dc.date.accessioned | 2015-09-22T15:50:58Z | |
dc.date.available | 2015-09-22T15:50:58Z | |
dc.date.created | 2015-08-19T12:27:27Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Brandt, Christine Lycke Doan, Nhat Trung Tønnesen, Siren Agartz, Ingrid Hugdahl, Kenneth Melle, Ingrid Andreassen, Ole Andreas Westlye, Lars Tjelta . Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis. NeuroImage: Clinical. 2015 | |
dc.identifier.uri | http://hdl.handle.net/10852/46088 | |
dc.description.abstract | Schizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural cortical and subcortical brain abnormalities have been documented, but little is known about how task-related brain activation is associated with brain anatomy in SZ compared to healthy controls (HC). Utilizing linked independent component analysis (LICA), a data-driven multimodal analysis approach, we investigated structure–function associations in a large sample of SZ (n = 96) and HC (n = 142). We tested for associations between task-positive (fronto-parietal) and task-negative (default-mode) brain networks derived from fMRI activation during an n-back working memory task, and brain structural measures of surface area, cortical thickness, and gray matter volume, and to what extent these associations differed in SZ compared to HC. A significant association (p < .05, corrected for multiple comparisons) was found between a component reflecting the task-positive fronto-parietal network and another component reflecting cortical thickness in fronto-temporal brain regions in SZ, indicating increased activation with increased thickness. Other structure–function associations across, between and within groups were generally moderate and significant at a nominal p-level only, with more numerous and stronger associations in SZ compared to HC. These results indicate a complex pattern of moderate associations between brain activation during cognitive processing and brain morphometry, and extend previous findings of fronto-temporal brain abnormalities in SZ by suggesting a coupling between cortical thickness of these brain regions and working memory-related brain activation. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Brandt, Christine Lycke | |
dc.creator.author | Doan, Nhat Trung | |
dc.creator.author | Tønnesen, Siren | |
dc.creator.author | Agartz, Ingrid | |
dc.creator.author | Hugdahl, Kenneth | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Andreassen, Ole Andreas | |
dc.creator.author | Westlye, Lars Tjelta | |
cristin.unitcode | 185,50,0,0 | |
cristin.unitname | Det medisinske fakultet | |
cristin.ispublished | false | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1258810 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NeuroImage: Clinical&rft.volume=&rft.spage=&rft.date=2015 | |
dc.identifier.jtitle | NeuroImage: Clinical | |
dc.identifier.volume | 9 | |
dc.identifier.startpage | 253 | |
dc.identifier.endpage | 263 | |
dc.identifier.doi | 10.1016/j.nicl.2015.08.010 | |
dc.identifier.urn | URN:NBN:no-50292 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2213-1582 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/46088/2/Brandt%2Bet%2Bal.%2B2015%2BNIClinical.pdf | |
dc.type.version | PublishedVersion | |