the conversion of the 5’ terminus from a triphosphate to a ...
Identification of a new interaction partner of the small GTPase Rab7b Restricted Access
Borg, Marita Jeanett Halsen (Master thesis / Masteroppgave, 2012)
The small GTPase Rab7b is localized to late endosomes and lysosomes and to the Golgi apparatus, and regulates the intracellular transport from late endosomal compartments to the Golgi. However, not much is known about ...
In vitro ekspresjonssystem for produksjon av bakteriosiner og immunitets proteiner Restricted Access
Skautvedt, Elisabeth (Master thesis / Masteroppgave, 2012)
The structures of the immunity proteins for the two-peptide bacteriocins have not been determined, although knowledge of these structures is of great interest as it may reveal at a molecular level how these proteins render ...
Significance of the metastasis-promoting protein S100A4 in chemotherapy sensitivity of colorectal cancer cell lines 
Frikstad, Kari-Anne Myrum (Master thesis / Masteroppgave, 2012)
Colorectal cancer (CRC) is a common type of cancer, and at present the TNM staging system is the only tool in routine clinical use for predicting patient outcome and making treatment decisions. Nuclear expression of the ...
Characterisation of Mycobacterium avium subspecies paratuberculosis reactiveT cells in goats 
Al-Touama, Zainab (Master thesis / Masteroppgave, 2012)
Paratuberculosis is a chronic enteric disease that affects ruminants. It is caused by Mycobacterium avium subsp. paratuberculosis (MAP) an obligated intracellular acid-fast bacilli that usually infect macrophages in the ...
The nitric oxide synthase protein system in Bacillus cereus : From gene to 3D structure Restricted Access
Lofstad, Marie (Master thesis / Masteroppgave, 2012)
DAXX-dependent recruitment of the histone variant H3.3 to PML bodies prior to chromatin deposition Restricted Access
Petronyte, Kristina (Master thesis / Masteroppgave, 2012)
The genome is organized into chromatin domains which can be distinguished by enrichment in post-translational modifications of histones and histone variants. Since the histone code has been discovered, little is known about ...
Development of biodegradable nanoparticle-based therapies against tuberculosis in a zebrafish model : working towards the encapsulation of antimicrobial agents and peptide-encoding DNA 
Madsen, Marie Paulsen (Master thesis / Masteroppgave, 2012)
At the moment, one-third of the world’s population is estimated to be infected with Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB) in humans. Our treatment strategies have been greatly challenged ...
Optimization of a cell free protein synthesis system for expression of Lactococcin A immunity protein Restricted Access
Awol, Mehdiya Selman (Master thesis / Masteroppgave, 2012)
Investigation of Readers and Writers of the Histone Code in Arabidopsis thaliana : An investigation of domains of the Arabidopsis thaliana proteins SUVR1, SUVR2 and SUVR4 Restricted Access
Jacobsen, Cathrine (Master thesis / Masteroppgave, 2012)
Epigenetic gene regulation is crucial in developmental processes, controlling which genes that are expressed at what times and in what tissues. Posttranslational modifications on histone tail residues yield various outcomes ...
Role of pro-inflammatory cytokines in persistent pain after disc herniation : nociceptive signaling and genetic susceptibility Restricted Access
Moen, Aurora (Master thesis / Masteroppgave, 2012)
Low back pain and sciatica after disc herniation may be caused by mechanical compression of the nerve roots, but also by the release of inflammatory substances from nucleus pulposus (NP) of the herniated disc. In the present ...
Activation of the supraspinal opioid systems after peripheral noxious conditioning and inhibition of histone deacetylases 
Johnsen, Kjærsti (Master thesis / Masteroppgave, 2012)
Previous studies show that the endogenous opioid system has an important role in the pain control system. In recent years, it has also been suggested that epigenetic modifications, such as acetylations, may affect pain ...
Identifisering av interaksjonspartnere til den SUMO-spesifikke proteasen SENP1, ansvarlig for økt genaktivering gjennom deSUMOylering Restricted Access
Moen, Lisa Marie (Master thesis / Masteroppgave, 2012)
The Role of Cid13 in the G1/S Checkpoint in Fission Yeast 
Taipale, Riikka (Master thesis / Masteroppgave, 2012)
This study was carried out at the Department of Cell Biology at the Institute of Cancer Research at the Oslo University Hospital as a part of my Master’s degree in molecular biosciences at the University of Oslo. Our group ...
