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Association between statin use and physical performance in home-dwelling older patients receiving polypharmacy: cross-sectional study 
Veddeng, Sigbjørn; Madland, Håkon; Molden, Espen; Wyller, Torgeir B.; Romskaug, Rita (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background In older patients with polypharmacy and multiple comorbidities, even low grades of statin-associated muscle symptoms may have clinical implications. The aim of this study was therefore to ...
A new automated and putatively versatile synthesis of the PSMA-ligand derivative [18F]DCFPyL using the FASTlabTM synthesizer 
Hoareau, Raphaël; Bach-Gansmo, Tore; Cumming, Paul; Olberg, Dag E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Noninvasive molecular imaging using peptides and biomolecules labelled with positron emitters has become important for detection of cancer and other diseases with PET (positron emission tomography). ...
In vitro models and methods for assessment of developmental neurotoxicity and neuroprotection 
Labba, Nils-Anders (Doctoral thesis / Doktoravhandling, 2022)
Developmental exposure to neurotoxic insult is thought to be a contributory factor in the increasing incidence of neurodevelopmental disorders. Xenobiotic-mediated neurodevelopmental toxication can be a prolonged, subtle ...
Medication dose calculation errors and other numeracy mishaps in hospitals: Analysis of the nature and enablers of incident reports 
Mulac, Alma; Hagesæther, Ellen; Granås, Anne Gerd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Aims To investigate medication dose calculation errors and other numeracy mishaps in hospitals and examine mechanisms and enablers which lead to such errors. Design A retrospective study using descriptive statistics ...
Stereoselective Synthesis, Configurational Assignment and Biological Evaluations of the Lipid Mediator RvD2n-3 DPA 
Reinertsen, Amalie Føreid; Primdahl, Karoline Gangestad; De Matteis, Roberta; Dalli, Jesmond; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Herein we report the first total synthesis of RvD2n-3 DPA, an endogenously formed mediator biosynthesized from the omega-3 fatty acid n-3 docosapentaenoic acid. The key steps are the Midland Alpine borane reduction, ...
Electromembrane extraction of polar substances – Status and perspectives 
Eie, Linda Vårdal; Pedersen-Bjergaard, Stig; Hansen, Frederik Andre (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
In this article, the scientific literature on electromembrane extraction (EME) of polar substances (log P < 2) is reviewed. EME is an extraction technique based on electrokinetic migration of analyte ions from an aqueous ...
Use of Drugs With Risk of Heart Rate-Related Problems is Common in Norwegian Dementia Patients Treated With Acetylcholinesterase Inhibitors: A Prevalence Study Based on the Norwegian Prescription Database 
Efjestad, Anne Sverdrup; Ihle-Hansen, Hege; Hjellvik, Vidar; Engedal, Knut; Blix, Hege Salvesen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background: Drugs commonly prescribed for heart rate control may induce adverse drug reactions in Alzheimer patients treated with acetylcholinesterase inhibitors (AChEIs). We have studied use of drugs with a known risk of ...
Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans: A systematic literature review 
Ngo, Elin Thuy Phuong; Spigset, Olav; Lupattelli, Angela; Panchaud, Alice; Annaert, Pieter; Allegaert, Karel; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Current data on use of antihistamines during breastfeeding and risks to the breastfed infant are insufficient. The aim of this systematic review was to provide an overview of studies measuring the levels of antihistamines ...
Use of Statins in Kidney Transplant Recipients in Norway 
Rønning, Marit; Hjellvik, Vidar; Sakshaug, Solveig; Blix, Hege Salvesen; Midtvedt, Karsten; Reisæter, Anna Varberg; Holdaas, Hallvard; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Kidney transplant recipients (KTRs) experience increased risk of cardiovascular disease. Guidelines recommend HMG-CoA reductase inhibitor (statin) therapy when tolerated. We aimed to study changes in the prescription of ...
The Glymphatic System in Parkinson's Disease Restricted Access
Seferi, Gezime (Master thesis / Masteroppgave, 2022)
Parkinson’s disease (PD) is the second most abundant neurodegenerative disease and is characterized by -synuclein aggregation in spreading Lewy bodies (spreading from the brain stem to the neocortex corresponding to ...
Self-Reported Medication Use among Pregnant and Breastfeeding Women during the COVID-19 Pandemic: A Cross-Sectional Study in Five European Countries 
Ceulemans, Michael; Foulon, Veerle; Panchaud, Alice; Winterfeld, Ursula; Pomar, Léo; Lambelet, Valentine; Cleary, Brian; O’Shaughnessy, Fergal; Passier, Anneke; Richardson, Jonathan Luke; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Insight into the epidemiology of perinatal medication use during the COVID-19 pandemic is scarce. Therefore, a cross-sectional study using an anonymous web survey was performed in Ireland, Norway, Switzerland, The Netherlands, ...
