Cardiovascular disease risk across psychosocial and genetic factors in severe mental disorders
Metadata
Show metadataAppears in the following Collection
- Institutt for klinisk medisin [10751]
Abstract
The aim of the thesis was to increase knowledge about cardiovascular disease (CVD) in severe mental disorders (SMDs). We examined the level of CVD risk factors during the past decade in patients with schizophrenia and bipolar disorder. We also assessed whether loneliness shares a genetic basis with SMDs and CVD. Finally, we investigated genetic overlap between bipolar disorder and CVD. The level of CVD risk factors was higher in patients with schizophrenia and bipolar disorder compared to controls and the general population. There was no reduction in CVD risk factors in schizophrenia during the past decade, while modest improvements were seen in bipolar disorder. Further, a substantial part of the genetic architecture of loneliness appears to influence SMDs and CVD. There was also extensive bidirectional genic overlap between bipolar disorder and CVD risk. The results indicate that CVD risk has remained high in schizophrenia with moderate improvements in bipolar disorder the last decade. The genetic discoveries provide novel insights into the shared genetic underpinnings of SMDs, loneliness and CVD.List of papers
Study I: Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Linn Rødevand L, Nils Eiel Steen, Torbjørn Elvsåshagen T, Daniel S. Quintana, Elina J. Reponen, Ragni H. Mørch, Synve H. Lunding, Trude S. J. Vedal, Ingrid Dieset, Ingrid Melle, Trine V. Lagerberg, Ole A. Andreassen. Acta Psychiatrica Scandinavia (2019); 139(4): 348-360. DOI: 10.1111/acps.13008. The article is included in the thesis. Also available at: https://doi.org/10.1111/acps.13008 |
Study II: Polygenic overlap and shared genetic loci between loneliness, severe mental disorders and cardiovascular disease risk factors suggest shared molecular mechanisms. Linn Rødevand, Shahram Bahrami, Oleksandr Frei, Aihua Lin, Osman Gani , Alexey Shadrin, Olav B. Smeland, Kevin S. O’Connell, Torbjørn Elvsåshagen, Adriano Winterton, Daniel S. Quintana, Guy F. L. Hindley, Maren C. F. Werner, Srdjan Djurovic, Anders M. Dale, Trine V. Lagerberg, Nils Eiel Steen, Ole A. Andreassen. Translational Psychiatry (2021); 11(1): 3. DOI: 10.1038/s41398-020-01142-4. The article is included in the thesis. Also available at: https://doi.org/10.1038/s41398-020-01142-4 |
Study III: Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes. Linn Rødevand, Shahram Bahrami, Oleksandr Frei, Yunhan Chu, Alexey Shadrin, Kevin S. O’Connell, Olav B. Smeland, Torbjørn Elvsåshagen, Guy F. L. Hindley, Srdjan Djurovic, Anders M. Dale, Trine V. Lagerberg, Nils Eiel Steen, Ole A. Andreassen. Translational Psychiatry (2021) July 23; 11(1):407. DOI: 10.1038/s41398-021-01527-z. The paper (author version) is included in the thesis. Published version is available at: https://doi.org/10.1038/s41398-021-01527-z |