Regulation of the gap junction protein connexin 43 during mitosis Restricted Access
Dahal-Koirala, Shiva (Master thesis / Masteroppgave, 2012)
Temperaturens rolle for vekst og overlevelse av Legionella bozemanii og Legionella pneumophila Restricted Access
Skårholen, Marte Tønsetengen (Master thesis / Masteroppgave, 2012)
Investigation of Novel Structures and Functions of Readers and Writers of the Histone Code in Arabidopsis thaliana 
Rahman, Mohummad Aminur (Doctoral thesis / Doktoravhandling, 2012)
Characterization of oxygen-dependent processes in the anoxia-tolerant crucian carp 
Sandvik, Guro Katrine (Doctoral thesis / Doktoravhandling, 2012)
Most vertebrates die within minutes when exposed to anoxia (no oxygen). However, a few exceptions exist, and a champion among these is the crucian carp, which at low temperatures can survive several months in an active ...
Åpent seminar: Fra imaging show til celler og proteinsrukturer 
Bakke, Oddmund; Andersson, K. Kristoffer (Journal article / Tidsskriftartikkel / PublishedVersion, 2012)
I anledning universitetets 200 års jubileum og Mat Nat Fakultetets 150 års jubileum i 2011 fikk vi i oppdrag å fylle en dag med cellebiologi/strukturbiologi og lage en kortfilm med moderne mikroskopi som tema. Den 12. ...
Selective targeting of cancer cells through inhibition of Checkpoint kinase 1 
Hasvold, Grete (Doctoral thesis / Doktoravhandling, 2012)
Characterization of novel methyltransferases METTL22 and FAM86A.1 Restricted Access
Ali, Qamar (Master thesis / Masteroppgave, 2012)
Proteins are subjected to various post-translational modifications (PTMs) that affect their activity, interaction and localization. Methylation is one such PTM that is well known to play a regulatory role in heterochromatin ...
DeltaPhage-a novel helper phage for high-valence pIX phagemid display 
Nilssen, Nicolay Rustad; Frigstad, Terje; Pollmann, Sylvie; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades. We recently reported a novel pIX phagemid display system that is characterized by a strong preference ...
Metagenomic and geochemical characterization of pockmarked sediments overlaying the Troll petroleum reservoir in the North Sea 
Håvelsrud, Othilde E; Haverkamp, Thomas H; Kristensen, Tom; Jakobsen, Kjetill S; Rike, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Pockmarks (depressions in the seabed) have been discovered throughout the world’s oceans and are often related to hydrocarbon seepage. Although high concentrations of pockmarks are present in ...
Human ALKBH4 Interacts with Proteins Associated with Transcription 
Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ...
Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism 
Iversen, Tore G; Frerker, Nadine; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background There is a huge effort in developing ligand-mediated targeting of nanoparticles to diseased cells and tissue. The plant toxin ricin has been shown to enter cells by utilizing both dynamin-dependent ...
Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction 
Mora, Antonio; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Previous studies have noted that drug targets appear to be associated with higher-degree or higher-centrality proteins in interaction networks. These studies explicitly or tacitly make choices ...
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor 
Andersen, Jan Terje; Dalhus, Bjørn; Cameron, Jason; Daba, Muluneh Bekele; Plumridge, Andrew; Evans, Leslie; Brennan, Stephen O.; Gunnarsen, Kristin Støen; Bjørås, Magnar; Sleep, Darrell; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Albumin is the most abundant protein in blood where it has a pivotal role as a transporter of fatty acids and drugs. Like IgG, albumin has long serum half-life, protected from degradation by pH-dependent recycling mediated ...
Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life 
Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
Studies of Ribonucleotide Reductase in Crucian Carp-An Oxygen Dependent Enzyme in an Anoxia Tolerant Vertebrate 
Sandvik, Guro Katrine; Tomter, Ane Berg; Bergan, Jonas; Zoppellaro, Giorgio; Barra, Anne-Laure; Røhr, Åsmund Kjendseth; Kolberg, Matthias; Ellefsen, Stian; Andersson, K. Kristoffer; Nilsson, Göran Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The enzyme ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, the precursors for DNA. RNR requires a thiyl radical to activate the substrate. In RNR of eukaryotes (class Ia ...
