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(Doctoral thesis / Doktoravhandling, 2024)
The Atlantic cod possesses a unique immune system, with an evolutionary loss of key genes crucial for antibody responses to conventional vaccines and combating infectious diseases in other vertebrates. This work found an ...
The Effect on Mutated Tau Expression in Higher Visual Areas on Visual Discrimination Learning Restricted Access
(Master thesis / Masteroppgave, 2023)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Eusociality is widely considered to evolve through kin selection, where the reproductive success of an individual’s close relative is favored at the expense of its own. High genetic relatedness ...
(Master thesis / Masteroppgave, 2023)
The euphausiid Meganyctiphanes norvegica performs diel vertical migrations (DVMs), staying in deeper waters during the day and ascending to the shallows at night. This behaviour is interpreted as a trade-off between food ...
(Doctoral thesis / Doktoravhandling, 2023)
In the future, pesticide transport and exposure in aquatic environments are expected to be altered by land-use and climate changes. These changes may lead to higher exposure concentrations and changes in agricultural ...
Turning off autophagy: Investigation of the role of TOR and the Ubiquitin Proteasome System. Restricted Access
(Master thesis / Masteroppgave, 2023)
Perturbations of perineuronal nets in the medial prefrontal cortex during learning of a visual discrimination task Restricted Access
(Master thesis / Masteroppgave, 2023)
(Doctoral thesis / Doktoravhandling, 2023)
Pharmaceuticals are an important part of human pollution. Their use has been linked to several well-known wildlife crises, such as a population collapse of vultures in India and Pakistan, or the feminisation of fish ...
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Harmful algal blooms can be devastating to local ecosystems as well as have major impacts on economy and aquaculture. Chrysochromulina leadbeateri caused the death of an estimated seven and a half million farmed salmon in ...
(Doctoral thesis / Doktoravhandling, 2023)
Research on persistent organic pollutants (POPs) in tropical regions is scarce, with most efforts concentrated in the Global North. This disparity is concerning as new contaminants are being synthesized and old contaminants ...
(Master thesis / Masteroppgave, 2022)
Cardiovascular disease (CVD) is a major contributor to both mortality and disability worldwide, with numbers of cases continuously rising. While CVD is commonly thought to primarily affect men, it is a main killer amongst ...
(Master thesis / Masteroppgave, 2022)
Characterization of the substrate interaction sites in factor seven activating protease (FSAP) Restricted Access
(Master thesis / Masteroppgave, 2022)
(Doctoral thesis / Doktoravhandling, 2022)
Many lakes worldwide are supersaturated with CO2, making them net emitters of CO2 to the atmosphere. In order to predict the future and be able to mitigate the effects of climate change, knowledge of the processes behind ...
(Doctoral thesis / Doktoravhandling, 2022)
Palladium nanoparticles (Pd NPs) offer a wide range of novel and exciting applications in catalysis, medicine, engineering, and electronics. Currently, these NPs are synthesized using conventional physical and chemical ...
(Doctoral thesis / Doktoravhandling, 2022)
Being exposed to psychosocial stress activates biological processes that is normally self-regulating. However, if this self-regulation fails it might have consequences. In this thesis it was shown that abusive supervision ...
(Doctoral thesis / Doktoravhandling, 2022)
Hardangervidda is the most extensive mountain plateau in Europe, where brown trout Salmo trutta is almost the only fish species present. A rich supply of crustacean food items such as Lepidurus arcticus, Gammarus lacustris ...
(Master thesis / Masteroppgave, 2022)
The microbiome is important for many functions in animals, for example digestion, skin health and communication. Microbiome and immune system interactions are especially interesting in relation to possible odour signalling. ...
(Doctoral thesis / Doktoravhandling, 2022)
In my PhD project, I studied the functions of three different proteins of the Rab family. The Rab proteins are most known for regulating the transport between the different organelles within the cell, but increasing evidence ...
Integration of DNA Methylation and Gene Expression in Lung Adenocarcinoma: Epigenetic Regulation, Patient Classification, and Prognosis Restricted Access
(Master thesis / Masteroppgave, 2022)
Despite the increased molecular understanding of lung cancer, advances in therapy, and reduced smoking rates in developed countries, lung cancer remains the deadliest cancer type in the world today. Lung adenocarcinoma ...
(Master thesis / Masteroppgave, 2022)
The major histocompatibility complex (MHC) genes are highly diverse in vertebrates and have demonstrated to yield a higher fitness with an optimal diversity that is neither too high nor too low. MHC based mate choice has ...
