Browsing Farmasøytisk institutt by Title
Now showing items 1489-1508 of 1934
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Abstract HER2 is a predictive biomarker for HER2-targeted therapeutics. For antibody–drug conjugates (ADCs; e.g., trastuzumab emtansine (T-DM1)), HER2 is utilized as a transport gate for cytotoxic agents into the cell. ADC ...
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(Master thesis / Hovedoppgave, 2003)Smalkjempe, Plantaginis lanceolatae herba, ble ekstrahert med 80 % etanol. Råekstraktet i vann ble fraksjonert (LLE) med en serie løsemidler (eter, etylacetat og n-butanol). Dette ga 4 råfraksjoner (E, A, B og V), hvorav ...
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(Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)A serum test called T50 assesses the overall propensity for calcification of the blood and is associated with cardiovascular outcomes. We aimed to examine T50 over time in kidney transplant recipients and also address any ...
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(Master thesis / Masteroppgave, 2010)
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(Master thesis / Masteroppgave, 2018)Introduksjon: Halsbrann er et velkjent symptom for mange mennesker. World Gastroenterology Organisation rapporterer at mer enn én tredjedel av vestens befolkning opplever halsbrann og omtrent 10% er plaget daglig. For ...
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(Master thesis / Masteroppgave, 2013)With approximately 50% of tumours bearing mutations in the TP53 gene, the tumour suppressor p53 is one of the most frequently altered proteins in human cancer. In tumours retaining wild-type p53, other aberrations including ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3 docosapentaenoic acid were recently isolated from murine inflammatory exudates and human primary cells. These compounds belong to a distinct ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)The secretion of extracellular vesicles (EVs) is a common process in Gram-negative bacteria and can be exploited for biotechnological applications. EVs pose a self-adjuvanting, non-replicative vaccine platform, where ...
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(Master thesis / Hovedoppgave, 2007)Det finnes indikasjoner på at den reelle holdbarhetstiden til Fenylefrin 0,1 mg/ml injeksjonsvæske som produseres på Sykehusapoteket ved Rikshospitalet reelt sett er lengre enn dagens 6 måneder. Dersom holdbarhetstiden kan ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative ...
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(Doctoral thesis / Doktoravhandling, 2020)Legumain is an enzyme present in most cells but its dysregulation is associated with several diseases. During stem cell differentiation, legumain stimulates fat cell and inhibits osteoblast differentiation. This thesis ...
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(Doctoral thesis / Doktoravhandling, 2017)Exercise can prevent and treat metabolic diseases. This thesis aimed to study energy metabolism in cultured human myotubes from subjects with different metabolic profile and training status, and to study effects of an in ...
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(Doctoral thesis / Doktoravhandling, 2013)Obesity and type 2 diabetes (T2D) are associated with reduced metabolic flexibility and the development of these conditions are positively associated with dietary saturated fatty acids (e.g. palmitic acid) and negatively ...
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(Doctoral thesis / Doktoravhandling, 2022)Obesity and cancer are increasing world-wide health problems. Though healthy lifestyle choices such as a balanced diet and regular exercise are effective strategies to counter the disease risks, effective treatment and ...
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(Doctoral thesis / Doktoravhandling, 2015)The prevalence of type 2 diabetes (T2D) has increased worldwide during the last decades. Obesity and accumulation of lipids in skeletal muscles are strongly associated with T2D. Much focus has been on the possibility of ...
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(Master thesis / Masteroppgave, 2009)Diabetes is one of the world’s greatest health related concerns, and it affects more and more people every year. The objective of this thesis was to investigate the various effects that the synthetic glucocorticoid ...
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(Master thesis / Masteroppgave, 2008)Abstract HEK 293 cells were transfected with LGMN-plasmid encoding rat legumain, to establish a cell line transiently and/or stably expressing legumain. In addition, HEK 293 cells and a number of melanoma cell lines (from ...
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(Doctoral thesis / Doktoravhandling, 2014)The studies presented in this thesis aimed to investigate the regulation of the cysteine protease legumain in various human cells (paper I-IV), effects of statins (paper II and III) and a legumain-cleavable colchicine ...
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(Master thesis / Hovedoppgave, 2004)