Studies of Electron Transport from Flavodoxin Reductase to NrdI in Bacillus cereus 
Skråmo, Silje (Master thesis / Masteroppgave, 2012)
Ribonucleotide reductase (RNR) catalyses the reduction of the four ribonucleotides to their corresponding deoxyribonucleotides needed for synthesis and repair of DNA. RNR is found in the genome of all living organisms, ...
Nucleus pulposus application onto rat spinal dorsal nerve roots leads to a persistent increase in spinal C-fibre responses, possibly due to upregulation of IL1α, IL1β and TNF 
Egeland, Nina Gran (Master thesis / Masteroppgave, 2012)
Sensitization of sensory neurons after noxious conditioning may be involved in many chronic pain states, including radiating low back pain and sciatica following disc herniation. Here, we examine such sensitization induced ...
Investigating BEACH domain containing proteins for a role in autophagy 
Holland, Petter (Master thesis / Masteroppgave, 2012)
The BEACH domain is common for a protein family that has expanded through eukaryotic evolution and contains eight human proteins. These proteins are generally very large and at their C-terminal ends contain a conserved set ...
Human Neil DNA glycosylases - Towards structure determination of a NEIL-DNA complex 
Johansen, Anette (Master thesis / Masteroppgave, 2012)
The repair of DNA damage is crucial for the maintenance of genome stability. In base excision repair, lesion-specific DNA glycosylases recognize and cleave a variety of base lesions. The human Nei-like (NEIL) DNA glycosylases ...
Engineering to improve serum half-life modulates classical Fcgamma receptor binding Restricted Access
Grevys, Algirdas (Master thesis / Masteroppgave, 2012)
Summary Antibodies act as adapter molecules that link recognition of foreign substances, such as bacteria and viruses, to elimination mechanisms mediated by cells and molecules of the innate immune system. Cells that express ...
Endosomal Maturation Is Controlled By A Rab7 Feedback Loop Concomitant With Vesicular Interactions 
Berg-Rolness, Håkon Schau (Master thesis / Masteroppgave, 2012)
Endosomal maturation controls trafficking and degradation of macromolecules in eukaryotic cells and represents an important regulatory point in the endocytic pathway. Progression through this phase is primarily recognized ...
TARGETING OF CANCER STEM CELLS BY LET-7 miRNA 
Serguienko, Anastassia (Master thesis / Masteroppgave, 2012)
miRNAs are short non-coding RNA that regulate gene expression at the post-transcriptional level by inhibiting the translation of mRNAs through pairing to their 3’ UTR. The let-7 family of miRNAs regulates cell differentiation ...
Studies of intracellular sorting of endocytosed ErbB3 Restricted Access
Fosdahl, Anne Marthe (Master thesis / Masteroppgave, 2012)
The ErbB family of tyrosine kinase receptors mediates the activation of a wide network of signaling pathways, which are important for cell growth, differentiation and survival. The four different ErbB proteins, EGFR, ErbB2, ...
Epigenetic regulation of neurogenic differentiation of adipose tissue stem cells 
Mastrangelopoulou, Maria (Master thesis / Masteroppgave, 2012)
Mesenchymal stem cells (MSCs) derived from adipose tissue are multipotent stem cells able to give rise into multiple cell types, not only of the mesodermal lineage, but also of the neuroectodermal lineage. In this study, ...
New insights into the regulation of the tumor suppressor proteins PTEN and Connexin 43 by post-translational modifications Restricted Access
Eilertsen, Ina Andrassy (Master thesis / Masteroppgave, 2012)
Transcriptome profiling of LH-producing gonadotropes in female medaka - with special emphasis on calcium-activated potassium channels 
Moen, Line Victoria (Master thesis / Masteroppgave, 2012)
The brain-pituitary-gonad axis regulates puberty and reproduction in all vertebrates. The two gonadotropins, FSH and LH are released from the pituitary and initiates maturing and growth of the gonads. To understand more ...
Altered expression of monocarboxylate and glucose transporters in an animal model of attention-deficit/hyperactivity disorder (ADHD) : An investigation of the Energy Deficiency Hypothesis of ADHD Restricted Access
Hefte, Marita Brandsar (Master thesis / Masteroppgave, 2012)
Attention-deficit/hyperactivity disorder (ADHD) is an early-onset and highly heritable human psychiatric disorder with negative adult outcomes. ADHD affects about 2 to 5 % of all children, mainly boys. The clinical symptoms ...
