A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium
dc.date.accessioned | 2021-09-29T16:15:31Z | |
dc.date.available | 2021-09-29T16:15:31Z | |
dc.date.created | 2021-09-21T16:15:19Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Gutman, Boris A. van Erp, Theo G.M. Alpert, Kathryn I. Ching, Christopher Isaev, Dmitry Ragothaman, Anjani Jahanshad, Neda Saremi, Arvin Zavaliangos-Petropulu, Artemis Glahn, David C. Shen, Li Cong, Shan Alnæs, Dag Andreassen, Ole Doan, Nhat Trung Westlye, Lars Tjelta Kochunov, Peter Satterthwaite, Theodore D. Wolf, Daniel H. Huang, Alexander J. Kessler, Charles Weideman, Andrea Nguyen, Dana Mueller, Bryon A. Faziola, Lawrence Potkin, Steven G. Preda, Adrian Mathalon, Daniel Bustillo, Juan R. Calhoun, Vince D. Ford, Judith M. Walton, Esther Ehrlich, Stefan Ducci, Giuseppe Banaj, Nerisa Piras, Fabrizio Piras, Federica Spalletta, Gianfranco Canales-Rodríguez, Erick J. Fuentes-Claramonte, Paola Pomarol-Clotet, Edith Radua, Joaquim Salvador, Raymond Sarró, Salvador Dickie, Erin W. Voineskos, Aristotle N. Tordesillas-Gutierrez, Diana Crespo-Facorro, Benedicto Setién-Suero, Esther van Son, Jacqueline Mayoral Borgwardt, Stefan Schönborn-Harrisberger, Fabienne Morris, Derek W. Donohoe, Gary Holleran, Laurena Cannon, Dara M. McDonald, Colm Corvin, Aiden Gill, Michael Filho, Geraldo Busatto Rosa, Pedro G. Serpa, Mauricio H. Zanetti, Marcus V. Lebedeva, Irina Kaleda, Vasily Tomyshev, Alexander S. Crow, Tim James, Anthony Cervenka, Simon Sellgren, Carl M Fatouros-Bergman, Helena Agartz, Ingrid Howells, Fleur M. Stein, Dan J. Temmingh, Henk Uhlmann, Anne De Zubicaray, Greig I McMahon, Katie L. Wright, Margaret J. Cobia, Derin Csernansky, John G. Thompson, Paul M. Turner, Jessica A. Wang, Lei . A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium. Human Brain Mapping. 2021 | |
dc.identifier.uri | http://hdl.handle.net/10852/88668 | |
dc.description.abstract | Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium | |
dc.type | Journal article | |
dc.creator.author | Gutman, Boris A. | |
dc.creator.author | van Erp, Theo G.M. | |
dc.creator.author | Alpert, Kathryn I. | |
dc.creator.author | Ching, Christopher | |
dc.creator.author | Isaev, Dmitry | |
dc.creator.author | Ragothaman, Anjani | |
dc.creator.author | Jahanshad, Neda | |
dc.creator.author | Saremi, Arvin | |
dc.creator.author | Zavaliangos-Petropulu, Artemis | |
dc.creator.author | Glahn, David C. | |
dc.creator.author | Shen, Li | |
dc.creator.author | Cong, Shan | |
dc.creator.author | Alnæs, Dag | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Doan, Nhat Trung | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Kochunov, Peter | |
dc.creator.author | Satterthwaite, Theodore D. | |
dc.creator.author | Wolf, Daniel H. | |
dc.creator.author | Huang, Alexander J. | |
dc.creator.author | Kessler, Charles | |
dc.creator.author | Weideman, Andrea | |
dc.creator.author | Nguyen, Dana | |
dc.creator.author | Mueller, Bryon A. | |
dc.creator.author | Faziola, Lawrence | |
dc.creator.author | Potkin, Steven G. | |
dc.creator.author | Preda, Adrian | |
dc.creator.author | Mathalon, Daniel | |
dc.creator.author | Bustillo, Juan R. | |
dc.creator.author | Calhoun, Vince D. | |
dc.creator.author | Ford, Judith M. | |
dc.creator.author | Walton, Esther | |
dc.creator.author | Ehrlich, Stefan | |
dc.creator.author | Ducci, Giuseppe | |
dc.creator.author | Banaj, Nerisa | |
dc.creator.author | Piras, Fabrizio | |
dc.creator.author | Piras, Federica | |
dc.creator.author | Spalletta, Gianfranco | |
dc.creator.author | Canales-Rodríguez, Erick J. | |
dc.creator.author | Fuentes-Claramonte, Paola | |
dc.creator.author | Pomarol-Clotet, Edith | |
dc.creator.author | Radua, Joaquim | |
dc.creator.author | Salvador, Raymond | |
dc.creator.author | Sarró, Salvador | |
dc.creator.author | Dickie, Erin W. | |
dc.creator.author | Voineskos, Aristotle N. | |
dc.creator.author | Tordesillas-Gutierrez, Diana | |
dc.creator.author | Crespo-Facorro, Benedicto | |
dc.creator.author | Setién-Suero, Esther | |
dc.creator.author | van Son, Jacqueline Mayoral | |
dc.creator.author | Borgwardt, Stefan | |
dc.creator.author | Schönborn-Harrisberger, Fabienne | |
dc.creator.author | Morris, Derek W. | |
dc.creator.author | Donohoe, Gary | |
dc.creator.author | Holleran, Laurena | |
dc.creator.author | Cannon, Dara M. | |
dc.creator.author | McDonald, Colm | |
dc.creator.author | Corvin, Aiden | |
dc.creator.author | Gill, Michael | |
dc.creator.author | Filho, Geraldo Busatto | |
dc.creator.author | Rosa, Pedro G. | |
dc.creator.author | Serpa, Mauricio H. | |
dc.creator.author | Zanetti, Marcus V. | |
dc.creator.author | Lebedeva, Irina | |
dc.creator.author | Kaleda, Vasily | |
dc.creator.author | Tomyshev, Alexander S. | |
dc.creator.author | Crow, Tim | |
dc.creator.author | James, Anthony | |
dc.creator.author | Cervenka, Simon | |
dc.creator.author | Sellgren, Carl M | |
dc.creator.author | Fatouros-Bergman, Helena | |
dc.creator.author | Agartz, Ingrid | |
dc.creator.author | Howells, Fleur M. | |
dc.creator.author | Stein, Dan J. | |
dc.creator.author | Temmingh, Henk | |
dc.creator.author | Uhlmann, Anne | |
dc.creator.author | De Zubicaray, Greig I | |
dc.creator.author | McMahon, Katie L. | |
dc.creator.author | Wright, Margaret J. | |
dc.creator.author | Cobia, Derin | |
dc.creator.author | Csernansky, John G. | |
dc.creator.author | Thompson, Paul M. | |
dc.creator.author | Turner, Jessica A. | |
dc.creator.author | Wang, Lei | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1936730 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Human Brain Mapping&rft.volume=&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Human Brain Mapping | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1002/hbm.25625 | |
dc.identifier.urn | URN:NBN:no-91290 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1065-9471 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/88668/2/A%2Bmeta-analysis%2Bof%2Bdeep%2Bbrain%2Bstructural%2Bshape%2Band%2Basymmetry%2Babnormalities%2Bin%2B2%252C833%2Bindividuals%2Bwith%2Bschizophrenia%2Bcompared%2Bwith%2B3%252C929%2Bhealthy%2Bvolunteers%2Bvia%2Bthe%2BENIGMA%2BConsortium.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | hbm.25625 |
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Psykologisk institutt [114]
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Institutt for klinisk medisin [137]
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