Co-administration of drugs with parenteral nutrition in the neonatal intensive care unit—physical compatibility between three components 
Nilsson, Niklas; Storesund, Ingebjørg; Tho, Ingunn; Nezvalova-Henriksen, Katerina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
There is a lack of compatibility data for intravenous therapy to neonatal intensive care unit (NICU) patients, and the purpose of this study was to contribute with documented physical compatibility data to ensure safe ...
Development and initial validation of MedHipPro-Q: a questionnaire assessing medication management of hip fracture patients in different care settings 
Henriksen, Ben T.; Andersson, Yvonne; Davies, Maren N.; Mathiesen, Liv; Krogseth, Maria; Andersen, Randi D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background A validated questionnaire to assess medication management of hip fracture patients within and outside the hospital setting was lacking. The study aims were to describe the hip fracture patient ...
Medication errors in hospitals: Exploring medication safety through incident reports and observation of practice 
Mulac, Alma (Doctoral thesis / Doktoravhandling, 2022)
Patient received a tenfold overdose with chemotherapy while in hospital’ was a recent headline in a Norwegian national newspaper, unfortunately not an isolated event. The procedure, treatment or medication that is supposed ...
COVID-19: information access, trust and adherence to health advice among migrants in Norway 
Madar, Ahmed A.; Benavente, Pierina; Czapka, Elżbieta; Herrero-Arias, Raquel; Haj-Younes, Jasmin; Hasha, Wegdan; Deeb, George; Møen, Kathy A.; Ortiz-Barreda, Gaby; Diaz, Esperanza (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Migrants in Norway bear a higher burden of COVID-19 infections and hospitalization as compared to non-migrants. The aim of our study was to understand how migrants perceive their own health risk, ...
Effect of pharmacist-led inhaler technique assessment service on readmissions in hospitalized COPD patients: a randomized, controlled pilot study 
Kebede, Adyam T.; Trapnes, Elin; Lea, Marianne; Abrahamsen, Bjørg; Mathiesen, Liv (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective To investigate the effect of pharmacist-led inhaler technique assessment service on readmissions and CAT-score in hospitalized COPD patients. Furthermore, to provide an effect estimate for sample ...
Migraine pharmacotherapy during pregnancy: Utilization patterns and associations with child neurodevelopment 
Harris, Gerd Marie Eskerud (Doctoral thesis / Doktoravhandling, 2022)
Migraine is a headache disorder most commonly affecting women of childbearing age. Knowledge about patterns of use and safety of migraine medications during pregnancy is limited. Most previous research has focused on risks ...
Functional analysis of psychiatric risk genes in zebrafish (Danio rerio): a focus on the L-type voltage-gated calcium channel subtypes CaV1.2 and CaV1.3 
Banono, Nancy Saana (Doctoral thesis / Doktoravhandling, 2021)
CACNA1C and CACNA1D are voltage-gated calcium channel genes that have been repeatedly associated with psychiatric disorders by various genomic studies. These genes are involved in gene expression regulation, neurotransmitter ...
Insulin secretion and action after pancreas transplantation. A retrospective single-center study 
Bleskestad, Kristiane Birkeland; Nordheim, Espen; Lindahl, Jørn Petter Hanto; Midtvedt, Karsten; Pihlstrøm, Hege Kampen; Horneland, Rune; Lee-Ødegård, Sindre; Åsberg, Anders; Jenssen, Trond Geir; Birkeland, Kåre Inge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
We explored glucometabolic and renal function after engraftment in all 159 consecutive patients with type 1 diabetes who received pancreas transplantation alone (PTA, n = 80) or simultaneous pancreas and kidney transplantation ...
Attention-Deficit/Hyperactivity Disorder in Children Following Prenatal Exposure to Antidepressants: results from the Norwegian Mother, Father and Child Cohort Study 
Lupattelli, Angela; Mahic, Milada; Handal, Marte; Ystrøm, Eivind; Reichborn-Kjennerud, Ted; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective To determine the association between child attention-deficit/hyperactivity disorder (ADHD) and prenatal exposure to selective serotonin (SSRI) and serotonin-norepinephrine (SNRI) reuptake inhibitor antidepressants, ...
Sars-cov-2 vaccine willingness among pregnant and breastfeeding women during the first pandemic wave: A cross-sectional study in Switzerland 
Stuckelberger, Sarah; Favre, Guillaume; Ceulemans, Michael; Nordeng, Hedvig Marie Egeland; Gerbier, Eva; Lambelet, Valentine; Stojanov, Milos; Winterfeld, Ursula; Baud, David; Panchaud, Alice; Pomar, Léo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
As pregnant women are at high risk of severe SARS-CoV-2 infection and COVID-19 vaccines are available in Switzerland, this study aimed to assess the willingness of Swiss pregnant and breastfeeding women to become vaccinated. ...
Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro 
Berntsen, Hanne Friis; Duale, Nur; Bjørklund, Cesilie Granum; Rangel-Huerta, Oscar Daniel; Dyrberg, Kine; Hofer, Tim; Rakkestad, Kirsten Eline; Østby, Gunn Charlotte; Halsne, Ruth; Boge, Gudrun Seeberg; Paulsen, Ragnhild Elisabeth; Myhre, Oddvar; Ropstad, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ...
