Background In older patients with polypharmacy and multiple comorbidities, even low grades of statin-associated muscle symptoms may have clinical implications. The aim of this study was therefore to ...

Background Noninvasive molecular imaging using peptides and biomolecules labelled with positron emitters has become important for detection of cancer and other diseases with PET (positron emission tomography). ...

Developmental exposure to neurotoxic insult is thought to be a contributory factor in the increasing incidence of neurodevelopmental disorders. Xenobiotic-mediated neurodevelopmental toxication can be a prolonged, subtle ...

Aims To investigate medication dose calculation errors and other numeracy mishaps in hospitals and examine mechanisms and enablers which lead to such errors. Design A retrospective study using descriptive statistics ...

Herein we report the first total synthesis of RvD2n-3 DPA, an endogenously formed mediator biosynthesized from the omega-3 fatty acid n-3 docosapentaenoic acid. The key steps are the Midland Alpine borane reduction, ...

In this article, the scientific literature on electromembrane extraction (EME) of polar substances (log P < 2) is reviewed. EME is an extraction technique based on electrokinetic migration of analyte ions from an aqueous ...

Background: Drugs commonly prescribed for heart rate control may induce adverse drug reactions in Alzheimer patients treated with acetylcholinesterase inhibitors (AChEIs). We have studied use of drugs with a known risk of ...

Current data on use of antihistamines during breastfeeding and risks to the breastfed infant are insufficient. The aim of this systematic review was to provide an overview of studies measuring the levels of antihistamines ...

Kidney transplant recipients (KTRs) experience increased risk of cardiovascular disease. Guidelines recommend HMG-CoA reductase inhibitor (statin) therapy when tolerated. We aimed to study changes in the prescription of ...

Parkinson’s disease (PD) is the second most abundant neurodegenerative disease and is characterized by -synuclein aggregation in spreading Lewy bodies (spreading from the brain stem to the neocortex corresponding to ...

Insight into the epidemiology of perinatal medication use during the COVID-19 pandemic is scarce. Therefore, a cross-sectional study using an anonymous web survey was performed in Ireland, Norway, Switzerland, The Netherlands, ...

There is a lack of compatibility data for intravenous therapy to neonatal intensive care unit (NICU) patients, and the purpose of this study was to contribute with documented physical compatibility data to ensure safe ...

Background A validated questionnaire to assess medication management of hip fracture patients within and outside the hospital setting was lacking. The study aims were to describe the hip fracture patient ...

Patient received a tenfold overdose with chemotherapy while in hospital’ was a recent headline in a Norwegian national newspaper, unfortunately not an isolated event. The procedure, treatment or medication that is supposed ...

Background Migrants in Norway bear a higher burden of COVID-19 infections and hospitalization as compared to non-migrants. The aim of our study was to understand how migrants perceive their own health risk, ...

Objective To investigate the effect of pharmacist-led inhaler technique assessment service on readmissions and CAT-score in hospitalized COPD patients. Furthermore, to provide an effect estimate for sample ...

Migraine is a headache disorder most commonly affecting women of childbearing age. Knowledge about patterns of use and safety of migraine medications during pregnancy is limited. Most previous research has focused on risks ...

CACNA1C and CACNA1D are voltage-gated calcium channel genes that have been repeatedly associated with psychiatric disorders by various genomic studies. These genes are involved in gene expression regulation, neurotransmitter ...

We explored glucometabolic and renal function after engraftment in all 159 consecutive patients with type 1 diabetes who received pancreas transplantation alone (PTA, n = 80) or simultaneous pancreas and kidney transplantation ...

Objective To determine the association between child attention-deficit/hyperactivity disorder (ADHD) and prenatal exposure to selective serotonin (SSRI) and serotonin-norepinephrine (SNRI) reuptake inhibitor antidepressants, ...

As pregnant women are at high risk of severe SARS-CoV-2 infection and COVID-19 vaccines are available in Switzerland, this study aimed to assess the willingness of Swiss pregnant and breastfeeding women to become vaccinated. ...

Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ...

Studies on PUFAs have been conducted to further investigate their health benefits. DHA has proven to be an activator of the BK channels in smooth muscle cells and therefore can lower the blood pressure. Initial studies ...

Recent research efforts focusing on the many mechanisms participating in the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators. These endogenous molecules include the lipoxins, ...

Aim Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular‐subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological ...

Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances (PFASs), brominated flame retardants (BFRs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are known to cause cancer, ...

Design and development of novel inorganic nanocarriers for encapsulation of natural antimicrobial substances for food packaging applications have received great interest during the last years. Natural nanoclays are the ...

Bakgrunn: Diabetes type 2 er en sykdom med en økende prevalens i verden. Sykdommen rammer mange organer i kroppen som bukspyttkjertel, lever, skjelettmuskulatur, nyrer, hjerne, tynntarm og fettvev. Insulinmangel og ...

Premature og kritisk syke nyfødte barn trenger ofte flere legemidler i tillegg til parenteral ernæring tilført kontinuerlig. Når disse skal administreres samtidig med få intravenøse innganger må disse administreres i samme ...

Abstract The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling ...

Bakgrunn: Angelica archangelica L., kvann, er en nordisk plante som tilhører skjermplantefamilien (Apiaceae). I Norge finnes det to underarter, strandkvann (Angelica archangelica subsp. litoralis) som vokser langs kysten ...

Abstract Persons with certain single nucleotide polymorphisms (SNPs) in the CACNA1D gene (encoding voltage-gated calcium channel subunit alpha 1-D) have increased risk of developing neuropsychiatric disorders such as ...

Background Patients are expected to participate in the hospital discharge process, assume self‐management after discharge and communicate relevant information to their general practitioner; however, patients report that ...

The bacterium Bacillus cereus is increasingly recognized as a major source of food-borne disease, as well as other severe infections. Biofilms are a common multicellular mode of growth, where bacteria can be protected ...

Background. Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach ...

Small cell lung cancer is an aggressive disease that requires early diagnosis to reduce patient mortality. Presently, there are two known biomarkers that are widely used for the detection and monitoring of small cell lung ...

Innledning: Multimorbiditet er i økende grad mer vanlig siden befolkningen blir eldre. Samtidig er det absolutte antallet av pasienter som lider av multimorbiditet høyere blant de som er yngre enn 65 år. Tilstanden kan ...

Introduksjon: Variasjon i legemiddelmetaboliserende enzymer er en viktig faktor med tanke på farmakokinetisk variabilitet. Cytokrom P450 (CYP) superfamilien står for metabolismen av omtrent 75% av alle legemidler som ...

Innledning Medisinske fremskritt og økt levealder bidrar til en økning i antall eldre multimorbide pasienter. Disse pasientene kjennetegnes et komplekst legemiddelregime hvor også fysiologiske og aldersrelaterte endringer ...

BACKGROUND. Methodology for estimation of cerebrospinal fluid (CSF) tracer clearance could have wide clinical application in predicting excretion of intrathecal drugs and metabolic solutes from brain metabolism and for ...

There is a worldwide concern on adverse health effects of dietary exposure to acrylamide (AA) due to its presence in commonly consumed foods. AA is formed when carbohydrate rich foods containing asparagine and reducing ...

Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care. Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to ...

Background Access to medicines information is important when treating patients, yet discrepancies in medication records are common. Many countries are developing shared medication lists across health care ...

Introduksjon: De siste årene har det blitt økt fokus på produksjon og tilgjengelighet av effektive og trygge legemidler for den pediatriske populasjonen. Ettersom Cytokrom P450 (CYP) 3A familien er av stor betydning når ...

‘Can I take this medication now that I am pregnant?’, is a question that many health care professionals have met during consultations with pregnant women. Between 60 and 96% of pregnant women use medications. Analgesics ...

Francisellosis in fish is caused by the facultative intracellular Gram-negative bacterial pathogens Francisella noatunensis ssp. noatunensis and Francisella orientalis. The disease is affecting both farmed and wild fish ...

Bakgrunn: Levealderen i samfunnet øker er assosiert med multimorbiditet. Pasienter som er multimorbide bruker ofte flere legemidler for å behandle de ulike sykdommene sine. Samtidig bruk av flere legemidler fører til høy ...

Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were used to explore the effects on developmental neurotoxicity by a complex defined mixture of persistent organic pollutants (POPs). Its ...

Melatonin is a key hormone involved in the photoperiodic signaling pathway. In both teleosts and mammals, melatonin produced in the pineal gland at night is released into the blood and cerebrospinal fluid, providing rhythmic ...

BAKGRUNN Det har vært interesse knyttet til bruken av antibiotika under covid-19-pandemien. I denne artikkelen presenterer vi forbruket av systemisk antibiotika i Norge i pandemiperioden. MATERIALE OG METODE Totalt ...

Bakgrunn: I 2020 utgjør innvandere omtrent 15% av befolkningen i Norge. Det kan være utfordrende for innvandrere å benytte helsetjenester i Norge fordi de møter en annen kultur, religion og språk enn det de er vant med. ...

Targeted delivery of antigen to antigen-presenting cells (APCs) enhances antigen presentation and thus, is a potent strategy for making more efficacious vaccines. This can be achieved by use of antibodies with specificity ...

Aims To study whether the preparation procedure, and its acidic and heating conditions, used by heroin users to prepare heroin for intravenous administration affects the final composition of the fluid to be injected. ...

Aims: The aim of this study was two-fold: i) to describe factors associated with antithyroid drug (ATD) treatmentduring gestation among women with hyperthyroidism in pregnancy, ii) to investigate the impact of ATDtreatment ...

Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state ...

Væskefase-mikroekstraksjon i 96-brønnsformat (96-brønns LPME) er en prøveopparbeidelsesmetode som ble introdusert i 2013. Formatet består av en donorplate, akseptorplate med PVDF-membranfilter i bunnen av hver brønn og en ...

Norwegian health survey data (1987–2003) were analyzed to determine if binge drinking increases the risk of incident major events from ischemic heart disease (IHD) and stroke. Among current drinkers reporting average alcohol ...

Purpose: Handgrip strength is an indicator of frailty and longevity in older adults. The association between psychotropic drug use and handgrip strength in older hospitalized patients was investigated in this study. Methods: ...

It remains uncertain whether pharmacokinetic changes following Roux-en-Y gastric bypass (RYGB) can be attributed to surgery-induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to ...

Objective β-cell replacement therapy (βCRT), including pancreas transplantation alone (PTA) and islet transplantation (ITX), is a treatment option for selected type 1 diabetes patients. All potential candidates for βCRT ...

E-prescribing is now widespread and, in some countries, has completely replaced paper prescriptions. In Norway, almost all prescribing is electronic, except for multidose drug dispensing (MDD), which is still sent to the ...

Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or formulations for local administration in the oral cavity due ...

Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following ...

When patented, brand-name antibiotics lose market exclusivity, generics typically enter the market at lower prices, which may increase consumption of the drug. To examine the effect of generic market entry on antibiotic ...

Purpose To estimate the association between Attention-Deficit/Hyperactivity Disorder (ADHD) in children in preschool and primary school, and prenatal exposure to non-steroidal anti-inflammatory drugs (NSAIDs) by timing ...

The rheological changes that occur during the chemical gelation of semidilute solutions of chitosan in the presence of the low-toxicity agent glyceraldehyde (GCA) are presented and discussed in detail. The entanglement ...

Aims Maternal antithyroid drug (ATD) use during pregnancy has been associated with an increased risk of birth defects in offspring. Uncertainty remains on the size of this risk and how it compares to untreated hyperthyroidism ...

The COVID-19 pandemic may be of particular concern for pregnant and breastfeeding women. We aimed to explore their beliefs about the coronavirus and COVID-19 vaccine willingness and to assess the impact of the pandemic on ...

When used during pregnancy, analgesics and psychotropics pass the placenta to enter the foetal circulation and may induce epigenetic modifications. Where such modifications occur and whether they disrupt normal foetal ...

Objective: The identification of potential risk factors for disease severity is of great importance in the treatment of multiple sclerosis. The influence of socioeconomic status on progression in multiple sclerosis (MS) ...

Biological samples such as blood and urine are extensively used for measuring different chemicals in the human (or animal) body, for example pharmaceutical drugs, drugs-of-abuse, or different metabolites. In addition to ...

Unresolved inflammation causes tissue damage and, eventually, underlies the development of chronic inflammatory diseases. The resolution phase of inflammation is a multifaceted and dynamic process regulated by bioactive ...

In many perinatal pharmacoepidemiologic studies, exposure to a medication is classified as “ever exposed” versus “never exposed” within each trimester or even over the entire pregnancy. This approach is often far from ...

Cancer is an important cause of childhood mortality, yet the etiology is largely unknown. A combination of pre- and postnatal factors is thought to be implicated, including maternal medication use. We aimed to provide: 1) ...

Aims: The aim of the study was two-fold: i) to determine the prevalence of medical care contact for infertility in European countries; ii) to map overall and long-term/chronic medication use during pregnancy in women who ...

Alzheimer’s disease (AD) is the most common cause of dementia. Globally, AD is among the 7 leading cause of death and significant affect the quality of life for the individuals affected and their relatives (World Health ...

Background Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness ...

Bakgrunn: Hypericum maculatum (firkantperikum) er en flerårig urt med utbredelse over store deler av Europa. Planten har lang tradisjon som medisinplante, og sammenlignes ofte med Hypericum perforatum (prikkperikum) som ...

Background Even with global efforts to prevent medication errors, they still occur and cause patient harm. Little systematic research has been done in Norway to address this issue. Objectives To describe the frequency, ...

Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting ...

Introduction Barcode medication administration (BCMA) can, if poorly implemented, cause disrupted workflow, increased workload and cause medication errors. Further exploration is needed of the causes of BCMA policy ...

In the present work, a pair of molecularly imprinted polymers (MIPs) targeting distinct peptide targets were packed into trap columns and combined for automated duplex analysis of two low abundant small cell lung cancer ...

Persistent organic pollutants (POPs) can reach the fetal brain and contribute to developmental neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken embryos to a POP mixture, containing ...