Clinical aspects and potential biomarkers in dry mouth and dry eye disease
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- Det odontologiske fakultet [1561]
Abstract
Dry mouth and dry eyes are common findings, especially in subjects on multiple medications. Primary Sjögren's syndrome (pSS) also causes dry mouth and dry eyes, and radiotherapy due to head and neck cancer (HNC) is known to lead to dry mouth. The aims of this thesis were to investigate possible relationships between dry mouth and dry eyes, evaluate clinical outcomes and explore saliva and tear biomarkers. The studies included HNC patients treated with radiotherapy, young elderly subjects and patients with pSS. The studies demonstrated a previously non-identified connection between dry mouth and dry eyes in both HNC and young elderly subjects. As expected, HNC patients were severely bothered by dry mouth, but symptoms of dry eyes were common in both groups. Differentially expressed cytokines, metabolites and proteins were identified in HNC and pSS patients. Overall, the findings underline the need for cooperation between various health professions. Moreover, detailed investigations of saliva and tears may improve the understanding of disease mechanisms behind dry mouth and dry eyes, hopefully leading to better patient care in the future.List of papers
Paper I. Westgaard KL, Hynne H, Amdal CD, Young A, Singh PB, Chen X, Rykke M, Hove LH, Aqrawi LA, Utheim TP, Herlofson BB, Jensen JL. Oral and ocular late effects in head and neck cancer patients treated with radiotherapy. Sci Rep. 2021 Feb 17;11(1):4026. DOI: 10.1038/s41598-021-83635-w. The article is included in the thesis. Also available at: https://doi.org/10.1038/s41598-021-83635-w |
Paper II. Aqrawi LA, Chen X, Hynne H, Amdal C, Reppe S, Aass HCD, Rykke M, Hove LH, Young A, Herlofson BB, Westgaard KL, Utheim TP, Galtung HK, Jensen JL. Cytokines explored in saliva and tears from radiated cancer patients correlate with clinical manifestations, influencing important immunoregulatory cellular pathways. Cells. 2020 Sep 8;9(9):2050. DOI: 10.3390/cells9092050. The article is included in the thesis. Also available at: https://doi.org/10.3390/cells9092050 |
Paper III. Hynne H, Tashbayev B, Diep, MT, Sødal ATT, Badian RA, Chen X, Lai X, Utheim TP, Hove LH, Jensen JL. The relationship between ocular and oral dryness in a cohort from the 65-year-old population in Norway. Sci Rep 12, 9805 (2022). DOI: 10.1038/s41598-022-13985-6. The article is included in the thesis. Also available at: https://doi.org/10.1038/s41598-022-13985-6 |
Paper IV. Hynne H, Sandås EM, Elgstøen KBP, Rootwelt H, Utheim TP, Galtung HK, Jensen JL. Saliva metabolomics in dry mouth patients with head and neck cancer or Sjögren’s syndrome. Cells. 2022 Jan 19: 11(3):323. DOI: 10.3390/cells11030323. The article is included in the thesis. Also available at: https://doi.org/10.3390/cells11030323 |
Paper V. Hynne H, Aqrawi LA, Jensen JL, Thiede B, Palm Ø, Amdal C, Westgaard KL, Herlofson BB, Utheim TP, Galtung KH. Proteomic profiling of saliva and tears in radiated head-andneck cancer patients as compared to primary Sjögren’s syndrome patients. Int. J. Mol. Sci. 2022, 23(7), 3714. DOI: 10.3390/ijms23073714. The article is included in the thesis. Also available at: https://doi.org/10.3390/ijms23073714 |