dc.date.accessioned | 2021-01-13T20:34:30Z | |
dc.date.available | 2021-01-13T20:34:30Z | |
dc.date.created | 2020-06-19T13:33:02Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Espenes, Ragna Kirsebom, Bjørn-Eivind Eriksson, Cecilia Magdalena Waterloo, Knut K Hessen, Erik Johnsen, Stein Harald Selnes, Per Fladby, Tormod . Amyloid plaques and symptoms of depression links to medical help-seeking due to subjective cognitive decline. Journal of Alzheimer's Disease. 2020, 75(3), 879-890 | |
dc.identifier.uri | http://hdl.handle.net/10852/82191 | |
dc.description.abstract | Background:
Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer’s disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic.
Objective:
To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive symptoms in SCD.
Methods:
We compared levels of cerebrospinal fluid (CSF) Aβ1 - 42, cognitive performance, and depressive symptoms (15-item Geriatric Depression Scale, GDS-15) between healthy controls (n = 88), SCD with a history of medical help seeking (SCD-HS, n = 67), and SCD non help-seekers (SCD-NHS, n = 44). Cases with evidence of amyloid plaques (CSF Aβ1 - 42 ≤708 ng/l) and symptoms of depression (GDS-15≥6) were determined in both SCD groups.
Results:
The SCD-HS group had lower CSF Aβ1 - 42 (p < 0.01), lower word list learning and memory recall (p < 0.0001), and an increased level of depressive symptoms (p < 0.0001) compared to controls and SCD-NHS cases. The SCD-HS group had more cases with symptoms of depression (n = 12, 18%) and amyloid plaques (n = 18, 27%) compared to SCD-NHS (n = 1, 2% and n = 7, 16%, respectively). None of the SCD-HS cases and only one SCD-NHS case had concurrent symptoms of depression and amyloid plaques. The SCD-HS cases showed equal word list learning and memory performance regardless of amyloid status or symptoms of depression.
Conclusion:
Medical help-seeking in SCD is associated with an increased risk of AD pathology or symptoms of depression. However, subtle memory deficits are seen in SCD help-seekers, also without amyloid plaques or symptoms of depression. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Amyloid plaques and symptoms of depression links to medical help-seeking due to subjective cognitive decline | |
dc.type | Journal article | |
dc.creator.author | Espenes, Ragna | |
dc.creator.author | Kirsebom, Bjørn-Eivind | |
dc.creator.author | Eriksson, Cecilia Magdalena | |
dc.creator.author | Waterloo, Knut K | |
dc.creator.author | Hessen, Erik | |
dc.creator.author | Johnsen, Stein Harald | |
dc.creator.author | Selnes, Per | |
dc.creator.author | Fladby, Tormod | |
cristin.unitcode | 185,17,5,0 | |
cristin.unitname | Psykologisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1816345 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Alzheimer's Disease&rft.volume=75&rft.spage=879&rft.date=2020 | |
dc.identifier.jtitle | Journal of Alzheimer's Disease | |
dc.identifier.volume | 75 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 879 | |
dc.identifier.endpage | 890 | |
dc.identifier.doi | https://doi.org/10.3233/JAD-190712 | |
dc.identifier.urn | URN:NBN:no-85105 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1387-2877 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/82191/2/artikkel79328.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/269774 | |