Search
Now showing items 1-100 of 1920
(Doctoral thesis / Doktoravhandling, 2024)
Immunotherapy holds immense promise in treating cancer, yet its effectiveness remains limited in treating most solid tumors due to the presence of immunosuppressive tumor microenvironment (TME), notably M2 macrophages. In ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Background.
Trabecular bone score (TBS) is a new tool to assess trabecular bone microarchitecture based on standard dual-energy x-ray absorptiometry (DXA) of lumbar spine images. TBS may be important to assess bone ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Daphne mezereum L., an important medicinal plant in Scandinavian folk medicine, was used to treat ailments such as diarrhea, swelling and stomach pain. A range of natural compounds have been isolated, but little attention ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
The secretion of extracellular vesicles (EVs) is a common process in Gram-negative bacteria and can be exploited for biotechnological applications. EVs pose a self-adjuvanting, non-replicative vaccine platform, where ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
The increasing need for personalized drug delivery requires developing systems with tailorable properties. The copolymer poly(vinyl alcohol-co-vinyl acetate) (PVA/PVAc) allows for adjusting the monomer ratio. This study ...
(Doctoral thesis / Doktoravhandling, 2024)
There is extensive interindividual variability in drug response and tolerability. This is to a major extent caused by differences in the metabolic capacities of the enzymes CYP3A4 and CYP2D6, which are important in the ...
(Doctoral thesis / Doktoravhandling, 2024)
The aquaculture industry is an important producer of food sources worldwide. Continuous vaccine development is required in aquaculture as many pathogens, such as Gram-negative bacteria, pose infection risks. Examples are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Objectives This study aims to assess risk factors for SARS-CoV-2 infection by combined design; first comparing positive cases to negative controls as determined by PCR testing and then comparing these two groups to an ...
(Journal article / Tidsskriftartikkel / PublishedVersion, 2024)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Abstract Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Background and aims Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It is challenging and time-consuming for clinicians to assess whether symptoms are caused by the statin or not, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Background
Adverse pregnancy outcomes (APO) may unmask or exacerbate a woman’s underlying risk for coronary heart disease (CHD). We estimated associations of maternal and paternal genetically predicted ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Traditional Chinese Medicine (TCM) herbal products are increasingly used in Europe, but prevalent authentication methods have significant gaps in detection. In this study, three authentication methods were tested in a ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
This study explores the traditional knowledge of plants used by traditional health practitioners (THPs) in the treatment of symptoms or syndromes related to mental illnesses in the district of Bamako in Mali, along with ...
(Master thesis / Masteroppgave, 2023)
Risikoen for alvorlig covid-19 i Norge i perioden 2020-2021 Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Inflammasjon er en prosess som ikke har et forutbestemt utfall; den oppløses eller bli kronisk. Kronisk inflammasjon kan forårsake irreversible skader i vev, og sees i mange sykdommer, inkludert astma, revmatoid artritt ...
Utvikling og validering av begrensede prøvetakingsstrategier for digoksin og rosuvastatin Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Polyunsaturated fatty acids are metabolically converted into lipid mediators which play an important role in the regulation of several biological processes, including inflammation, resolution, and homeostasis. The ...
Effekter av krillolje på energimetabolisme i humane skjelettmuskelceller og leverceller Restricted Access
(Master thesis / Masteroppgave, 2023)
(Doctoral thesis / Doktoravhandling, 2023)
Neonatal and paediatric intensive care patients are in need of numerous intravenous (i.v.) drugs. The majority of drugs, including parenteral nutrition (PN) and buffered electrolyte solutions, used in the intensive care ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Introduction
The COVID-19 pandemic resulted in changes in prescription patterns and fillings for certain medications, but little is known about its impact on the dispensing of cardiovascular drugs.
Methods
Trends ...
(Doctoral thesis / Doktoravhandling, 2023)
The traditional use and poisonous properties of Aconitum species are mainly due to the presence of alkaloids, which have been extensively studied. However, limited attention has been paid to their low-toxic natural products. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Shotgun metagenome sequencing data obtained from a host environment will usually be contaminated with sequences from the host organism. Host sequences should be removed before further analysis ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Imaging of in vitro neuronal differentiation and measurements of cell morphologies have led to novel insights into neuronal development. Live-cell imaging techniques and large datasets of images ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
The objective of this study was to describe pregnancy- and birth-related experiences of postpartum women during the third wave of the COVID-19 pandemic and their association with mental health outcomes. An online questionnaire ...
(Doctoral thesis / Doktoravhandling, 2023)
Up to 80% of pregnant women experience nausea and vomiting during pregnancy (NVP). NVP has been shown to impact pregnant women’s life negatively. Early recognition and sufficient management are recommended to prevent ...
(Journal article / Tidsskriftartikkel / PublishedVersion, 2023)
Fecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers. Colorectal cancer (CRC) screening based on the fecal immunochemical test (FIT) is an ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Aim Children have largely been unaffected by severe COVID‐19 compared to adults, but data suggest that they may have experienced new conditions after developing the disease. We compared outcomes in children who ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Ethnopharmacological relevance
Gentiana purpurea was one of the most important medicinal plants in Norway during the 18th and 19th centuries, and the roots were used against different types of gastrointestinal and airway ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Treatment-resistant schizophrenia affects approximately 30% of individuals with the disorder. Clozapine is the medication of choice in treatment-resistant schizophrenia, but optimizing administration and dose ...
(Master thesis / Masteroppgave, 2023)
Sammendrag Bakgrunn Glioblastoma multiforme (GBM) er den mest maligne og aggressive tumorformen av gliomer i sentralnervesystemet. Denne kreftformen har svært dårlig prognose til tross for dagens standardbehandling, som ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Introduction Psychotic‐like experiences (PLE) have been associated with the subsequent emergence of psychotic disorders as well as several other domains of psychopathology. In this twin study, we estimated the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
In response to the World Health Organization's (WHO) call to develop alternative antibacterial methods, we investigate endogenous compounds and biopolymers. Lumichrome (LC) is an endogenous, lipophilic degradation product ...
(Master thesis / Masteroppgave, 2023)
Bakgrunn: Menyanthes trifoliata L., også kjent som bukkeblad, er en medisinplante som vokser i fuktige vannområder. Planten tilhører bukkebladfamilien (Menyanthaceae) og er kjent for å regulere appetitt samt stimulere ...
Glymphatic clearance in the Parkinson’s disease trajectory: periarterial and perivenous aquaporin-4 localization Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Tysbast (Daphne mezereum L.) er en giftig plante som tilhører tysbastfamilien, Thymelaeaceae. I Norge vokser tysbast i store deler av landet, unntatt Troms og Finnmark. Planten har spilt en viktig rolle i norsk trolldoms- ...
(Master thesis / Masteroppgave, 2023)
En rekke proteiner er viktige biomarkører som forekommer i biologiske matriks i svært lave konsentrasjoner. Det skaper en utfordring når Dried Blood Spot (DBS) benyttes som prøvetaking, ettersom et begrenset volum påsettes ...
(Doctoral thesis / Doktoravhandling, 2023)
Type 2 Diabetes Mellitus (T2DM) is on the rise due to our modern lifestyle. This condition disturbs our body's ability to handle insulin and affects not only the peripheral parts of our body but also our brain. In our ...
(Master thesis / Masteroppgave, 2023)
The use of doping in sport has increased for elite athletes and noncompetitive athletes to improve performance during practice and in competition. Growth hormone releasing hormones (GHRH) and their synthetic analogues are ...
(Master thesis / Masteroppgave, 2023)
Dried Blood Spots (DBS) har blitt brukt i nyfødtscreening i flere tiår. Den brukes også som en prøvetakingsteknikk innenfor detektering og kvantifisering av ulike sykdomsbiomarkører. Bestemmelse av proteiner fra DBS kan ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Hip fracture patients face a patient safety threat due to medication discrepancies and adverse drug reactions when they have a combination of high age, polypharmacy and several care transitions. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Rising environmental awareness drives green consumers to purchase sustainable cosmetics based on natural bioactive compounds. The aim of this study was to deliver Rosa canina L. extract as a botanical ingredient in an ...
