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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
A fusion gene is a hybrid gene consisting of parts from two previously independent genes. Chromosomal rearrangements leading to gene breakage are frequent in high-grade serous ovarian carcinomas ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)
To identify phosphoproteins that might play a role in naringin-sensitive hepatocellular cytoskeletal disruption and apoptosis induced by algal toxins, hepatocyte extracts were separated by gel electrophoresis and immunostained ...
Characterization of the human RFX transcription factor family by regulatory and target gene analysis
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn2+ ion is bound by a motif also present in other metal dependent ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Intercellular communication is pivotal in optimizing and synchronizing cellular responses to keep homeostasis and to respond adequately to external stimuli. In the central nervous system (CNS), glutamatergic and GABAergic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Background
Cardiovascular disease is a major cause of mortality and morbidity worldwide, and primary prevention efforts are poorly developed in people at high cardiovascular risk. On this background, we ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Cultured epidermal cell sheets (CECS) are used in regenerative medicine in patients with burns, and have potential to treat limbal stem cell deficiency (LSCD), as demonstrated in animal models. Despite widespread use, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The six transmembrane protein of prostate 2 (STAMP2) is an androgen‐regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Aquaporin-4 (AQP4) water channels are concentrated in astrocytic endfoot membranes at the brain–blood and brain–cerebrospinal fluid interfaces. The mechanisms underpinning the polarized distribution of AQP4 are poorly ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
With this latest release of ReMap (http://remap.cisreg.eu), we present a unique collection of regulatory regions in human, as a result of a large-scale integrative analysis of ChIP-seq experiments for hundreds of transcriptional ...
(Doctoral thesis / Doktoravhandling, 2020)
Transcriptional regulation is a crucial process for cell differentiation and development. This process is tightly coordinated by the binding of key proteins, called transcription factors (TFs), to the DNA in a sequence-specific ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
GIVE is a framework and library for creating portable and personalized genome browsers. It makes visualizing genomic data as easy as building a laboratory homepage.
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Dendrodendritic electrical signaling via gap junctions is now an accepted feature of neuronal communication in mammalian brain, whereas axodendritic and axosomatic gap junctions have rarely been described. We present ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background. We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented. ...
(Doctoral thesis / Doktoravhandling, 2016)
This thesis is comprised of four papers that make up my doctoral degree thesis at the University of Oslo (UiO). These papers focus on the molecular and functional aspects of the brain-blood interface, with special attention ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The competence-stimulating peptide (CSP) and the sigX-inducing peptide (XIP) are known to induce Streptococcus mutans competence for genetic transformation. For both pheromones, direct identification of the native peptides ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in which cytosolic components and organelles are sequestered by specialized autophagic membranes and degraded through the lysosomal system. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
ABSTRACT
Late endosomes and lysosomes (endolysosomes) receive proteins and cargo from the secretory, endocytic and autophagic pathways. Although these pathways and the degradative processes of endolysosomes are ...
(Journal article / Tidsskriftartikkel / AcceptedVersion, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The secretory and autophagy pathways can be thought of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembrane system. In analogy to anabolic and catabolic pathways in metabolism, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Increased expression of interleukin 6 (IL-6) is associated with poor prognosis and chemoresistance in many different carcinomas, but its role in head and neck squamous cell carcinoma (HNSCC) is still unsettled. Analyzing ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The sodium dependent bicarbonate transporter NCBE/NBCn2 is predominantly expressed in the central nervous system (CNS). The highest protein concentrations are found in the choroid plexus. The primary function of this ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Connexin 43 (Cx43), the predominant gap junction (GJ) protein, directly interacts with the A-kinase-anchoring protein (AKAP) Ezrin in human cytotrophoblasts and a rat liver epithelial cells (IAR20). The Cx43-Ezrin–protein ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Förster Resonance Energy Transfer , abbreviated FRET , is a fluorescence phenomenon, which can be used to study and map co-localizations and dynamics of co-localizations at nanometer precision on a light microscope. FRET ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
A common task for scientists relies on comparing lists of genes or genomic regions derived from high-throughput sequencing experiments. While several tools exist to intersect and visualize sets ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Bulk autophagy is characterized by the sequestration of large portions of cytoplasm into double/multi-membrane structures termed autophagosomes. Here a simple protocol to monitor this process is described. Moreover, typical ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Trace or chromatogram files (raw data) are produced by automatic nucleic acid sequencing equipment or sequencers. Each file contains information which can be interpreted by specialised software ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Cancer immunotherapy has finally come of age, demonstrated by recent progress in strategies that engage the endogenous adaptive immune response in tumor killing. Occasionally, significant and durable tumor regression has ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background
Attitudes to, and practices of, scientific authorship vary. We have studied this variation among researchers in a university hospital and medical school in Norway.
