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dc.date.accessioned2016-10-26T06:53:28Z
dc.date.available2017-04-12T22:31:10Z
dc.date.created2016-05-30T11:06:47Z
dc.date.issued2016
dc.identifier.citationFjell, Anders Martin Sneve, Markus Handal Grydeland, Håkon Storsve, Andreas Berg Walhovd, Kristine B . The Disconnected Brain and Executive Function Decline in Aging. Cerebral Cortex. 2016
dc.identifier.urihttp://hdl.handle.net/10852/52947
dc.description.abstractHigher order speeded cognitive abilities depend on efficient coordination of activity across the brain, rendering them vulnerable to age reductions in structural and functional brain connectivity. The concept of “disconnected aging” has been invoked, suggesting that degeneration of connections between distant brain regions cause cognitive reductions. However, it has not been shown that changes in cognitive functions over time can be explained by simultaneous changes in brain connectivity. We followed 119 young and middle-aged (23–52 years) and older (63–86 years) adults for 3.3 years with repeated assessments of structural and functional brain connectivity and executive functions. We found unique age-related longitudinal reductions in executive function over and above changes in more basic cognitive processes. Intriguingly, 82.5% of the age-related decline in executive function could be explained by changes in connectivity over time. While both structural and functional connectivity changes were related to longitudinal reductions in executive function, only structural connectivity change could explain the age-specific decline. This suggests that the major part of the age-related reductions in executive function can be attributed to micro- and macrostructural alterations in brain connectivity. Although correlational in nature, we believe the present results constitute evidence for a “disconnected brain” view on cognitive aging. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral Cortex following peer review. The version of record is available online at: http://dx.doi.org/10.1093/cercor/bhw082.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherOxford University Press
dc.titleThe Disconnected Brain and Executive Function Decline in Agingen_US
dc.typeJournal articleen_US
dc.creator.authorFjell, Anders Martin
dc.creator.authorSneve, Markus Handal
dc.creator.authorGrydeland, Håkon
dc.creator.authorStorsve, Andreas Berg
dc.creator.authorWalhovd, Kristine B
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1358294
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2016
dc.identifier.jtitleCerebral Cortex
dc.identifier.doihttp://dx.doi.org/10.1093/cercor/bhw082
dc.identifier.urnURN:NBN:no-56285
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1047-3211
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/52947/1/s1-ln22820685161171723-1939656818Hwf1541594443IdV-202670996022820685PDF_HI0001.pdf
dc.type.versionAcceptedVersion


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