Ultrasound of hand osteoarthritis. Validity, reliability and predictive value of ultrasonography in patients with hand osteoarthritis
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AbstractOsteoarthritis (OA) is the most common musculoskeletal disorder. During the past decades, the concepts of OA have been forever changed with the application of modern imaging techniques such as ultrasonography. While traditionally considered a non-inflammatory “wear-and-tear” disorder of the cartilage, we now acknowledge OA as a complex and multi-tissue disorder of the whole joint, involving cartilage, subchondral bone, ligaments and (increasingly recognized) inflammation of the synovium. Plain radiographs, the current standard for detecting disease incidence and progression, are insensitive and nonspecific to critical changes in joint structure. Ultrasound can visulize both bony and soft tissue aspects of a joint, and detects structural changes that may be early signs of future OA and potential targets for treatment. Exploring the validity and reliability of meaningful sonographic features is critical for their application in future research and clinical practice. With this thesis, the aim is to demonstrate the potentials (and limitations) of ultrasonography as a diagnostic tool in hand OA and how sonographic biomarkers can be used to detect early OA and predict disease progression.
List of papers
|I. Mathiessen A, Haugen IK, Slatkowsky-Christensen B, Bøyesen P, Kvien TK, Hammer HB. Ultrasonographic assessment of osteophytes in 127 patients with hand osteoarthritis: exploring reliability and associations to MRI, radiographs and clinical joint findings. Ann Rheum Dis 2013;72:51-6. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1136/annrheumdis-2011-201195|
|II. Hammer HB, Iagnocco A, Mathiessen A, Filippucci E, Gandjbakhch F, Kortekaas MC, Moller I, Naredo E, Wakefield RJ, Aegerter P, D'Agostino MA. Global ultrasound assessment of structural lesions in osteoarthritis: a reliability study by the OMERACT ultrasonography group on scoring cartilage and osteophytes in finger joints. Ann Rheum Dis 2016;75:402-7. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1136/annrheumdis-2014-206289|
|III. Mathiessen A, Slatkowsky-Christensen B, Kvien TK, Haugen IK and Hammer HB. Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5 years. Ann Rheum Dis 2016;75:825-30. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1136/annrheumdis-2015-207241|
|IV. Mathiessen A, Slatkowsky-Christensen B, Kvien TK, Haugen IK, Hammer HB. Ultrasound-detected osteophytes predict the development of radiographic and clinical features of hand osteoarthritis in the same finger joints 5 years later. RMD Open 2017; [Epub ahead of print]. The article is included in the thesis. Also available in DUO: http://urn.nb.no/URN:NBN:no-62436|