Initial studies towards new activators of the BK channel 
Askari, Lawin (Master thesis / Masteroppgave, 2021)
Studies on PUFAs have been conducted to further investigate their health benefits. DHA has proven to be an activator of the BK channels in smooth muscle cells and therefore can lower the blood pressure. Initial studies ...
Stereoselective syntheses and biological activities of E-series resolvins 
Vik, Anders; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Recent research efforts focusing on the many mechanisms participating in the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators. These endogenous molecules include the lipoxins, ...
L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1 
Lambertus, Marvin; Øverberg, Linda Thøring; Andersson, Krister Andreas; Hjelden, Malin Sørli; Hadzic, Alena; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Geiseler, Samuel; Morland, Cecilie (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Aim Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular‐subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological ...
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation 
Davidsen, Nichlas; Lauvås, Anna Jacobsen; Myhre, Oddvar; Ropstad, Erik; Carpi, Donatella; Mendoza-de Gyves, Emilio; Berntsen, Hanne Friis; Dirven, Hubert; Paulsen, Ragnhild Elisabeth; Bal-Price, Anna; Pistollato, Francesca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances (PFASs), brominated flame retardants (BFRs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are known to cause cancer, ...
Inorganic Nanocarriers for Encapsulation of Natural Antimicrobial Compounds for Potential Food Packaging Application: A Comparative Study 
Gulin-Sarfraz, Tina; Kalantzopoulos, Georgios N.; Pettersen, Marit Kvalvåg; Åsli, Anette Wold; Tho, Ingunn; Axelsson, Lars Torsten; Sarfraz, Jawad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Design and development of novel inorganic nanocarriers for encapsulation of natural antimicrobial substances for food packaging applications have received great interest during the last years. Natural nanoclays are the ...
Effekter av FKBP51-hemmeren SAFit2 på glukoseopptak i skjelettmuskelceller og fettceller 
Maricic, Stefan (Master thesis / Masteroppgave, 2021)
Bakgrunn: Diabetes type 2 er en sykdom med en økende prevalens i verden. Sykdommen rammer mange organer i kroppen som bukspyttkjertel, lever, skjelettmuskulatur, nyrer, hjerne, tynntarm og fettvev. Insulinmangel og ...
Forlikelighet av legemidler og TPN gitt som parallellinfusjon til premature og nyfødte - Hyppig brukte legemidler ved nyfødtintensivavdelinger og fysikalske forlikelighetstester av utvalgte kombinasjoner Restricted Access
Holm, Tone Huseby (Master thesis / Masteroppgave, 2021)
Premature og kritisk syke nyfødte barn trenger ofte flere legemidler i tillegg til parenteral ernæring tilført kontinuerlig. Når disse skal administreres samtidig med få intravenøse innganger må disse administreres i samme ...
Overview of CAPICE-Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network 
Rajula, Hema Sekhar Reddy; Manchia, Mirko; Agarwal, Kratika; Akingbuwa, Wonuola A.; Allegrini, Andrea G.; Diemer, Elizabeth; Doering, Sabrina; Haan, Elis; Jami, Eshim S.; Karhunen, Ville; Leone, Marica; Schellhas, Laura; Thompson, Ashley; Van den Berg, Stéphanie M.; Bergen, Sarah E.; Kuja-Halkola, Ralf; Hammerschlag, Anke R.; Järvelin, Marjo-Riitta; Leval, Amy; Lichtenstein, Paul; Lundstrom, Sebastian; Mauri, Matteo; Munafò, Marcus R.; Myers, David; Plomin, Robert; Rimfeld, Kaili; Tiemeier, Henning; Ystrøm, Eivind; Fanos, Vassilios; Bartels, Meike; Middeldorp, Christel M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling ...
Beslutningsvansker hos gravide kvinner ved bruk av antidepressiva under svangerskapet – en miks metode studie Restricted Access
Younas, Iram (Master thesis / Masteroppgave, 2021)
Struktur-og aktivitetsstudier av isolerte polysakkarider fra strandkvann (Angelica archangelica subsp. litoralis) og fjellkvann (Angelica archangelica subsp. archangelica) 
Esam, Nabila (Master thesis / Masteroppgave, 2021)
Bakgrunn: Angelica archangelica L., kvann, er en nordisk plante som tilhører skjermplantefamilien (Apiaceae). I Norge finnes det to underarter, strandkvann (Angelica archangelica subsp. litoralis) som vokser langs kysten ...
Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? 
Banono, Nancy Saana; Gawel, Kinga Aurelia; De Witte, Linus; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Persons with certain single nucleotide polymorphisms (SNPs) in the CACNA1D gene (encoding voltage-gated calcium channel subunit alpha 1-D) have increased risk of developing neuropsychiatric disorders such as ...
Discharge processes and medicines communication from the patient perspective: A qualitative study at an internal medicines ward in Norway 
Rognan, Stine; Kälvemark Sporrong, Sofia; Bengtsson, Kajsa; Lie, Helene Berg; Andersson, Yvonne; Mowe, Morten; Mathiesen, Liv (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Patients are expected to participate in the hospital discharge process, assume self‐management after discharge and communicate relevant information to their general practitioner; however, patients report that ...
Cellular signaling and molecular regulation governing motility, biofilm formation, and virulence in the Bacillus cereus group 
Smith, Veronika (Doctoral thesis / Doktoravhandling, 2021)
The bacterium Bacillus cereus is increasingly recognized as a major source of food-borne disease, as well as other severe infections. Biofilms are a common multicellular mode of growth, where bacteria can be protected ...
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? 
Onsøien, Mari Olsen; Midtvedt, Karsten; Reisæter, Anna Varberg; Aasarød, Knut; Waldum-Grevbo, Bård; Vikse, Bjørn Egil; Eriksen, Bjørn Odvar; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background. Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach ...
Molecularly Imprinted Polymers for the Analysis of Small Cell Lung Cancer Biomarkers by Liquid Chromatography-Tandem Mass Spectrometry 
McKitterick, Nicholas (Doctoral thesis / Doktoravhandling, 2021)
Small cell lung cancer is an aggressive disease that requires early diagnosis to reduce patient mortality. Presently, there are two known biomarkers that are widely used for the detection and monitoring of small cell lung ...
Effekt av farmasøytintervensjon på potensiell uhensiktsmessig forskrivning hos multimorbide pasienter ≤ 65 år 
Syversen, Malin Olsen (Master thesis / Masteroppgave, 2021)
Innledning: Multimorbiditet er i økende grad mer vanlig siden befolkningen blir eldre. Samtidig er det absolutte antallet av pasienter som lider av multimorbiditet høyere blant de som er yngre enn 65 år. Tilstanden kan ...
Development of a method for in vitro investigation of CYP3A activity in human liver microsomes 
Fjell, Vilde (Master thesis / Masteroppgave, 2021)
Introduksjon: Variasjon i legemiddelmetaboliserende enzymer er en viktig faktor med tanke på farmakokinetisk variabilitet. Cytokrom P450 (CYP) superfamilien står for metabolismen av omtrent 75% av alle legemidler som ...
Effekt av farmasøytintervensjon på kvaliteten av legemiddelbehandlingen hos multimorbide pasienter >65 år - Effekt vurdert etter START-2/STOPP-2 verktøyet 
Shah, Sarah Farhin (Master thesis / Masteroppgave, 2021)
Innledning Medisinske fremskritt og økt levealder bidrar til en økning i antall eldre multimorbide pasienter. Disse pasientene kjennetegnes et komplekst legemiddelregime hvor også fysiologiske og aldersrelaterte endringer ...
Development of a population pharmacokinetic model describing enterohepatic circulation based on total concentrations of mycophenolic acid and its inactive glucuronide metabolite 
Kongsvik, Rebecca Irene (Master thesis / Masteroppgave, 2021)
Clinical application of intrathecal gadobutrol for assessment ofcerebrospinal fluid tracer clearance to blood 
Eide, Per Kristian; Mariussen, Espen; Uggerud, Hilde Thelle; Pripp, Are Hugo; Lashkarivand, Aslan; Hassel, Bjørnar; Christensen, Hege Staaland; Hovd, Markus Herberg; Ringstad, Geir Andre (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
BACKGROUND. Methodology for estimation of cerebrospinal fluid (CSF) tracer clearance could have wide clinical application in predicting excretion of intrathecal drugs and metabolic solutes from brain metabolism and for ...
Kitosanbaserte vaginale filmer med faste lipidnanopartikler: fremstilling og karakterisering 
Yan, Jiaen (Master thesis / Masteroppgave, 2021)
Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps 
Lindeman, Birgitte; Johansson, Ylva; Andreassen, Mathilda; Husøy, Trine; Dirven, Hubert; Hofer, Tim; Knutsen, Helle Katrine; Caspersen, Ida Henriette; Vejrup, Kristine; Paulsen, Ragnhild Elisabeth; Alexander, Jan; Forsby, Anna; Myhre, Oddvar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
There is a worldwide concern on adverse health effects of dietary exposure to acrylamide (AA) due to its presence in commonly consumed foods. AA is formed when carbohydrate rich foods containing asparagine and reducing ...
A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: A randomized controlled trial 
Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Fjeld, Katrine Gahre; Hove, Lene Hystad; Malterud, Karl Egil; Saghaug, Elisabeth; Slaaen, Joran; Sundal, Tone; Tollisen, Anita; Lerdal, Anners (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care. Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to ...
Implementation of a shared medication list in primary care – a controlled pre-post study of medication discrepancies 
Josendal, Anette V.; Bergmo, Trine S.; Granas, Anne G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Access to medicines information is important when treating patients, yet discrepancies in medication records are common. Many countries are developing shared medication lists across health care ...
CYP3A activity in the pediatric population 
Herlofsen, Tine Marie (Master thesis / Masteroppgave, 2021)
Introduksjon: De siste årene har det blitt økt fokus på produksjon og tilgjengelighet av effektive og trygge legemidler for den pediatriske populasjonen. Ettersom Cytokrom P450 (CYP) 3A familien er av stor betydning når ...
Childhood outcomes after prenatal exposure to analgesics or antibiotics 
Hjorth, Sarah (Doctoral thesis / Doktoravhandling, 2021)
‘Can I take this medication now that I am pregnant?’, is a question that many health care professionals have met during consultations with pregnant women. Between 60 and 96% of pregnant women use medications. Analgesics ...
The Use of Extracellular Membrane Vesicles for Immunization against Francisellosis in Nile Tilapia (Oreochromis niloticus) and Atlantic cod (Gadus morhua L.) 
Mertes, Verena; Kashulin, Alexander; Lagos, Leidy; Ciani, Elia; Colquhoun, Duncan John; Haslene-Hox, Hanne; Sletta, Håvard; Sørum, Henning; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Francisellosis in fish is caused by the facultative intracellular Gram-negative bacterial pathogens Francisella noatunensis ssp. noatunensis and Francisella orientalis. The disease is affecting both farmed and wild fish ...
Crosstalk between skeletal muscle and liver cells Restricted Access
Ahmed, Waqar (Master thesis / Masteroppgave, 2021)
Vil en klinisk farmasøyt i teamet som jobber etter IMM-modellen gjøre kvaliteten i legemiddellisten i epikrisen bedre? 
Nguyen, Tram Bich Michelle (Master thesis / Masteroppgave, 2021)
Bakgrunn: Levealderen i samfunnet øker er assosiert med multimorbiditet. Pasienter som er multimorbide bruker ofte flere legemidler for å behandle de ulike sykdommene sine. Samtidig bruk av flere legemidler fører til høy ...
En kvalitativ studie om kompatibilitet av legemidler og parenteral ernæring brukt ved Barne- og ungdomsklinikken ved Haukeland Universitetssjukehus: Fokusgruppeintervju med vaktfarmasøyter Restricted Access
Katana, Vanja (Master thesis / Masteroppgave, 2021)
Studie av ulike væskemembraner til elektromembran ekstraksjon av polare basiske stoffer 
Tirandaz, Shima (Master thesis / Masteroppgave, 2021)
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro 
Yadav, Ajay; Verhaegen, Steven; Verbruggen, Evelien; Kerhoas, Marie; Huiberts, Eva Henriëtte Willemijn; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Paulsen, Ragnhild Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were used to explore the effects on developmental neurotoxicity by a complex defined mixture of persistent organic pollutants (POPs). Its ...
Effects of Melatonin on Anterior Pituitary Plasticity: A Comparison Between Mammals and Teleosts 
Ciani, Elia; Haug, Trude M; Maugars, Gersende Marie Aimee; Weltzien, Finn-Arne; Falcón, Jack; Fontaine, Romain (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Melatonin is a key hormone involved in the photoperiodic signaling pathway. In both teleosts and mammals, melatonin produced in the pineal gland at night is released into the blood and cerebrospinal fluid, providing rhythmic ...
Bruk av antibiotika under covid-19-pandemien 
Blix, Hege Salvesen; Høye, Sigurd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
BAKGRUNN Det har vært interesse knyttet til bruken av antibiotika under covid-19-pandemien. I denne artikkelen presenterer vi forbruket av systemisk antibiotika i Norge i pandemiperioden. MATERIALE OG METODE Totalt ...
Språkbarrierer mellom apotekansatte og innvandrere - Kartlegging av behov for kommunikasjonsverktøy med metoden Design Thinking Restricted Access
Nguyen, Nhu Nhu (Master thesis / Masteroppgave, 2021)
Bakgrunn: I 2020 utgjør innvandere omtrent 15% av befolkningen i Norge. Det kan være utfordrende for innvandrere å benytte helsetjenester i Norge fordi de møter en annen kultur, religion og språk enn det de er vant med. ...
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses 
Høydahl, Lene; Frigstad, Terje; Rasmussen, Ingunn B; Øynebråten, Inger; Schjetne, Karoline W; Andersen, Jan Terje; Michaelsen, Terje Einar; Lunde, Elin; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Targeted delivery of antigen to antigen-presenting cells (APCs) enhances antigen presentation and thus, is a potent strategy for making more efficacious vaccines. This can be achieved by use of antibodies with specificity ...
Does the preparation for intravenous administration affect the composition of heroin injections? A controlled laboratory study 
Andersen, Jannike Mørch; Bogen, Inger Lise; Brochmann, Gerd-Wenche; Mørland, Jørg Gustav; Vindenes, Vigdis; Boix Escolan, Fernando (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Aims To study whether the preparation procedure, and its acidic and heating conditions, used by heroin users to prepare heroin for intravenous administration affects the final composition of the fluid to be injected. ...