(Master thesis / Masteroppgave, 2023)
Inflammasjon spiller en sentral rolle i mange kroniske sykdommer og den kan oppløses gjennom en aktiv prosess som krever samspill mellom en stor gruppe av endogene substanser som stammer fra flerumettede fettsyrer. Molekylene ...
(Master thesis / Masteroppgave, 2023)
(Doctoral thesis / Doktoravhandling, 2023)
To study the effect of medicines or identify use of narcotics, we must be able to measure trace amounts of chemical compounds in the body. Thanks to years of technological advancement and innovation in analytical chemistry, ...
(Doctoral thesis / Doktoravhandling, 2023)
The complex and costly process of drug development has traditionally relied on empirical methods and involved extensive, time-consuming trials in vivo, i.e., on living organisms. However, with our society’s heightened ...
Advancements in Filling Filament and direct powder 3D printing of pharmaceuticals with the purpose of personalized medicine Restricted Access
(Master thesis / Masteroppgave, 2023)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Replacing in vivo with in vitro studies can increase sustainability in the development of medicines. This principle has already been applied in the biowaiver approach based on the biopharmaceutical classification system, ...
(Master thesis / Masteroppgave, 2023)
Screening of liquid membranes for electromembrane extraction of peptides Restricted Access
(Master thesis / Masteroppgave, 2023)
LC-MS/MS determination of Growth Hormone Releasing Hormone Analogs in Dried Matrix Spots Restricted Access
(Master thesis / Masteroppgave, 2023)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background.
Short-term survival after kidney transplantation is excellent but long-term survival remains suboptimal. The aim of the study was to explore the relationship between soluble α-Klotho (sKlotho) and intact ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Aims The extensive variability in cytochrome P450 2D6 (CYP2D6) metabolism is mainly caused by genetic polymorphisms. However, there is large, unexplained variability in CYP2D6 metabolism within CYP2D6 genotype subgroups. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Dried blood spot samples are simple to prepare and transport, enabling safe andaccessible diagnostics, both locally and globally. We review dried blood spot sam-ples for clinical analysis, focusing on liquid chromatography-mass ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique, high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This LSEC scavenger function has been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Aims Atomoxetine is mainly metabolized by CYP2D6 while CYP2C19 plays a secondary role. It is known that patients carrying genotypes encoding decreased/absent CYP2D6 metabolism obtain higher atomoxetine concentrations and ...
(Master thesis / Masteroppgave, 2023)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract The association between antidepressant continuation during pregnancy and postpartum mental health in women with obsessive-compulsive disorder (OCD) is uncertain. We identified 1317 women with live-birth singleton ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background Early graft loss following kidney transplantation is mainly a result of acute rejection or surgical complications, while long-term kidney allograft loss is more complex. We examined the association between ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
The etiology of autism spectrum disorder (ASD) is multifactorial, involving genetic and environmental contributors such as endocrine-disrupting chemicals (EDCs).
Objective
To evaluate the association ...
(Doctoral thesis / Doktoravhandling, 2023)
Approximately 4 in 5 women use medication(s) during pregnancy. Yet, women also report concerns about the fetal safety of medications, as studies find associations between medication exposure before birth (i.e., prenatally) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract
Objectives
To investigate the effect of integrated medicines management provided to hospitalised multimorbid patients on the quality of drug treatment at discharge measured as the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was ...
Interactions in Aqueous Mixtures of Cationic Hydroxyethyl Cellulose and Different Anionic Bile Salts
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
It is known that the reduction of blood cholesterol can be accomplished through foods containing a large number of dietary fibers; this process is partially related to the binding of bile salt to fibers. To gain new insights ...
Effekt av β-laktamase hemmere på β-laktam resistens i Bacillus cereus. Ekspresjon av sink-homeostase genet zur som respons på forbindelsene APC148 og APC247 Restricted Access
(Master thesis / Masteroppgave, 2023)
Microglial activation in the trajectory of Parkinson's Disease Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Bakgrunn: Selv om legemidler er et gode og de helsemessige gevinster kan være store, er det dessverre negative aspekter rundt legemiddelbruk. Legemidler kan medføre legemiddelrelaterte problemer, som igjen kan resultere i ...