Spectroscopic Studies of the Iron- and Manganese Reconstituted Tyrosyl Radical in Bacillus cereus Ribonucleotide Reductase R2 Protein 
Tomter, Ane Berg; Zoppellaro, Giorgio; Bell, Caleb B.; Barra, Anne-Laure; Andersen, Niels Højmark; Solomon, Edward I.; Andersson, K. Kristoffer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Ribonucleotide reductase (RNR) catalyzes the rate limiting step in DNA synthesis where ribonucleotides are reduced to the corresponding deoxyribonucleotides. Class Ib RNRs consist of two homodimeric subunits: R1E, which ...
The antinociceptive effect of the FAAH inhibitior URB597 is blocked by the opioid receptor antagonist naloxone Restricted Access
Mahmood, Aqsa (Master thesis / Masteroppgave, 2011)
Previous studies indicate that inhibition of fatty acid amide hydrolase (FAAH) activity may result in accumulation of endocannabinoids both in the brain and the spinal cord. Furthermore, it has been suggested that the ...
Intracellular trafficking of the human invariant chain isoforms, Iip33 and Iip35 Restricted Access
Sand, Kine Marita Knudsen (Master thesis / Masteroppgave, 2011)
The invariant chain (Ii) has for many years been known to have important functions in MHC class II antigen presentation. There are four isoforms of Ii in humans: Iip33, Iip35, Iip41 and Iip43. The two shorter isoforms ...
Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage 
Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor ...
Functional analysis of STAMP1 and a putative interaction partner in prostate cancer Restricted Access
Eikenes, Åsmund Husabø (Master thesis / Masteroppgave, 2011)
Odorant-specific endocytosis : Mapping the connectivity within the olfactory system in crucian carp, Carassius carassius Restricted Access
Hansson, Kenth-Arne (Master thesis / Masteroppgave, 2011)
Molecular characterization and gene expression analysis of calcium-activated potassium channels in Atlantic co 
Vaule, Stine Berg (Master thesis / Masteroppgave, 2011)
Characterisation of the fish pathogen Francisella in cells and zebrafish : Developing an assay for testing the delivery of drugs and vaccines using the nanoparticle system Restricted Access
Hope, Anne Paulenz (Master thesis / Masteroppgave, 2011)
Developmental tracing of lhb gene expression in medaka (Oryzias latipes) using the stable tg(lhb:GFP) line and generation of a corresponding tg(fshb:RFP) line 
Lifjeld, Rikke (Master thesis / Masteroppgave, 2011)
Targeted delivery of resurfaced gp120 to antigen-presenting cells, a novel vaccine concept in HIV vaccine development Restricted Access
Kabashi, Saranda (Master thesis / Masteroppgave, 2011)
DNA vaccines have the ability to induce humoral and cellular immune responses but their efficiency needs further improvement. One strategy is to target the antigen to surface receptors on antigen-presenting cells (APCs), ...
Uttrykk av glypikanvarianter i MDCK II-celler 
Engedahl, Guro Elisabeth (Master thesis / Masteroppgave, 2011)
Epitelcellelinjen ”Madin-Darby canine kidney” (MDCK) er en velstudert polarisert cellelinje som danner tette cellelag med separate apikale og basolaterale membrandomener, som ved hjelp av polarisert transport av nysyntetiserte ...
Human Endonuclease V - Cloning, Expression, Purification and Biochemical Characterization Restricted Access
Heggelund, Julie Elisabeth (Master thesis / Masteroppgave, 2011)
Multiple DNA damaging agents cause deaminations of the bases of DNA. If not repaired, these can lead to mutations, which in turn can result in dangerous diseases. Endonuclease V (EndoV) is a highly conserved gene from ...
The regulation of Gb3 biosynthesis in cancer cells: Implications for membrane dynamics 
Lukoseviciüté, Simona (Master thesis / Masteroppgave, 2011)
Gb3 (Gal α1-4, Gal β1-4, Glc β1-1, Ceramide) is a neutral glycosphingolipid specifically expressed in several human tissues, and is recognised as a receptor for Shiga toxins. Gb3 has been demonstrated to be upregulated in ...
Towards the development of nanobead vaccines against salmon pathogens: : establishment of cold-water fish infection models Restricted Access
Kavaliauskis, Arturas (Master thesis / Masteroppgave, 2011)
As the fish farming industry is growing all over the world, economic losses caused by diseases are also increasing. In Norway one fifth of the farmed fish are lost due to viral diseases; there is no treatment for viral ...
