• English
    • Norsk
  • English 
    • English
    • Norsk
  • Administration
View Item 
  •   Home
  • Øvrige samlinger
  • Høstingsarkiver
  • CRIStin høstingsarkiv
  • View Item
  •   Home
  • Øvrige samlinger
  • Høstingsarkiver
  • CRIStin høstingsarkiv
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The Disconnected Brain and Executive Function Decline in Aging

Fjell, Anders Martin; Sneve, Markus Handal; Grydeland, Håkon; Storsve, Andreas Berg; Walhovd, Kristine B
Journal article; AcceptedVersion; Peer reviewed
View/Open
s1-ln2282068516 ... 996022820685PDF_HI0001.pdf (1.962Mb)
Year
2016
Permanent link
http://urn.nb.no/URN:NBN:no-56285

CRIStin
1358294

Metadata
Show metadata
Appears in the following Collection
  • Psykologisk institutt [2924]
  • CRIStin høstingsarkiv [15979]
Original version
Cerebral Cortex. 2016, DOI: http://dx.doi.org/10.1093/cercor/bhw082
Abstract
Higher order speeded cognitive abilities depend on efficient coordination of activity across the brain, rendering them vulnerable to age reductions in structural and functional brain connectivity. The concept of “disconnected aging” has been invoked, suggesting that degeneration of connections between distant brain regions cause cognitive reductions. However, it has not been shown that changes in cognitive functions over time can be explained by simultaneous changes in brain connectivity. We followed 119 young and middle-aged (23–52 years) and older (63–86 years) adults for 3.3 years with repeated assessments of structural and functional brain connectivity and executive functions. We found unique age-related longitudinal reductions in executive function over and above changes in more basic cognitive processes. Intriguingly, 82.5% of the age-related decline in executive function could be explained by changes in connectivity over time. While both structural and functional connectivity changes were related to longitudinal reductions in executive function, only structural connectivity change could explain the age-specific decline. This suggests that the major part of the age-related reductions in executive function can be attributed to micro- and macrostructural alterations in brain connectivity. Although correlational in nature, we believe the present results constitute evidence for a “disconnected brain” view on cognitive aging.

This is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral Cortex following peer review. The version of record is available online at: http://dx.doi.org/10.1093/cercor/bhw082.
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy
 

 

For students / employeesSubmit master thesisAccess to restricted material

Browse

All of DUOCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

For library staff

Login
RSS Feeds
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy