dc.date.accessioned | 2019-12-20T09:18:43Z | |
dc.date.available | 2019-12-20T09:18:43Z | |
dc.date.created | 2019-01-21T09:35:31Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Grydeland, Håkon Vértes, Petra Váša, František Romero-Garcia, Rafael Whitaker, Kirstie Aaron F., Alexander-Bloch Bjørnerud, Atle Patel, Ameera X. Sederevicius, Donatas Tamnes, Christian Krog Westlye, Lars Tjelta White, Simon Walhovd, Kristine B Fjell, Anders Martin Bullmore, Edward T. . Waves of Maturation and Senescence in Microstructural MRI Markers of Human Cortical Myelination over the Lifespan. Cerebral Cortex. 2018 | |
dc.identifier.uri | http://hdl.handle.net/10852/71815 | |
dc.description.abstract | Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8–85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of seven cytoarchitectonic classes. From the first derivatives of these generally inverted-U trajectories, we defined three milestones: the age at peak growth; the age at onset of a stable plateau; and the age at the onset of decline. Age at peak growth had a bimodal distribution comprising an early (pre-pubertal) wave of primary sensory and motor cortices and a later (post-pubertal) wave of association, insular and limbic cortices. Most regions reached stability in the 30-s but there was a second wave reaching stability in the 50-s. Age at onset of decline was also bimodal: in some right hemisphere regions, the curve declined from the 60-s, but in other left hemisphere regions, there was no significant decline from the stable plateau. These results are consistent with regionally heterogeneous waves of intracortical myelinogenesis and age-related demyelination. | en_US |
dc.language | EN | |
dc.publisher | Oxford University Press | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Waves of Maturation and Senescence in Microstructural MRI Markers of Human Cortical Myelination over the Lifespan | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Grydeland, Håkon | |
dc.creator.author | Vértes, Petra | |
dc.creator.author | Váša, František | |
dc.creator.author | Romero-Garcia, Rafael | |
dc.creator.author | Whitaker, Kirstie | |
dc.creator.author | Aaron F., Alexander-Bloch | |
dc.creator.author | Bjørnerud, Atle | |
dc.creator.author | Patel, Ameera X. | |
dc.creator.author | Sederevicius, Donatas | |
dc.creator.author | Tamnes, Christian Krog | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | White, Simon | |
dc.creator.author | Walhovd, Kristine B | |
dc.creator.author | Fjell, Anders Martin | |
dc.creator.author | Bullmore, Edward T. | |
cristin.unitcode | 185,17,5,0 | |
cristin.unitname | Psykologisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1661898 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2018 | |
dc.identifier.jtitle | Cerebral Cortex | |
dc.identifier.pagecount | 13 | |
dc.identifier.doi | https://doi.org/10.1093/cercor/bhy330 | |
dc.identifier.urn | URN:NBN:no-74937 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1047-3211 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/71815/2/bhy330.pdf | |
dc.type.version | PublishedVersion | |