Antithyroid drug treatment and pregnancy outcomes among women with hyperthyroidism in pregnancy: A norwegian population-based registry-linkage study 
El Khalil, Nebghouha; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Aims: The aim of this study was two-fold: i) to describe factors associated with antithyroid drug (ATD) treatmentduring gestation among women with hyperthyroidism in pregnancy, ii) to investigate the impact of ATDtreatment ...
Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion 
Kissi, Eric Ofosu; Nilsson, Robin; Nogueira, Liebert Parreiras; Larsson, Anette; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state ...
Væskefase-mikroekstraksjon med dype eutektiske løsemidler 
Tran, Kim Tu Thi (Master thesis / Masteroppgave, 2021)
Væskefase-mikroekstraksjon i 96-brønnsformat (96-brønns LPME) er en prøveopparbeidelsesmetode som ble introdusert i 2013. Formatet består av en donorplate, akseptorplate med PVDF-membranfilter i bunnen av hver brønn og en ...
Associations of Binge Drinking With the Risks of Ischemic Heart Disease and Stroke: A Study of Pooled Norwegian Health Surveys 
Degerud, Eirik Magnus Meek; Høiseth, Gudrun; Mørland, Jørg; Ariansen, Inger Kristine Holtermann; Graff-Iversen, Sidsel; Ystrøm, Eivind; Zuccolo, Luisa; Tell, Grethe S.; Næss, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Norwegian health survey data (1987–2003) were analyzed to determine if binge drinking increases the risk of incident major events from ischemic heart disease (IHD) and stroke. Among current drinkers reporting average alcohol ...
«Går dette sammen?» Hvordan løses kompatibilitetsproblemer mellom intravenøse legemidler og parenteral ernæring på Nyfødtintensiv ved Barne- og ungdomsklinikken, Haukeland universitetssjukehus? En kvalitativ studie basert på flere metoder Restricted Access
Stojkovic, Slavisa (Master thesis / Masteroppgave, 2021)
Evaluating the influence of UWL and its composition on permeability profiling of two model drugs Restricted Access
Randelov, Elizabeta (Master thesis / Masteroppgave, 2021)
Electromembrane extraction of peptides using deep eutectic solvents as liquid membranes 
Martinovic, Gordana (Master thesis / Masteroppgave, 2021)
Association between psychotropic drug use and handgrip strength in older hospitalized patients 
Sandvik, Miriam Kristine; Watne, Leiv; Brugård, Anniken; Wang-Hansen, Marte Sofie; Kersten, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Purpose: Handgrip strength is an indicator of frailty and longevity in older adults. The association between psychotropic drug use and handgrip strength in older hospitalized patients was investigated in this study. Methods: ...
Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity – a non-randomized three-armed controlled trial 
Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege Staaland; Krogstad, Veronica; Wegler, Christine; Angeles, Philip Carlo Soriano; Wollmann, Birgit Malene Tovik; Hole, Kristine; Sandbu, Rune; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran; Jansson-Löfmark, Rasmus; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
It remains uncertain whether pharmacokinetic changes following Roux-en-Y gastric bypass (RYGB) can be attributed to surgery-induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to ...
Patient selection for islet or solid organ pancreas transplantation: experiences from a multidisciplinary outpatient-clinic approach 
Nordheim, Espen; Lindahl, Jørn Petter Hanto; Carlsen, Rasmus Kirkeskov; Åsberg, Anders; Birkeland, Kåre I.; Horneland, Rune; Boye, Birgitte; Scholz, Hanne; Jenssen, Trond Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective β-cell replacement therapy (βCRT), including pancreas transplantation alone (PTA) and islet transplantation (ITX), is a treatment option for selected type 1 diabetes patients. All potential candidates for βCRT ...
From Paper to E-Prescribing of Multidose Drug Dispensing: A Qualitative Study of Workflow in a Community Care Setting 
Jøsendal, Anette Vik; Bergmo, Trine Strand (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
E-prescribing is now widespread and, in some countries, has completely replaced paper prescriptions. In Norway, almost all prescribing is electronic, except for multidose drug dispensing (MDD), which is still sent to the ...
Interactions of natural deep eutectic solvents (NADES) with artificial and natural membranes 
Nystedt, Helene Liepelt; Grønlien, Krister Gjestvang; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or formulations for local administration in the oral cavity due ...
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding 
Amundsen, Siri; Nordeng, Hedvig; Nordeng, Hedvig Marie Egeland; Fuskevåg, Ole Martin; Nordmo, Elisabet; Nordmo, Elisabet N; Sager, Georg; Spigset, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following ...
The effect of generic market entry on antibiotic prescriptions in the United States 
Kållberg, Cecilia Birgit Maria; Hudson, Jemma; Blix, Hege Salvesen; Årdal, Christine Oline; Klein, E; Lindbæk, Morten; Outterson, Kevin; Røttingen, John-Arne; Laxminarayan, Ramanan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
When patented, brand-name antibiotics lose market exclusivity, generics typically enter the market at lower prices, which may increase consumption of the drug. To examine the effect of generic market entry on antibiotic ...
