Abstract
Dental implants have achieved a great success in replacing missing teeth. However, biologic complications are still an occurring problem. Various types of surface modifications of implants have been used to improve implant integration and peri-implant healing, such as various types of surface coatings. Polyphenols are a group of naturally occurring compounds with antioxidant and anti-inflammatory properties. Polyphenolic surface coatings have recently been developed and investigated, aiming towards an improved wound healing and implant integration. In this study, surface coatings containing the polyphenolic molecules tannic acid and pyrogallol with varying pH values are used. The antioxidant capacity of coated titanium surfaces is investigated using the ABTS radical scavenging assay. In addition, the capacity of reducing ROS in human gingival fibroblasts is also qualitatively tested using confocal imaging microscopy. The obtained results show radical scavenging capacity of tannic acid and pyrogallol, in addition to capability of reducing ROS in human gingival fibroblasts. Tannic acid coating with pH 6.8 was a more effective antioxidant in solutions and more effective at inhibiting ROS in human gingival fibroblasts compared to pH 7.8 and pyrogallol coatings.