dc.date.accessioned | 2023-01-25T17:41:35Z | |
dc.date.available | 2023-01-25T17:41:35Z | |
dc.date.created | 2022-10-31T15:09:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Stavem, Knut Einvik, Gunnar Tholin, Birgitte Ghanima, Waleed Hessen, Erik Lundqvist, Christofer . Cognitive function in non-hospitalized patients 8–13 months after acute COVID-19 infection: A cohort study in Norway. PLOS ONE. 2022, 17(8) | |
dc.identifier.uri | http://hdl.handle.net/10852/99162 | |
dc.description.abstract | Studies have reported reduced cognitive function following COVID-19 illness, mostly from hospital settings with short follow-up times. This study recruited non-hospitalized COVID-19 patients from a general population to study prevalence of late cognitive impairment and associations with initial symptoms. We invited patients with PCR-confirmed COVID-19. A postal questionnaire addressed basic demographics, initial COVID-19 symptoms and co-morbidity about 4 months after diagnosis. About 7 months later, we conducted cognitive tests using the Cambridge Neuropsychological Test Automated Battery, comprising four tests for short-term memory, attention and executive function. We present descriptive statistics using z-scores relative to UK population norms and defined impairment as z-score <-1.5. We used multivariable logistic regression with impairment as outcome. Continuous domain scores were analysed by multiple linear regression. Of the initial 458 participants; 305 were invited, and 234 (77%) completed cognitive testing. At median 11 (range 8–13) months after PCR positivity, cognitive scores for short term memory, visuospatial processing, learning and attention were lower than norms (p≤0.001). In each domain, 4–14% were cognitively impaired; 68/232 (29%) were impaired in ≥ 1 of 4 tests. There was no association between initial symptom severity and impairment. Multivariable linear regression showed association between spatial working memory and initial symptom load (6–9 symptoms vs. 0–5, coef. 4.26, 95% CI: 0.65; 7.86). No other dimension scores were associated with symptom load. At median 11 months after out-of-hospital SARS-Cov-2 infection, minor cognitive impairment was seen with little association between COVID-19 symptom severity and outcome. | |
dc.language | EN | |
dc.publisher | PLOS | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Cognitive function in non-hospitalized patients 8–13 months after acute COVID-19 infection: A cohort study in Norway | |
dc.title.alternative | ENEngelskEnglishCognitive function in non-hospitalized patients 8–13 months after acute COVID-19 infection: A cohort study in Norway | |
dc.type | Journal article | |
dc.creator.author | Stavem, Knut | |
dc.creator.author | Einvik, Gunnar | |
dc.creator.author | Tholin, Birgitte | |
dc.creator.author | Ghanima, Waleed | |
dc.creator.author | Hessen, Erik | |
dc.creator.author | Lundqvist, Christofer | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og lab fag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2066964 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLOS ONE&rft.volume=17&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | PLOS ONE | |
dc.identifier.volume | 17 | |
dc.identifier.issue | 8 | |
dc.identifier.pagecount | 16 | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0273352 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0273352 | |