Prenatal Exposure to Non-Steroidal Anti-Inflammatory Drugs and Risk of Attention-Deficit/Hyperactivity Disorder - a Follow-Up Study in the Norwegian Mother, Father and Child Cohort 
Andersen, Sarah Hjorth; Lupattelli, Angela; Handal, Marte; Spigset, Olav; Ystrøm, Eivind; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Purpose To estimate the association between Attention-Deficit/Hyperactivity Disorder (ADHD) in children in preschool and primary school, and prenatal exposure to non-steroidal anti-inflammatory drugs (NSAIDs) by timing ...
Novel Inhibitors of Fibroblast Activation Protein Restricted Access
Esmailkhel, Nawid (Master thesis / Masteroppgave, 2021)
Glyceraldehyde as an Efficient Chemical Crosslinker Agent for the Formation of Chitosan Hydrogels 
Carmona, Pierre; Tasici, Anca M.; Sande, Sverre Arne; Knudsen, Kenneth Dahl; Nyström, Bo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The rheological changes that occur during the chemical gelation of semidilute solutions of chitosan in the presence of the low-toxicity agent glyceraldehyde (GCA) are presented and discussed in detail. The entanglement ...
Antithyroid drug use during pregnancy and the risk of birth defects in offspring: systematic review and meta-analysis of observational studies with methodological considerations 
Morales, Daniel R.; Fonkwen, Lionel; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Aims Maternal antithyroid drug (ATD) use during pregnancy has been associated with an increased risk of birth defects in offspring. Uncertainty remains on the size of this risk and how it compares to untreated hyperthyroidism ...
Vaccine Willingness and Impact of the COVID-19 Pandemic on Women’s Perinatal Experiences and Practices - A Multinational, Cross-Sectional Study Covering the First Wave of the Pandemic 
Ceulemans, Michael; Foulon, Veerle; Panchaud, Alice; Winterfeld, Ursula; Pomar, Léo; Lambelet, Valentine; Cleary, Brian; O’Shaughnessy, Fergal; Passier, Anneke; Richardson, Jonathan L.; Allegaert, Karel; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The COVID-19 pandemic may be of particular concern for pregnant and breastfeeding women. We aimed to explore their beliefs about the coronavirus and COVID-19 vaccine willingness and to assess the impact of the pandemic on ...
3D printing: Development of hollow shell containers for direct powder printing of Pharmaceutical tablets Restricted Access
Nguyen, Hung Trung (Master thesis / Masteroppgave, 2021)
Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies 
Olstad, Emilie Willoch; Nordeng, Hedvig Marie Egeland; Gervin, Kristina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
When used during pregnancy, analgesics and psychotropics pass the placenta to enter the foetal circulation and may induce epigenetic modifications. Where such modifications occur and whether they disrupt normal foetal ...
Maternal education has significant influence on progression in multiple sclerosis 
Flemmen, Heidi Øyen; Simonsen, Cecilia Smith; Broch, Line; Brunborg, Cathrine; Berg-Hansen, Pål; Moen, Stine Marit; Kersten, Hege; Celius, Elisabeth Gulowsen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective: The identification of potential risk factors for disease severity is of great importance in the treatment of multiple sclerosis. The influence of socioeconomic status on progression in multiple sclerosis (MS) ...
Electromembrane extraction of polar pharmaceutical bases and endogenous metabolites 
Hansen, Frederik André (Doctoral thesis / Doktoravhandling, 2021)
Biological samples such as blood and urine are extensively used for measuring different chemicals in the human (or animal) body, for example pharmaceutical drugs, drugs-of-abuse, or different metabolites. In addition to ...
Synthetic Efforts Towards benzo-RvD1n-3 DPA Restricted Access
Mahammed, Najma Mahamud (Master thesis / Masteroppgave, 2021)
Unresolved inflammation causes tissue damage and, eventually, underlies the development of chronic inflammatory diseases. The resolution phase of inflammation is a multifaceted and dynamic process regulated by bioactive ...
Synthesis and development of stable mimics of 8,9-epoxyeicosatrienoic acid Restricted Access
Mohammad, Rawand Salam (Master thesis / Masteroppgave, 2021)
Longitudinal Methods for Modeling Exposures in Pharmacoepidemiologic Studies in Pregnancy 
Wood, Mollie; Lupattelli, Angela; Palmsten, Kristin; Bandoli, Gretchen; Hurault-Delarue, Caroline; Damase-Michel, Christine; Chambers, Christina D.; Nordeng, Hedvig Marie Egeland; van Gelder, Marleen M.H.J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
In many perinatal pharmacoepidemiologic studies, exposure to a medication is classified as “ever exposed” versus “never exposed” within each trimester or even over the entire pregnancy. This approach is often far from ...