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
We here report a novel phage display selection strategy enabling fast and easy selection of thermostabilized proteins. The approach is illustrated with stabilization of an aggregation-prone soluble single chain T cell ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Itch-producing compounds stimulate receptors expressed on small diameter fibers that innervate the skin. Many of the currently known pruritogen receptors are Gq Protein-Coupled Receptors (GqPCR), ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Albumin has a serum half-life of 3 weeks in humans. This has been utilized to extend the serum persistence of biopharmaceuticals that are fused to albumin. In light of the fact that the neonatal Fc receptor (FcRn) is a key ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Antibodies are key molecules in the fight against infections. Although previously thought to mediate protection solely in the extracellular environment, recent research has revealed that antibody-mediated protection extends ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Recorded potentials in the extracellular space (ECS) of the brain is a standard measure of population activity in neural tissue. Computational models that simulate the relationship between the ECS potential and its underlying ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Inhibition of the tankyrase enzymes (TNKS1 and TNKS2) has recently been shown to induce highly dynamic assemblies of β-catenin destruction complex components known as degradasomes, which promote degradation of β-catenin ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Executive functions are often affected in autism spectrum disorders (ASD). The underlying biology is however not well known. In the DSM-5, ASD is characterized by difficulties in two domains: Social Interaction and Repetitive ...
(Doctoral thesis / Doktoravhandling, 2017)
Previous work on the calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) has focussed, in particular, on the contribution of CaMKK2 as an androgen receptor target gene to the development and progression of prostate cancer. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The immense increase in availability of genomic scale datasets, such as those provided by the ENCODE and Roadmap Epigenomics projects, presents unprecedented opportunities for individual researchers to pose novel falsifiable ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Albumin is an abundant blood protein that acts as a transporter of a plethora of small molecules like fatty acids, hormones, toxins, and drugs. In addition, it has an unusual long serum half-life in humans of nearly 3 ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Strategies to improve communication in people with dementia are warranted. We examined the effect of the Sonas programme on communication ability in persons with moderate to severe dementia.
Methods: A 24-week ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wide range of molecules such as fatty acids, metabolites, hormones, and toxins. In addition, it binds a variety of drugs. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Extracellular fibroblast growth factor 1 (FGF1) acts through cell surface tyrosine kinase receptors, but FGF1 can also act directly in the cell nucleus, as a result of nuclear import of endogenously produced, non-secreted ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Prostate cancer is the second most common cause of cancer-associated deaths in men and signalling via a transcription factor called androgen receptor (AR) is an important driver of the disease. Androgen treatment is known ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Wnt signalling is prevented by the proteosomal degradation of β-catenin, which occurs in a destruction complex containing adenomatous polyposis coli (APC), APC-like (APCL), Axin and Axin2. Truncating mutations of the APC ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Current clinical algorithms are unable to precisely predict which colorectal cancer patients would benefit from adjuvant chemotherapy, and there is a need for novel biomarkers to improve the selection of patients. The ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Whole transcriptome sequencing was used to study a small round cell tumor in which a t(4;19)(q35;q13) was part of the complex karyotype but where the initial reverse transcriptase PCR (RT-PCR) examination did not detect a ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
The ability to appraise claims about the benefits and harms of treatments is crucial for informed health care decision-making. This research aims to enable children in East African primary schools (the clusters) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Glutamine synthetase (GS) is ubiquitously expressed in mammalian organisms and is a key enzyme in nitrogen metabolism. It is the only known enzyme capable of synthesising glutamine, an amino acid with many critical roles ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background
Activated protein C (PC) is a serine protease that regulates blood coagulation by inactivating coagulation factors Va and VIIIa. PC deficiency is an autosomally inherited disorder associated with ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Myolipoma of soft tissue is an extremely rare benign tumor composed of mature adipose tissue and smooth muscle cells. It is found predominantly in women. The cytogenetic and molecular genetic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
The ability to detect neoplasia-specific fusion genes is important not only in cancer research, but also increasingly in clinical settings to ensure that correct diagnosis is made and the optimal ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background