(Doctoral thesis / Doktoravhandling, 2022)
River ecosystems are hot-spots of biodiversity, hosting many unique species and providing key ecosystem services. Nowadays these ecosystems are threatened by multiple stressors and human impact is the paramount reason. ...
Screening for Compounds that Can Alter Unfolded Protein Response Activity in Prostate Cancer Cells Restricted Access
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
Farmland bird populations in Europe have experienced a decline the last forty years due to agricultural intensification and land abandonment. This included Yellowhammer (Emberiza citrinella) populations. Yellowhammer ...
(Doctoral thesis / Doktoravhandling, 2022)
The vast diversity of species we encounter in nature has always fascinated scientists, thus the evolutionary processes responsible for the origin of new species (speciation) is a topic of constant interest among biologists. ...
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
Den økende populariteten til sanking har gjort at tradisjonell kunnskap (TEK) om sanking i Norge nå blir diskutert gjennom mange steder, inkludert litteratur, litteratur på nettet, sosiale medier og in situ kurs. Bruken ...
Dynamic regulation of autophagy by metabolic circuits in S. cerevisiae Restricted Access
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
Pancreatic ductal adenocarcinoma (PDAC), often referred to as pancreatic cancer is one of the most aggressive and deadliest cancer types, with a 5-year survival rate of less than 10%. PDAC is characterized by vague, ...
(Doctoral thesis / Doktoravhandling, 2022)
Climate change and human activities are currently affecting species around us in a variety of ways. For instance, many species are expanding their range and settling further north in the northern hemisphere as the climate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background
Cystoscopy is the gold standard for bladder cancer detection, but is costly, invasive and has imperfect diagnostic accuracy. We aimed to identify novel and accurate DNA methylation biomarkers ...
(Doctoral thesis / Doktoravhandling, 2021)
Plague is a disease of rodents and is transmitted through their fleas. Humans are only occasionally infected. Direct human-to-human transmission through droplets happens rarely. The low plague activity in humans nowadays ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Forest loss and degradation are the most significant threats to terrestrial biodiversity in the tropics. Promoting flagship or umbrella species is a strategy that can be used to conserve intact forests and restore degraded ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Ongoing climate change threatens biodiversity and directly affects the stability of plant-animal communities. However, it is unclear how the species diversity of biological communities responds to natural climate warming, ...
(Master thesis / Masteroppgave, 2021)
We exposed the microbiome derived from two species of cod, from the outer and inner Oslo fjord to extracts derived from car tire rubber. To determine toxicity we look at growth rate and bacterial diversity as endpoints. ...
(Master thesis / Masteroppgave, 2021)
In this study, we assessed the potential synergistic effects of XBP1 and ATF4 on cell growth in two different PCa cell lines. Through simultaneous siRNA-mediated knockdown of ATF4 and total XBP1, we analyzed effects on ...
(Doctoral thesis / Doktoravhandling, 2021)
Nanoparticles are small particles in the nanometer size range, undetectable by the human eye. Nowadays nanoparticles are investigated as carriers of therapeutic drugs to increase treatment effect and minimize side effects ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
The Benthic Invertebrates of Icelandic Waters programme (BIOICE) was conducted between 1991 and 2004, for the purpose of gathering specimens within the Icelandic Exclusive Economic Zone (59° 58′N – 69° 35‘N and 30° 52’W – ...
Investigation of endosperm development using molecular techniques in model and non-model species of Arabidopsis Restricted Access
(Master thesis / Masteroppgave, 2021)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
porocarps (fruit bodies) are the sexual reproductive stage in the life cycle of many fungi. They are highly nutritious and consequently vulnerable to grazing by birds and small mammals, and invertebrates, and can be infected ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Lipid nanocapsules (LNCs) have proven their efficacy in delivering different drugs to various cancers, but no studies have yet described their uptake mechanisms, paclitaxel (PTX) delivery or resulting cytotoxicity towards ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) ...
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
Combining RIAD and CAR T cell therapy - Experimental studies exploring the effect of blocking tumor immune evasion Restricted Access
(Master thesis / Masteroppgave, 2021)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Herbivores modify the structure and function of tundra ecosystems. Understanding their impacts is necessary to assess the responses of these ecosystems to ongoing environmental changes. However, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
ABSTRACT
Plantations of Norway spruce have been established well beyond its natural range in many parts of the world, potentially impacting native microbial ecosystems and the processes they mediate. In this ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The arctic tundra is undergoing climate-driven changes and there are serious concerns related to the future of arctic biodiversity and altered ecological processes under possible climate change scenarios. Arctic land surface ...