Maternal Medication Use and Childhood Cancer in Offspring - Systematic Review and Considerations for Researchers 
Andersen, Sarah Hjorth; Hemmingsen, Caroline H.; Bénévent, Justine; Broe, Anne; Pottegaard, Anton; Mørch, Lina S.; Leinonen, Maarit K.; Kjaer, Susanne K.; Hargreave, Marie; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Cancer is an important cause of childhood mortality, yet the etiology is largely unknown. A combination of pre- and postnatal factors is thought to be implicated, including maternal medication use. We aimed to provide: 1) ...
Medical care contact for infertility and related medication use during pregnancy – a european, cross-sectional web-based study 
Ilic, Miljana; Nordeng, Hedvig Marie Egeland; Lupattelli, Angela (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Aims: The aim of the study was two-fold: i) to determine the prevalence of medical care contact for infertility in European countries; ii) to map overall and long-term/chronic medication use during pregnancy in women who ...
Microglia activation and Lipid droplet pathology in animal models of type 2 diabetes and Alzheimer’s disease 
Havik, Mona (Master thesis / Masteroppgave, 2021)
Alzheimer’s disease (AD) is the most common cause of dementia. Globally, AD is among the 7 leading cause of death and significant affect the quality of life for the individuals affected and their relatives (World Health ...
Undersøkelse av takrolimusindusert tremor hos nyretransplanterte pasienter Restricted Access
Ellefsen, Benedicte (Master thesis / Masteroppgave, 2021)
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants 
Kværner, Ane S.; Birkeland, Einar; Bucher-Johannessen, Cecilie; Vinberg, Elina; Nordby, Jan I.; Kangas, Harri; Bemanian, Vahid; Ellonen, Pekka; Botteri, Edoardo; Natvig, Erik; Rognes, Torbjørn; Hovig, Eivind; Lyle, Robert; Ambur, Ole H.; de Vos, Willem M.; Bultman, Scott; Hjartåker, Anette; Landberg, Rikard; Song, Mingyang; Blix, Hege S.; Ursin, Giske; Randel, Kristin R.; de Lange, Thomas; Hoff, Geir; Holme, Øyvind; Berstad, Paula; Rounge, Trine B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness ...
Biologisk effekt og karakterisering av polyfenoler fra Hypericum maculatum 
Ali, Hafsa (Master thesis / Masteroppgave, 2021)
Bakgrunn: Hypericum maculatum (firkantperikum) er en flerårig urt med utbredelse over store deler av Europa. Planten har lang tradisjon som medisinplante, og sammenlignes ofte med Hypericum perforatum (prikkperikum) som ...
Fundamental investigations in paper based smart sampling - Can streptavidin act as an anchor for biotinylated monoclonal antibodies? Restricted Access
Anam Ul Haq, Anam Ul Haq (Master thesis / Masteroppgave, 2021)
Nanoparticulate systems for hydration of dry mucous membranes and protection of teeth Restricted Access
Vasilic, Danijela (Master thesis / Masteroppgave, 2021)
Interactions in Aqueous Mixtures of Cationic Hydroxyethyl Cellulose and Oppositely Charged Bile Salts – Potential Systems for Pharmaceutical Applications 
Tan, Julia Jianwei (Master thesis / Masteroppgave, 2021)
Severe and fatal medication errors in hospitals: findings from the Norwegian Incident Reporting System 
Mulac, Alma; Taxis, Katja; Hagesæther, Ellen; Granås, Anne Gerd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Even with global efforts to prevent medication errors, they still occur and cause patient harm. Little systematic research has been done in Norway to address this issue. Objectives To describe the frequency, ...
Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding 
Bjørk, Marte-Helene; Kristoffersen, Espen Saxhaug; Tronvik, Erling Andreas; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting ...
Barcode medication administration technology use in hospital practice: a mixed-methods observational study of policy deviations 
Mulac, Alma; Mathiesen, Liv; Taxis, Katja; Granås, Anne Gerd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Introduction Barcode medication administration (BCMA) can, if poorly implemented, cause disrupted workflow, increased workload and cause medication errors. Further exploration is needed of the causes of BCMA policy ...
Studies on the cysteine protease legumain in the central nervous system during neuroinflammation 
Christiansen, Cathrine Lilleheil (Master thesis / Masteroppgave, 2021)
On-line duplex molecularly imprinted solid-phase extraction for analysis of low-abundant biomarkers in human serum by liquid chromatography-tandem mass spectrometry 
McKitterick, Nicholas; Bicak, Tugrul Cem; Switnicka-Plak, Magdalena; Cormack, Peter A. G.; Reubsaet, Leon; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
In the present work, a pair of molecularly imprinted polymers (MIPs) targeting distinct peptide targets were packed into trap columns and combined for automated duplex analysis of two low abundant small cell lung cancer ...
Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure 
Yadav, Ajay; Verhaegen, Steven; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Berg, Vidar; Lyche, Jan Ludvig; Sabaredzovic, Azemira; Haug, Line Småstuen; Myhre, Oddvar; Zimmer, Karin Elisabeth; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Boix, Fernando (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Persistent organic pollutants (POPs) can reach the fetal brain and contribute to developmental neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken embryos to a POP mixture, containing ...
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