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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) are highly effective in treating rheumatoid arthritis (RA), albeit high drug cost has restricted their use in ...
(Doctoral thesis / Doktoravhandling, 2017)
Parasitten Toxoplasma gondii kan forårsake alvorlig fosterskade som fosterdød, hjerneskade og synsnedsettelse dersom en kvinne smittes mens hun er gravid. Er hun smittet før svangerskapet, har hun antistoffer som beskytter ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background: Cannabidiol (CBD) is considered a promising neuroprotectant after perinatal hypoxia-ischemia (HI). We have previously studied the effects of CBD 1 mg/kg in the early phase after global HI in piglets. In contrast ...
(Doctoral thesis / Doktoravhandling, 2018)
The burden of hepatitis C virus (HCV) related liver disease among people who inject drugs (PWID) is increasing. Current highly efficient, simple, and tolerable directacting antiviral (DAA) HCV treatment provides new ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objective To create and validate an objective and reliable score to assess referral quality in gastroenterology. Design An observational multicentre study. Setting and participants 25 gastroenterologists participated in ...
(Doctoral thesis / Doktoravhandling, 2017)
Hypoxic-ischemic insults in the perinatal period rank globally among the three leading causes of newborn mortality. Many of the newborns that survive the initial insult are developing disordered brain function known as ...
(Doctoral thesis / Doktoravhandling, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Social dysfunction is common in patients with psychotic disorders. Oxytocin is a neuropeptide with a central role in social behavior. This study aims to explore the relationship between oxytocin pathway genes and symptoms ...
(Doctoral thesis / Doktoravhandling, 2017)
Base excision repair (BER) is the primary pathway for repair of oxidative DNA damage caused by various agents including reactive oxygen species. BER is initiated by DNA glycosylases that recognize and remove damaged DNA ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Every year around 50 million unintended pregnancies worldwide are terminated by induced abortion. Even in countries, where it is legalized and performed in a safe environment, abortion carries ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Cervical cancer is a major problem in women and it is important to find a suitable and acceptable screening method, especially among young in low-resource areas for future human papillomavirus ...
(Doctoral thesis / Doktoravhandling, 2018)
Sundby and co-workers have in this thesis studied the isolated effects of applying mild negative pressure (-40 mrnHg) to the limb on foot macro- and microcirculation in healthy volunteers, patients with peripheral arterial ...
(Doctoral thesis / Doktoravhandling, 2017)
Childbirth may have a profound impact on maternal circulation. Vaginal delivery exposes the parturient to cardiovascular stress, but the evidence is very limited. Spinal hypotension during caesarean delivery has been studied ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background The present study explored and compared the immediate responses in markers of inflammation and angiogenesis in maintenance heart transplant (HTx) recipients before, during and after sessions of high-intensity ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Even though progressive rhinosinusitis with osteitis is a major clinical problem in granulomatosis with polyangiitis (GPA), there are no studies on how GPA-related osteitis develops over time, ...
(Doctoral thesis / Doktoravhandling, 2018)
Lung cancer is the leading cause of cancer death in men and women worldwide. Surgical resection is recommended treatment for limited disease of non-small cell lung cancer. Biological factors such as age, body mass index, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
The phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution ...
(Doctoral thesis / Doktoravhandling, 2014)
This study was conducted within a naturalistic setting at the Department for Trauma Treatment at Modum Bad Psychiatric Center, Norway. Several follow-up studies have shown that adults with polysymptomatology related to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: In addition to care-related burdens, most caregivers of a person with dementia perceive a variety of positive and satisfying experiences, such as feeling needed and useful in their family caregiving role. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
The World Health Organization has set an ambitious goal of eliminating viral hepatitis as a major public health threat by 2030. However, in sub-Saharan Africa, antiviral treatment of chronic ...
(Doctoral thesis / Doktoravhandling, 2015)
(Doctoral thesis / Doktoravhandling, 2017)
The complement system is part of the immediate innate immune response to pending danger. However, uncontrolled activation contributes to the pathophysiology of many human diseases. Complement inhibitory therapy is approved ...
(Doctoral thesis / Doktoravhandling, 2017)
In her thesis Coping and depression in late life, Guro Hanevold Bjørkløf examines the relations between experienced control, coping strategies and depression.
Depression is the most common mood disorder among older ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Chronic rhinosinusitis display a variety of different phenotypes. The symptoms of disease are characterised by various signs and symptoms such as nasal congestion, nasal discharge, pressure ...
(Doctoral thesis / Doktoravhandling, 2019)
The huge discrepancy between the number of patients waiting for a liver transplant (LT) and the availability of donor organs have forced the transplant community to explore the use of extended criteria donors, of which old ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
It is widely accepted that exercise capacity in healthy individuals is limited by the cardiac function, while the respiratory system is considered oversized. Although there is physiological, ...
(Doctoral thesis / Doktoravhandling, 2018)
Osteoarthritis (OA) is the most common musculoskeletal disorder. During the past decades, the concepts of OA have been forever changed with the application of modern imaging techniques such as ultrasonography. While ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
(Doctoral thesis / Doktoravhandling, 2015)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
From 2013 a midwife-led continuity model of care was implemented in the Nablus region in occupied Palestine, involving a governmental hospital and ten rural villages. This study analysed the relation between ...
(Doctoral thesis / Doktoravhandling, 2018)
Data from Swedish health care registries, being nationwide and linkable with other registers by using personal identification number, provides an excellent source for disease insights from various aspects. Paper I showed ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Fear of childbirth (FOC) could have significant impact on women’s childbearing choices and experience. Culture affects the way women conceptualize childbirth, influencing the fears and expectations ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was undertaken to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Aims: To investigate changes in social network and quality of life of a substance use disorder cohort as they progressed through treatment.
Design: Multi-site, prospective, observational study of 338 adults entering ...
Long-term impact of intrauterine fetal death on quality of life and depression: a case–control study
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Intrauterine fetal death (IUFD) is a serious incidence that has been shown to impact mothers’ psychological well-being in the short-term. Long-term quality of life (QOL) and depression after IUFD ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background
In 2010 the Norwegian Parliament introduced amendments to the Health Personnel Act requiring all health personnel to inform and offer help to their patients’ children and families. We evaluated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Objectives: (1) To investigate the experiences of women with a previous stillbirth and their appraisal of the care they received at the hospital. (2) To assess the long-term level of post-traumatic stress symptoms (PTSS) ...
(Doctoral thesis / Doktoravhandling, 2008)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
In this paper, based on molecular hybridization, a series of [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazine was synthesized and their antiproliferative activities against 5 cancer cell lines (MGC-803, ...
(Doctoral thesis / Doktoravhandling, 2018)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with ...
(Doctoral thesis / Doktoravhandling, 2013)
(Doctoral thesis / Doktoravhandling, 2013)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Objective To assess the distribution of high-sensitivity cardiac troponin T (hs-cTnT) concentrations in stable chronic obstructive pulmonary disease (COPD), and whether hs-cTnT is associated with pulmonary function.
Design ...
(Chapter / Bokkapittel / AcceptedVersion; Peer reviewed, 2009)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Cervical cancer is a major cause of morbidity and mortality among women yet access to treatment and care remains a huge challenge in Zimbabwe. The objective of this study was to investigate health ...
(Doctoral thesis / Doktoravhandling, 2012)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Personality is considered as an important aspect in persons with psychotic disorders. Several studies have investigated personality in schizophrenia. However, no study has investigated stability ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
This review summarizes studies on eating disorders in pregnancy and the postpartum period that have been conducted as part of the broader Norwegian Mother and Child Cohort Study (MoBa). Prior to the 2000s, empirical ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: High prevalence of mental disorders among foster children highlight the need to examine the mental health of children placed out of home. We examined the properties of the Strengths and Difficulties Questionnaire ...
(Doctoral thesis / Doktoravhandling, 2014)
Introduction: Shoulder pain is a common, persistent and disabling disease. The restoration of abnormal movement-patterns is often an important goal in the treatment of patients with shoulder pain. The International ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Outcome after trauma depends on patient characteristics, quality of care, and random events. The TRISS model predicts probability of survival (Ps) adjusted for Injury Severity Score (ISS), Revised Trauma Score ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: A body mass index (BMI) adjusted weight loss grading system (WLGS) is related to survival in patients with cancer. The aim of this study was to examine the applicability of the WLGS by confirming its prognostic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Menstrual migraine without aura (MM) affects approximately 20% of female migraineurs in the general population. The aim of the present study was to investigate the influence of contraception on the attacks of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, ...
(Doctoral thesis / Doktoravhandling, 2015)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, and socioeconomic status, and irrespective of a history ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Diagnostic imaging of the head is used with increasing frequency, and often includes the paranasal sinuses, where incidental opacifications are found. To determine the clinical relevance of such findings can ...
(Doctoral thesis / Doktoravhandling, 2013)
(Doctoral thesis / Doktoravhandling, 2017)
Personality disorders are defined as enduring and maladaptive patterns of experiencing, coping, and relating to others. In DSM-IV as well as ICD-10, personality disorders may be diagnosed in adolescents when the individual’s ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Objective: To systematically review studies of cognitive remediation therapy (CRT) for anorexia nervosa (AN), and to discuss findings with references to clinical practice and future research.
Method: The literature was ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Suicide mortality and the rates by specific methods in a population may change over time in response to concurrent changes in relevant factors in society. This study aimed to identify significant ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Despite the high prevalence of insomnia in patients with advanced cancer, there are no randomized controlled trials on pharmacological interventions for insomnia in this group of patients. A ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Quality of life (QoL) is an important measure and outcome within chronic disease management and treatment, including substance use disorders (SUD). The aim of this paper was to investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Background
Mental health disorders are common among people in prison, but their prevalence in the Scandinavian prison population remain unclear. In this multinational register study, we examined the prevalence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
There is emerging evidence for the effectiveness of psychodynamic psychotherapy for depressive disorders. However, we know less of how this relation-focused therapy mode is experienced and what ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiology ...