(Master thesis / Masteroppgave, 2021)
Camera trapping is an increasingly important tool in animal ecology that is generally targeted towards large mammals, and especially large carnivores. Nonetheless, the cameras are triggered by all large and medium-sized ...
(Master thesis / Masteroppgave, 2021)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
In the face of increasing drug resistance, the development of new anthelmintics is critical for controlling nematodes that parasitise livestock. Although hymenopteran venom toxins have attracted attention for applications ...
Investigating the cellular mechanism of muscle memory in female mice subjected to testosterone treatment Restricted Access
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
Macrophages are essential innate immune cells which have increasingly become attractive manipulable targets in designing therapies, given their significant involvement in the pathophysiology of several diseases, including ...
(Master thesis / Masteroppgave, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
Research in evolutionary biology is driven by curiosity about the evolution of complex organisms. Their origin and maintenance depend on two conflicting properties ‐ evolvability and robustness. Evolvability is the ability ...
(Master thesis / Masteroppgave, 2020)
The purpose of this study was to find whether exosomes can function as biomarkers for acute leukemia in children, with the long-term goal to assess whether exosomes can be used to predict risk of relapse.
(Master thesis / Masteroppgave, 2020)
Understanding the role of RNA binding protein QKI in the regulation of H2A.Z variants in breast cancer Restricted Access
(Master thesis / Masteroppgave, 2020)
Breast cancer is the most predominant form of cancer in females worldwide. High throughput gene expression analysis has led to classification of breast cancer into distinct molecular subtypes (Parker et al., 2009; Perou ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Advances in whole genome sequencing strategies have provided the opportunity for genomic and comparative genomic analysis of a vast variety of organisms. The analysis results are highly dependent on the quality ...
(Master thesis / Masteroppgave, 2020)
As an effect of climate change and alterations in land use, the ranges of roe deer and also that of their ectoparasites, like the sheep tick (Ixodes ricinus) are expanding. This has also increased the occurrence of tick-borne ...
(Doctoral thesis / Doktoravhandling, 2020)
DNA damaging agents, such as ionizing radiation and many chemotherapeutic drugs, are used in cancer treatment to kill cancer cells. However, networks of signaling cascades induced by DNA damage counteract this by leading ...
Synergia PRR-fecta: Harnessing pathogen-recognition receptor synergy to produce high levels of IL-12p70 & prime dendritic cells for use in cancer immunotherapy Restricted Access
(Master thesis / Masteroppgave, 2020)
Progress in the production of consistent, viable anti-cancer vaccines has been hampered by the lack of a fitting adjuvant capable of eliciting a targeted, cytotoxic response against tumours. The cytokine interleukin 12p70 ...
Establishing expansion microscopy for observation of perineuronal net ultrastructure Restricted Access
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
The surface of Gram-negative bacteria is perforated by β-barrel proteins called outer membrane proteins (OMPs). These β-barrels are integral to the outer membrane (OM) and are essential for the viability of the bacterial ...
(Master thesis / Masteroppgave, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
In her PhD thesis, Synnøve Smebye Botnen investigated the diversity and community ecology of Arctic fungi, from beforehand a poorly studied group of organisms. Climate change will have major impacts on Arctic ecosystems ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Plague has been known since ancient times as a re‐emerging infectious disease, causing considerable socioeconomic burden in regional hotspots. To better understand the epidemiological cycle of the causative agent of the ...
(Doctoral thesis / Doktoravhandling, 2020)
Targeting the DNA damage response to selectively kill cancer cells is a topic of great interest in the field of cancer research. Inhibitors of the cell cycle checkpoint kinases WEE1, CHK1 and ATR have been developed, and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Global economic value of agriculture production resulting from animal pollination services has been estimated to be $235–$577 billion. This estimate is based on quantification of crops that are available at the global ...
(Master thesis / Masteroppgave, 2020)
Urban natur er lite forsket på sammenlignet med uberørt natur, men naturen i og rundt byene er viktig å ha kunnskap om for å kunne ta gode og bærekraftige avgjørelser i byplanlegging og vern av natur. Naturen i og rundt ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A key process affecting variation in the recruitment of fish into fisheries is the spatio-temporal overlap between prey and predator (match-mismatch hypothesis, MMH). The Northeast Arctic cod Gadus morhua and its dominant ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Incomplete lineage sorting (ILS) can lead to biased divergence time estimates. To explore if and how ILS has influenced the results of a recent worldwide phylogeny of three-spined sticklebacks (Gasterosteus aculeatus), we ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Epidemiological studies have found strong associations between air pollution and respiratory effects including development and/or exacerbation of asthma and chronic obstructive pulmonary disease (COPD) as well as increased ...