(Master thesis / Masteroppgave, 2023)
Organtransplantasjon har i flere tiår vært tilgjengelig som et behandlingsalternativ for barn med terminal organsvikt i Norge, hovedsakelig transplantasjoner av hjerte, nyrer og lever. For å unngå avstøtning av det ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Objective
To examine the potential influence of a ketogenic diet on serum concentrations of antiseizure medications (ASMs) in children with drug resistant epilepsy.
Methods
We investigated the serum concentrations ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Fungal β-glucans are compounds with the potential to activate the innate immune system, in part through binding to the receptor dectin-1. In the present study, small-scale methods for preparing dectin-1a binding microparticles ...
(Master thesis / Masteroppgave, 2023)
(Doctoral thesis / Doktoravhandling, 2023)
Can treatment with benzodiazepines and z-hypnotics during pregnancy affect the unborn child’s brain development? Benzodiazepines and z-hypnotics are medications mainly prescribed to treat anxiety disorders and insomnia. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Aconitum septentrionale is known to contain toxic diterpene alkaloids, while other bioactive compounds in the plant remain unclear. The aim of this study was to explore the phenolic compounds and polysaccharides ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative cleavage of crystalline polysaccharides such as cellulose and are crucial for the conversion of plant biomass in Nature and in industrial applications. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Child temperament traits and mothers' emotional symptoms relating to anxiety and depression may drive changes in one another, leading to their ‘co-development’ across time. Alternatively, links between mother ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
In order to solubilize poorly soluble active pharmaceutical ingredients, various strategies have been implemented over the years, including the use of nanocarriers, such as cyclodextrins and liposomes. However, improving ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Human liver tissue is composed of heterogeneous mixtures of different cell types and their cellular stoichiometry can provide information on hepatic physiology and disease progression. Deconvolution algorithms for the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Prenatal exposure to antiseizure medication (ASM) may lead to low plasma folate concentrations and is associated with impaired neurodevelopment.
Objectives
To examine whether maternal genetic liability ...
(Master thesis / Masteroppgave, 2023)
Hensikt Hensikten med studien var å kartlegge antibiotikavalg i behandlingen av pyelonefritt og urosepsis ved Sørlandet sykehus HF (SSHF) og undersøke hvor stor andel av pasientene som fikk behandling i tråd med nasjonal ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Introduction
Rosuvastatin pharmacokinetics is mainly dependent on the activity of hepatic uptake transporter OATP1B1. In this study, we aimed to investigate and disentangle the effect of Roux-en-Y gastric bypass (RYGB) ...
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Faktoriell undersøkelse av polymerdekkede liposomer for lokalbehandling av munnhulen Restricted Access
(Master thesis / Masteroppgave, 2023)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background: While adherence to cancer prevention recommendations is linked to lower risk of colorectal cancer (CRC), few have studied associations across the entire spectrum of colorectal carcinogenesis. Here, we studied ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Objective
To investigate the effect of an academic detailing intervention on the utilisation of type 2 diabetes medication among general practitioners.
Design
We developed an academic detailing campaign based on the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain development, leading to a continuum of neurodevelopmental difficulties. Recognizing the deficiency of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
In response to the growing ethical and environmental concerns associated with animal testing, numerous in vitro tools of varying complexity and biorelevance have been developed and adopted in pharmaceutical research and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background and Objective
Midazolam is the preferred clinical probe drug for assessing CYP3A activity. We have previously shown substantial intraindividual variability in midazolam absolute bioavailability and clearance ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Objective
Based on the principle of the autonomy of the patient, shared decision-making (SDM) is the ideal approach in clinical encounters. In SDM, patients and healthcare professionals (HCPs) share knowledge and power ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Studies assessing associations between prenatal exposure to antidepressants, maternal depression, and offspring DNA methylation (DNAm) have been inconsistent. Here, we investigated whether prenatal exposure to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Pharmacoepigenetic studies are important to understand the mechanisms through which medications influence the developing fetus. For instance, we and others have reported associations between prenatal paracetamol exposure ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Kidney transplant recipients (KTRs) experienced reduced SARS-CoV-2 vaccine response and were at increased risk of severe COVID-19. It is unknown if level of vaccine induced anti-receptor binding domain IgG ...