Microarray Comparative Genomic Hybridization (array CGH) provides a means to examine DNA copy number aberrations. Various platforms, brands and underlying technologies are available, facing the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Pancreatic adenocarcinoma is a lethal disease with 5-year survival of less than 5%. 5-fluorouracil (5-FU) is a principal first-line therapy, but treatment only extends survival modestly and is seldom curative. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The study of proteins and the interactions between them, known as Protein-Protein Interactions (PPI), is extremely important in interpreting all biological cellular functions. In this article, a new web tool called ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
Background
The Atlantic salmon is an important aquaculture species and a very interesting species biologically, since it spawns in fresh water and develops through several stages before becoming a smolt, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
Colorectal cancer (CRC) is a heterogeneous disease that, on the molecular level, can be characterized by inherent genomic instabilities; chromosome instability and microsatellite instability. In ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The main objective of this study was to map global geneexpression in order to provide information about the populations of mRNA species participating in murine tooth development at 24 h intervals, starting at the eleventh ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
The members of the protein kinase C (PKC) family consist of serine/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKCδ, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Upon stimulation of the T cell receptor, proteins involved in proximal T cell signaling gather in lipid rafts to guide external stimuli to the intracellular compartment through the formation of signaling complexes. The ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The androgen receptor is a key transcription factor contributing to the development of all stages of prostate cancer (PCa). In addition, other transcription factors have been associated with poor prognosis in PCa, amongst ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
The present study was performed to compare blood product consumption and clinical results in consecutive, unselected trauma patients during the first 6 months of year 2002, 2004 and 2007.
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
Rapid means to discover and enumerate unknown mutations in the exons of human genes on a pangenomic scale are needed to discover the genes carrying inherited risk for common diseases or the genes ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
Background
As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify the genomic mechanisms for specific traits is becoming more important in breeding and management of the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
Background
The behaviour of children with Attention-Deficit / Hyperactivity Disorder is often described as highly variable, in addition to being hyperactive, impulsive and inattentive. One reason might be ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
An altered processing of emotions may contribute to a reduced ability for social interaction and communication in autism spectrum disorder, ASD. We investigated how face-emotion recognition in ASD is different from typically ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian carcinomas (n = 52) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
Alcohol use is increasing among women in Africa, and comparable information about women's current alcohol use is needed to inform national and international health policies relevant to the entire ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their ...
Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
Sequencing of the human genome has led to most genes being available in BAC or PAC vectors. However, limited functional information has been assigned to most of these genes. Techniques for the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background
Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
Protein kinase C epsilon (PKCϵ) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKCϵ is important ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs).
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The mechanisms of successful epigenetic reprogramming in cancer are not well characterized as they involve coordinated removal of repressive marks and deposition of activating marks by a large number of histone and DNA ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Chemokines are attractive candidates for vaccine adjuvants due to their ability to recruit the immune cells. Lactic acid bacteria (LAB)-based delivery vehicles have potential to be used as a cheap and safe option ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
There is a huge effort in developing ligand-mediated targeting of nanoparticles to diseased cells and tissue. The plant toxin ricin has been shown to enter cells by utilizing both dynamin-dependent ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Simulation experiments were used to show the impact of varying extraction efficiency, aliquot proportion, and PCR efficiency on the heterozygote balance of a range of diploid and haploid cells. Reducing either parameters ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
The iRefIndex consolidates protein interaction data from ten databases in a rigorous manner using sequence-based hash keys. Working with consolidated interaction data comes with distinct challenges: ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression–methylation ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Chromosomal rearrangements such as inversions can play a crucial role in maintaining polymorphism underlying complex traits and contribute to the process of speciation. In Atlantic cod (Gadus morhua), inversions of several ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein ...