dc.date.accessioned | 2021-12-20T07:28:18Z | |
dc.date.available | 2021-12-20T07:28:18Z | |
dc.date.created | 2021-11-30T09:35:16Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Ottesen, Akiah Hegelstad, Wenche Joa, Inge Ilner, Stein E. Opjordsmoen Rund, Bjørn Rishovd Røssberg, Jan Ivar Simonsen, Erik Johannessen, Jan Olav Larsen, Tor Ketil Haahr, Ulrik H. McGlashan, T.H. Friis, Svein Melle, Ingrid . Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis. Psychological Medicine. 2021, 1-10 | |
dc.identifier.uri | http://hdl.handle.net/10852/89652 | |
dc.description.abstract | Background
To what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, we compare symptom trajectories and remission over the first 2 years of treatment in FEP with and without CIT and examine if differences are linked to the use of antipsychotics.
Methods
FEP (N = 191) were recruited from in- and outpatient services 1997–2000, and assessed at baseline, 3 months, 1 and 2 years. Inclusion criteria were 15–65 years, actively psychotic with a DSM-IV diagnosis of psychotic disorder and no previous adequate treatment for psychosis. Antipsychotic medication is reported as defined daily dosage (DDD). CIT (<18) was assessed with the Brief Betrayal Trauma Survey, and symptomatic remission based on scores from the Positive and Negative Syndrome Scale.
Results
CIT (n = 63, 33%) was not associated with symptomatic remission at 2 years follow-up (71% in remission, 14% in relapse), or time to first remission (CIT 12/ no-CIT 9 weeks, p = 0.51). Those with CIT had significantly more severe positive, depressive, and excited symptoms. FEP with physical (N = 39, 20%) or emotional abuse (N = 22, 14, 7%) had higher DDD at 1 year (p < 0.05). Mean DDD did not excerpt a significant between-group effect on symptom trajectories of positive symptoms.
Conclusion
Results indicate that antipsychotic medication is equally beneficial in the achievement of symptomatic remission in FEP after 2 years independent of CIT. Still, FEP patients with CIT had more severe positive, depressive, and excited symptoms throughout. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis | |
dc.type | Journal article | |
dc.creator.author | Ottesen, Akiah | |
dc.creator.author | Hegelstad, Wenche | |
dc.creator.author | Joa, Inge | |
dc.creator.author | Ilner, Stein E. Opjordsmoen | |
dc.creator.author | Rund, Bjørn Rishovd | |
dc.creator.author | Røssberg, Jan Ivar | |
dc.creator.author | Simonsen, Erik | |
dc.creator.author | Johannessen, Jan Olav | |
dc.creator.author | Larsen, Tor Ketil | |
dc.creator.author | Haahr, Ulrik H. | |
dc.creator.author | McGlashan, T.H. | |
dc.creator.author | Friis, Svein | |
dc.creator.author | Melle, Ingrid | |
cristin.unitcode | 185,53,0,0 | |
cristin.unitname | Institutt for klinisk medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1961387 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychological Medicine&rft.volume=&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Psychological Medicine | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 10 | |
dc.identifier.doi | https://doi.org/10.1017/S003329172100427X | |
dc.identifier.urn | URN:NBN:no-92266 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0033-2917 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/89652/1/childhood-trauma-antipsychotic-medication-and-symptom-remission-in-first-episode-psychosis.pdf | |
dc.type.version | PublishedVersion | |