(Doctoral thesis / Doktoravhandling, 2007)
Cardiac contractility is largely regulated through transients in intracellular Ca2+ concentration ([Ca2+]i). [Ca2+]i is under the influence of the sarcolemmal Na+/Ca2+-exchanger, which is regulated by the intracellular Na+ ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
The aim of this study was to analyze the expression, biological role and clinical relevance of autotaxin (ATX), the enzyme synthetizing lysophosphatidic acid (LPA), and LPA receptors (LPAR) in high-grade serous carcinoma ...
(Doctoral thesis / Doktoravhandling, 2013)
(Doctoral thesis / Doktoravhandling, 2010)
Forhøyet blodtrykk i lungearterien (pulmonal arteriell hypertensjon = PAH) er en sykdomstilstand med høy dødelighet som opptrer bl.a. som alvorlig følgesykdom ved medfødte hjertefeil. Oppfølgingsstudien til barnekardiolog ...
(Doctoral thesis / Doktoravhandling, 2007)
The main aim of the present thesis was to identify possible shortcomings in diagnostics and treatment in order to improve the outcome for ovarian cancer patients. Especially, the implications of referral practices were ...
(Doctoral thesis / Doktoravhandling, 2007)
Thrombophilia can be defined as an increased, persistent tendency to venous thrombosis. It can be acquired or inherited. The annual incidence of venous thrombosis is about 1 per 1000 in the adult population. Inherited ...
(Doctoral thesis / Doktoravhandling, 2007)
In the case of most diseases drug therapy will enhance health-related quality of life. However, inappropriate use of drugs may be harmful and could evoke new adverse symptoms. This has been known for centuries but, it was ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background
In South-Eastern Norway, genetic testing for BRCA1 and BRCA2 is offered to breast cancer patients by their treating surgeon or oncologist. Genetic counselling from a geneticist or a genetic ...
(Doctoral thesis / Doktoravhandling, 2011)
(Doctoral thesis / Doktoravhandling, 2018)
Cardiac troponins are intracellular proteins existing solely in cardiac myocytes. Highly sensitive troponin assays have revealed low levels of circulating troponins in individuals with atrial fibrillation that have been ...
(Doctoral thesis / Doktoravhandling, 2007)
Initiation of DNA replication in the bacterium Escherichia coli (E. coli) occurs once per cell cycle at a unique origin site named oriC. The initiator, DnaA, is essential for initiation from oriC. Two control systems have ...
(Doctoral thesis / Doktoravhandling, 2007)
For colorectal cancer surgery is the main and most efficient treatment. In spite of this many patients later suffer from metastases or tumour recurrence. One cause may be peritoneal dissemination of free cancer cells ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Focal cartilage injuries in the knee might have devastating effect due to the predisposition of early onset osteoarthritis. Various surgical treatment options are available, however no statistically ...
(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2012)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background Primary immunodeficiency diseases (PIDDs) are clinically and genetically heterogeneous disorders thus far associated with mutations in more than 300 genes. The clinical phenotypes derived from distinct genotypes ...
(Doctoral thesis / Doktoravhandling, 2013)
High throughput technologies, like next generation sequencing, in combination with assays for probing epigenetic marks, have made it possible to map the epigenetic landscapes of cell types. With the new information the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Despite its commonality, there is a paucity of literature on miscarriage in non-Western societies. In particular, there is little understanding of how people ascribe cause to miscarriage. This ...
(Doctoral thesis / Doktoravhandling, 2013)
(Doctoral thesis / Doktoravhandling, 2013)
ErbB proteins are a family of receptor tyrosine kinases that includes epidermal growth factor receptor (EGFR), ErbB2, ErbB3 and ErbB4. ErbB proteins govern many physiological processes during development and in an adult ...
(Doctoral thesis / Doktoravhandling, 2012)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Alcohol use is a major public health problem with vast implications for poor, war-torn countries. The objective of this study was to describe prevalence of alcohol use and risky drinking across ...
(Doctoral thesis / Doktoravhandling, 2010)
In recent years, there has been an ongoing debate in the health region of Eastern Norway concerning the management of patients with Traumatic Brain Injury (TBI), in order to better understand the extent of problems with ...
(Doctoral thesis / Doktoravhandling, 2016)
Pancreatic neuroendocrine neoplasms (PNENs) comprise approximately five percent of neoplasms originating from the pancreas. Surgical resection is an important treatment option for PNENs because it alone offers the possibility ...
(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2012)
Zopiclone is one of the most commonly prescribed sleep medications in the world. Driving in the morning, after regular nighttime zopiclone consumption, is, by many, considered to be safe traffic wise, due to the fast ...
(Doctoral thesis / Doktoravhandling, 2010)
Elektiv ortopedisk kirurgi hos pasienter med revmatisk leddsykdom
Revmatiske sykdommer fører ofte til leddsmerter og redusert fysisk funksjon. I denne studien rapporterte en stor gruppe pasienter med leddgikt en generell ...