Populasjonsundersøkelser av dragehode (Dracocephalum ruyschiana) - med fokus på isolasjon, areal, naturtyper og gjengroing på utvalgte lokaliteter i Sørøst-Norge Restricted Access
(Master thesis / Masteroppgave, 2020)
Sammendrag Mange arter er i dag truet med utrydning fordi stadig mer areal blir tatt i bruk eller endret av mennesker. En av disse artene er dragehode (Dracocephalum ruyschiana), som er i kategorien sårbar (VU) på rødlista ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sustainable production of biofuels from lignocellulose feedstocks depends on cheap enzymes for degradation of such biomass. Plants offer a safe and cost‐effective production platform for biopharmaceuticals, vaccines and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Graph-based reference genomes have become popular as they allow read mapping and follow-up analyses in settings where the exact haplotypes underlying a high-throughput sequencing experiment are ...
Molecular mechanisms involved in the regulation of the gap junction channel protein connexin43 by the E3 ubiquitin ligase ITCH Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The aim of the present study was to investigate effects of defined mixtures of polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× = H) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Chromatin post‐translational modifications are thought to be important for epigenetic effects on gene expression. Methylation of histone N‐terminal tail lysine residues constitutes one of many such modifications, executed ...
Colorectal Cancer and the Goblets of Mucins: Effects of Hypersecreting Goblet Cells and Mucus Accumulation in disease Restricted Access
(Master thesis / Masteroppgave, 2020)
Transatlantic studies of mesopelagic ecosystems Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Oceanographic conditions in the Arctic are changing, with sea ice cover decreasing and sea temperatures increasing. Our understanding of the effects on marine populations in the area is, however, limited. ...
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Genomic imprinting regulates parent‐specific transcript dosage during seed development and is mainly confined to the endosperm. Elucidation of the function of many imprinted genes has been hampered by the lack of corresponding ...
(Master thesis / Masteroppgave, 2020)
Ecosystems all over the world are affected by climate change, and especially so high latitude and altitude ecosystems. One consequence of global warming in Norway is an upward shift in the mountain birch forest line. A ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Prolonged exposure to bullying behaviors may give rise to symptoms such as anxiety, depression and chronic pain. Earlier data suggest that these symptoms often are associated with stress-induced low-grade systemic inflammation. ...
Effekter av eksponering for bisfenol A på juvenil torsk (Gadus morhua) Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Yersinia ruckeri causes enteric redmouth disease (ERM) that mainly affects salmonid fishes and leads to significant economic losses in the aquaculture industry. An increasing number of outbreaks and the lack of effective ...
(Doctoral thesis / Doktoravhandling, 2020)
The food we eat can have a huge environmental impact. Steaks, tomatoes and bread are typically farmed and transported using fossil resources, while nutrients are lost and much of the product is wasted on its way to our ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Fossil sequences provide observations of phenotypes within a lineage over time and represent essential data for increasing our understanding of phyletic evolution beyond microevolutionary timescales. I investigate if fossil ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Understanding the biological processes involved in genetic differentiation and divergence between populations within species is a pivotal aim in evolutionary biology. One particular phenomenon that requires clarification ...
(Master thesis / Masteroppgave, 2020)
Character displacement has been a process discussed by biologist ever since Darwin visited the Galapagos in the 19th century. Similar species occurring together will sometimes diverge in characters to avoid hybridization ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Yersinia pestis is transmitted from fleas to rodents when the bacterium develops an extensive biofilm in the foregut of a flea, starving it into a feeding frenzy, or, alternatively, during a brief period directly after ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Factor VII activating protease (FSAP) is a circulating serine protease implicated in thrombosis, atherosclerosis, stroke, and cancer. Using an overexpression strategy, we have systematically investigated the role of protease ...
(Master thesis / Masteroppgave, 2020)
(Chapter / Bokkapittel / PublishedVersion; Peer reviewed, 2020)
The SpyCatcher-SpyTag system was developed seven years ago as a method for protein ligation. It is based on a modified domain from a Streptococcus pyogenes surface protein (SpyCatcher), which recognizes a cognate 13-amino-acid ...