| dc.date.accessioned | 2022-10-14T12:18:34Z | |
| dc.date.available | 2022-10-14T12:18:34Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | http://hdl.handle.net/10852/97240 | |
| dc.description.abstract | Affective lability entails rapid, excessive and unpredictable changes between different affective states. The overall aim of the thesis was to provide new insight into the characteristics and correlates of affective lability in psychotic disorders. This was explored in three cross-sectional studies which are part of the ongoing Thematically Organized Psychosis research study at the Norwegian Centre for Mental Disorders Research. The studies found that affective lability was higher in psychotic disorders compared to healthy controls, and that it was associated with increased symptom burden. Affective lability was highest in bipolar II disorder and equally high in bipolar I disorder and schizophrenia. Affective fluctuations between anxiety-depression and depression-elation were most prominent in all diagnostic groups and no differences between the dispersions of affective lability were found. Also, elevated affective lability in the anxiety-depression domain was associated with reduced social functioning. Collectively, the results suggest that there should be increased focus on assessment and treatment of affective lability in clinical practice with patients with psychotic disorders. | en_US |
| dc.language.iso | en | en_US |
| dc.relation.haspart | Study I. Affective lability across psychosis spectrum disorders. Høegh, M.C., Melle, I., Aminoff, S.R., Laskemoen, J.F., Büchmann, C.B., Ueland, T., Lagerberg, T.V. (2020). European Psychiatry, 63(1), e53, 1–8. DOI: 10.1192/j.eurpsy.2020.44. The article is included in the thesis. Also available at: https://doi.org/10.1192/j.eurpsy.2020.44 | |
| dc.relation.haspart | Study II. Characterization of affective lability across subgroups of psychosis spectrum disorders. Høegh, M.C., Melle, I., Aminoff, S.R., Haatveit, B., Olsen, S.H., Huflåtten, I.B., Ueland, T., Lagerberg, T.V. (2021). International Journal of Bipolar Disorders, 9:34. DOI: 10.1186/s40345-021-00238-0. The article is included in the thesis. Also available at: https://doi.org/10.1186/s40345-021-00238-0 | |
| dc.relation.haspart | Study III. Affective lability and social functioning in severe mental disorders. Høegh, M.C., Melle, I., Aminoff, S.R., Olsen, S.H., Lunding, S.H., Ueland, T., Lagerberg. T.V. (2022). European Archives of Psychiatry and Clinical Neuroscience, DOI: 10.1007/s00406-022-01380-1. The article is included in the thesis. Also available at: https://doi.org/10.1007/s00406-022-01380-1 | |
| dc.relation.uri | https://doi.org/10.1192/j.eurpsy.2020.44 | |
| dc.relation.uri | https://doi.org/10.1186/s40345-021-00238-0 | |
| dc.relation.uri | https://doi.org/10.1007/s00406-022-01380-1 | |
| dc.title | Affective lability in psychosis spectrum disorders: characteristics and correlates | en_US |
| dc.type | Doctoral thesis | en_US |
| dc.creator.author | Høegh, Margrethe Collier | |
| dc.type.document | Doktoravhandling | en_US |