Osteogenic differentiation of mesenchymal stem cells : Identification of potential regulators Restricted Access
Egeland, Eivind Valen (Master thesis / Masteroppgave, 2011)
Osteogenic differentiation of mesenchymal stem cells (MSC) is a tightly regulated process, inducing large changes in cell phenotype and gene expression. Characterization of these expressional changes may be important in ...
The importance of Gcn2 and Rad3 in cell-cycle regulation of the G2/M transition 
Rothe, Christiane (Master thesis / Masteroppgave, 2011)
Topological requirements for protein glycosylation in Neisseria gonorrhoeae Restricted Access
Andersen, Heidi (Master thesis / Masteroppgave, 2011)
Abstract The gram negative obligate human bacterium N. gonorrhoeae possesses a general O-linked glycosylation system with several target proteins. So far twelve glycoproteins have been identified. In all cases where the ...
Cell context-dependent differences in interaction with Shiga toxin Restricted Access
Nymark, Carl-Martin (Master thesis / Masteroppgave, 2011)
Cells that grow in a restricted area will eventually become confluent. At that point normal cells will stop dividing, while cancer cells, with their invasive properties, will continue dividing. It has been known for quite ...
Intracellulær trafikkering av hNCU-G1 i HeLa celler Restricted Access
Zain, Gadah Sheik (Master thesis / Masteroppgave, 2011)
Eskild sin gruppe har klonet hNCU-G1 som viser seg å være et protein med en mulig dobbeltfunksjon. Proteinet ble vist til å være lokalisert i kjernen hvor det kan fungere som en transkripsjonsfaktor og kjernereseptor ...
Cell-Cycle Analysis of Fission Yeast Cells by Flow Cytometry 
Knutsen, Jon Halvor Jonsrud; Rein, Idun Dale; Rothe, Christiane; Stokke, Trond; Grallert, Beáta; Boye, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The cell cycle of the fission yeast, Schizosaccharomyces pombe, does not easily lend itself to analysis by flow cytometry, mainly because cells in G1 and G2 phase contain the same amount of DNA. This occurs because fission ...
Binding of recombinant protein disulfide isomerase I (PDII) from Chlamydomonas reinhardtii to the 5' untranslated region of Chlamydomonas rbcL transcripts 
Warsame, Ahmed Mohamed Ali (Master thesis / Masteroppgave, 2011)
Chlamydomonas reinhardtii is a widely used model organism to study chloroplast gene expression and photosynthetic processes. In this project we worked to identify a novel trans-acting factor that is thought to contribute ...
Characterization of a novel helper phage for high valence pIX display 
Nilssen, Nicolay Rustad (Master thesis / Masteroppgave, 2011)
Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades, arguably with most success in the field of drug discovery. Despite being a mature and dominating ...
Study of FcRn binding and FcRn mediated transport of IgGs, Fc fragments and fusions Restricted Access
Foss, Stian (Master thesis / Masteroppgave, 2011)
The genome sequence of Atlantic cod reveals a unique immune system 
Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex ...
Proposal of a new method to measure FRET quantitatively in living or fixed biomedical specimens on a laser microscope 
Helm, Paul Johannes; Ottersen, Ole Petter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Förster Resonance Energy Transfer , abbreviated FRET , is a fluorescence phenomenon, which can be used to study and map co-localizations and dynamics of co-localizations at nanometer precision on a light microscope. FRET ...
Identification of cancer-specific transcripts by computational analysis of genome-scale expression data at exon resolution Restricted Access
Johannessen, Bjarne (Master thesis / Masteroppgave, 2011)
Fusion genes have key roles in the development and progression of many human cancers. Detection of oncogenic fusion genes is already implemented in routine diagnostics and fusion proteins are targets in molecularly tailored ...
The Possible Role of STAMP1 in Breast Cancer Cell Proliferation 
Fosslie, Madeleine Lystad (Master thesis / Masteroppgave, 2011)
Characterization of proteoglycan expression by B lymphocytes Restricted Access
Stien, Kristine Bye (Master thesis / Masteroppgave, 2011)
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential 
Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC; Gerritsen, J.; Zhao, Y; Kleijer, M; Sandlie, Inger; de Haas, Masja; Jonsdottir, I; van der Schoot, CE; Vidarsson, G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and ...
PIAS1 interacts with FLASH and enhances its co-activation of c-Myb 
Alm-Kristiansen, Anne H; Lorenzo, Petra I; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit; Sæther, Thomas; Gabrielsen, Odd S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background FLASH is a huge nuclear protein involved in various cellular functions such as apoptosis signalling, NF-κB activation, S-phase regulation, processing of histone pre-mRNAs, and co-regulation of ...
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines 
Ohnstad, Hege O; Paulsen, Erik B; Noordhuis, Paul; Berg, Marianne; Lothe, Ragnhild A; Vassilev, Lyubomir T; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
Identification of surface proteins in Enterococcus faecalis V583 
Bøhle, Liv A; Riaz, Tahira; Egge-Jacobsen, Wolfgang; Skaugen, Morten; Busk, Øyvind L; Eijsink, Vincent G; Mathiesen, Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Surface proteins are a key to a deeper understanding of the behaviour of Gram-positive bacteria interacting with the human gastro-intestinal tract. Such proteins contribute to cell wall synthesis ...
A metagenomic study of methanotrophic microorganisms in Coal Oil Point seep sediments 
Håvelsrud, Elise O; Haverkamp, Thomas H; Kristensen, Tom; Jakobsen, Kjetill S; Rike, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Methane oxidizing prokaryotes in marine sediments are believed to function as a methane filter reducing the oceanic contribution to the global methane emission. In the anoxic parts of the sediments, ...
Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential 
Stratford, Eva W; Castro, Russell; Wennerstrøm, Anna; Holm, Ruth; Munthe, Else; Lauvrak, Silje; Bjerkehagen, Bodil; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
Patients Referred to a Norwegian Trauma Centre: effect of transfer distance on injury patterns, use of resources and outcomes 
Kristiansen, Thomas; Lossius, Hans M; Søreide, Kjetil; Steen, Petter A; Gaarder, Christine; Næss, Pål A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Triage and interhospital transfer are central to trauma systems. Few studies have addressed transferred trauma patients. This study investigated transfers of variable distances to OUH (Oslo ...
iRefR: an R package to manipulate the iRefIndex consolidated protein interaction database 
Mora, Antonio; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The iRefIndex addresses the need to consolidate protein interaction data into a single uniform data resource. iRefR provides the user with access to this data source from an R environment. ...
iRefScape. A Cytoscape plug-in for visualization and data mining of protein interaction data from iRefIndex 
Razick, Sabry; Mora, Antonio; Michalickova, Katerina; Boddie, Paul; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The iRefIndex consolidates protein interaction data from ten databases in a rigorous manner using sequence-based hash keys. Working with consolidated interaction data comes with distinct challenges: ...
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts 
Kuijjer, Marieke L; Namløs, Heidi M; Hauben, Esther I; Machado, Isidro; Kresse, Stine H; Serra, Massimo; Llombart-Bosch, Antonio; Hogendoorn, Pancras C; Meza-Zepeda, Leonardo A; Myklebost, Ola; Cleton-Jansen, Anne-Marie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last ...
Polymeric human Fc-fusion proteins with modified effector functions 
Mekhaiel, David N. A.; Czajkowsky, Daniel M.; Andersen, Jan Terje; Shi, Jianguo; El-Faham, Marwa; Doenhoff, Michael; McIntosh, Richard S.; Sandlie, Inger; He, Jianfeng; Hu, Jun; Shao, Zhifeng; Pleass, Richard J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The success of Fc-fusion bio-therapeutics has spurred the development of other Fc-fusion products for treating and/or vaccinating against a range of diseases. We describe a method to modulate their function by converting ...
Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage 
Løset, Geir Åge; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein ...
The role of ERM proteins in binding and intracellular transport of Shiga toxin 
Kvalvaag, Audun Sverre Myrset (Master thesis / Masteroppgave, 2011)
In addition to providing morphological support, the actin cytoskeleton is involved in cell motility, endocytosis and intracellular transport. Cytoskeletal interaction with the membrane is an essential part of these processes ...
DNA methylation biomarkers for colorectal cancer detection: CDO1, DCLK1, ZNF331 and ZSCAN18 
Vedeld, Hege Marie (Master thesis / Masteroppgave, 2011)
Colorectal cancer is one of the most prevalent causes of cancer deaths worldwide, with an estimated 1500 deaths each year in Norway alone. Early detection of colorectal cancer may significantly reduce this number, and it ...
Synthesis and transport of glycoproteins and proteoglycans in the apical and basolateral secretory pathways of epithelial MDCK cells 
Hafte, Tilahun Tolesa (Doctoral thesis / Doktoravhandling, 2011)
Sorting of newly synthesized proteins in the secretory pathway of polarized cells is governed by signals of proteinacous nature or post-translationally added structures such as glycans. Among all polarized cell types, ...
Studies on c-type cytochromes exhibiting "large g-max"/HALS EPR behaviour 
Harbitz, Espen (Doctoral thesis / Doktoravhandling, 2011)
Små vannløselige c cytokrommer finnes i elektrontransportkjeder i alle livets domener, og har essensielle roller i metabolismen. De inneholder jernatomer bundet i den plane kofaktoren hem. Disse jernatomene er koordinert ...
MHC II and the endocytic pathway; Regulation by Invariant Chain 
Landsverk, Ole Jørgen Bjarnason (Doctoral thesis / Doktoravhandling, 2011)
A Practical Approach to T-Cell Receptor Cloning and Expression 
Wälchli, Sebastien; Løset, Geir Åge; Kumari, Shraddha; Johansen, Jorunn; Yang, Weiwen; Sandlie, Inger; Olweus, Johanna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Although cloning and expression of T-cell Receptors (TcRs) has been performed for almost two decades, these procedures are still challenging. For example, the use of T-cell clones that have undergone limited expansion as ...
Effekt av 1,25-dihydroksyvitamin D3 og PPAR på lipidmetabolisme i humane myotuber 
Kraft, Kaja Meberg (Master thesis / Masteroppgave, 2011)
Sorting and modification of rGH variants 
Erichsen, Einar Bredo (Master thesis / Masteroppgave, 2011)
Charachterization of the PX-BAR protein Sorting Nexin 18 in autophagy Restricted Access
Søreng, Kristiane (Master thesis / Masteroppgave, 2011)
Autophagy is an important growth regulatory process in eukaryotic cells. Dysfunctional autophagy can cause tumorigenesis and neurodegenerative diseases due to accumulation of defective cellular substructures and protein ...
Characterization of LSAMP, a novel candidate tumor suppressor gene in osteosarcomas Restricted Access
Barøy, Tale (Master thesis / Masteroppgave, 2011)
Osteosarcomas are the most common primary malignant tumors of bone. They are highly aggressive with poor prognosis, and display complex genomic aberrations. Previously, our group has identified a frequently deleted region ...
Synthesis and transport of Syndecan 1 and 4 variants in MDCK cells 
Kasem, Mayes (Master thesis / Masteroppgave, 2011)
Syndecans (Syns) are transmembrane heparan sulfate proteoglycans (HSPGs) and comprise a family of four members, Syn 1-4. Syns have important roles as cell surface receptors involved in cell-cell and/or cell-matrix interactions. ...
Cancer immunosurveillance mediated by CD4+ T cells - focus on dendritic cells and interleukin-1 secretion Restricted Access
Alfsnes, Katrine (Master thesis / Masteroppgave, 2011)
Tumor-specific CD4+ T cells coordinate the adaptive immune response against cancer. Dendritic cells (DCs) are professional antigen presenting cells that are believed to be important for the initial activation of naïve ...
Molecular and genetic analysis of the MADS-box Type I transcription factors AGAMOUS-LIKE 28 and AGAMOUS-LIKE 36 Restricted Access
Stø, Ida Myhrer (Master thesis / Masteroppgave, 2011)
Abstract Seed development requires a coordinated interplay between different transcriptional programs in the embryo, the endosperm and the maternally derived seed coat. In angiosperms, the embryo and the endosperm are ...
Characterization of global gene expression after S100A4 mRNA transfection 
Ouren, Agnethe (Master thesis / Masteroppgave, 2011)
Gene therapy strategies have been intensively studied for over 20 years. However, there are yet no gene therapy protocols in conventional use. In this project, a gene delivery protocol was optimized for the transient ...
Transcript variation and protein expression in testicular germ cell tumours Restricted Access
Hoff, Andreas Midbøe (Master thesis / Masteroppgave, 2011)
Testicular germ cell tumours are the most frequent type of cancer in young adult Caucasian males. Yet, it is one of the neoplastic diseases with the best prognosis and outcome, making it an ideal model for curative disease. ...
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